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The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile.

Hshieh TT, Vasunilashorn SM, D'Aquila ML, Arnold SE, Dickerson BC, Fong TG, Jones RN, Marcantonio ER, Schmitt EM, Xu G, Gou Y, Chen F, Kunze LJ, Vlassakov KV, Abdeen AR, Lange JK, Earp BE, Touroutoglou A, Carlyle BC, Kivisakk-Webb P, Travison TG, Dillon ST, Libermann TA, Inouye SK; RISE Study Group.

Alzheimers Dement (Amst). 2019 Nov 6;11:752-762. doi: 10.1016/j.dadm.2019.09.004. eCollection 2019 Dec.


The Caregiver Burden of Delirium in Older Adults With Alzheimer Disease and Related Disorders.

Fong TG, Racine AM, Fick DM, Tabloski P, Gou Y, Schmitt EM, Hshieh TT, Metzger E, Bertrand SE, Marcantonio ER, Jones RN, Inouye SK.

J Am Geriatr Soc. 2019 Dec;67(12):2587-2592. doi: 10.1111/jgs.16199. Epub 2019 Oct 12.


Protocol for the electroencephalography guidance of anesthesia to alleviate geriatric syndromes (ENGAGES-Canada) study: A pragmatic, randomized clinical trial.

Deschamps A, Saha T, El-Gabalawy R, Jacobsohn E, Overbeek C, Palermo J, Robichaud S, Dumont AA, Djaiani G, Carroll J, Kavosh MS, Tanzola R, Schmitt EM, Inouye SK, Oberhaus J, Mickle A, Ben Abdallah A, Avidan MS, Clinical Trials Group CPA.

F1000Res. 2019 Jul 23;8:1165. doi: 10.12688/f1000research.19213.1. eCollection 2019.


Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence.

Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, Metzger E, Pascual-Leone A, Schmitt EM, Shafi M, Cavallari M, Dai W, Dillon ST, McElhaney J, Guttmann C, Hshieh T, Kuchel G, Libermann T, Ngo L, Press D, Saczynski J, Vasunilashorn S, O'Connor M, Kimchi E, Strauss J, Wong B, Belkin M, Ayres D, Callery M, Pomposelli F, Wright J, Schermerhorn M, Abrantes T, Albuquerque A, Bertrand S, Brown A, Callahan A, D'Aquila M, Dowal S, Fox M, Gallagher J, Anna Gersten R, Hodara A, Helfand B, Inloes J, Kettell J, Kuczmarska A, Nee J, Nemeth E, Ochsner L, Palihnich K, Parisi K, Puelle M, Rastegar S, Vella M, Xu G, Bryan M, Guess J, Enghorn D, Gross A, Gou Y, Habtemariam D, Isaza I, Kosar C, Rockett C, Tommet D, Gruen T, Ross M, Tasker K, Gee J, Kolanowski A, Pisani M, de Rooij S, Rogers S, Studenski S, Stern Y, Whittemore A, Gottlieb G, Orav J, Sperling R; SAGES Study Group*.

Anesthesiology. 2019 Sep;131(3):477-491. doi: 10.1097/ALN.0000000000002729.


Use of an expert panel to identify domains and indicators of delirium severity.

Schulman-Green D, Schmitt EM, Fong TG, Vasunilashorn SM, Gallagher J, Marcantonio ER, Brown CH 4th, Clark D, Flaherty JH, Gleason A, Gordon S, Kolanowski AM, Neufeld KJ, O'Connor M, Pisani MA, Robinson TN, Verghese J, Wald HL, Jones RN, Inouye SK; BASIL Study Group.

Qual Life Res. 2019 Sep;28(9):2565-2578. doi: 10.1007/s11136-019-02201-0. Epub 2019 May 17.


Use of the confusion assessment method in multicentre delirium trials: training and standardisation.

Green JR, Smith J, Teale E, Collinson M, Avidan MS, Schmitt EM, Inouye SK, Young J.

BMC Geriatr. 2019 Apr 15;19(1):107. doi: 10.1186/s12877-019-1129-8.


Perspectives on the Delirium Experience and Its Burden: Common Themes Among Older Patients, Their Family Caregivers, and Nurses.

Schmitt EM, Gallagher J, Albuquerque A, Tabloski P, Lee HJ, Gleason L, Weiner LS, Marcantonio ER, Jones RN, Inouye SK, Schulman-Green D.

Gerontologist. 2019 Mar 14;59(2):327-337. doi: 10.1093/geront/gnx153.


Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery: The ENGAGES Randomized Clinical Trial.

Wildes TS, Mickle AM, Ben Abdallah A, Maybrier HR, Oberhaus J, Budelier TP, Kronzer A, McKinnon SL, Park D, Torres BA, Graetz TJ, Emmert DA, Palanca BJ, Goswami S, Jordan K, Lin N, Fritz BA, Stevens TW, Jacobsohn E, Schmitt EM, Inouye SK, Stark S, Lenze EJ, Avidan MS; ENGAGES Research Group.

JAMA. 2019 Feb 5;321(5):473-483. doi: 10.1001/jama.2018.22005.


Assessment of Instruments for Measurement of Delirium Severity: A Systematic Review.

Jones RN, Cizginer S, Pavlech L, Albuquerque A, Daiello LA, Dharmarajan K, Gleason LJ, Helfand B, Massimo L, Oh E, Okereke OI, Tabloski P, Rabin LA, Yue J, Marcantonio ER, Fong TG, Hshieh TT, Metzger ED, Erickson K, Schmitt EM, Inouye SK; Better Assessment of Illness (BASIL) Study Group.

JAMA Intern Med. 2019 Feb 1;179(2):231-239. doi: 10.1001/jamainternmed.2018.6975.


Reliability and accuracy of delirium assessments among investigators at multiple international centres.

Maybrier HR, Mickle AM, Escallier KE, Lin N, Schmitt EM, Upadhyayula RT, Wildes TS, Mashour GA, Palihnich K, Inouye SK, Avidan MS; PODCAST Research Group.

BMJ Open. 2018 Nov 21;8(11):e023137. doi: 10.1136/bmjopen-2018-023137.


The Better Assessment of Illness Study for Delirium Severity: Study Design, Procedures, and Cohort Description.

Hshieh TT, Fong TG, Schmitt EM, Marcantonio ER, D'Aquila ML, Gallagher J, Xu G, Guo YR, Abrantes TF, Bertrand SE, Jones RN, Inouye SK; for the BASIL Study Group.

Gerontology. 2019;65(1):20-29. doi: 10.1159/000490386. Epub 2018 Jul 20.


Correction for retest effects across repeated measures of cognitive functioning: a longitudinal cohort study of postoperative delirium.

Racine AM, Gou Y, Fong TG, Marcantonio ER, Schmitt EM, Travison TG, Inouye SK, Jones RN.

BMC Med Res Methodol. 2018 Jul 3;18(1):69. doi: 10.1186/s12874-018-0530-x.


Delirium Burden in Patients and Family Caregivers: Development and Testing of New Instruments.

Racine AM, D'Aquila M, Schmitt EM, Gallagher J, Marcantonio ER, Jones RN, Inouye SK, Schulman-Green D; BASIL Study Group .

Gerontologist. 2019 Sep 17;59(5):e393-e402. doi: 10.1093/geront/gny041.


Clinical outcomes in older surgical patients with mild cognitive impairment.

Racine AM, Fong TG, Gou Y, Travison TG, Tommet D, Erickson K, Jones RN, Dickerson BC, Metzger E, Marcantonio ER, Schmitt EM, Inouye SK.

Alzheimers Dement. 2018 May;14(5):590-600. doi: 10.1016/j.jalz.2017.10.010. Epub 2017 Nov 27.


Delirium Severity Post-Surgery and its Relationship with Long-Term Cognitive Decline in a Cohort of Patients without Dementia.

Vasunilashorn SM, Fong TG, Albuquerque A, Marcantonio ER, Schmitt EM, Tommet D, Gou Y, Travison TG, Jones RN, Inouye SK.

J Alzheimers Dis. 2018;61(1):347-358. doi: 10.3233/JAD-170288.


The Cognitive Reserve Model in the Development of Delirium: The Successful Aging After Elective Surgery Study.

Cizginer S, Marcantonio E, Vasunilashorn S, Pascual-Leone A, Shafi M, Schmitt EM, Inouye SK, Jones RN.

J Geriatr Psychiatry Neurol. 2017 Nov;30(6):337-345. doi: 10.1177/0891988717732152. Erratum in: J Geriatr Psychiatry Neurol. 2019 Feb 12;:891988719831507.


Network for Investigation of Delirium across the U.S.: Advancing the Field of Delirium with a New Interdisciplinary Research Network.

Fick DM, Auerbach AD, Avidan MS, Busby-Whitehead J, Ely EW, Jones RN, Marcantonio ER, Needham DM, Pandharipande P, Robinson TN, Schmitt EM, Travison TG, Inouye SK; NIDUS Delirium Network.

J Am Geriatr Soc. 2017 Oct;65(10):2158-2160. doi: 10.1111/jgs.14942. Epub 2017 Jun 20. No abstract available.


High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery.

Vasunilashorn SM, Dillon ST, Inouye SK, Ngo LH, Fong TG, Jones RN, Travison TG, Schmitt EM, Alsop DC, Freedman SD, Arnold SE, Metzger ED, Libermann TA, Marcantonio ER.

J Am Geriatr Soc. 2017 Aug;65(8):e109-e116. doi: 10.1111/jgs.14913. Epub 2017 May 26.


Network for Investigation of Delirium Across the U.S. (NIDUS): Advancing the Field of Delirium with a New Interdisciplinary Research Network.

Fick DM, Auerbach AD, Avidan MS, Busby-Whitehead J, Ely EW, Jones RN, Marcantonio ER, Needham DM, Pandharipande P, Robinson TN, Schmitt EM, Travison TG, Inouye SK.

J Gerontol Nurs. 2017 May 1;43(5):4-6. doi: 10.3928/00989134-20170411-01. No abstract available.


Prediction of Long-term Cognitive Decline Following Postoperative Delirium in Older Adults.

Devore EE, Fong TG, Marcantonio ER, Schmitt EM, Travison TG, Jones RN, Inouye SK.

J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1697-1702. doi: 10.1093/gerona/glx030.


Association Between Hospital Readmission and Acute and Sustained Delays in Functional Recovery During 18 Months After Elective Surgery: The Successful Aging after Elective Surgery Study.

Pisani MA, Albuquerque A, Marcantonio ER, Jones RN, Gou RY, Fong TG, Schmitt EM, Tommet D, Isaza Aizpurua II, Alsop DC, Inouye SK, Travison TG.

J Am Geriatr Soc. 2017 Jan;65(1):51-58. doi: 10.1111/jgs.14549. Epub 2016 Nov 29.


Preoperative Cognitive Performance Dominates Risk for Delirium Among Older Adults.

Jones RN, Marcantonio ER, Saczynski JS, Tommet D, Gross AL, Travison TG, Alsop DC, Schmitt EM, Fong TG, Cizginer S, Shafi MM, Pascual-Leone A, Inouye SK.

J Geriatr Psychiatry Neurol. 2016 Nov;29(6):320-327. doi: 10.1177/0891988716666380. Epub 2016 Sep 21.


The SAGES telephone neuropsychological battery: correlation with in-person measures.

Bunker L, Hshieh TT, Wong B, Schmitt EM, Travison T, Yee J, Palihnich K, Metzger E, Fong TG, Inouye SK.

Int J Geriatr Psychiatry. 2017 Sep;32(9):991-999. doi: 10.1002/gps.4558. Epub 2016 Aug 9.


Response to Paul Regal.

Schmitt EM, Inouye SK.

J Am Geriatr Soc. 2016 Aug;64(8):1750-1. doi: 10.1111/jgs.14193. Epub 2016 Jul 26. No abstract available.


Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance.

Hshieh TT, Dai W, Cavallari M, Guttmann CR, Meier DS, Schmitt EM, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Gou YR, Travison TG, Fong TG, Ngo L, Inouye SK, Alsop DC; SAGES Study Group.

J Cereb Blood Flow Metab. 2017 Apr;37(4):1386-1397. doi: 10.1177/0271678X16656014. Epub 2016 Jan 1.


Derivation and Validation of a Severity Scoring Method for the 3-Minute Diagnostic Interview for Confusion Assessment Method--Defined Delirium.

Vasunilashorn SM, Guess J, Ngo L, Fick D, Jones RN, Schmitt EM, Kosar CM, Saczynski JS, Travison TG, Inouye SK, Marcantonio ER.

J Am Geriatr Soc. 2016 Aug;64(8):1684-9. doi: 10.1111/jgs.14234. Epub 2016 Jul 4.


Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) study: a pragmatic, randomised clinical trial.

Wildes TS, Winter AC, Maybrier HR, Mickle AM, Lenze EJ, Stark S, Lin N, Inouye SK, Schmitt EM, McKinnon SL, Muench MR, Murphy MR, Upadhyayula RT, Fritz BA, Escallier KE, Apakama GP, Emmert DA, Graetz TJ, Stevens TW, Palanca BJ, Hueneke R, Melby S, Torres B, Leung JM, Jacobsohn E, Avidan MS.

BMJ Open. 2016 Jun 15;6(6):e011505. doi: 10.1136/bmjopen-2016-011505. Erratum in: BMJ Open. 2016 Jun 27;6(6):e011505corr1.


Quantifying the Severity of a Delirium Episode Throughout Hospitalization: the Combined Importance of Intensity and Duration.

Vasunilashorn SM, Marcantonio ER, Gou Y, Pisani MA, Travison TG, Schmitt EM, Jones RN, Inouye SK.

J Gen Intern Med. 2016 Oct;31(10):1164-71. doi: 10.1007/s11606-016-3671-9. Epub 2016 Jun 3.


The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients.

Inouye SK, Marcantonio ER, Kosar CM, Tommet D, Schmitt EM, Travison TG, Saczynski JS, Ngo LH, Alsop DC, Jones RN.

Alzheimers Dement. 2016 Jul;12(7):766-75. doi: 10.1016/j.jalz.2016.03.005. Epub 2016 Apr 18.


The Successful Aging after Elective Surgery (SAGES) Study: Cohort Description and Data Quality Procedures.

Schmitt EM, Saczynski JS, Kosar CM, Jones RN, Alsop DC, Fong TG, Metzger E, Cooper Z, Marcantonio ER, Travison T, Inouye SK; SAGES Study Group.

J Am Geriatr Soc. 2015 Dec;63(12):2463-2471. doi: 10.1111/jgs.13793. Epub 2015 Dec 14.


Head circumference as a useful surrogate for intracranial volume in older adults.

Hshieh TT, Fox ML, Kosar CM, Cavallari M, Guttmann CR, Alsop D, Marcantonio ER, Schmitt EM, Jones RN, Inouye SK.

Int Psychogeriatr. 2016 Jan;28(1):157-62. doi: 10.1017/S104161021500037X.


Effect of Delirium and Other Major Complications on Outcomes After Elective Surgery in Older Adults.

Gleason LJ, Schmitt EM, Kosar CM, Tabloski P, Saczynski JS, Robinson T, Cooper Z, Rogers SO Jr, Jones RN, Marcantonio ER, Inouye SK.

JAMA Surg. 2015 Dec;150(12):1134-40. doi: 10.1001/jamasurg.2015.2606.


Delirium superimposed on dementia: A quantitative and qualitative evaluation of informal caregivers and health care staff experience.

Morandi A, Lucchi E, Turco R, Morghen S, Guerini F, Santi R, Gentile S, Meagher D, Voyer P, Fick DM, Schmitt EM, Inouye SK, Trabucchi M, Bellelli G.

J Psychosom Res. 2015 Oct;79(4):272-80. doi: 10.1016/j.jpsychores.2015.06.012. Epub 2015 Aug 9.


Delirium superimposed on dementia: A quantitative and qualitative evaluation of patient experience.

Morandi A, Lucchi E, Turco R, Morghen S, Guerini F, Santi R, Gentile S, Meagher D, Voyer P, Fick D, Schmitt EM, Inouye SK, Trabucchi M, Bellelli G.

J Psychosom Res. 2015 Oct;79(4):281-7. doi: 10.1016/j.jpsychores.2015.07.010. Epub 2015 Aug 8.


Neuropsychological profiles of an elderly cohort undergoing elective surgery and the relationship between cognitive performance and delirium.

Fong TG, Hshieh TT, Wong B, Tommet D, Jones RN, Schmitt EM, Puelle MR, Saczynski JS, Marcantonio ER, Inouye SK.

J Am Geriatr Soc. 2015 May;63(5):977-82. doi: 10.1111/jgs.13383. Epub 2015 May 4.


Brain atrophy and white-matter hyperintensities are not significantly associated with incidence and severity of postoperative delirium in older persons without dementia.

Cavallari M, Hshieh TT, Guttmann CR, Ngo LH, Meier DS, Schmitt EM, Marcantonio ER, Jones RN, Kosar CM, Fong TG, Press D, Inouye SK, Alsop DC; SAGES Study Group.

Neurobiol Aging. 2015 Jun;36(6):2122-9. doi: 10.1016/j.neurobiolaging.2015.02.024. Epub 2015 Feb 28.


Cognitive and Physical Demands of Activities of Daily Living in Older Adults: Validation of Expert Panel Ratings.

Successful Aging after Elective Surgery Functional Measures Working Group, Fong TG, Gleason LJ, Wong B, Habtemariam D, Jones RN, Schmitt EM, de Rooij SE, Saczynski JS, Gross AL, Bean JF, Brown CJ, Fick DM, Gruber-Baldini AL, O'Connor M, Tabloski PA, Marcantonio ER, Inouye SK.

PM R. 2015 Jul;7(7):727-735. doi: 10.1016/j.pmrj.2015.01.018. Epub 2015 Feb 4.



Kosar CM, Tabloski PA, Travison TG, Jones RN, Schmitt EM, Puelle MR, Inloes JB, Saczynski JS, Marcantonio ER, Meagher D, Reid MC, Inouye SK.

Lancet Psychiatry. 2014 Nov;1(6):431-436.


The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts.

Inouye SK, Kosar CM, Tommet D, Schmitt EM, Puelle MR, Saczynski JS, Marcantonio ER, Jones RN.

Ann Intern Med. 2014 Apr 15;160(8):526-533. doi: 10.7326/M13-1927.


Novel risk markers and long-term outcomes of delirium: the successful aging after elective surgery (SAGES) study design and methods.

Schmitt EM, Marcantonio ER, Alsop DC, Jones RN, Rogers SO Jr, Fong TG, Metzger E, Inouye SK; SAGES Study Group.

J Am Med Dir Assoc. 2012 Nov;13(9):818.e1-10. doi: 10.1016/j.jamda.2012.08.004. Epub 2012 Sep 19.


An animal model of MYC-driven medulloblastoma.

Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, Northcott PA, Taylor MD, Pfister SM, Febbo PG, Wechsler-Reya RJ.

Cancer Cell. 2012 Feb 14;21(2):155-67. doi: 10.1016/j.ccr.2011.12.021.


A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.

Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF.

Science. 2012 Jan 20;335(6066):348-53. doi: 10.1126/science.1212728. Epub 2011 Dec 8.


The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo.

Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3665-70. doi: 10.1073/pnas.1019736108. Epub 2011 Feb 9.


Adult day health center participation and health-related quality of life.

Schmitt EM, Sands LP, Weiss S, Dowling G, Covinsky K.

Gerontologist. 2010 Aug;50(4):531-40. doi: 10.1093/geront/gnp172. Epub 2010 Jan 27.


Course evaluation and assessment: examples of a learner-centered approach.

Schmitt EM, Hu AC, Bachrach PS.

Gerontol Geriatr Educ. 2008;29(3):290-300. doi: 10.1080/02701960802359524.


Older adults' and case managers' perceptions of smoking and smoking cessation.

Schmitt EM, Tsoh JY, Dowling GA, Hall SM.

J Aging Health. 2005 Dec;17(6):717-33.


Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.

Sengupta TK, Schmitt EM, Ivashkiv LB.

Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9499-504.


Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

Williams BO, Schmitt EM, Remington L, Bronson RT, Albert DM, Weinberg RA, Jacks T.

EMBO J. 1994 Sep 15;13(18):4251-9.


Tumour predisposition in mice heterozygous for a targeted mutation in Nf1.

Jacks T, Shih TS, Schmitt EM, Bronson RT, Bernards A, Weinberg RA.

Nat Genet. 1994 Jul;7(3):353-61.


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