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A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge.

Winkler T, Sass FA, Duda GN, Schmidt-Bleek K.

Bone Joint Res. 2018 May 5;7(3):232-243. doi: 10.1302/2046-3758.73.BJR-2017-0270.R1. eCollection 2018 Mar.


Distinct Housing Conditions Reveal a Major Impact of Adaptive Immunity on the Course of Obesity-Induced Type 2 Diabetes.

Sbierski-Kind J, Kath J, Brachs S, Streitz M, von Herrath MG, Kühl AA, Schmidt-Bleek K, Mai K, Spranger J, Volk HD.

Front Immunol. 2018 May 28;9:1069. doi: 10.3389/fimmu.2018.01069. eCollection 2018.


Clinical and Research Approaches to Treat Non-union Fracture.

Schlundt C, Bucher CH, Tsitsilonis S, Schell H, Duda GN, Schmidt-Bleek K.

Curr Osteoporos Rep. 2018 Apr;16(2):155-168. doi: 10.1007/s11914-018-0432-1. Review.


Immunology Guides Skeletal Muscle Regeneration.

Sass FA, Fuchs M, Pumberger M, Geissler S, Duda GN, Perka C, Schmidt-Bleek K.

Int J Mol Sci. 2018 Mar 13;19(3). pii: E835. doi: 10.3390/ijms19030835. Review.


Leptin-deficiency eradicates the positive effect of traumatic brain injury on bone healing: histological analyses in a combined trauma mouse model.

Seemann R, Graef F, Garbe A, Keller J, Huang F, Duda G, Schmidt-Bleek K, Schaser KD, Tsitsilonis S.

J Musculoskelet Neuronal Interact. 2018 Mar 1;18(1):32-41.


Mechanobiologically optimized 3D titanium-mesh scaffolds enhance bone regeneration in critical segmental defects in sheep.

Pobloth AM, Checa S, Razi H, Petersen A, Weaver JC, Schmidt-Bleek K, Windolf M, Tatai AÁ, Roth CP, Schaser KD, Duda GN, Schwabe P.

Sci Transl Med. 2018 Jan 10;10(423). pii: eaam8828. doi: 10.1126/scitranslmed.aam8828.


Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature.

Reismann D, Stefanowski J, Günther R, Rakhymzhan A, Matthys R, Nützi R, Zehentmeier S, Schmidt-Bleek K, Petkau G, Chang HD, Naundorf S, Winter Y, Melchers F, Duda G, Hauser AE, Niesner RA.

Nat Commun. 2017 Dec 18;8(1):2153. doi: 10.1038/s41467-017-01538-9.


In-situ tissue regeneration through SDF-1α driven cell recruitment and stiffness-mediated bone regeneration in a critical-sized segmental femoral defect.

Cipitria A, Boettcher K, Schoenhals S, Garske DS, Schmidt-Bleek K, Ellinghaus A, Dienelt A, Peters A, Mehta M, Madl CM, Huebsch N, Mooney DJ, Duda GN.

Acta Biomater. 2017 Sep 15;60:50-63. doi: 10.1016/j.actbio.2017.07.032. Epub 2017 Jul 21.


T Lymphocytes Influence the Mineralization Process of Bone.

El Khassawna T, Serra A, Bucher CH, Petersen A, Schlundt C, Könnecke I, Malhan D, Wendler S, Schell H, Volk HD, Schmidt-Bleek K, Duda GN.

Front Immunol. 2017 May 24;8:562. doi: 10.3389/fimmu.2017.00562. eCollection 2017.


Impaired fracture healing with high non-union rates remains irreversible after traumatic brain injury in leptin-deficient mice.

Graef F, Seemann R, Garbe A, Schmidt-Bleek K, Schaser KD, Keller J, Duda G, Tsitsilonis S.

J Musculoskelet Neuronal Interact. 2017 Jun 1;17(2):78-85.


Tubular open-porous β-tricalcium phosphate polycaprolactone scaffolds as guiding structure for segmental bone defect regeneration in a novel sheep model.

Pobloth AM, Schell H, Petersen A, Beierlein K, Kleber C, Schmidt-Bleek K, Duda GN.

J Tissue Eng Regen Med. 2018 Apr;12(4):897-911. doi: 10.1002/term.2446. Epub 2017 Jun 29.


* Demineralized Bone Matrix as a Carrier for Bone Morphogenetic Protein-2: Burst Release Combined with Long-Term Binding and Osteoinductive Activity Evaluated In Vitro and In Vivo.

Huber E, Pobloth AM, Bormann N, Kolarczik N, Schmidt-Bleek K, Schell H, Schwabe P, Duda GN, Wildemann B.

Tissue Eng Part A. 2017 Dec;23(23-24):1321-1330. doi: 10.1089/ten.TEA.2017.0005. Epub 2017 Apr 28.


A Pronounced Inflammatory Activity Characterizes the Early Fracture Healing Phase in Immunologically Restricted Patients.

Hoff P, Gaber T, Strehl C, Jakstadt M, Hoff H, Schmidt-Bleek K, Lang A, Röhner E, Huscher D, Matziolis G, Burmester GR, Schmidmaier G, Perka C, Duda GN, Buttgereit F.

Int J Mol Sci. 2017 Mar 8;18(3). pii: E583. doi: 10.3390/ijms18030583.


The haematoma and its role in bone healing.

Schell H, Duda GN, Peters A, Tsitsilonis S, Johnson KA, Schmidt-Bleek K.

J Exp Orthop. 2017 Dec;4(1):5. doi: 10.1186/s40634-017-0079-3. Epub 2017 Feb 7. Review.


CD31+ Cells From Peripheral Blood Facilitate Bone Regeneration in Biologically Impaired Conditions Through Combined Effects on Immunomodulation and Angiogenesis.

Sass FA, Schmidt-Bleek K, Ellinghaus A, Filter S, Rose A, Preininger B, Reinke S, Geissler S, Volk HD, Duda GN, Dienelt A.

J Bone Miner Res. 2017 May;32(5):902-912. doi: 10.1002/jbmr.3062. Epub 2017 Mar 1.


Osteotomy models - the current status on pain scoring and management in small rodents.

Lang A, Schulz A, Ellinghaus A, Schmidt-Bleek K.

Lab Anim. 2016 Dec;50(6):433-441. Review.


Immunological characterization of the early human fracture hematoma.

Hoff P, Gaber T, Strehl C, Schmidt-Bleek K, Lang A, Huscher D, Burmester GR, Schmidmaier G, Perka C, Duda GN, Buttgereit F.

Immunol Res. 2016 Dec;64(5-6):1195-1206.


Future Treatment Strategies for Delayed Bone Healing: An Osteoimmunologic Approach.

Schmidt-Bleek K, Marcucio R, Duda G.

J Am Acad Orthop Surg. 2016 Oct;24(10):e134-5. doi: 10.5435/JAAOS-D-16-00513. No abstract available.


Establishment of a preclinical ovine screening model for the investigation of bone tissue engineering strategies in cancellous and cortical bone defects.

Pobloth AM, Johnson KA, Schell H, Kolarczik N, Wulsten D, Duda GN, Schmidt-Bleek K.

BMC Musculoskelet Disord. 2016 Mar 1;17:111. doi: 10.1186/s12891-016-0964-4.


Immune modulation as a therapeutic strategy in bone regeneration.

Schlundt C, Schell H, Goodman SB, Vunjak-Novakovic G, Duda GN, Schmidt-Bleek K.

J Exp Orthop. 2015 Dec;2(1):1. doi: 10.1186/s40634-014-0017-6. Epub 2015 Feb 7.


BMPs in bone regeneration: Less is more effective, a paradigm-shift.

Schmidt-Bleek K, Willie BM, Schwabe P, Seemann P, Duda GN.

Cytokine Growth Factor Rev. 2016 Feb;27:141-8. doi: 10.1016/j.cytogfr.2015.11.006. Epub 2015 Nov 25. Review.


Traumatic brain injury and bone healing: radiographic and biomechanical analyses of bone formation and stability in a combined murine trauma model.

Locher RJ, Lünnemann T, Garbe A, Schaser K, Schmidt-Bleek K, Duda G, Tsitsilonis S.

J Musculoskelet Neuronal Interact. 2015 Dec;15(4):309-15.


Macrophages in bone fracture healing: Their essential role in endochondral ossification.

Schlundt C, El Khassawna T, Serra A, Dienelt A, Wendler S, Schell H, van Rooijen N, Radbruch A, Lucius R, Hartmann S, Duda GN, Schmidt-Bleek K.

Bone. 2018 Jan;106:78-89. doi: 10.1016/j.bone.2015.10.019. Epub 2015 Oct 31.


Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners.

Lei H, Schmidt-Bleek K, Dienelt A, Reinke P, Volk HD.

Front Pharmacol. 2015 Sep 2;6:184. doi: 10.3389/fphar.2015.00184. eCollection 2015.


Boon and Bane of Inflammation in Bone Tissue Regeneration and Its Link with Angiogenesis.

Schmidt-Bleek K, Kwee BJ, Mooney DJ, Duda GN.

Tissue Eng Part B Rev. 2015 Aug;21(4):354-64. doi: 10.1089/ten.TEB.2014.0677. Epub 2015 Apr 1. Review.


Temporal profile of inflammatory response to fracture and hemorrhagic shock: Proposal of a novel long-term survival murine multiple trauma model.

Kleber C, Becker CA, Malysch T, Reinhold JM, Tsitsilonis S, Duda GN, Schmidt-Bleek K, Schaser KD.

J Orthop Res. 2015 Jul;33(7):965-70. doi: 10.1002/jor.22857. Epub 2015 Mar 31.


The effect of traumatic brain injury on bone healing: an experimental study in a novel in vivo animal model.

Tsitsilonis S, Seemann R, Misch M, Wichlas F, Haas NP, Schmidt-Bleek K, Kleber C, Schaser KD.

Injury. 2015 Apr;46(4):661-5. doi: 10.1016/j.injury.2015.01.044. Epub 2015 Jan 31.


Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome.

Degenkolbe E, Schwarz C, Ott CE, König J, Schmidt-Bleek K, Ellinghaus A, Schmidt T, Lienau J, Plöger F, Mundlos S, Duda GN, Willie BM, Seemann P.

Bone. 2015 Apr;73:111-9. doi: 10.1016/j.bone.2014.12.017. Epub 2014 Dec 24.


T and B cells participate in bone repair by infiltrating the fracture callus in a two-wave fashion.

Könnecke I, Serra A, El Khassawna T, Schlundt C, Schell H, Hauser A, Ellinghaus A, Volk HD, Radbruch A, Duda GN, Schmidt-Bleek K.

Bone. 2014 Jul;64:155-65. doi: 10.1016/j.bone.2014.03.052. Epub 2014 Apr 8.


Initiation and early control of tissue regeneration - bone healing as a model system for tissue regeneration.

Schmidt-Bleek K, Petersen A, Dienelt A, Schwarz C, Duda GN.

Expert Opin Biol Ther. 2014 Feb;14(2):247-59. doi: 10.1517/14712598.2014.857653. Review.


In serum veritas-in serum sanitas? Cell non-autonomous aging compromises differentiation and survival of mesenchymal stromal cells via the oxidative stress pathway.

Geissler S, Textor M, Schmidt-Bleek K, Klein O, Thiele M, Ellinghaus A, Jacobi D, Ode A, Perka C, Dienelt A, Klose J, Kasper G, Duda GN, Strube P.

Cell Death Dis. 2013 Dec 19;4:e970. doi: 10.1038/cddis.2013.501.


The need for transparency and good practices in the qPCR literature.

Bustin SA, Benes V, Garson J, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley G, Wittwer CT, Schjerling P, Day PJ, Abreu M, Aguado B, Beaulieu JF, Beckers A, Bogaert S, Browne JA, Carrasco-Ramiro F, Ceelen L, Ciborowski K, Cornillie P, Coulon S, Cuypers A, De Brouwer S, De Ceuninck L, De Craene J, De Naeyer H, De Spiegelaere W, Deckers K, Dheedene A, Durinck K, Ferreira-Teixeira M, Fieuw A, Gallup JM, Gonzalo-Flores S, Goossens K, Heindryckx F, Herring E, Hoenicka H, Icardi L, Jaggi R, Javad F, Karampelias M, Kibenge F, Kibenge M, Kumps C, Lambertz I, Lammens T, Markey A, Messiaen P, Mets E, Morais S, Mudarra-Rubio A, Nakiwala J, Nelis H, Olsvik PA, Pérez-Novo C, Plusquin M, Remans T, Rihani A, Rodrigues-Santos P, Rondou P, Sanders R, Schmidt-Bleek K, Skovgaard K, Smeets K, Tabera L, Toegel S, Van Acker T, Van den Broeck W, Van der Meulen J, Van Gele M, Van Peer G, Van Poucke M, Van Roy N, Vergult S, Wauman J, Tshuikina-Wiklander M, Willems E, Zaccara S, Zeka F, Vandesompele J.

Nat Methods. 2013 Nov;10(11):1063-7. doi: 10.1038/nmeth.2697.


Preoperative irradiation for the prevention of heterotopic ossification induces local inflammation in humans.

Hoff P, Rakow A, Gaber T, Hahne M, Sentürk U, Strehl C, Fangradt M, Schmidt-Bleek K, Huscher D, Winkler T, Matziolis D, Matziolis G, Badakhshi H, Burmester GR, Duda GN, Perka C, Buttgereit F.

Bone. 2013 Jul;55(1):93-101. doi: 10.1016/j.bone.2013.03.020. Epub 2013 Apr 6.


Terminally differentiated CD8⁺ T cells negatively affect bone regeneration in humans.

Reinke S, Geissler S, Taylor WR, Schmidt-Bleek K, Juelke K, Schwachmeyer V, Dahne M, Hartwig T, Akyüz L, Meisel C, Unterwalder N, Singh NB, Reinke P, Haas NP, Volk HD, Duda GN.

Sci Transl Med. 2013 Mar 20;5(177):177ra36. doi: 10.1126/scitranslmed.3004754. Erratum in: Sci Transl Med. 2013 May 29;5(187):187er4.


Are pentraxin 3 and transsignaling early markers for immunologic injury severity in polytrauma? A pilot study.

Kleber C, Becker CA, Schmidt-Bleek K, Schaser KD, Haas NP.

Clin Orthop Relat Res. 2013 Sep;471(9):2822-30. doi: 10.1007/s11999-013-2922-x.


CD133: enhancement of bone healing by local transplantation of peripheral blood cells in a biologically delayed rat osteotomy model.

Preininger B, Duda G, Gerigk H, Bruckner J, Ellinghaus A, Sass FA, Perka C, Schmidt-Bleek K, Dienelt A.

PLoS One. 2013;8(2):e52650. doi: 10.1371/journal.pone.0052650. Epub 2013 Feb 14.


Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model.

Hoff P, Maschmeyer P, Gaber T, Schütze T, Raue T, Schmidt-Bleek K, Dziurla R, Schellmann S, Lohanatha FL, Röhner E, Ode A, Burmester GR, Duda GN, Perka C, Buttgereit F.

Cell Mol Immunol. 2013 Mar;10(2):151-8. doi: 10.1038/cmi.2012.56. Epub 2013 Feb 11.


Deterioration of fracture healing in the mouse model of NF1 long bone dysplasia.

El Khassawna T, Toben D, Kolanczyk M, Schmidt-Bleek K, Koennecke I, Schell H, Mundlos S, Duda GN.

Bone. 2012 Oct;51(4):651-60. doi: 10.1016/j.bone.2012.07.011. Epub 2012 Jul 31.


Biomaterial delivery of morphogens to mimic the natural healing cascade in bone.

Mehta M, Schmidt-Bleek K, Duda GN, Mooney DJ.

Adv Drug Deliv Rev. 2012 Sep;64(12):1257-76. doi: 10.1016/j.addr.2012.05.006. Epub 2012 May 22. Review.


Initial immune reaction and angiogenesis in bone healing.

Schmidt-Bleek K, Schell H, Lienau J, Schulz N, Hoff P, Pfaff M, Schmidt G, Martin C, Perka C, Buttgereit F, Volk HD, Duda G.

J Tissue Eng Regen Med. 2014 Feb;8(2):120-30. doi: 10.1002/term.1505. Epub 2012 Apr 11.


An experimental setup to evaluate innovative therapy options for the enhancement of bone healing using BMP as a benchmark--a pilot study.

Preininger B, Gerigk H, Bruckner J, Perka C, Schell H, Ellinghaus A, Schmidt-Bleek K, Duda G.

Eur Cell Mater. 2012 Apr 10;23:262-71; discussion 271-2.


Inflammatory phase of bone healing initiates the regenerative healing cascade.

Schmidt-Bleek K, Schell H, Schulz N, Hoff P, Perka C, Buttgereit F, Volk HD, Lienau J, Duda GN.

Cell Tissue Res. 2012 Mar;347(3):567-73. doi: 10.1007/s00441-011-1205-7. Epub 2011 Jul 26.


CD73 and CD29 concurrently mediate the mechanically induced decrease of migratory capacity of mesenchymal stromal cells.

Ode A, Kopf J, Kurtz A, Schmidt-Bleek K, Schrade P, Kolar P, Buttgereit F, Lehmann K, Hutmacher DW, Duda GN, Kasper G.

Eur Cell Mater. 2011 Jul 6;22:26-42.


Immunologically restricted patients exhibit a pronounced inflammation and inadequate response to hypoxia in fracture hematomas.

Hoff P, Gaber T, Schmidt-Bleek K, Sentürk U, Tran CL, Blankenstein K, Lütkecosmann S, Bredahl J, Schüler HJ, Simon P, Wassilew G, Unterhauser F, Burmester GR, Schmidmaier G, Perka C, Duda GN, Buttgereit F.

Immunol Res. 2011 Oct;51(1):116-22. doi: 10.1007/s12026-011-8235-9.


Time kinetics of bone defect healing in response to BMP-2 and GDF-5 characterised by in vivo biomechanics.

Wulsten D, Glatt V, Ellinghaus A, Schmidt-Bleek K, Petersen A, Schell H, Lienau J, Sebald W, Plöger F, Seemann P, Duda GN.

Eur Cell Mater. 2011 Feb 11;21:177-92.


A 5-mm femoral defect in female but not in male rats leads to a reproducible atrophic non-union.

Mehta M, Schell H, Schwarz C, Peters A, Schmidt-Bleek K, Ellinghaus A, Bail HJ, Duda GN, Lienau J.

Arch Orthop Trauma Surg. 2011 Jan;131(1):121-9. doi: 10.1007/s00402-010-1155-7. Epub 2010 Jul 23.


The early fracture hematoma and its potential role in fracture healing.

Kolar P, Schmidt-Bleek K, Schell H, Gaber T, Toben D, Schmidmaier G, Perka C, Buttgereit F, Duda GN.

Tissue Eng Part B Rev. 2010 Aug;16(4):427-34. doi: 10.1089/ten.TEB.2009.0687. Review.


Insight into the molecular pathophysiology of delayed bone healing in a sheep model.

Lienau J, Schmidt-Bleek K, Peters A, Weber H, Bail HJ, Duda GN, Perka C, Schell H.

Tissue Eng Part A. 2010 Jan;16(1):191-9. doi: 10.1089/ten.TEA.2009.0187.


Cellular composition of the initial fracture hematoma compared to a muscle hematoma: a study in sheep.

Schmidt-Bleek K, Schell H, Kolar P, Pfaff M, Perka C, Buttgereit F, Duda G, Lienau J.

J Orthop Res. 2009 Sep;27(9):1147-51. doi: 10.1002/jor.20901.


Differential regulation of blood vessel formation between standard and delayed bone healing.

Lienau J, Schmidt-Bleek K, Peters A, Haschke F, Duda GN, Perka C, Bail HJ, Schütze N, Jakob F, Schell H.

J Orthop Res. 2009 Sep;27(9):1133-40. doi: 10.1002/jor.20870.

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