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Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products.

Petrlova J, Petruk G, Huber RG, McBurnie EW, van der Plas MJA, Bond PJ, Puthia M, Schmidtchen A.

J Biol Chem. 2020 Feb 7. pii: jbc.RA120.012741. doi: 10.1074/jbc.RA120.012741. [Epub ahead of print]


A dual-action peptide-containing hydrogel targets wound infection and inflammation.

Puthia M, Butrym M, Petrlova J, Strömdahl AC, Andersson MÅ, Kjellström S, Schmidtchen A.

Sci Transl Med. 2020 Jan 1;12(524). pii: eaax6601. doi: 10.1126/scitranslmed.aax6601.


A C-terminal peptide of TFPI-1 facilitates cytosolic delivery of nucleic acid cargo into mammalian cells.

Fazil MHUT, Chalasani MLS, Choong YK, Schmidtchen A, Verma NK, Saravanan R.

Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183093. doi: 10.1016/j.bbamem.2019.183093. Epub 2019 Oct 28.


Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting.

Saleh K, Strömdahl AC, Riesbeck K, Schmidtchen A.

Front Med (Lausanne). 2019 Jul 12;6:159. doi: 10.3389/fmed.2019.00159. eCollection 2019.


Multiscale modeling of innate immune receptors: Endotoxin recognition and regulation by host defense peptides.

Holdbrook DA, Huber RG, Marzinek JK, Stubbusch A, Schmidtchen A, Bond PJ.

Pharmacol Res. 2019 Sep;147:104372. doi: 10.1016/j.phrs.2019.104372. Epub 2019 Jul 24. Review.


Degradable dendritic nanogels as carriers for antimicrobial peptides.

Nordström R, Andrén OCJ, Singh S, Malkoch M, Davoudi M, Schmidtchen A, Malmsten M.

J Colloid Interface Sci. 2019 Oct 15;554:592-602. doi: 10.1016/j.jcis.2019.07.028. Epub 2019 Jul 13.


[Superficial surgical site infections in dermatologic surgery].

Saleh K, Schmidtchen A.

Lakartidningen. 2019 Mar 26;116. pii: FHM6. Review. Swedish.


Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1α,25-dihydroxyvitamin D3.

Suri BK, Schmidtchen A, Verma NK.

Exp Dermatol. 2019 Aug;28(8):976-980. doi: 10.1111/exd.13976. Epub 2019 Jul 3.


Interaction of Laponite with Membrane Components-Consequences for Bacterial Aggregation and Infection Confinement.

Malekkhaiat Häffner S, Nyström L, Browning KL, Mörck Nielsen H, Strömstedt AA, van der Plas MJA, Schmidtchen A, Malmsten M.

ACS Appl Mater Interfaces. 2019 May 1;11(17):15389-15400. doi: 10.1021/acsami.9b03527. Epub 2019 Apr 17.


Variability in the diagnosis of surgical-site infections after full-thickness skin grafting: an international survey.

Palmgren J, Paoli J, Schmidtchen A, Saleh K.

Br J Dermatol. 2019 May;180(5):1169-1175. doi: 10.1111/bjd.17517. Epub 2019 Feb 4.


A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis.

Tenland E, Krishnan N, Rönnholm A, Kalsum S, Puthia M, Mörgelin M, Davoudi M, Otrocka M, Alaridah N, Glegola-Madejska I, Sturegård E, Schmidtchen A, Lerm M, Robertson BD, Godaly G.

Tuberculosis (Edinb). 2018 Dec;113:231-238. doi: 10.1016/ Epub 2018 Oct 30.


Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies.

Martinengo L, Olsson M, Bajpai R, Soljak M, Upton Z, Schmidtchen A, Car J, Järbrink K.

Ann Epidemiol. 2019 Jan;29:8-15. doi: 10.1016/j.annepidem.2018.10.005. Epub 2018 Nov 12.


The humanistic and economic burden of chronic wounds: A systematic review.

Olsson M, Järbrink K, Divakar U, Bajpai R, Upton Z, Schmidtchen A, Car J.

Wound Repair Regen. 2019 Jan;27(1):114-125. doi: 10.1111/wrr.12683. Epub 2018 Dec 2.


TFPI-2 Protects Against Gram-Negative Bacterial Infection.

Ali MN, Kasetty G, Elvén M, Alyafei S, Jovic S, Egesten A, Herwald H, Schmidtchen A, Papareddy P.

Front Immunol. 2018 Sep 11;9:2072. doi: 10.3389/fimmu.2018.02072. eCollection 2018.


Bacteria Display Differential Growth and Adhesion Characteristics on Human Hair Shafts.

Kerk SK, Lai HY, Sze SK, Ng KW, Schmidtchen A, Adav SS.

Front Microbiol. 2018 Sep 7;9:2145. doi: 10.3389/fmicb.2018.02145. eCollection 2018.


Thrombin and Plasmin Alter the Proteome of Neutrophil Extracellular Traps.

Lim CH, Adav SS, Sze SK, Choong YK, Saravanan R, Schmidtchen A.

Front Immunol. 2018 Jul 9;9:1554. doi: 10.3389/fimmu.2018.01554. eCollection 2018.


Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides.

Saravanan R, Holdbrook DA, Petrlova J, Singh S, Berglund NA, Choong YK, Kjellström S, Bond PJ, Malmsten M, Schmidtchen A.

Nat Commun. 2018 Jul 17;9(1):2762. doi: 10.1038/s41467-018-05242-0.


Peptide-Loaded Microgels as Antimicrobial and Anti-Inflammatory Surface Coatings.

Nyström L, Strömstedt AA, Schmidtchen A, Malmsten M.

Biomacromolecules. 2018 Aug 13;19(8):3456-3466. doi: 10.1021/acs.biomac.8b00776. Epub 2018 Jul 18.


Collagen VI Contains Multiple Host Defense Peptides with Potent In Vivo Activity.

Abdillahi SM, Maaß T, Kasetty G, Strömstedt AA, Baumgarten M, Tati R, Nordin SL, Walse B, Wagener R, Schmidtchen A, Mörgelin M.

J Immunol. 2018 Aug 1;201(3):1007-1020. doi: 10.4049/jimmunol.1700602. Epub 2018 Jun 20.


Influence of pH on the activity of thrombin-derived antimicrobial peptides.

Holdbrook DA, Singh S, Choong YK, Petrlova J, Malmsten M, Bond PJ, Verma NK, Schmidtchen A, Saravanan R.

Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2374-2384. doi: 10.1016/j.bbamem.2018.06.002. Epub 2018 Jun 6.


A Thermodynamic Funnel Drives Bacterial Lipopolysaccharide Transfer in the TLR4 Pathway.

Huber RG, Berglund NA, Kargas V, Marzinek JK, Holdbrook DA, Khalid S, Piggot TJ, Schmidtchen A, Bond PJ.

Structure. 2018 Aug 7;26(8):1151-1161.e4. doi: 10.1016/j.str.2018.04.007. Epub 2018 May 17.


Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes.

Suri BK, Verma NK, Schmidtchen A.

Acta Derm Venereol. 2018 Aug 29;98(8):762-765. doi: 10.2340/00015555-2963.


Identification of Antibacterial Components in Human Hair Shafts.

Subbaiah RS, Kerk SK, Lian Y, Lunny D, Sze SK, Ng KW, Schmidtchen A, Adav SS.

Acta Derm Venereol. 2018 Jul 11;98(7):708-710. doi: 10.2340/00015555-2952. No abstract available.


Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins.

Adav SS, Subbaiaih RS, Kerk SK, Lee AY, Lai HY, Ng KW, Sze SK, Schmidtchen A.

Sci Rep. 2018 Jan 25;8(1):1599. doi: 10.1038/s41598-018-20041-9.


Membrane interactions of microgels as carriers of antimicrobial peptides.

Nordström R, Nyström L, Andrén OCJ, Malkoch M, Umerska A, Davoudi M, Schmidtchen A, Malmsten M.

J Colloid Interface Sci. 2018 Mar 1;513:141-150. doi: 10.1016/j.jcis.2017.11.014. Epub 2017 Nov 6.


Conformational Aspects of High Content Packing of Antimicrobial Peptides in Polymer Microgels.

Singh S, Datta A, Borro BC, Davoudi M, Schmidtchen A, Bhunia A, Malmsten M.

ACS Appl Mater Interfaces. 2017 Nov 22;9(46):40094-40106. doi: 10.1021/acsami.7b13714. Epub 2017 Nov 9.


Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo.

Saravanan R, Adav SS, Choong YK, van der Plas MJA, Petrlova J, Kjellström S, Sze SK, Schmidtchen A.

Sci Rep. 2017 Oct 13;7(1):13136. doi: 10.1038/s41598-017-13197-3.


Thrombin-derived host defence peptide modulates neutrophil rolling and migration in vitro and functional response in vivo.

Lim CH, Puthia M, Butrym M, Tay HM, Lee MZY, Hou HW, Schmidtchen A.

Sci Rep. 2017 Sep 11;7(1):11201. doi: 10.1038/s41598-017-11464-x.


Need for Improved Definition of "Chronic Wounds" in Clinical Studies.

Kyaw BM, Järbrink K, Martinengo L, Car J, Harding K, Schmidtchen A.

Acta Derm Venereol. 2018 Jan 12;98(1):157-158. doi: 10.2340/00015555-2786. Review. No abstract available.


Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis.

Sonesson A, Przybyszewska K, Eriksson S, Mörgelin M, Kjellström S, Davies J, Potempa J, Schmidtchen A.

Sci Rep. 2017 Aug 18;7(1):8689. doi: 10.1038/s41598-017-08046-2.


Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria.

Hansen FC, Strömdahl AC, Mörgelin M, Schmidtchen A, van der Plas MJA.

Front Immunol. 2017 Jul 21;8:843. doi: 10.3389/fimmu.2017.00843. eCollection 2017.


Membrane interactions and antimicrobial effects of layered double hydroxide nanoparticles.

Malekkhaiat Häffner S, Nyström L, Nordström R, Xu ZP, Davoudi M, Schmidtchen A, Malmsten M.

Phys Chem Chem Phys. 2017 Sep 13;19(35):23832-23842. doi: 10.1039/c7cp02701j.


Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism.

Petrlova J, Hansen FC, van der Plas MJA, Huber RG, Mörgelin M, Malmsten M, Bond PJ, Schmidtchen A.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4213-E4222. doi: 10.1073/pnas.1619609114. Epub 2017 May 4.


Tryptophan end-tagging for promoted lipopolysaccharide interactions and anti-inflammatory effects.

Singh S, Datta A, Schmidtchen A, Bhunia A, Malmsten M.

Sci Rep. 2017 Mar 16;7(1):212. doi: 10.1038/s41598-017-00188-7.


The humanistic and economic burden of chronic wounds: a protocol for a systematic review.

Järbrink K, Ni G, Sönnergren H, Schmidtchen A, Pang C, Bajpai R, Car J.

Syst Rev. 2017 Jan 24;6(1):15. doi: 10.1186/s13643-016-0400-8.


A New Look for ActaDV with More Rapid Publication.

Vahlquist A, Schmidtchen A, Andersson A.

Acta Derm Venereol. 2017 Jan 4;97(1):3. doi: 10.2340/00015555-2592. No abstract available.


Can dressings soaked with polyhexanide reduce bacterial loads in full-thickness skin grafting? A randomized controlled trial.

Saleh K, Sonesson A, Persson K, Riesbeck K, Schmidtchen A.

J Am Acad Dermatol. 2016 Dec;75(6):1221-1228.e4. doi: 10.1016/j.jaad.2016.07.020. Epub 2016 Sep 27.


Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review.

Järbrink K, Ni G, Sönnergren H, Schmidtchen A, Pang C, Bajpai R, Car J.

Syst Rev. 2016 Sep 8;5(1):152. doi: 10.1186/s13643-016-0329-y.


Saliva induces expression of antimicrobial peptides and promotes intracellular killing of bacteria in keratinocytes by epidermal growth factor receptor transactivation.

Mohanty T, Alberius P, Schmidtchen A, Reiss K, Schröder JM, Sørensen OE.

Br J Dermatol. 2017 Feb;176(2):403-412. doi: 10.1111/bjd.14883. Epub 2017 Jan 24.


Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses.

van der Plas MJ, Bhongir RK, Kjellström S, Siller H, Kasetty G, Mörgelin M, Schmidtchen A.

Nat Commun. 2016 May 16;7:11567. doi: 10.1038/ncomms11567.


Membrane interactions of mesoporous silica nanoparticles as carriers of antimicrobial peptides.

Braun K, Pochert A, Lindén M, Davoudi M, Schmidtchen A, Nordström R, Malmsten M.

J Colloid Interface Sci. 2016 Aug 1;475:161-170. doi: 10.1016/j.jcis.2016.05.002. Epub 2016 May 5.


Role of Aromatic Amino Acids in Lipopolysaccharide and Membrane Interactions of Antimicrobial Peptides for Use in Plant Disease Control.

Datta A, Bhattacharyya D, Singh S, Ghosh A, Schmidtchen A, Malmsten M, Bhunia A.

J Biol Chem. 2016 Jun 17;291(25):13301-17. doi: 10.1074/jbc.M116.719575. Epub 2016 May 2.


Pronounced peptide selectivity for melanoma through tryptophan end-tagging.

Duong DT, Singh S, Bagheri M, Verma NK, Schmidtchen A, Malmsten M.

Sci Rep. 2016 Apr 27;6:24952. doi: 10.1038/srep24952.


Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases.

Eklund Y, Aronsson A, Schmidtchen A, Relander T.

Acta Derm Venereol. 2016 Jun 15;96(5):669-73. doi: 10.2340/00015555-2337.


NLF20: an antimicrobial peptide with therapeutic potential against invasive Pseudomonas aeruginosa infection.

Papareddy P, Kasetty G, Kalle M, Bhongir RK, Mörgelin M, Schmidtchen A, Malmsten M.

J Antimicrob Chemother. 2016 Jan;71(1):170-80. doi: 10.1093/jac/dkv322. Epub 2015 Oct 26.


Different Procoagulant Activity of Therapeutic Mesenchymal Stromal Cells Derived from Bone Marrow and Placental Decidua.

Moll G, Ignatowicz L, Catar R, Luecht C, Sadeghi B, Hamad O, Jungebluth P, Dragun D, Schmidtchen A, Ringdén O.

Stem Cells Dev. 2015 Oct 1;24(19):2269-79. doi: 10.1089/scd.2015.0120. Epub 2015 Aug 24.


The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes.

Hansen FC, Kalle-Brune M, van der Plas MJ, Strömdahl AC, Malmsten M, Mörgelin M, Schmidtchen A.

J Immunol. 2015 Jun 1;194(11):5397-406. doi: 10.4049/jimmunol.1403009. Epub 2015 Apr 24.


Anti-endotoxic and antibacterial effects of a dermal substitute coated with host defense peptides.

Kasetty G, Kalle M, Mörgelin M, Brune JC, Schmidtchen A.

Biomaterials. 2015;53:415-25. doi: 10.1016/j.biomaterials.2015.02.111. Epub 2015 Mar 18.


Surgical site infections in dermatologic surgery: etiology, pathogenesis, and current preventative measures.

Saleh K, Schmidtchen A.

Dermatol Surg. 2015 May;41(5):537-49. doi: 10.1097/DSS.0000000000000364. Review.


(Lipo)polysaccharide interactions of antimicrobial peptides.

Schmidtchen A, Malmsten M.

J Colloid Interface Sci. 2015 Jul 1;449:136-42. doi: 10.1016/j.jcis.2014.11.024. Epub 2014 Nov 20. Review.


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