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Items: 27

1.

Assessment of stem cell differentiation based on genome-wide expression profiles.

Godoy P, Schmidt-Heck W, Hellwig B, Nell P, Feuerborn D, Rahnenführer J, Kattler K, Walter J, Blüthgen N, Hengstler JG.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170221. doi: 10.1098/rstb.2017.0221. Review.

PMID:
29786556
2.

Gene expression profiling of human bronchial epithelial cells exposed to fine particulate matter (PM2.5) from biomass combustion.

Popadić D, Heßelbach K, Richter-Brockmann S, Kim GJ, Flemming S, Schmidt-Heck W, Häupl T, Bonin M, Dornhof R, Achten C, Günther S, Humar M, Merfort I.

Toxicol Appl Pharmacol. 2018 May 15;347:10-22. doi: 10.1016/j.taap.2018.03.024. Epub 2018 Mar 26. No abstract available.

PMID:
29596927
3.

Verticillium dahliae-Arabidopsis Interaction Causes Changes in Gene Expression Profiles and Jasmonate Levels on Different Time Scales.

Scholz SS, Schmidt-Heck W, Guthke R, Furch ACU, Reichelt M, Gershenzon J, Oelmüller R.

Front Microbiol. 2018 Feb 13;9:217. doi: 10.3389/fmicb.2018.00217. eCollection 2018.

4.

Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility.

Rennert C, Eplinius F, Hofmann U, Johänning J, Rolfs F, Schmidt-Heck W, Guthke R, Gebhardt R, Ricken AM, Matz-Soja M.

Arch Toxicol. 2017 Nov;91(11):3677-3687. doi: 10.1007/s00204-017-1999-5. Epub 2017 May 30.

PMID:
28560483
5.

Global Transcriptional Response of Human Liver Cells to Ethanol Stress of Different Strength Reveals Hormetic Behavior.

Schmidt-Heck W, Wönne EC, Hiller T, Menzel U, Koczan D, Damm G, Seehofer D, Knöspel F, Freyer N, Guthke R, Dooley S, Zeilinger K.

Alcohol Clin Exp Res. 2017 May;41(5):883-894. doi: 10.1111/acer.13361. Epub 2017 Mar 27.

PMID:
28226195
6.

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG.

Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23.

7.

Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis.

Matz-Soja M, Rennert C, Schönefeld K, Aleithe S, Boettger J, Schmidt-Heck W, Weiss TS, Hovhannisyan A, Zellmer S, Klöting N, Schulz A, Kratzsch J, Guthke R, Gebhardt R.

Elife. 2016 May 17;5. pii: e13308. doi: 10.7554/eLife.13308.

8.

Corrigendum to "Gene networks and transcription factor motifs defining the differentiation of human stem cells into hepatocyte-like cells" [J Hepatol 2015;63:934-942].

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG.

J Hepatol. 2016 Feb;64(2):525-526. doi: 10.1016/j.jhep.2015.11.003. Epub 2015 Dec 2. No abstract available.

9.

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes.

Cameron K, Tan R, Schmidt-Heck W, Campos G, Lyall MJ, Wang Y, Lucendo-Villarin B, Szkolnicka D, Bates N, Kimber SJ, Hengstler JG, Godoy P, Forbes SJ, Hay DC.

Stem Cell Reports. 2015 Dec 8;5(6):1250-1262. doi: 10.1016/j.stemcr.2015.10.016. Epub 2015 Nov 25.

10.

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG.

J Hepatol. 2015 Oct;63(4):934-42. doi: 10.1016/j.jhep.2015.05.013. Epub 2015 May 25. Erratum in: J Hepatol. 2016 Feb;64(2):525-6. J Hepatol. 2016 Feb;64(2):525-526.

11.

Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.

Schmidt-Heck W, Matz-Soja M, Aleithe S, Marbach E, Guthke R, Gebhardt R.

Mol Biosyst. 2015 Aug;11(8):2190-7. doi: 10.1039/c5mb00129c.

PMID:
26010061
12.

Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.

Macheleidt J, Scherlach K, Neuwirth T, Schmidt-Heck W, Straßburger M, Spraker J, Baccile JA, Schroeder FC, Keller NP, Hertweck C, Heinekamp T, Brakhage AA.

Mol Microbiol. 2015 Apr;96(1):148-62. doi: 10.1111/mmi.12926. Epub 2015 Mar 11.

13.

Toxicogenomics directory of chemically exposed human hepatocytes.

Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16.

PMID:
25399406
14.

Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as an important contributor to hypoxic survival.

Kroll K, Pähtz V, Hillmann F, Vaknin Y, Schmidt-Heck W, Roth M, Jacobsen ID, Osherov N, Brakhage AA, Kniemeyer O.

Eukaryot Cell. 2014 Sep;13(9):1241-53. doi: 10.1128/EC.00084-14. Epub 2014 Aug 1.

15.

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity.

Campos G, Schmidt-Heck W, Ghallab A, Rochlitz K, Pütter L, Medinas DB, Hetz C, Widera A, Cadenas C, Begher-Tibbe B, Reif R, Günther G, Sachinidis A, Hengstler JG, Godoy P.

Arch Toxicol. 2014 Jun;88(6):1267-80. doi: 10.1007/s00204-014-1240-8. Epub 2014 Apr 20.

PMID:
24748426
16.

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels.

Matz-Soja M, Aleithe S, Marbach E, Böttger J, Arnold K, Schmidt-Heck W, Kratzsch J, Gebhardt R.

Cell Commun Signal. 2014 Feb 18;12:11. doi: 10.1186/1478-811X-12-11.

17.

The extended TILAR approach: a novel tool for dynamic modeling of the transcription factor network regulating the adaption to in vitro cultivation of murine hepatocytes.

Vlaic S, Schmidt-Heck W, Matz-Soja M, Marbach E, Linde J, Meyer-Baese A, Zellmer S, Guthke R, Gebhardt R.

BMC Syst Biol. 2012 Nov 29;6:147. doi: 10.1186/1752-0509-6-147.

18.

Transcriptome and functional analysis of mating in the basidiomycete Schizophyllum commune.

Erdmann S, Freihorst D, Raudaskoski M, Schmidt-Heck W, Jung EM, Senftleben D, Kothe E.

Eukaryot Cell. 2012 May;11(5):571-89. doi: 10.1128/EC.05214-11. Epub 2011 Dec 30.

19.

Analysis and Design of Stimulus Response Curves of E. coli.

Kremling A, Goehler A, Jahreis K, Nees M, Auerbach B, Schmidt-Heck W, Kökpinar O, Geffers R, Rinas U, Bettenbrock K.

Metabolites. 2012 Nov 12;2(4):844-71. doi: 10.3390/metabo2040844.

20.

More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli.

Göhler AK, Kökpinar Ö, Schmidt-Heck W, Geffers R, Guthke R, Rinas U, Schuster S, Jahreis K, Kaleta C.

BMC Syst Biol. 2011 Dec 14;5:197. doi: 10.1186/1752-0509-5-197.

21.

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.

Zellmer S, Schmidt-Heck W, Godoy P, Weng H, Meyer C, Lehmann T, Sparna T, Schormann W, Hammad S, Kreutz C, Timmer J, von Weizsäcker F, Thürmann PA, Merfort I, Guthke R, Dooley S, Hengstler JG, Gebhardt R.

Hepatology. 2010 Dec;52(6):2127-36. doi: 10.1002/hep.23930. Epub 2010 Oct 26.

PMID:
20979052
22.

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.

Schroeckh V, Scherlach K, Nützmann HW, Shelest E, Schmidt-Heck W, Schuemann J, Martin K, Hertweck C, Brakhage AA.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14558-63. doi: 10.1073/pnas.0901870106. Epub 2009 Aug 6.

23.

Heterogeneous expression of suppressor of cytokine signalling 2 (SOCS-2) in liver tissue.

Zellmer S, Sickinger S, Schmidt-Heck W, Guthke R, Gebhardt R.

J Anat. 2009 Aug;215(2):176-83. doi: 10.1111/j.1469-7580.2009.01085.x. Epub 2009 May 14.

24.

Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes.

Acikgöz A, Karim N, Giri S, Schmidt-Heck W, Bader A.

Toxicol Appl Pharmacol. 2009 Jan 15;234(2):179-91. doi: 10.1016/j.taap.2008.09.029. Epub 2008 Oct 15.

PMID:
18983865
25.

Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.

Glahn F, Schmidt-Heck W, Zellmer S, Guthke R, Wiese J, Golka K, Hergenröder R, Degen GH, Lehmann T, Hermes M, Schormann W, Brulport M, Bauer A, Bedawy E, Gebhardt R, Hengstler JG, Foth H.

Arch Toxicol. 2008 Aug;82(8):513-24. doi: 10.1007/s00204-008-0331-9. Epub 2008 Jul 25.

PMID:
18654764
26.

Monitoring of transcriptome and proteome profiles to investigate the cellular response of E. coli towards recombinant protein expression under defined chemostat conditions.

Dürrschmid K, Reischer H, Schmidt-Heck W, Hrebicek T, Guthke R, Rizzi A, Bayer K.

J Biotechnol. 2008 May 20;135(1):34-44. doi: 10.1016/j.jbiotec.2008.02.013. Epub 2008 Mar 4.

PMID:
18405993
27.

Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors.

Guthke R, Zeilinger K, Sickinger S, Schmidt-Heck W, Buentemeyer H, Iding K, Lehmann J, Pfaff M, Pless G, Gerlach JC.

Bioprocess Biosyst Eng. 2006 Apr;28(5):331-40. Epub 2006 Mar 21.

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