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Items: 1 to 50 of 53

1.

Loxapine for Treatment of Patients With Refractory, Chemotherapy-Induced Neuropathic Pain: A Prematurely Terminated Pilot Study Showing Efficacy But Limited Tolerability.

Schmiedl S, Peters D, Schmalz O, Mielke A, Rossmanith T, Diop S, Piefke M, Thürmann P, Schmidtko A.

Front Pharmacol. 2019 Jul 25;10:838. doi: 10.3389/fphar.2019.00838. eCollection 2019.

2.

Narciclasine exerts anti-inflammatory actions by blocking leukocyte-endothelial cell interactions and down-regulation of the endothelial TNF receptor 1.

Stark A, Schwenk R, Wack G, Zuchtriegel G, Hatemler MG, Bräutigam J, Schmidtko A, Reichel CA, Bischoff I, Fürst R.

FASEB J. 2019 Aug;33(8):8771-8781. doi: 10.1096/fj.201802440R. Epub 2019 Apr 24.

PMID:
31017817
3.

Distinct functions of soluble guanylyl cyclase isoforms NO-GC1 and NO-GC2 in inflammatory and neuropathic pain processing.

Petersen J, Mergia E, Kennel L, Drees O, Steubing RD, Real CI, Kallenborn-Gerhardt W, Lu R, Friebe A, Koesling D, Schmidtko A.

Pain. 2019 Mar;160(3):607-618. doi: 10.1097/j.pain.0000000000001440.

PMID:
30422870
4.

Human adenovirus type 17 from species D transduces endothelial cells and human CD46 is involved in cell entry.

Liu J, Boehme P, Zhang W, Fu J, Yumul R, Mese K, Tsoukas R, Solanki M, Kaufmann M, Lu R, Schmidtko A, Stewart AF, Lieber A, Ehrhardt A.

Sci Rep. 2018 Sep 7;8(1):13442. doi: 10.1038/s41598-018-31713-x.

5.

cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators.

Peters S, Paolillo M, Mergia E, Koesling D, Kennel L, Schmidtko A, Russwurm M, Feil R.

Int J Mol Sci. 2018 Aug 7;19(8). pii: E2313. doi: 10.3390/ijms19082313.

6.

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.

Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, Merk D.

J Med Chem. 2018 Jul 12;61(13):5758-5764. doi: 10.1021/acs.jmedchem.8b00458. Epub 2018 Jun 22.

PMID:
29878767
7.

The Absence of Sensory Axon Bifurcation Affects Nociception and Termination Fields of Afferents in the Spinal Cord.

Tröster P, Haseleu J, Petersen J, Drees O, Schmidtko A, Schwaller F, Lewin GR, Ter-Avetisyan G, Winter Y, Peters S, Feil S, Feil R, Rathjen FG, Schmidt H.

Front Mol Neurosci. 2018 Feb 8;11:19. doi: 10.3389/fnmol.2018.00019. eCollection 2018.

8.

Correction to: Meeting report of the 8th International Conference on "cGMP BcGMP: generators, effectors, and therapeutic implications" at Bamberg, Germany, from June 23 to 25, 2017.

Friebe A, Sandner P, Schmidtko A.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar;391(3):347. doi: 10.1007/s00210-018-1472-x.

PMID:
29362847
9.

Meeting report of the 8th International Conference on cGMP "cGMP: generators, effectors, and therapeutic implications" at Bamberg, Germany, from June 23 to 25, 2017.

Friebe A, Sandner P, Schmidtko A.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec;390(12):1177-1188. doi: 10.1007/s00210-017-1429-5. Epub 2017 Oct 10. Erratum in: Naunyn Schmiedebergs Arch Pharmacol. 2018 Jan 24;:.

10.

KCa3.1 channels modulate the processing of noxious chemical stimuli in mice.

Lu R, Flauaus C, Kennel L, Petersen J, Drees O, Kallenborn-Gerhardt W, Ruth P, Lukowski R, Schmidtko A.

Neuropharmacology. 2017 Oct;125:386-395. doi: 10.1016/j.neuropharm.2017.08.021. Epub 2017 Aug 18.

PMID:
28823609
11.

Rab7-a novel redox target that modulates inflammatory pain processing.

Kallenborn-Gerhardt W, Möser CV, Lorenz JE, Steger M, Heidler J, Scheving R, Petersen J, Kennel L, Flauaus C, Lu R, Edinger AL, Tegeder I, Geisslinger G, Heide H, Wittig I, Schmidtko A.

Pain. 2017 Jul;158(7):1354-1365. doi: 10.1097/j.pain.0000000000000920.

PMID:
28394828
12.

Cleavage of SNAP-25 ameliorates cancer pain in a mouse model of melanoma.

Olbrich K, Costard L, Möser CV, Syhr KM, King-Himmelreich TS, Wolters MC, Schmidtko A, Geisslinger G, Niederberger E.

Eur J Pain. 2017 Jan;21(1):101-111. doi: 10.1002/ejp.904. Epub 2016 Jun 15.

PMID:
27301493
13.

The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.

Syhr KMJ, Boosen M, Hohmann SW, Longen S, Köhler Y, Pfeilschifter J, Beck KF, Geisslinger G, Schmidtko A, Kallenborn-Gerhardt W.

Brain Res. 2015 Oct 22;1624:380-389. doi: 10.1016/j.brainres.2015.07.058. Epub 2015 Aug 10.

PMID:
26271715
14.

Nitric oxide-mediated pain processing in the spinal cord.

Schmidtko A.

Handb Exp Pharmacol. 2015;227:103-17. doi: 10.1007/978-3-662-46450-2_6. Review.

PMID:
25846616
15.

Slack channels expressed in sensory neurons control neuropathic pain in mice.

Lu R, Bausch AE, Kallenborn-Gerhardt W, Stoetzer C, Debruin N, Ruth P, Geisslinger G, Leffler A, Lukowski R, Schmidtko A.

J Neurosci. 2015 Jan 21;35(3):1125-35. doi: 10.1523/JNEUROSCI.2423-14.2015.

16.

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

Kallenborn-Gerhardt W, Hohmann SW, Syhr KM, Schröder K, Sisignano M, Weigert A, Lorenz JE, Lu R, Brüne B, Brandes RP, Geisslinger G, Schmidtko A.

Pain. 2014 Oct;155(10):2161-70. doi: 10.1016/j.pain.2014.08.013. Epub 2014 Aug 17.

PMID:
25139590
17.

Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice.

Syhr KM, Kallenborn-Gerhardt W, Lu R, Olbrich K, Schmitz K, Männich J, Ferreiros-Bouzas N, Geisslinger G, Niederberger E, Schmidtko A.

Pharmacol Biochem Behav. 2014 Sep;124:389-95. doi: 10.1016/j.pbb.2014.07.009. Epub 2014 Jul 18.

PMID:
25042778
18.

Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing.

Kallenborn-Gerhardt W, Lu R, Bothe A, Thomas D, Schlaudraff J, Lorenz JE, Lippold N, Real CI, Ferreirós N, Geisslinger G, Del Turco D, Schmidtko A.

Anesthesiology. 2014 Aug;121(2):372-82. doi: 10.1097/ALN.0000000000000270.

PMID:
24758774
19.

Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury.

Lorenz JE, Kallenborn-Gerhardt W, Lu R, Syhr KM, Eaton P, Geisslinger G, Schmidtko A.

Antioxid Redox Signal. 2014 Oct 1;21(10):1504-15. doi: 10.1089/ars.2013.5585. Epub 2014 Mar 5.

20.

BKCa channels expressed in sensory neurons modulate inflammatory pain in mice.

Lu R, Lukowski R, Sausbier M, Zhang DD, Sisignano M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A.

Pain. 2014 Mar;155(3):556-65. doi: 10.1016/j.pain.2013.12.005. Epub 2013 Dec 11.

PMID:
24333777
21.

Direct intrathecal drug delivery in mice for detecting in vivo effects of cGMP on pain processing.

Lu R, Schmidtko A.

Methods Mol Biol. 2013;1020:215-21. doi: 10.1007/978-1-62703-459-3_14.

PMID:
23709036
22.

Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.

Kallenborn-Gerhardt W, Lu R, Syhr KM, Heidler J, von Melchner H, Geisslinger G, Bangsow T, Schmidtko A.

Antioxid Redox Signal. 2013 Dec 10;19(17):2013-23. doi: 10.1089/ars.2012.4958. Epub 2013 Apr 19.

23.

NOXious signaling in pain processing.

Kallenborn-Gerhardt W, Schröder K, Geisslinger G, Schmidtko A.

Pharmacol Ther. 2013 Mar;137(3):309-17. doi: 10.1016/j.pharmthera.2012.11.001. Epub 2012 Nov 9. Review.

PMID:
23146925
24.

NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury.

Kallenborn-Gerhardt W, Schröder K, Del Turco D, Lu R, Kynast K, Kosowski J, Niederberger E, Shah AM, Brandes RP, Geisslinger G, Schmidtko A.

J Neurosci. 2012 Jul 25;32(30):10136-45. doi: 10.1523/JNEUROSCI.6227-11.2012.

25.

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.

Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C.

J Neurosci. 2012 May 2;32(18):6364-72. doi: 10.1523/JNEUROSCI.5793-11.2012.

26.

Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury.

Lu R, Kallenborn-Gerhardt W, Geisslinger G, Schmidtko A.

PLoS One. 2011;6(12):e29240. doi: 10.1371/journal.pone.0029240. Epub 2011 Dec 14.

27.

Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2.

Kallenborn-Gerhardt W, Lu R, Lorenz J, Gao W, Weiland J, Del Turco D, Deller T, Laube B, Betz H, Geisslinger G, Schmidtko A.

Behav Brain Res. 2012 Jan 1;226(1):106-11. doi: 10.1016/j.bbr.2011.09.002. Epub 2011 Sep 8.

PMID:
21924294
28.

The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia.

Möser CV, Kynast K, Baatz K, Russe OQ, Ferreirós N, Costiuk H, Lu R, Schmidtko A, Tegeder I, Geisslinger G, Niederberger E.

J Immunol. 2011 Sep 1;187(5):2617-25. doi: 10.4049/jimmunol.1004088. Epub 2011 Aug 3.

29.

CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity.

Heine S, Michalakis S, Kallenborn-Gerhardt W, Lu R, Lim HY, Weiland J, Del Turco D, Deller T, Tegeder I, Biel M, Geisslinger G, Schmidtko A.

J Neurosci. 2011 Aug 3;31(31):11184-92. doi: 10.1523/JNEUROSCI.6159-10.2011.

30.

A novel signaling pathway that modulates inflammatory pain.

Kallenborn-Gerhardt W, Schmidtko A.

J Neurosci. 2011 Jan 19;31(3):798-800. doi: 10.1523/JNEUROSCI.5285-10.2011. No abstract available.

31.

Ziconotide for treatment of severe chronic pain.

Schmidtko A, Lötsch J, Freynhagen R, Geisslinger G.

Lancet. 2010 May 1;375(9725):1569-77. doi: 10.1016/S0140-6736(10)60354-6. Epub 2010 Apr 21.

PMID:
20413151
32.

Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia.

Altis K, Schmidtko A, Angioni C, Kuczka K, Schmidt H, Geisslinger G, Lötsch J, Tegeder I.

Pain. 2009 Dec 15;147(1-3):116-21. doi: 10.1016/j.pain.2009.08.018. Epub 2009 Sep 16.

PMID:
19762153
33.

Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever.

Gao W, Schmidtko A, Wobst I, Lu R, Angioni C, Geisslinger G.

J Physiol Pharmacol. 2009 Jun;60(2):145-50.

34.

No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing.

Schmidtko A, Tegeder I, Geisslinger G.

Trends Neurosci. 2009 Jun;32(6):339-46. doi: 10.1016/j.tins.2009.01.010. Epub 2009 May 4. Review.

PMID:
19414201
35.

Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2).

Gao W, Schmidtko A, Lu R, Brenneis C, Angioni C, Schmidt R, Geisslinger G.

Eur J Pharmacol. 2009 Apr 17;608(1-3):28-31. doi: 10.1016/j.ejphar.2009.01.051. Epub 2009 Feb 26.

PMID:
19249295
36.

Toponomics analysis of functional interactions of the ubiquitin ligase PAM (Protein Associated with Myc) during spinal nociceptive processing.

Pierre S, Maeurer C, Coste O, Becker W, Schmidtko A, Holland S, Wittpoth C, Geisslinger G, Scholich K.

Mol Cell Proteomics. 2008 Dec;7(12):2475-85. doi: 10.1074/mcp.M800201-MCP200. Epub 2008 Aug 26.

37.

cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.

Schmidtko A, Gao W, König P, Heine S, Motterlini R, Ruth P, Schlossmann J, Koesling D, Niederberger E, Tegeder I, Friebe A, Geisslinger G.

J Neurosci. 2008 Aug 20;28(34):8568-76. doi: 10.1523/JNEUROSCI.2128-08.2008.

38.

Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn.

Schmidtko A, Luo C, Gao W, Geisslinger G, Kuner R, Tegeder I.

Pain. 2008 Oct 31;139(3):632-43. doi: 10.1016/j.pain.2008.06.018. Epub 2008 Aug 12.

PMID:
18701217
39.

Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain.

Schmidtko A, Gao W, Sausbier M, Rauhmeier I, Sausbier U, Niederberger E, Scholich K, Huber A, Neuhuber W, Allescher HD, Hofmann F, Tegeder I, Ruth P, Geisslinger G.

J Neurosci. 2008 Feb 6;28(6):1320-30. doi: 10.1523/JNEUROSCI.5037-07.2008.

40.

The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.

Niederberger E, Ehnert C, Gao W, Coste O, Schmidtko A, Popp L, Gall CV, Korf HW, Tegeder I, Geisslinger G.

Biochem Biophys Res Commun. 2007 Oct 12;362(1):75-80. doi: 10.1016/j.bbrc.2007.07.148. Epub 2007 Aug 6.

PMID:
17692820
41.

Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB.

Niederberger E, Schmidtko A, Gao W, Kühlein H, Ehnert C, Geisslinger G.

Eur J Pharmacol. 2007 Mar 15;559(1):55-60. Epub 2006 Dec 12.

PMID:
17217946
42.

Pharmacological and histopathological characterization of a hyperalgesia model induced by freeze lesion.

Schmidtko A, Burian M, Altis K, Hardt K, Angioni C, Schmidt R, Podda M, Geisslinger G.

Pain. 2007 Feb;127(3):287-95. Epub 2006 Dec 26.

PMID:
17189672
43.

The glutamate transporter GLAST is involved in spinal nociceptive processing.

Niederberger E, Schmidtko A, Coste O, Marian C, Ehnert C, Geisslinger G.

Biochem Biophys Res Commun. 2006 Jul 28;346(2):393-9. Epub 2006 Jun 5.

PMID:
16765320
44.

Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord.

Schmidtko A, Del Turco D, Coste O, Ehnert C, Niederberger E, Ruth P, Deller T, Geisslinger G, Tegeder I.

Pain. 2005 May;115(1-2):171-81.

PMID:
15836980
45.

The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia.

Kunz S, Niederberger E, Ehnert C, Coste O, Pfenninger A, Kruip J, Wendrich TM, Schmidtko A, Tegeder I, Geisslinger G.

Pain. 2004 Jul;110(1-2):409-18.

PMID:
15275793
46.

Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.

Tegeder I, Del Turco D, Schmidtko A, Sausbier M, Feil R, Hofmann F, Deller T, Ruth P, Geisslinger G.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3253-7. Epub 2004 Feb 18.

47.

Protein associated with Myc (PAM) is involved in spinal nociceptive processing.

Ehnert C, Tegeder I, Pierre S, Birod K, Nguyen HV, Schmidtko A, Geisslinger G, Scholich K.

J Neurochem. 2004 Feb;88(4):948-57.

48.

G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.

Tegeder I, Grösch S, Schmidtko A, Häussler A, Schmidt H, Niederberger E, Scholich K, Geisslinger G.

Cancer Res. 2003 Apr 15;63(8):1846-52.

50.

Modulation of spinal nociceptive processing through the glutamate transporter GLT-1.

Niederberger E, Schmidtko A, Rothstein JD, Geisslinger G, Tegeder I.

Neuroscience. 2003;116(1):81-7.

PMID:
12535941

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