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Items: 1 to 50 of 337

1.

Low burden of minimal residual disease prior to transplantation in children with very high risk acute lymphoblastic leukaemia: The NOPHO ALL2008 experience.

Ifversen M, Turkiewicz D, Marquart HV, Winiarski J, Buechner J, Mellgren K, Arvidson J, Rascon J, Körgvee LT, Madsen HO, Abrahamsson J, Lund B, Jonsson OG, Heilmann C, Heyman M, Schmiegelow K, Vettenranta K.

Br J Haematol. 2019 Jan 24. doi: 10.1111/bjh.15761. [Epub ahead of print]

PMID:
30680711
2.

Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood: A Danish Population-Based Cohort Study.

Jensen MV, Rugbjerg K, de Fine Licht S, Johansen C, Schmiegelow K, Andersen KK, Winther JF.

JAMA Netw Open. 2018 Jun 1;1(2):e180349. doi: 10.1001/jamanetworkopen.2018.0349.

3.

Posterior reversible encephalopathy syndrome in children with acute lymphoblastic leukemia: Clinical characteristics, risk factors, course, and outcome of disease.

Anastasopoulou S, Eriksson MA, Heyman M, Wang C, Niinimäki R, Mikkel S, Vaitkevičienė GE, Johannsdottir IM, Myrberg IH, Jonsson OG, Als-Nielsen B, Schmiegelow K, Banerjee J, Harila-Saari A, Ranta S.

Pediatr Blood Cancer. 2018 Dec 27:e27594. doi: 10.1002/pbc.27594. [Epub ahead of print]

PMID:
30592147
4.

An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression.

Haider Z, Larsson P, Landfors M, Köhn L, Schmiegelow K, Flaegstad T, Kanerva J, Heyman M, Hultdin M, Degerman S.

Cancer Med. 2019 Jan;8(1):311-324. doi: 10.1002/cam4.1917. Epub 2018 Dec 21.

5.

Minimal residual disease quantification by flow cytometry provides reliable risk stratification in T-cell acute lymphoblastic leukemia.

Modvig S, Madsen HO, Siitonen SM, Rosthøj S, Tierens A, Juvonen V, Osnes LTN, Vålerhaugen H, Hultdin M, Thörn I, Matuzeviciene R, Stoskus M, Marincevic M, Fogelstrand L, Lilleorg A, Toft N, Jónsson OG, Pruunsild K, Vaitkeviciene G, Vettenranta K, Lund B, Abrahamsson J, Schmiegelow K, Marquart HV.

Leukemia. 2018 Dec 14. doi: 10.1038/s41375-018-0307-6. [Epub ahead of print]

PMID:
30552401
6.

Maternal use of hormonal contraception and risk of childhood leukaemia - Authors' reply.

Hargreave M, Mørch LS, Andersen KK, Winther JF, Schmiegelow K, Kjaer SK.

Lancet Oncol. 2018 Dec;19(12):e659. doi: 10.1016/S1470-2045(18)30849-0. No abstract available.

PMID:
30507419
7.

Trypsin encoding PRSS1-PRSS2 variation influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report.

Wolthers BO, Frandsen TL, Patel CJ, Abaji R, Attarbaschi A, Barzilai S, Colombini A, Escherich G, Grosjean M, Krajinovic M, Larsen E, Liang DC, Möricke A, Rasmussen KK, Samarasinghe S, Silverman LB, van der Sluis IM, Stanulla M, Tulstrup M, Yadav R, Yang W, Zapotocka E, Gupta R, Schmiegelow K.

Haematologica. 2018 Nov 22. pii: haematol.2018.199356. doi: 10.3324/haematol.2018.199356. [Epub ahead of print]

8.

Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008.

Højfeldt SG, Wolthers BO, Tulstrup M, Abrahamsson J, Gupta R, Harila-Saari A, Heyman M, Henriksen LT, Jónsson ÒG, Lähteenmäki PM, Lund B, Pruunsild K, Vaitkeviciene G, Schmiegelow K, Albertsen BK; Nordic Society of Paediatric Haematology Oncology (NOPHO) group.

Br J Haematol. 2019 Feb;184(3):405-417. doi: 10.1111/bjh.15660. Epub 2018 Nov 18.

PMID:
30450575
9.

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update.

Relling MV, Schwab M, Whirl-Carrillo M, Suarez-Kurtz G, Pui CH, Stein CM, Moyer AM, Evans WE, Klein TE, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ.

Clin Pharmacol Ther. 2018 Nov 17. doi: 10.1002/cpt.1304. [Epub ahead of print]

PMID:
30447069
10.

Methotrexate polyglutamate levels and co-distributions in childhood acute lymphoblastic leukemia maintenance therapy.

Nersting J, Nielsen SN, Grell K, Paerregaard M, Abrahamsson J, Lund B, Jonsson OG, Pruunsild K, Vaitkeviciene G, Kanerva J, Schmiegelow K; Nordic Society of Paediatric Haematology and Oncology (NOPHO).

Cancer Chemother Pharmacol. 2019 Jan;83(1):53-60. doi: 10.1007/s00280-018-3704-7. Epub 2018 Oct 15.

PMID:
30324220
11.

Neonatal Inflammatory Markers Are Associated with Childhood B-cell Precursor Acute Lymphoblastic Leukemia.

Søegaard SH, Rostgaard K, Skogstrand K, Wiemels JL, Schmiegelow K, Hjalgrim H.

Cancer Res. 2018 Sep 15;78(18):5458-5463. doi: 10.1158/0008-5472.CAN-18-0831.

PMID:
30217873
12.

Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia.

Wolthers BO, Mogensen PR, Frandsen TL, Abrahamsson J, Behrendtz M, Heyman M, Lohi O, Norén-Nyström U, Ruud E, Schmiegelow K.

Pediatr Blood Cancer. 2019 Jan;66(1):e27437. doi: 10.1002/pbc.27437. Epub 2018 Sep 14.

PMID:
30216644
13.

NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.

Tulstrup M, Grosjean M, Nielsen SN, Grell K, Wolthers BO, Wegener PS, Jonsson OG, Lund B, Harila-Saari A, Abrahamsson J, Vaitkeviciene G, Pruunsild K, Toft N, Holm M, Hulegårdh E, Liestøl S, Griskevicius L, Punab M, Wang J, Carroll WL, Zhang Z, Dalgaard MD, Gupta R, Nersting J, Schmiegelow K.

Leukemia. 2018 Dec;32(12):2527-2535. doi: 10.1038/s41375-018-0245-3. Epub 2018 Sep 10.

PMID:
30201983
14.

Maternal use of hormonal contraception and risk of childhood leukaemia: a nationwide, population-based cohort study.

Hargreave M, Mørch LS, Andersen KK, Winther JF, Schmiegelow K, Kjaer SK.

Lancet Oncol. 2018 Oct;19(10):1307-1314. doi: 10.1016/S1470-2045(18)30479-0. Epub 2018 Sep 6.

PMID:
30197174
15.

[Insufficient evidence in prophylactic therapy of chemotherapy-induced nausea and vomiting in children and adolescents].

Eliasen A, Callesen MT, Dalhoff KP, Rechnitzer C, Schmiegelow K, Schrøder H, Tuckuviene R, Holst H.

Ugeskr Laeger. 2018 Aug 27;180(35). pii: V11170851. Danish.

PMID:
30152323
16.

Putative new childhood leukemia cancer predisposition syndrome caused by germline bi-allelic missense mutations in DDX41.

Diness BR, Risom L, Frandsen TL, Hansen B, Andersen MK, Schmiegelow K, Wadt KAW.

Genes Chromosomes Cancer. 2018 Dec;57(12):670-674. doi: 10.1002/gcc.22680. Epub 2018 Oct 11.

PMID:
30144193
17.

Pediatric cancer families' participation in whole-genome sequencing research in Denmark: Parent perspectives.

Byrjalsen A, Stoltze U, Wadt K, Hjalgrim LL, Gerdes AM, Schmiegelow K, Wahlberg A.

Eur J Cancer Care (Engl). 2018 Nov;27(6):e12877. doi: 10.1111/ecc.12877. Epub 2018 Jul 17.

PMID:
30016002
18.

Comparing osteonecrosis clinical phenotype, timing, and risk factors in children and young adults treated for acute lymphoblastic leukemia.

Mogensen SS, Harila-Saari A, Mäkitie O, Myrberg IH, Niinimäki R, Vestli A, Hafsteinsdottir S, Griškevicius L, Saks K, Hallböök H, Retpen J, Helt LR, Toft N, Schmiegelow K, Frandsen TL; Nordic Society of Paediatric Haematology and Oncology (NOPHO) group.

Pediatr Blood Cancer. 2018 Oct;65(10):e27300. doi: 10.1002/pbc.27300. Epub 2018 Jun 26.

PMID:
29943905
19.

Sperm DNA Integrity is Unaffected by Thiopurine Treatment in Men With Inflammatory Bowel Disease.

Grosen A, Nersting J, Bungum M, Christensen LA, Schmiegelow K, Spanò M, Julsgaard M, Cordelli E, Leter G, Larsen PB, Hvas CL, Kelsen J.

J Crohns Colitis. 2019 Jan 1;13(1):3-11. doi: 10.1093/ecco-jcc/jjy086.

PMID:
29917107
20.

The cost of cure.

Schmiegelow K, Frandsen TL.

Lancet Haematol. 2018 Nov;5(11):e504-e505. doi: 10.1016/S2352-3026(18)30070-X. Epub 2018 Jun 12. No abstract available.

PMID:
29907548
21.

Testing physical function in children undergoing intense cancer treatment-a RESPECT feasibility study.

Nielsen MKF, Christensen JF, Frandsen TL, Thorsteinsson T, Andersen LB, Christensen KB, Nersting J, Faber M, Schmiegelow K, Larsen HB.

Pediatr Blood Cancer. 2018 Aug;65(8):e27100. doi: 10.1002/pbc.27100. Epub 2018 May 9.

PMID:
29741279
22.

International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.

Hrusak O, de Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Möricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, Stokley S, Zemanova Z, Moorman AV, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Dworzak M, Buldini B, Basso G, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, Luria D, Feuerstein T, Kolenova A, Svec P, Kreminska O, Rabin KR, Polychronopoulou S, da Costa E, Marquart HV, Kattamis A, Ratei R, Reinhardt D, Choi JK, Schrappe M, Stary J.

Blood. 2018 Jul 19;132(3):264-276. doi: 10.1182/blood-2017-12-821363. Epub 2018 May 2.

PMID:
29720486
23.

[Germ line mutations causing paediatric cancer predisposition syndromes are common in children and adolescents with cancer].

Stoltze UK, Byrjalsen A, Hjalgrim LL, Wahlberg A, Gupta R, Gerdes AM, Wadt K, Schmiegelow K.

Ugeskr Laeger. 2018 Apr 23;180(17). pii: V07170566. Danish.

PMID:
29717702
24.

Association between body mass index and pancreatitis in children with acute lymphoblastic leukemia.

Mogensen PR, Wolthers BO, Grell K, Schmiegelow K, Frandsen TL.

Pediatr Blood Cancer. 2018 Aug;65(8):e27071. doi: 10.1002/pbc.27071. Epub 2018 Apr 18. No abstract available.

PMID:
29667750
25.

Thromboembolism in acute lymphoblastic leukemia: results of NOPHO ALL2008 protocol treatment in patients aged 1 to 45 years.

Rank CU, Toft N, Tuckuviene R, Grell K, Nielsen OJ, Frandsen TL, Marquart HVH, Albertsen BK, Tedgård U, Hallböök H, Ruud E, Jarvis KB, Quist-Paulsen P, Huttunen P, Wartiovaara-Kautto U, Jónsson ÓG, Trakymiene SS, Griškevičius L, Saks K, Punab M, Schmiegelow K.

Blood. 2018 May 31;131(22):2475-2484. doi: 10.1182/blood-2018-01-827949. Epub 2018 Apr 16.

26.

All-cause mortality rates and home deaths decreased in children with life-limiting diagnoses in Denmark between 1994 and 2014.

Lykke C, Ekholm O, Schmiegelow K, Olsen M, Sjøgren P.

Acta Paediatr. 2018 Oct;107(10):1781-1785. doi: 10.1111/apa.14331. Epub 2018 Apr 19.

PMID:
29566441
27.

Interactions Between Thiopurine Metabolites, Adalimumab, and Antibodies Against Adalimumab in Previously Infliximab-Treated Patients with Inflammatory Bowel Disease.

Holmstrøm RB, Mogensen DV, Brynskov J, Ainsworth MA, Nersting J, Schmiegelow K, Steenholdt C.

Dig Dis Sci. 2018 Jun;63(6):1583-1591. doi: 10.1007/s10620-018-5020-9. Epub 2018 Mar 21.

PMID:
29564674
28.

DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia.

Borssén M, Nordlund J, Haider Z, Landfors M, Larsson P, Kanerva J, Schmiegelow K, Flaegstad T, Jónsson ÓG, Frost BM, Palle J, Forestier E, Heyman M, Hultdin M, Lönnerholm G, Degerman S.

Clin Epigenetics. 2018 Mar 5;10:31. doi: 10.1186/s13148-018-0466-3. eCollection 2018.

29.

MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia.

Evensen NA, Madhusoodhan PP, Meyer J, Saliba J, Chowdhury A, Araten DJ, Nersting J, Bhatla T, Vincent TL, Teachey D, Hunger SP, Yang J, Schmiegelow K, Carroll WL.

Haematologica. 2018 May;103(5):830-839. doi: 10.3324/haematol.2017.176362. Epub 2018 Feb 15.

30.

Role of TPMT and ITPA variants in mercaptopurine disposition.

Gerbek T, Ebbesen M, Nersting J, Frandsen TL, Appell ML, Schmiegelow K.

Cancer Chemother Pharmacol. 2018 Mar;81(3):579-586. doi: 10.1007/s00280-018-3525-8. Epub 2018 Feb 1.

PMID:
29387964
31.

Clinical characteristics and registry-validated extended pedigrees of germline TP53 mutation carriers in Denmark.

Stoltze U, Skytte AB, Roed H, Hasle H, Ejlertsen B, Overeem Hansen TV, Schmiegelow K, Gerdes AM, Wadt K.

PLoS One. 2018 Jan 11;13(1):e0190050. doi: 10.1371/journal.pone.0190050. eCollection 2018.

32.

Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening.

Schäfer D, Olsen M, Lähnemann D, Stanulla M, Slany R, Schmiegelow K, Borkhardt A, Fischer U.

Blood. 2018 Feb 15;131(7):821-826. doi: 10.1182/blood-2017-09-808402. Epub 2018 Jan 8. No abstract available.

33.

A Role for Thiopurine Metabolites in the Synergism Between Thiopurines and Infliximab in Inflammatory Bowel Disease.

Mogensen DV, Brynskov J, Ainsworth MA, Nersting J, Schmiegelow K, Steenholdt C.

J Crohns Colitis. 2018 Feb 28;12(3):298-305. doi: 10.1093/ecco-jcc/jjx149.

PMID:
29145599
34.

Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance.

Ramsey LB, Balis FM, O'Brien MM, Schmiegelow K, Pauley JL, Bleyer A, Widemann BC, Askenazi D, Bergeron S, Shirali A, Schwartz S, Vinks AA, Heldrup J.

Oncologist. 2018 Jan;23(1):52-61. doi: 10.1634/theoncologist.2017-0243. Epub 2017 Oct 27.

35.

Individualized 6-mercaptopurine increments in consolidation treatment of childhood acute lymphoblastic leukemia: A NOPHO randomized controlled trial.

Tulstrup M, Frandsen TL, Abrahamsson J, Lund B, Vettenranta K, Jonsson OG, Marquart HVH, Albertsen BK, Heyman M, Schmiegelow K.

Eur J Haematol. 2018 Jan;100(1):53-60. doi: 10.1111/ejh.12979. Epub 2017 Nov 9.

PMID:
28983968
36.

Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring.

Søegaard SH, Rostgaard K, Kamper-Jørgensen M, Schmiegelow K, Hjalgrim H.

Br J Cancer. 2018 Jan;118(1):117-120. doi: 10.1038/bjc.2017.351. Epub 2017 Oct 3.

37.

Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?

Erdmann F, Winther JF, Dalton SO, Zeeb H, Krøyer A, Bautz A, Schmiegelow K, Schüz J.

Int J Cancer. 2018 Feb 15;142(4):671-680. doi: 10.1002/ijc.31082. Epub 2017 Oct 16.

38.

Youth friendly communication in a transition clinic aimed at adolescents with chronic illness.

Hanghøj S, Boisen KA, Schmiegelow K, Hølge-Hazelton B.

Int J Adolesc Med Health. 2017 Aug 29. pii: /j/ijamh.ahead-of-print/ijamh-2017-0083/ijamh-2017-0083.xml. doi: 10.1515/ijamh-2017-0083. [Epub ahead of print]

PMID:
28850549
39.

Results of NOPHO ALL2008 treatment for patients aged 1-45 years with acute lymphoblastic leukemia.

Toft N, Birgens H, Abrahamsson J, Griškevičius L, Hallböök H, Heyman M, Klausen TW, Jónsson ÓG, Palk K, Pruunsild K, Quist-Paulsen P, Vaitkeviciene G, Vettenranta K, Åsberg A, Frandsen TL, Marquart HV, Madsen HO, Norén-Nyström U, Schmiegelow K.

Leukemia. 2018 Mar;32(3):606-615. doi: 10.1038/leu.2017.265. Epub 2017 Aug 18.

PMID:
28819280
40.

A qualitative study of decision-making on Phase III randomized clinical trial participation in paediatric oncology: Adolescents' and parents' perspectives and preferences.

Ingersgaard MV, Tulstrup M, Schmiegelow K, Larsen HB.

J Adv Nurs. 2018 Jan;74(1):110-118. doi: 10.1111/jan.13407. Epub 2017 Sep 10.

PMID:
28771784
41.

Cardiorespiratory fitness and physical function in children with cancer from diagnosis throughout treatment.

Thorsteinsson T, Larsen HB, Schmiegelow K, Thing LF, Krustrup P, Pedersen MT, Christensen KB, Mogensen PR, Helms AS, Andersen LB.

BMJ Open Sport Exerc Med. 2017 May 12;3(1):e000179. doi: 10.1136/bmjsem-2016-000179. eCollection 2017.

42.

Asparaginase-associated pancreatitis in childhood acute lymphoblastic leukaemia: an observational Ponte di Legno Toxicity Working Group study.

Wolthers BO, Frandsen TL, Baruchel A, Attarbaschi A, Barzilai S, Colombini A, Escherich G, Grell K, Inaba H, Kovacs G, Liang DC, Mateos M, Mondelaers V, Möricke A, Ociepa T, Samarasinghe S, Silverman LB, van der Sluis IM, Stanulla M, Vrooman LM, Yano M, Zapotocka E, Schmiegelow K; Ponte di Legno Toxicity Working Group.

Lancet Oncol. 2017 Sep;18(9):1238-1248. doi: 10.1016/S1470-2045(17)30424-2. Epub 2017 Jul 20.

PMID:
28736188
43.

Prolonged first-line PEG-asparaginase treatment in pediatric acute lymphoblastic leukemia in the NOPHO ALL2008 protocol-Pharmacokinetics and antibody formation.

Tram Henriksen L, Gottschalk Højfeldt S, Schmiegelow K, Frandsen TL, Skov Wehner P, Schrøder H, Klug Albertsen B; Nordic Society of Pediatric Hematology and Oncology, NOPHO Group.

Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26686. Epub 2017 Jun 29.

PMID:
28660740
44.

EEG with extreme delta brush in young female with methotrexate neurotoxicity supports NMDA receptor involvement.

Schmidt LS, Kjær TW, Schmiegelow K, Born AP.

Eur J Paediatr Neurol. 2017 Sep;21(5):795-797. doi: 10.1016/j.ejpn.2017.05.008. Epub 2017 Jun 15.

PMID:
28655493
45.

Liposomal Cytarabine Induces Less Neurocognitive Dysfunction Than Intrathecal Methotrexate in an Animal Model.

Thomsen AM, Gulinello ME, Wen J, Schmiegelow K, Cole PD.

J Pediatr Hematol Oncol. 2018 Mar;40(2):e91-e96. doi: 10.1097/MPH.0000000000000888.

PMID:
28654460
46.

Cerebellar mutism syndrome in children with brain tumours of the posterior fossa.

Wibroe M, Cappelen J, Castor C, Clausen N, Grillner P, Gudrunardottir T, Gupta R, Gustavsson B, Heyman M, Holm S, Karppinen A, Klausen C, Lönnqvist T, Mathiasen R, Nilsson P, Nysom K, Persson K, Rask O, Schmiegelow K, Sehested A, Thomassen H, Tonning-Olsson I, Zetterqvist B, Juhler M.

BMC Cancer. 2017 Jun 21;17(1):439. doi: 10.1186/s12885-017-3416-0.

47.

Do cytogenetics of acute lymphoblastic leukaemia blasts affect required duration and intensity of maintenance therapy? - Authors' reply.

Schmiegelow K, Nielsen SN, Grell K.

Lancet Oncol. 2017 Jun;18(6):e292. doi: 10.1016/S1470-2045(17)30348-0. No abstract available.

PMID:
28593847
48.

Early presentation of osteonecrosis in acute lymphoblastic leukemia: Two children from the Nordic and Baltic cohort.

Mogensen SS, Harila-Saari A, Frandsen TL, Lähteenmäki P, Castor A, Kohonen I, Schmiegelow K, Mäkitie O.

Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26624. Epub 2017 May 18.

PMID:
28521072
49.

Children with low-risk acute lymphoblastic leukemia are at highest risk of second cancers.

Nielsen SN, Eriksson F, Rosthoej S, Andersen MK, Forestier E, Hasle H, Hjalgrim LL, Aasberg A, Abrahamsson J, Heyman M, Jónsson ÓG, Pruunsild K, Vaitkeviciené GE, Vettenranta K, Schmiegelow K.

Pediatr Blood Cancer. 2017 Oct;64(10). doi: 10.1002/pbc.26518. Epub 2017 May 13.

PMID:
28500740
50.

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.

Moriyama T, Nishii R, Lin TN, Kihira K, Toyoda H, Jacob N, Kato M, Koh K, Inaba H, Manabe A, Schmiegelow K, Yang JJ, Hori H.

Pharmacogenet Genomics. 2017 Jun;27(6):236-239. doi: 10.1097/FPC.0000000000000282.

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