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Analysis of Yeast Killer Toxin K1 Precursor Processing via Site-Directed Mutagenesis: Implications for Toxicity and Immunity.

Gier S, Schmitt MJ, Breinig F.

mSphere. 2020 Feb 12;5(1). pii: e00979-19. doi: 10.1128/mSphere.00979-19.


Saccharomyces cerevisiae: First Steps to a Suitable Model System To Study the Function and Intracellular Transport of Human Kidney Anion Exchanger 1.

Sarder HAM, Li X, Funaya C, Cordat E, Schmitt MJ, Becker B.

mSphere. 2020 Jan 29;5(1). pii: e00802-19. doi: 10.1128/mSphere.00802-19.


Yeast Viral Killer Toxin K1 Induces Specific Host Cell Adaptions via Intrinsic Selection Pressure.

Gier S, Simon M, Gasparoni G, Khalifa S, Schulz MH, Schmitt MJ, Breinig F.

Appl Environ Microbiol. 2020 Feb 3;86(4). pii: e02446-19. doi: 10.1128/AEM.02446-19. Print 2020 Feb 3.


Targeted delivery of functionalized PLGA nanoparticles to macrophages by complexation with the yeast Saccharomyces cerevisiae.

Kiefer R, Jurisic M, Dahlem C, Koch M, Schmitt MJ, Kiemer AK, Schneider M, Breinig F.

Biotechnol Bioeng. 2020 Mar;117(3):776-788. doi: 10.1002/bit.27226. Epub 2019 Nov 28.


Substitution of cysteines in the yeast viral killer toxin K1 precursor reveals novel insights in heterodimer formation and immunity.

Gier S, Lermen M, Schmitt MJ, Breinig F.

Sci Rep. 2019 Sep 11;9(1):13127. doi: 10.1038/s41598-019-49621-z.


Transcriptomics of a KDELR1 knockout cell line reveals modulated cell adhesion properties.

Blum A, Khalifa S, Nordström K, Simon M, Schulz MH, Schmitt MJ.

Sci Rep. 2019 Jul 23;9(1):10611. doi: 10.1038/s41598-019-47027-5.


Transcriptome Kinetics of Saccharomyces cerevisiae in Response to Viral Killer Toxin K1.

Gier S, Simon M, Nordström K, Khalifa S, Schulz MH, Schmitt MJ, Breinig F.

Front Microbiol. 2019 May 16;10:1102. doi: 10.3389/fmicb.2019.01102. eCollection 2019.


Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.

Serresi M, Siteur B, Hulsman D, Company C, Schmitt MJ, Lieftink C, Morris B, Cesaroni M, Proost N, Beijersbergen RL, van Lohuizen M, Gargiulo G.

J Exp Med. 2018 Dec 3;215(12):3115-3135. doi: 10.1084/jem.20180801. Epub 2018 Nov 28.


Cherenkov detector analysis for implosions with multiple nuclear reactions.

Zylstra AB, Herrmann HW, Kim YH, Meaney K, Geppert-Kleinrath H, Schmitt MJ, Hoffman NM, Leatherland A, Gales S.

Rev Sci Instrum. 2018 Oct;89(10):10I103. doi: 10.1063/1.5038901.


Diffusion-dominated mixing in moderate convergence implosions.

Zylstra AB, Hoffman NM, Herrmann HW, Schmitt MJ, Kim YH, Meaney K, Leatherland A, Gales S, Forrest C, Glebov VY, Schoff M, Hoppe M, Ravelo N.

Phys Rev E. 2018 Jun;97(6-1):061201. doi: 10.1103/PhysRevE.97.061201.


Correction: Becker, B. et al. Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing.

Becker B, Schmitt MJ.

Toxins (Basel). 2018 Mar 23;10(4). pii: E132. doi: 10.3390/toxins10040132. No abstract available.


Production of fluorescent and cytotoxic K28 killer toxin variants through high cell density fermentation of recombinant Pichia pastoris.

Giesselmann E, Becker B, Schmitt MJ.

Microb Cell Fact. 2017 Dec 19;16(1):228. doi: 10.1186/s12934-017-0844-0.


Maturation and cytokine pattern of human dendritic cells in response to different yeasts.

Bazan SB, Walch-Rückheim B, Schmitt MJ, Breinig F.

Med Microbiol Immunol. 2018 Feb;207(1):75-81. doi: 10.1007/s00430-017-0528-8. Epub 2017 Nov 21.


Yeast Killer Toxin K28: Biology and Unique Strategy of Host Cell Intoxication and Killing.

Becker B, Schmitt MJ.

Toxins (Basel). 2017 Oct 20;9(10). pii: E333. doi: 10.3390/toxins9100333. Review. Erratum in: Toxins (Basel). 2018 Mar 23;10 (4):.


Primary T cells for mRNA-mediated immunotoxin delivery.

Eggers R, Philippi A, Altmeyer MO, Breinig F, Schmitt MJ.

Gene Ther. 2018 Jan;25(1):47-53. doi: 10.1038/gt.2017.87. Epub 2017 Sep 22.


Simultaneous measurement of the HT and DT fusion burn histories in inertial fusion implosions.

Zylstra AB, Herrmann HW, Kim YH, McEvoy AM, Schmitt MJ, Hale G, Forrest C, Glebov VY, Stoeckl C.

Rev Sci Instrum. 2017 May;88(5):053504. doi: 10.1063/1.4983923.


Cysteine residues in a yeast viral A/B toxin crucially control host cell killing via pH-triggered disulfide rearrangements.

Suzuki Y, Schwartz SL, Mueller NC, Schmitt MJ.

Mol Biol Cell. 2017 Apr 15;28(8):1123-1131. doi: 10.1091/mbc.E16-12-0842. Epub 2017 Feb 22.


Yeast Reporter Assay to Identify Cellular Components of Ricin Toxin A Chain Trafficking.

Becker B, Schnöder T, Schmitt MJ.

Toxins (Basel). 2016 Dec 6;8(12). pii: E366.


H/KDEL receptors mediate host cell intoxication by a viral A/B toxin in yeast.

Becker B, Blum A, Gießelmann E, Dausend J, Rammo D, Müller NC, Tschacksch E, Steimer M, Spindler J, Becherer U, Rettig J, Breinig F, Schmitt MJ.

Sci Rep. 2016 Aug 5;6:31105. doi: 10.1038/srep31105.


Demonstration of Fuel Hot-Spot Pressure in Excess of 50 Gbar for Direct-Drive, Layered Deuterium-Tritium Implosions on OMEGA.

Regan SP, Goncharov VN, Igumenshchev IV, Sangster TC, Betti R, Bose A, Boehly TR, Bonino MJ, Campbell EM, Cao D, Collins TJ, Craxton RS, Davis AK, Delettrez JA, Edgell DH, Epstein R, Forrest CJ, Frenje JA, Froula DH, Gatu Johnson M, Glebov VY, Harding DR, Hohenberger M, Hu SX, Jacobs-Perkins D, Janezic R, Karasik M, Keck RL, Kelly JH, Kessler TJ, Knauer JP, Kosc TZ, Loucks SJ, Marozas JA, Marshall FJ, McCrory RL, McKenty PW, Meyerhofer DD, Michel DT, Myatt JF, Obenschain SP, Petrasso RD, Radha PB, Rice B, Rosenberg MJ, Schmitt AJ, Schmitt MJ, Seka W, Shmayda WT, Shoup MJ, Shvydky A, Skupsky S, Solodov AA, Stoeckl C, Theobald W, Ulreich J, Wittman MD, Woo KM, Yaakobi B, Zuegel JD.

Phys Rev Lett. 2016 Jul 8;117(2):025001. doi: 10.1103/PhysRevLett.117.025001. Epub 2016 Jul 7. Erratum in: Phys Rev Lett. 2016 Jul 29;117(5):059903.


Low Fuel Convergence Path to Direct-Drive Fusion Ignition.

Molvig K, Schmitt MJ, Albright BJ, Dodd ES, Hoffman NM, McCall GH, Ramsey SD.

Phys Rev Lett. 2016 Jun 24;116(25):255003. doi: 10.1103/PhysRevLett.116.255003. Epub 2016 Jun 24.


Cargo binding promotes KDEL receptor clustering at the mammalian cell surface.

Becker B, Shaebani MR, Rammo D, Bubel T, Santen L, Schmitt MJ.

Sci Rep. 2016 Jun 29;6:28940. doi: 10.1038/srep28940.


How Victim Sensitivity leads to Uncooperative Behavior via Expectancies of Injustice.

Maltese S, Baumert A, Schmitt MJ, MacLeod C.

Front Psychol. 2016 Jan 13;6:2059. doi: 10.3389/fpsyg.2015.02059. eCollection 2015.


Surface-modified yeast cells: A novel eukaryotic carrier for oral application.

Kenngott EE, Kiefer R, Schneider-Daum N, Hamann A, Schneider M, Schmitt MJ, Breinig F.

J Control Release. 2016 Feb 28;224:1-7. doi: 10.1016/j.jconrel.2015.12.054. Epub 2016 Jan 5.


Coexpression of human perforin improves yeast-mediated delivery of DNA and mRNA to mammalian antigen-presenting cells.

Walch-Rückheim B, Kiefer R, Geginat G, Schmitt MJ, Breinig F.

Gene Ther. 2016 Jan;23(1):103-7. doi: 10.1038/gt.2015.77. Epub 2015 Aug 20.


Redox diversity in ERAD-mediated protein retrotranslocation from the endoplasmic reticulum: a complex puzzle.

Suzuki Y, Schmitt MJ.

Biol Chem. 2015 May;396(5):539-54. doi: 10.1515/hsz-2014-0299. Review.


Schizosaccharomyces pombe: a novel transport vehicle of functional DNA and mRNA into mammalian antigen-presenting cells.

Walch-Rückheim B, Schmitt MJ, Breinig F.

Vaccine. 2014 Oct 21;32(46):6029-33. doi: 10.1016/j.vaccine.2014.09.011. Epub 2014 Sep 17.


Heat treatment improves antigen-specific T cell activation after protein delivery by several but not all yeast genera.

Bazan SB, Breinig T, Schmitt MJ, Breinig F.

Vaccine. 2014 May 7;32(22):2591-8. doi: 10.1016/j.vaccine.2014.03.043. Epub 2014 Mar 24.


Gamma-hydroxybutyrate, acting through an anti-apoptotic mechanism, protects native and amyloid-precursor-protein-transfected neuroblastoma cells against oxidative stress-induced death.

Wendt G, Kemmel V, Patte-Mensah C, Uring-Lambert B, Eckert A, Schmitt MJ, Mensah-Nyagan AG.

Neuroscience. 2014 Mar 28;263:203-15. doi: 10.1016/j.neuroscience.2013.12.067. Epub 2014 Jan 20.


Bacterial cyclic AMP-phosphodiesterase activity coordinates biofilm formation.

Kalivoda EJ, Brothers KM, Stella NA, Schmitt MJ, Shanks RM.

PLoS One. 2013 Jul 29;8(7):e71267. doi: 10.1371/journal.pone.0071267. Print 2013.


Structure guided design of a series of sphingosine kinase (SphK) inhibitors.

Gustin DJ, Li Y, Brown ML, Min X, Schmitt MJ, Wanska M, Wang X, Connors R, Johnstone S, Cardozo M, Cheng AC, Jeffries S, Franks B, Li S, Shen S, Wong M, Wesche H, Xu G, Carlson TJ, Plant M, Morgenstern K, Rex K, Schmitt J, Coxon A, Walker N, Kayser F, Wang Z.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4608-16. doi: 10.1016/j.bmcl.2013.06.030. Epub 2013 Jun 20.


mRNA delivery to human dendritic cells by recombinant yeast and activation of antigen-specific memory T cells.

Breinig F, Breinig T, Schmitt MJ.

Methods Mol Biol. 2013;969:163-84. doi: 10.1007/978-1-62703-260-5_11. Review.


Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells.

Schmitt MJ, Philippidou D, Reinsbach SE, Margue C, Wienecke-Baldacchino A, Nashan D, Behrmann I, Kreis S.

Cell Commun Signal. 2012 Dec 17;10(1):41. doi: 10.1186/1478-811X-10-41.


MiRNA-29: a microRNA family with tumor-suppressing and immune-modulating properties.

Schmitt MJ, Margue C, Behrmann I, Kreis S.

Curr Mol Med. 2013 May;13(4):572-85. Review.


AtTPR7 is a chaperone-docking protein of the Sec translocon in Arabidopsis.

Schweiger R, Müller NC, Schmitt MJ, Soll J, Schwenkert S.

J Cell Sci. 2012 Nov 1;125(Pt 21):5196-207. doi: 10.1242/jcs.111054. Epub 2012 Aug 16.


Adapting yeast as model to study ricin toxin a uptake and trafficking.

Becker B, Schmitt MJ.

Toxins (Basel). 2011 Jul;3(7):834-47. doi: 10.3390/toxins3070834. Epub 2011 Jul 5.


Novel yeast bioassay for high-throughput screening of matrix metalloproteinase inhibitors.

Diehl B, Hoffmann TM, Mueller NC, Burkhart JL, Kazmaier U, Schmitt MJ.

Appl Environ Microbiol. 2011 Dec;77(24):8573-7. doi: 10.1128/AEM.06111-11. Epub 2011 Oct 14.


Delivery of functional DNA and messenger RNA to mammalian phagocytic cells by recombinant yeast.

Walch B, Breinig T, Schmitt MJ, Breinig F.

Gene Ther. 2012 Mar;19(3):237-45. doi: 10.1038/gt.2011.121. Epub 2011 Aug 25.


Uptake of various yeast genera by antigen-presenting cells and influence of subcellular antigen localization on the activation of ovalbumin-specific CD8 T lymphocytes.

Bazan SB, Geginat G, Breinig T, Schmitt MJ, Breinig F.

Vaccine. 2011 Oct 19;29(45):8165-73. doi: 10.1016/j.vaccine.2011.07.141. Epub 2011 Aug 19.


Yeast-based protein delivery to mammalian phagocytic cells is increased by coexpression of bacterial listeriolysin.

Walch B, Breinig T, Geginat G, Schmitt MJ, Breinig F.

Microbes Infect. 2011 Oct;13(11):908-13. doi: 10.1016/j.micinf.2011.05.006. Epub 2011 May 27.


Demonstration of ignition radiation temperatures in indirect-drive inertial confinement fusion hohlraums.

Glenzer SH, MacGowan BJ, Meezan NB, Adams PA, Alfonso JB, Alger ET, Alherz Z, Alvarez LF, Alvarez SS, Amick PV, Andersson KS, Andrews SD, Antonini GJ, Arnold PA, Atkinson DP, Auyang L, Azevedo SG, Balaoing BN, Baltz JA, Barbosa F, Bardsley GW, Barker DA, Barnes AI, Baron A, Beeler RG, Beeman BV, Belk LR, Bell JC, Bell PM, Berger RL, Bergonia MA, Bernardez LJ, Berzins LV, Bettenhausen RC, Bezerides L, Bhandarkar SD, Bishop CL, Bond EJ, Bopp DR, Borgman JA, Bower JR, Bowers GA, Bowers MW, Boyle DT, Bradley DK, Bragg JL, Braucht J, Brinkerhoff DL, Browning DF, Brunton GK, Burkhart SC, Burns SR, Burns KE, Burr B, Burrows LM, Butlin RK, Cahayag NJ, Callahan DA, Cardinale PS, Carey RW, Carlson JW, Casey AD, Castro C, Celeste JR, Chakicherla AY, Chambers FW, Chan C, Chandrasekaran H, Chang C, Chapman RF, Charron K, Chen Y, Christensen MJ, Churby AJ, Clancy TJ, Cline BD, Clowdus LC, Cocherell DG, Coffield FE, Cohen SJ, Costa RL, Cox JR, Curnow GM, Dailey MJ, Danforth PM, Darbee R, Datte PS, Davis JA, Deis GA, Demaret RD, Dewald EL, Di Nicola P, Di Nicola JM, Divol L, Dixit S, Dobson DB, Doppner T, Driscoll JD, Dugorepec J, Duncan JJ, Dupuy PC, Dzenitis EG, Eckart MJ, Edson SL, Edwards GJ, Edwards MJ, Edwards OD, Edwards PW, Ellefson JC, Ellerbee CH, Erbert GV, Estes CM, Fabyan WJ, Fallejo RN, Fedorov M, Felker B, Fink JT, Finney MD, Finnie LF, Fischer MJ, Fisher JM, Fishler BT, Florio JW, Forsman A, Foxworthy CB, Franks RM, Frazier T, Frieder G, Fung T, Gawinski GN, Gibson CR, Giraldez E, Glenn SM, Golick BP, Gonzales H, Gonzales SA, Gonzalez MJ, Griffin KL, Grippen J, Gross SM, Gschweng PH, Gururangan G, Gu K, Haan SW, Hahn SR, Haid BJ, Hamblen JE, Hammel BA, Hamza AV, Hardy DL, Hart DR, Hartley RG, Haynam CA, Heestand GM, Hermann MR, Hermes GL, Hey DS, Hibbard RL, Hicks DG, Hinkel DE, Hipple DL, Hitchcock JD, Hodtwalker DL, Holder JP, Hollis JD, Holtmeier GM, Huber SR, Huey AW, Hulsey DN, Hunter SL, Huppler TR, Hutton MS, Izumi N, Jackson JL, Jackson MA, Jancaitis KS, Jedlovec DR, Johnson B, Johnson MC, Johnson T, Johnston MP, Jones OS, Kalantar DH, Kamperschroer JH, Kauffman RL, Keating GA, Kegelmeyer LM, Kenitzer SL, Kimbrough JR, King K, Kirkwood RK, Klingmann JL, Knittel KM, Kohut TR, Koka KG, Kramer SW, Krammen JE, Krauter KG, Krauter GW, Krieger EK, Kroll JJ, La Fortune KN, Lagin LJ, Lakamsani VK, Landen OL, Lane SW, Langdon AB, Langer SH, Lao N, Larson DW, Latray D, Lau GT, Le Pape S, Lechleiter BL, Lee Y, Lee TL, Li J, Liebman JA, Lindl JD, Locke SF, Loey HK, London RA, Lopez FJ, Lord DM, Lowe-Webb RR, Lown JG, Ludwigsen AP, Lum NW, Lyons RR, Ma T, MacKinnon AJ, Magat MD, Maloy DT, Malsbury TN, Markham G, Marquez RM, Marsh AA, Marshall CD, Marshall SR, Maslennikov IL, Mathisen DG, Mauger GJ, Mauvais M-, McBride JA, McCarville T, McCloud JB, McGrew A, McHale B, MacPhee AG, Meeker JF, Merill JS, Mertens EP, Michel PA, Miller MG, Mills T, Milovich JL, Miramontes R, Montesanti RC, Montoya MM, Moody J, Moody JD, Moreno KA, Morris J, Morriston KM, Nelson JR, Neto M, Neumann JD, Ng E, Ngo QM, Olejniczak BL, Olson RE, Orsi NL, Owens MW, Padilla EH, Pannell TM, Parham TG, Patterson RW Jr, Pavel G, Prasad RR, Pendlton D, Penko FA, Pepmeier BL, Petersen DE, Phillips TW, Pigg D, Piston KW, Pletcher KD, Powell CL, Radousky HB, Raimondi BS, Ralph JE, Rampke RL, Reed RK, Reid WA, Rekow VV, Reynolds JL, Rhodes JJ, Richardson MJ, Rinnert RJ, Riordan BP, Rivenes AS, Rivera AT, Roberts CJ, Robinson JA, Robinson RB, Robison SR, Rodriguez OR, Rogers SP, Rosen MD, Ross GF, Runkel M, Runtal AS, Sacks RA, Sailors SF, Salmon JT, Salmonson JD, Saunders RL, Schaffer JR, Schindler TM, Schmitt MJ, Schneider MB, Segraves KS, Shaw MJ, Sheldrick ME, Shelton RT, Shiflett MK, Shiromizu SJ, Shor M, Silva LL, Silva SA, Skulina KM, Smauley DA, Smith BE, Smith LK, Solomon AL, Sommer S, Soto JG, Spafford NI, Speck DE, Springer PT, Stadermann M, Stanley F, Stone TG, Stout EA, Stratton PL, Strausser RJ, Suter LJ, Sweet W, Swisher MF, Tappero JD, Tassano JB, Taylor JS, Tekle EA, Thai C, Thomas CA, Thomas A, Throop AL, Tietbohl GL, Tillman JM, Town RP, Townsend SL, Tribbey KL, Trummer D, Truong J, Vaher J, Valadez M, Van Arsdall P, Van Prooyen AJ, Vergel de Dios EO, Vergino MD, Vernon SP, Vickers JL, Villanueva GT, Vitalich MA, Vonhof SA, Wade FE, Wallace RJ, Warren CT, Warrick AL, Watkins J, Weaver S, Wegner PJ, Weingart MA, Wen J, White KS, Whitman PK, Widmann K, Widmayer CC, Wilhelmsen K, Williams EA, Williams WH, Willis L, Wilson EF, Wilson BA, Witte MC, Work K, Yang PS, Young BK, Youngblood KP, Zacharias RA, Zaleski T, Zapata PG, Zhang H, Zielinski JS, Kline JL, Kyrala GA, Niemann C, Kilkenny JD, Nikroo A, Van Wonterghem BM, Atherton LJ, Moses EI.

Phys Rev Lett. 2011 Feb 25;106(8):085004. Epub 2011 Feb 25. Erratum in: Phys Rev Lett. 2011 Mar 11;106(10):109903.


Modeling the National Ignition Facility neutron imaging system.

Wilson DC, Grim GP, Tregillis IL, Wilke MD, Patel MV, Sepke SM, Morgan GL, Hatarik R, Loomis EN, Wilde CH, Oertel JA, Fatherley VE, Clark DD, Fittinghoff DN, Bower DE, Schmitt MJ, Marinak MM, Munro DH, Merrill FE, Moran MJ, Wang TS, Danly CR, Hilko RA, Batha SH, Frank M, Buckles R.

Rev Sci Instrum. 2010 Oct;81(10):10D335. doi: 10.1063/1.3496993.


Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.

Li S, Spooner RA, Allen SC, Guise CP, Ladds G, Schnöder T, Schmitt MJ, Lord JM, Roberts LM.

Mol Biol Cell. 2010 Aug 1;21(15):2543-54. doi: 10.1091/mbc.E09-08-0743. Epub 2010 Jun 2.


RNA-directed DNA methylation and plant development require an IWR1-type transcription factor.

Kanno T, Bucher E, Daxinger L, Huettel B, Kreil DP, Breinig F, Lind M, Schmitt MJ, Simon SA, Gurazada SG, Meyers BC, Lorkovic ZJ, Matzke AJ, Matzke M.

EMBO Rep. 2010 Jan;11(1):65-71. doi: 10.1038/embor.2009.246. Epub 2009 Dec 11.


A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms.

Carroll SY, Stirling PC, Stimpson HE, Giesselmann E, Schmitt MJ, Drubin DG.

Dev Cell. 2009 Oct;17(4):552-60. doi: 10.1016/j.devcel.2009.08.006.


Wave optics simulation of atmospheric turbulence and reflective speckle effects in CO2 lidar.

Nelson DH, Walters DL, Mackerrow EP, Schmitt MJ, Quick CR, Porch WM, Petrin RR.

Appl Opt. 2000 Apr 20;39(12):1857-71.


Viral induced yeast apoptosis.

Schmitt MJ, Reiter J.

Biochim Biophys Acta. 2008 Jul;1783(7):1413-7. doi: 10.1016/j.bbamcr.2008.01.017. Epub 2008 Feb 7. Review.


Effect of speckle on lidar pulse-pair ratio statistics.

Mackerrow EP, Schmitt MJ, Thompson DC.

Appl Opt. 1997 Nov 20;36(33):8650-69.


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