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Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota.

Denny JE, Schmidt NW.

Sci Rep. 2019 Aug 16;9(1):11952. doi: 10.1038/s41598-019-48454-0.


Correction: Intestinal short-chain fatty acid composition does not explain gut microbiota-mediated effects on malaria severity.

Chakravarty S, Mandal RK, Duff ML, Yuan F, Zhang X, Schmidt NW.

PLoS One. 2019 Jun 6;14(6):e0218250. doi: 10.1371/journal.pone.0218250. eCollection 2019.


Intestinal short-chain fatty acid composition does not explain gut microbiota-mediated effects on malaria severity.

Chakravarty S, Mandal RK, Duff ML, Schmidt NW.

PLoS One. 2019 Mar 27;14(3):e0214449. doi: 10.1371/journal.pone.0214449. eCollection 2019. Erratum in: PLoS One. 2019 Jun 6;14(6):e0218250.


Differential Sensitivity to Plasmodium yoelii Infection in C57BL/6 Mice Impacts Gut-Liver Axis Homeostasis.

Denny JE, Powers JB, Castro HF, Zhang J, Joshi-Barve S, Campagna SR, Schmidt NW.

Sci Rep. 2019 Mar 5;9(1):3472. doi: 10.1038/s41598-019-40266-6.


Longitudinal analysis of infant stool bacteria communities before and after acute febrile malaria and artemether/lumefantrine treatment.

Mandal RK, Crane RJ, Berkley JA, Gumbi W, Wambua J, Ngoi JM, Ndungu FM, Schmidt NW.

J Infect Dis. 2018 Dec 24. doi: 10.1093/infdis/jiy740. [Epub ahead of print]


Malaria and the Microbiome: A Systematic Review.

Ippolito MM, Denny JE, Langelier C, Sears CL, Schmidt NW.

Clin Infect Dis. 2018 Nov 28;67(12):1831-1839. doi: 10.1093/cid/ciy374.


A long-lived Aβ oligomer resistant to fibrillization.

Nick M, Wu Y, Schmidt NW, Prusiner SB, Stöhr J, DeGrado WF.

Biopolymers. 2018 Aug;109(8):e23096. doi: 10.1002/bip.23096. Epub 2018 Jan 10.


Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity.

Schnaider L, Brahmachari S, Schmidt NW, Mensa B, Shaham-Niv S, Bychenko D, Adler-Abramovich L, Shimon LJW, Kolusheva S, DeGrado WF, Gazit E.

Nat Commun. 2017 Nov 8;8(1):1365. doi: 10.1038/s41467-017-01447-x.


Designing Hybrid Antibiotic Peptide Conjugates To Cross Bacterial Membranes.

Deshayes S, Xian W, Schmidt NW, Kordbacheh S, Lieng J, Wang J, Zarmer S, Germain SS, Voyen L, Thulin J, Wong GC, Kasko AM.

Bioconjug Chem. 2017 Mar 15;28(3):793-804. doi: 10.1021/acs.bioconjchem.6b00725. Epub 2017 Mar 1.


The accommodation index measures the perturbation associated with insertions and deletions in coiled-coils: Application to understand signaling in histidine kinases.

Schmidt NW, Grigoryan G, DeGrado WF.

Protein Sci. 2017 Mar;26(3):414-435. doi: 10.1002/pro.3095. Epub 2017 Feb 23. Review.


Functional Characteristics of the Gut Microbiome in C57BL/6 Mice Differentially Susceptible to Plasmodium yoelii.

Stough JM, Dearth SP, Denny JE, LeCleir GR, Schmidt NW, Campagna SR, Wilhelm SW.

Front Microbiol. 2016 Sep 27;7:1520. eCollection 2016.


S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages.

Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL.

PLoS Pathog. 2016 Jun 29;12(6):e1005705. doi: 10.1371/journal.ppat.1005705. eCollection 2016 Jun.


Reinventing Cell Penetrating Peptides Using Glycosylated Methionine Sulfonium Ion Sequences.

Kramer JR, Schmidt NW, Mayle KM, Kamei DT, Wong GC, Deming TJ.

ACS Cent Sci. 2015 May 27;1(2):83-8. doi: 10.1021/acscentsci.5b00054. Epub 2015 Apr 15.


Local and Long-Distance Calling: Conversations between the Gut Microbiota and Intra- and Extra-Gastrointestinal Tract Infections.

Denny JE, Powell WL, Schmidt NW.

Front Cell Infect Microbiol. 2016 Apr 11;6:41. doi: 10.3389/fcimb.2016.00041. eCollection 2016. Review.


A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes.

Lee EY, Lee CK, Schmidt NW, Jin F, Lande R, Curk T, Frenkel D, Dobnikar J, Gilliet M, Wong GCL.

Adv Colloid Interface Sci. 2016 Jun;232:17-24. doi: 10.1016/j.cis.2016.02.003. Epub 2016 Feb 19. Review.


Composition of the gut microbiota modulates the severity of malaria.

Villarino NF, LeCleir GR, Denny JE, Dearth SP, Harding CL, Sloan SS, Gribble JL, Campagna SR, Wilhelm SW, Schmidt NW.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2235-40. doi: 10.1073/pnas.1504887113. Epub 2016 Feb 8.


Liquid-crystalline ordering of antimicrobial peptide-DNA complexes controls TLR9 activation.

Schmidt NW, Jin F, Lande R, Curk T, Xian W, Lee C, Frasca L, Frenkel D, Dobnikar J, Gilliet M, Wong GC.

Nat Mater. 2015 Jul;14(7):696-700. doi: 10.1038/nmat4298. Epub 2015 Jun 8.


Erythropoietin-producing hepatocellular receptor B2 receptor tyrosine kinase: A novel regulator of infection- and inflammation-induced liver fibrosis.

Butler NS, Schmidt NW.

Hepatology. 2015 Sep;62(3):680-3. doi: 10.1002/hep.27868. Epub 2015 May 26. No abstract available.


Antimalarial activity of tulathromycin in a murine model of malaria.

Villarino N, Denny JE, Schmidt NW.

Antimicrob Agents Chemother. 2015;59(6):3672-4. doi: 10.1128/AAC.02858-14. Epub 2015 Apr 13.


Pentobra: A Potent Antibiotic with Multiple Layers of Selective Antimicrobial Mechanisms against Propionibacterium Acnes.

Schmidt NW, Agak GW, Deshayes S, Yu Y, Blacker A, Champer J, Xian W, Kasko AM, Kim J, Wong GCL.

J Invest Dermatol. 2015 Jun;135(6):1581-1589. doi: 10.1038/jid.2015.40. Epub 2015 Feb 10.


Plasmodium suppresses expansion of T cell responses to heterologous infections.

White CE, Villarino NF, Sloan SS, Ganusov VV, Schmidt NW.

J Immunol. 2015 Jan 15;194(2):697-708. doi: 10.4049/jimmunol.1401745. Epub 2014 Dec 10.


Engineering persister-specific antibiotics with synergistic antimicrobial functions.

Schmidt NW, Deshayes S, Hawker S, Blacker A, Kasko AM, Wong GC.

ACS Nano. 2014 Sep 23;8(9):8786-93. doi: 10.1021/nn502201a. Epub 2014 Aug 18.


Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides.

Lee MW, Chakraborty S, Schmidt NW, Murgai R, Gellman SH, Wong GC.

Biochim Biophys Acta. 2014 Sep;1838(9):2269-79. doi: 10.1016/j.bbamem.2014.04.007. Epub 2014 Apr 14.


CD8+ T Cell Responses to Plasmodium and Intracellular Parasites.

Villarino N, Schmidt NW.

Curr Immunol Rev. 2013 Aug;9(3):169-178.


Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission.

Schmidt NW, Mishra A, Wang J, DeGrado WF, Wong GC.

J Am Chem Soc. 2013 Sep 18;135(37):13710-9. doi: 10.1021/ja400146z. Epub 2013 Sep 6.


A critical evaluation of random copolymer mimesis of homogeneous antimicrobial peptides.

Hu K, Schmidt NW, Zhu R, Jiang Y, Lai GH, Wei G, Palermo EF, Kuroda K, Wong GC, Yang L.

Macromolecules. 2013;46(5):1908-1915.


Molecular basis for nanoscopic membrane curvature generation from quantum mechanical models and synthetic transporter sequences.

Schmidt NW, Lis M, Zhao K, Lai GH, Alexandrova AN, Tew GN, Wong GC.

J Am Chem Soc. 2012 Nov 21;134(46):19207-16. doi: 10.1021/ja308459j. Epub 2012 Nov 9.


Dynamics of confined water reconstructed from inelastic x-ray scattering measurements of bulk response functions.

Coridan RH, Schmidt NW, Lai GH, Abbamonte P, Wong GC.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Mar;85(3 Pt 1):031501. Epub 2012 Mar 8.


Arginine in α-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior.

Schmidt NW, Tai KP, Kamdar K, Mishra A, Lai GH, Zhao K, Ouellette AJ, Wong GC.

J Biol Chem. 2012 Jun 22;287(26):21866-72. doi: 10.1074/jbc.M112.358721. Epub 2012 May 7.


Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection.

Schmidt NW, Khanolkar A, Hancox L, Heusel JW, Harty JT.

Eur J Immunol. 2012 Mar;42(3):629-40. doi: 10.1002/eji.201141902. Epub 2012 Jan 18.


Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions.

Mishra A, Lai GH, Schmidt NW, Sun VZ, Rodriguez AR, Tong R, Tang L, Cheng J, Deming TJ, Kamei DT, Wong GC.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16883-8. doi: 10.1073/pnas.1108795108. Epub 2011 Oct 3.


Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites.

Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT.

Cell Host Microbe. 2011 Jun 16;9(6):451-62. doi: 10.1016/j.chom.2011.05.008.


Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization.

Schmidt NW, Mishra A, Lai GH, Davis M, Sanders LK, Tran D, Garcia A, Tai KP, McCray PB, Ouellette AJ, Selsted ME, Wong GC.

J Am Chem Soc. 2011 May 4;133(17):6720-7. doi: 10.1021/ja200079a. Epub 2011 Apr 7.


Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity.

Schmidt NW, Butler NS, Harty JT.

J Immunol. 2011 May 15;186(10):5873-84. doi: 10.4049/jimmunol.1100194. Epub 2011 Apr 1.


Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.

Schmidt NW, Harty JT.

J Immunol. 2011 Apr 1;186(7):3836-40. doi: 10.4049/jimmunol.1003949. Epub 2011 Feb 28.


Small-angle X-ray scattering studies of peptide-lipid interactions using the mouse paneth cell α-defensin cryptdin-4.

Mishra A, Tai KP, Schmidt NW, Ouellette AJ, Wong GC.

Methods Enzymol. 2011;492:127-49. doi: 10.1016/B978-0-12-381268-1.00016-1.


Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.

Schmidt NW, Butler NS, Badovinac VP, Harty JT.

PLoS Pathog. 2010 Jul 15;6(7):e1000998. doi: 10.1371/journal.ppat.1000998.


Ultrafast imaging and the phase problem for inelastic X-ray scattering.

Abbamonte P, Wong GC, Cahill DG, Reed JP, Coridan RH, Schmidt NW, Lai GH, Joe YI, Casa D.

Adv Mater. 2010 Mar 12;22(10):1141-7. doi: 10.1002/adma.200904098.


Hydration dynamics at femtosecond time scales and angstrom length scales from inelastic x-ray scattering.

Coridan RH, Schmidt NW, Lai GH, Godawat R, Krisch M, Garde S, Abbamonte P, Wong GC.

Phys Rev Lett. 2009 Dec 4;103(23):237402. Epub 2009 Dec 3.


Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites.

Butler NS, Schmidt NW, Harty JT.

J Immunol. 2010 Mar 1;184(5):2528-38. doi: 10.4049/jimmunol.0903529. Epub 2010 Jan 22.


Hydration structures near finite-sized nanoscopic objects reconstructed using inelastic x-ray scattering measurements.

Coridan RH, Schmidt NW, Lai GH, Wong GC.

J Phys Condens Matter. 2009 Oct 21;21(42):424115. doi: 10.1088/0953-8984/21/42/424115. Epub 2009 Sep 30.


CD8 T cell immunity to Plasmodium permits generation of protective antibodies after repeated sporozoite challenge.

Schmidt NW, Butler NS, Harty JT.

Vaccine. 2009 Oct 19;27(44):6103-6. doi: 10.1016/j.vaccine.2009.08.025. Epub 2009 Aug 25.


Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids.

Yang L, Gordon VD, Trinkle DR, Schmidt NW, Davis MA, DeVries C, Som A, Cronan JE Jr, Tew GN, Wong GC.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20595-600. doi: 10.1073/pnas.0806456105. Epub 2008 Dec 23.


Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.

Schmidt NW, Podyminogin RL, Butler NS, Badovinac VP, Tucker BJ, Bahjat KS, Lauer P, Reyes-Sandoval A, Hutchings CL, Moore AC, Gilbert SC, Hill AV, Bartholomay LC, Harty JT.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14017-22. doi: 10.1073/pnas.0805452105. Epub 2008 Sep 9.


IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6.

Sehra S, Bruns HA, Ahyi AN, Nguyen ET, Schmidt NW, Michels EG, von Bülow GU, Kaplan MH.

J Immunol. 2008 Mar 1;180(5):3551-9.


Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge.

Elzey BD, Schmidt NW, Crist SA, Kresowik TP, Harty JT, Nieswandt B, Ratliff TL.

Blood. 2008 Apr 1;111(7):3684-91. doi: 10.1182/blood-2007-05-091728. Epub 2008 Feb 6.


Bruton's tyrosine kinase is required for TLR-induced IL-10 production.

Schmidt NW, Thieu VT, Mann BA, Ahyi AN, Kaplan MH.

J Immunol. 2006 Nov 15;177(10):7203-10.


p53 regulates Btk-dependent B cell proliferation but not differentiation.

Schmidt NW, Mayo LD, Donner DB, Kaplan MH.

J Leukoc Biol. 2006 Apr;79(4):852-9. Epub 2006 Feb 3.


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