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Items: 30

1.

Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.

Wlodarska M, Luo C, Kolde R, d'Hennezel E, Annand JW, Heim CE, Krastel P, Schmitt EK, Omar AS, Creasey EA, Garner AL, Mohammadi S, O'Connell DJ, Abubucker S, Arthur TD, Franzosa EA, Huttenhower C, Murphy LO, Haiser HJ, Vlamakis H, Porter JA, Xavier RJ.

Cell Host Microbe. 2017 Jul 12;22(1):25-37.e6. doi: 10.1016/j.chom.2017.06.007.

2.

Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.

Bürstner N, Roggo S, Ostermann N, Blank J, Delmas C, Freuler F, Gerhartz B, Hinniger A, Hoepfner D, Liechty B, Mihalic M, Murphy J, Pistorius D, Rottmann M, Thomas JR, Schirle M, Schmitt EK.

Chembiochem. 2015 Nov;16(17):2433-6. doi: 10.1002/cbic.201500472. Epub 2015 Oct 16.

PMID:
26472355
3.

Natural products as probes in pharmaceutical research.

Schmitt EK, Hoepfner D, Krastel P.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):249-60. doi: 10.1007/s10295-015-1691-9. Epub 2015 Oct 5. Review.

PMID:
26438431
4.

Luteipulveratus halotolerans sp. nov., an actinobacterium (Dermacoccaceae) from forest soil.

Juboi H, Basik AA, Shamsul SSG, Arnold P, Schmitt EK, Sanglier JJ, Yeo TC.

Int J Syst Evol Microbiol. 2015 Nov;65(11):4113-4120. doi: 10.1099/ijsem.0.000548. Epub 2015 Aug 21.

PMID:
26303235
5.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

6.

Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties.

Krastel P, Roggo S, Schirle M, Ross NT, Perruccio F, Aspesi P Jr, Aust T, Buntin K, Estoppey D, Liechty B, Mapa F, Memmert K, Miller H, Pan X, Riedl R, Thibaut C, Thomas J, Wagner T, Weber E, Xie X, Schmitt EK, Hoepfner D.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10149-54. doi: 10.1002/anie.201505069. Epub 2015 Jul 15.

PMID:
26179970
7.

The novolactone natural product disrupts the allosteric regulation of Hsp70.

Hassan AQ, Kirby CA, Zhou W, Schuhmann T, Kityk R, Kipp DR, Baird J, Chen J, Chen Y, Chung F, Hoepfner D, Movva NR, Pagliarini R, Petersen F, Quinn C, Quinn D, Riedl R, Schmitt EK, Schitter A, Stams T, Studer C, Fortin PD, Mayer MP, Sadlish H.

Chem Biol. 2015 Jan 22;22(1):87-97. doi: 10.1016/j.chembiol.2014.11.007. Epub 2014 Dec 24.

8.

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

Hoepfner D, Helliwell SB, Sadlish H, Schuierer S, Filipuzzi I, Brachat S, Bhullar B, Plikat U, Abraham Y, Altorfer M, Aust T, Baeriswyl L, Cerino R, Chang L, Estoppey D, Eichenberger J, Frederiksen M, Hartmann N, Hohendahl A, Knapp B, Krastel P, Melin N, Nigsch F, Oakeley EJ, Petitjean V, Petersen F, Riedl R, Schmitt EK, Staedtler F, Studer C, Tallarico JA, Wetzel S, Fishman MC, Porter JA, Movva NR.

Microbiol Res. 2014 Feb-Mar;169(2-3):107-20. doi: 10.1016/j.micres.2013.11.004. Epub 2013 Dec 1.

9.

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.

Hoepfner D, McNamara CW, Lim CS, Studer C, Riedl R, Aust T, McCormack SL, Plouffe DM, Meister S, Schuierer S, Plikat U, Hartmann N, Staedtler F, Cotesta S, Schmitt EK, Petersen F, Supek F, Glynne RJ, Tallarico JA, Porter JA, Fishman MC, Bodenreider C, Diagana TT, Movva NR, Winzeler EA.

Cell Host Microbe. 2012 Jun 14;11(6):654-63. doi: 10.1016/j.chom.2012.04.015.

10.

Natural products as catalysts for innovation: a pharmaceutical industry perspective.

Schmitt EK, Moore CM, Krastel P, Petersen F.

Curr Opin Chem Biol. 2011 Aug;15(4):497-504. doi: 10.1016/j.cbpa.2011.05.018. Review.

PMID:
21684800
11.

The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease.

Schmitt EK, Riwanto M, Sambandamurthy V, Roggo S, Miault C, Zwingelstein C, Krastel P, Noble C, Beer D, Rao SP, Au M, Niyomrattanakit P, Lim V, Zheng J, Jeffery D, Pethe K, Camacho LR.

Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5889-91. doi: 10.1002/anie.201101740. Epub 2011 May 11. No abstract available.

PMID:
21563281
12.

Spiroindolones, a potent compound class for the treatment of malaria.

Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT.

Science. 2010 Sep 3;329(5996):1175-80. doi: 10.1126/science.1193225.

13.

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C, Goh A, Schmitt EK, Krastel P, Francotte E, Kuhen K, Plouffe D, Henson K, Wagner T, Winzeler EA, Petersen F, Brun R, Dartois V, Diagana TT, Keller TH.

J Med Chem. 2010 Jul 22;53(14):5155-64. doi: 10.1021/jm100410f.

PMID:
20568778
14.

Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo.

Gandhirajan RK, Staib PA, Minke K, Gehrke I, Plickert G, Schlösser A, Schmitt EK, Hallek M, Kreuzer KA.

Neoplasia. 2010 Apr;12(4):326-35.

15.

Local membrane mechanics of pore-spanning bilayers.

Mey I, Stephan M, Schmitt EK, Müller MM, Ben Amar M, Steinem C, Janshoff A.

J Am Chem Soc. 2009 May 27;131(20):7031-9. doi: 10.1021/ja809165h.

PMID:
19453196
16.

Imaging and patterning of pore-suspending membranes with scanning ion conductance microscopy.

Böcker M, Muschter S, Schmitt EK, Steinem C, Schäffer TE.

Langmuir. 2009 Mar 3;25(5):3022-8. doi: 10.1021/la8034227.

PMID:
19437710
17.

Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.

Morris RP, Leeds JA, Naegeli HU, Oberer L, Memmert K, Weber E, LaMarche MJ, Parker CN, Burrer N, Esterow S, Hein AE, Schmitt EK, Krastel P.

J Am Chem Soc. 2009 Apr 29;131(16):5946-55. doi: 10.1021/ja900488a.

PMID:
19338336
18.

Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells.

Minke KS, Staib P, Puetter A, Gehrke I, Gandhirajan RK, Schlösser A, Schmitt EK, Hallek M, Kreuzer KA.

Eur J Haematol. 2009 Mar;82(3):165-75. doi: 10.1111/j.1600-0609.2008.01188.x. Epub 2008 Nov 20.

PMID:
19067737
19.

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis.

Kurabachew M, Lu SH, Krastel P, Schmitt EK, Suresh BL, Goh A, Knox JE, Ma NL, Jiricek J, Beer D, Cynamon M, Petersen F, Dartois V, Keller T, Dick T, Sambandamurthy VK.

J Antimicrob Chemother. 2008 Oct;62(4):713-9. doi: 10.1093/jac/dkn269. Epub 2008 Jun 27.

PMID:
18587134
20.

Micro-BLMs on highly ordered porous silicon substrates: rupture process and lateral mobility.

Weiskopf D, Schmitt EK, Klühr MH, Dertinger SK, Steinem C.

Langmuir. 2007 Aug 28;23(18):9134-9. Epub 2007 Jul 27.

PMID:
17655338
21.

Channel activity of OmpF monitored in nano-BLMs.

Schmitt EK, Vrouenraets M, Steinem C.

Biophys J. 2006 Sep 15;91(6):2163-71. Epub 2006 Jun 16.

22.

Recent developments in antibacterial drug discovery: microbe-derived natural products--from collection to the clinic.

Leeds JA, Schmitt EK, Krastel P.

Expert Opin Investig Drugs. 2006 Mar;15(3):211-26. Review.

PMID:
16503759
23.
24.

Regulation of cephalosporin biosynthesis.

Schmitt EK, Hoff B, Kück U.

Adv Biochem Eng Biotechnol. 2004;88:1-43. Review.

PMID:
15719551
26.

Winged helix transcription factor CPCR1 is involved in regulation of beta-lactam biosynthesis in the fungus Acremonium chrysogenum.

Schmitt EK, Bunse A, Janus D, Hoff B, Friedlin E, Kürnsteiner H, Kück U.

Eukaryot Cell. 2004 Feb;3(1):121-34.

27.

Development of molecular tools for the mulundocandin producer Aspergillus sydowii: DNA-mediated transformation and reporter gene expression.

Schmitt EK, Eilinghoff B, Olliger R, Decker H, Kück U.

Appl Microbiol Biotechnol. 2002 Apr;58(5):625-31. Epub 2002 Jan 16.

PMID:
11956745
30.

Phosphonate Utilization by the Glyphosate-Degrading Pseudomonas sp. Strain PG2982.

Shinabarger DL, Schmitt EK, Braymer HD, Larson AD.

Appl Environ Microbiol. 1984 Nov;48(5):1049-50.

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