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Pre-existing neutralizing antibodies prevent CD8 T cell-mediated immunopathology following respiratory syncytial virus infection.

Schmidt ME, Meyerholz DK, Varga SM.

Mucosal Immunol. 2019 Dec 16. doi: 10.1038/s41385-019-0243-4. [Epub ahead of print]


Translational Model-Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ-54175446, a P2X7 Receptor Antagonist.

Xu Y, Miao X, Ravenstijn P, Hijzen A, Schmidt ME, Nandy P, Zhou H.

Clin Transl Sci. 2019 Oct 23. doi: 10.1111/cts.12711. [Epub ahead of print]


Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy.

Zimmer P, Schmidt ME, Prentzell MT, Berdel B, Wiskemann J, Kellner KH, Debus J, Ulrich C, Opitz CA, Steindorf K.

Front Oncol. 2019 Sep 25;9:962. doi: 10.3389/fonc.2019.00962. eCollection 2019.


Dielectric-Screening Reduction-Induced Large Transport Gap in Suspended Sub-10 nm Graphene Nanoribbon Functional Devices.

Schmidt ME, Muruganathan M, Kanzaki T, Iwasaki T, Hammam AMM, Suzuki S, Ogawa S, Mizuta H.

Small. 2019 Nov;15(46):e1903025. doi: 10.1002/smll.201903025. Epub 2019 Oct 1.


Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data.

VAN Vulpen JK, Sweegers MG, Peeters PHM, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, Galvão DA, Chinapaw MJ, Steindorf K, Irwin ML, Stuiver MM, Hayes S, Griffith KA, Mesters I, Knoop H, Goedendorp MM, Mutrie N, Daley AJ, McConnachie A, Bohus M, Thorsen L, Schulz KH, Short CE, James EL, Plotnikoff RC, Schmidt ME, Ulrich CM, VAN Beurden M, Oldenburg HS, Sonke GS, VAN Harten WH, Schmitz KH, Winters-Stone KM, Velthuis MJ, Taaffe DR, VAN Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-DE Leeuw IM, Brug J, May AM, Buffart LM.

Med Sci Sports Exerc. 2020 Feb;52(2):303-314. doi: 10.1249/MSS.0000000000002154.


Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses.

Bernard P, Savard J, Steindorf K, Sweegers MG, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, May AM, Galvao DA, Chinapaw MJ, Stuiver MM, Griffith KA, Mesters I, Knoop H, Goedendorp MM, Bohus M, Thorsen L, Schmidt ME, Ulrich CM, Sonke GS, van Harten W, Winters-Stone KM, Velthuis MJ, Taaffe DR, van Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-de Leeuw IM, Brug J, Buffart LM.

J Psychosom Res. 2019 Sep;124:109746. doi: 10.1016/j.jpsychores.2019.109746. Epub 2019 Jun 23. Review.


No Evidence for Effect of Exercise on Transcriptome of NK Cells in Breast Cancer Patients Undergoing Adjuvant Therapy: Results From a Pilot Study.

Pal A, Zimmer P, Schmidt ME, Hummel M, Ulrich CM, Wiskemann J, Steindorf K.

Front Physiol. 2019 Jul 25;10:959. doi: 10.3389/fphys.2019.00959. eCollection 2019.


NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor.

Bowers MS, Cacheaux LP, Sahu SU, Schmidt ME, Sennello JA, Leaderbrand K, Khan MA, Kroes RA, Moskal JR.

J Neurochem. 2019 Aug 3. doi: 10.1111/jnc.14845. [Epub ahead of print]


Identification of Novel Respiratory Syncytial Virus CD4+ and CD8+ T Cell Epitopes in C57BL/6 Mice.

Schmidt ME, Varga SM.

Immunohorizons. 2019 Jan 14;3(1):1-12. doi: 10.4049/immunohorizons.1800056.


[11C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson's disease and healthy volunteers.

Van Weehaeghe D, Koole M, Schmidt ME, Deman S, Jacobs AH, Souche E, Serdons K, Sunaert S, Bormans G, Vandenberghe W, Van Laere K.

Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2051-2064. doi: 10.1007/s00259-019-04369-6. Epub 2019 Jun 26.


Return to work after breast cancer: The role of treatment-related side effects and potential impact on quality of life.

Schmidt ME, Scherer S, Wiskemann J, Steindorf K.

Eur J Cancer Care (Engl). 2019 Jul;28(4):e13051. doi: 10.1111/ecc.13051. Epub 2019 Apr 29.


Vaccination with a Single-Cycle Respiratory Syncytial Virus Is Immunogenic and Protective in Mice.

Schmidt ME, Oomens AGP, Varga SM.

J Immunol. 2019 Jun 1;202(11):3234-3245. doi: 10.4049/jimmunol.1900050. Epub 2019 Apr 19.


Effects of physical and mind-body exercise on sleep problems during and after breast cancer treatment: a systematic review and meta-analysis.

Kreutz C, Schmidt ME, Steindorf K.

Breast Cancer Res Treat. 2019 Jul;176(1):1-15. doi: 10.1007/s10549-019-05217-9. Epub 2019 Apr 6.


Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance.

Martin DDO, Schmidt ME, Nguyen YT, Lazic N, Hayden MR.

FASEB J. 2019 Mar;33(3):3190-3197. doi: 10.1096/fj.201701510RRR. Epub 2018 Nov 13.


Secondary prevention of Alzheimer's dementia: neuroimaging contributions.

Ten Kate M, Ingala S, Schwarz AJ, Fox NC, Chételat G, van Berckel BNM, Ewers M, Foley C, Gispert JD, Hill D, Irizarry MC, Lammertsma AA, Molinuevo JL, Ritchie C, Scheltens P, Schmidt ME, Visser PJ, Waldman A, Wardlaw J, Haller S, Barkhof F.

Alzheimers Res Ther. 2018 Oct 30;10(1):112. doi: 10.1186/s13195-018-0438-z. Review.


AMYPAD Diagnostic and Patient Management Study: Rationale and design.

Frisoni GB, Barkhof F, Altomare D, Berkhof J, Boccardi M, Canzoneri E, Collij L, Drzezga A, Farrar G, Garibotto V, Gismondi R, Gispert JD, Jessen F, Kivipelto M, Lopes Alves I, Molinuevo JL, Nordberg A, Payoux P, Ritchie C, Savicheva I, Scheltens P, Schmidt ME, Schott JM, Stephens A, van Berckel B, Vellas B, Walker Z, Raffa N.

Alzheimers Dement. 2019 Mar;15(3):388-399. doi: 10.1016/j.jalz.2018.09.003. Epub 2018 Oct 16. Erratum in: Alzheimers Dement. 2019 Nov;15(11):1505.


Targeting Exercise Interventions to Patients With Cancer in Need: An Individual Patient Data Meta-Analysis.

Buffart LM, Sweegers MG, May AM, Chinapaw MJ, van Vulpen JK, Newton RU, Galvão DA, Aaronson NK, Stuiver MM, Jacobsen PB, Verdonck-de Leeuw IM, Steindorf K, Irwin ML, Hayes S, Griffith KA, Lucia A, Herrero-Roman F, Mesters I, van Weert E, Knoop H, Goedendorp MM, Mutrie N, Daley AJ, McConnachie A, Bohus M, Thorsen L, Schulz KH, Short CE, James EL, Plotnikoff RC, Arbane G, Schmidt ME, Potthoff K, van Beurden M, Oldenburg HS, Sonke GS, van Harten WH, Garrod R, Schmitz KH, Winters-Stone KM, Velthuis MJ, Taaffe DR, van Mechelen W, José Kersten M, Nollet F, Wenzel J, Wiskemann J, Brug J, Courneya KS.

J Natl Cancer Inst. 2018 Nov 1;110(11):1190-1200. doi: 10.1093/jnci/djy161.


18F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446.

Koole M, Schmidt ME, Hijzen A, Ravenstijn P, Vandermeulen C, Van Weehaeghe D, Serdons K, Celen S, Bormans G, Ceusters M, Zhang W, Van Nueten L, Kolb H, de Hoon J, Van Laere K.

J Nucl Med. 2019 May;60(5):683-690. doi: 10.2967/jnumed.118.216747. Epub 2018 Sep 27.


Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data.

Sweegers MG, Altenburg TM, Brug J, May AM, van Vulpen JK, Aaronson NK, Arbane G, Bohus M, Courneya KS, Daley AJ, Galvao DA, Garrod R, Griffith KA, Van Harten WH, Hayes SC, Herrero-Román F, Kersten MJ, Lucia A, McConnachie A, van Mechelen W, Mutrie N, Newton RU, Nollet F, Potthoff K, Schmidt ME, Schmitz KH, Schulz KH, Sonke G, Steindorf K, Stuiver MM, Taaffe DR, Thorsen L, Twisk JW, Velthuis MJ, Wenzel J, Winters-Stone KM, Wiskemann J, Chin A Paw MJ, Buffart LM.

Br J Sports Med. 2019 Jul;53(13):812. doi: 10.1136/bjsports-2018-099191. Epub 2018 Sep 4.


Cytokines and CD8 T cell immunity during respiratory syncytial virus infection.

Schmidt ME, Varga SM.

Cytokine. 2018 Jul 18. pii: S1043-4666(18)30297-7. doi: 10.1016/j.cyto.2018.07.012. [Epub ahead of print]


Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease.

Schmidt ME, Buren C, Mackay JP, Cheung D, Dal Cengio L, Raymond LA, Hayden MR.

BMC Biol. 2018 Jun 27;16(1):58. doi: 10.1186/s12915-018-0526-3.


Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort.

Kühl T, Behrens S, Jung AY, Obi N, Thöne K, Schmidt ME, Becher H, Chang-Claude J.

Brain Behav Immun. 2018 Oct;73:252-260. doi: 10.1016/j.bbi.2018.05.009. Epub 2018 May 18.


Quality of life, problems, and needs of disease-free breast cancer survivors 5 years after diagnosis.

Schmidt ME, Wiskemann J, Steindorf K.

Qual Life Res. 2018 Aug;27(8):2077-2086. doi: 10.1007/s11136-018-1866-8. Epub 2018 May 8.


The CD8 T Cell Response to Respiratory Virus Infections.

Schmidt ME, Varga SM.

Front Immunol. 2018 Apr 9;9:678. doi: 10.3389/fimmu.2018.00678. eCollection 2018. Review.


Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers.

Postnov A, Schmidt ME, Pemberton DJ, de Hoon J, van Hecken A, van den Boer M, Zannikos P, van der Ark P, Palmer JA, Rassnick S, Celen S, Bormans G, van Laere K.

Clin Transl Sci. 2018 Jul;11(4):397-404. doi: 10.1111/cts.12548. Epub 2018 Mar 25.


Controlled fabrication of electrically contacted carbon nanoscrolls.

Schmidt ME, Hammam AMM, Iwasaki T, Kanzaki T, Muruganathan M, Ogawa S, Mizuta H.

Nanotechnology. 2018 Jun 8;29(23):235605. doi: 10.1088/1361-6528/aab82c. Epub 2018 Mar 20.


Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.

Ehrnhoefer DE, Martin DDO, Schmidt ME, Qiu X, Ladha S, Caron NS, Skotte NH, Nguyen YTN, Vaid K, Southwell AL, Engemann S, Franciosi S, Hayden MR.

Acta Neuropathol Commun. 2018 Mar 6;6(1):16. doi: 10.1186/s40478-018-0518-0.


[Exercise and Physical Activity During and after Cancer - Who Benefits most, What is Proven?]

Steindorf K, Schmidt ME, Zimmer P.

Dtsch Med Wochenschr. 2018 Mar;143(5):309-315. doi: 10.1055/s-0043-106885. Epub 2018 Mar 5. German.


Structurally Controlled Large-Area 10 nm Pitch Graphene Nanomesh by Focused Helium Ion Beam Milling.

Schmidt ME, Iwasaki T, Muruganathan M, Haque M, Van Ngoc H, Ogawa S, Mizuta H.

ACS Appl Mater Interfaces. 2018 Mar 28;10(12):10362-10368. doi: 10.1021/acsami.8b00427. Epub 2018 Mar 14.


Exercise behavior and physical fitness in patients with advanced lung cancer.

Titz C, Hummler S, Schmidt ME, Thomas M, Steins M, Wiskemann J.

Support Care Cancer. 2018 Aug;26(8):2725-2736. doi: 10.1007/s00520-018-4105-5. Epub 2018 Feb 26.


L-Thyroxine intake as a potential risk factor for the development of fatigue in breast cancer patients undergoing chemotherapy.

Schmidt ME, Wiskemann J, Johnson T, Habermann N, Schneeweiss A, Steindorf K.

Support Care Cancer. 2018 Aug;26(8):2561-2569. doi: 10.1007/s00520-018-4095-3. Epub 2018 Feb 14.


Biomarker pattern of ARIA-E participants in phase 3 randomized clinical trials with bapineuzumab.

Liu E, Wang D, Sperling R, Salloway S, Fox NC, Blennow K, Scheltens P, Schmidt ME, Streffer J, Novak G, Einstein S, Booth K, Ketter N, Brashear HR; ELN115727-301/302 Investigator Group.

Neurology. 2018 Mar 6;90(10):e877-e886. doi: 10.1212/WNL.0000000000005060. Epub 2018 Feb 2.


Diffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-β-induced pathology.

Praet J, Manyakov NV, Muchene L, Mai Z, Terzopoulos V, de Backer S, Torremans A, Guns PJ, Van De Casteele T, Bottelbergs A, Van Broeck B, Sijbers J, Smeets D, Shkedy Z, Bijnens L, Pemberton DJ, Schmidt ME, Van der Linden A, Verhoye M.

Alzheimers Res Ther. 2018 Jan 9;10(1):1. doi: 10.1186/s13195-017-0329-8.


Determining best practices in reconnoitering sites for habitability potential on Mars using a semi-autonomous rover: A GeoHeuristic Operational Strategies Test.

Yingst RA, Berger J, Cohen BA, Hynek B, Schmidt ME.

Acta Astronaut. 2017 Mar;132:268-281. doi: 10.1016/j.actaastro.2016.12.018. Epub 2016 Dec 18.


Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.

Schmidt ME, Knudson CJ, Hartwig SM, Pewe LL, Meyerholz DK, Langlois RA, Harty JT, Varga SM.

PLoS Pathog. 2018 Jan 2;14(1):e1006810. doi: 10.1371/journal.ppat.1006810. eCollection 2018 Jan.


Effects of physical exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy.

van Vulpen JK, Schmidt ME, Velthuis MJ, Wiskemann J, Schneeweiss A, Vermeulen RCH, Habermann N, Ulrich CM, Peeters PHM, van der Wall E, May AM, Steindorf K.

Breast Cancer Res Treat. 2018 Apr;168(2):421-431. doi: 10.1007/s10549-017-4608-7. Epub 2017 Dec 12.


Determinants of physical, affective, and cognitive fatigue during breast cancer therapy and 12 months follow-up.

Schmidt ME, Wiskemann J, Schneeweiss A, Potthoff K, Ulrich CM, Steindorf K.

Int J Cancer. 2018 Mar 15;142(6):1148-1157. doi: 10.1002/ijc.31138. Epub 2017 Nov 13.


Host genetics play a critical role in controlling CD8 T cell function and lethal immunopathology during chronic viral infection.

Christiaansen AF, Schmidt ME, Hartwig SM, Varga SM.

PLoS Pathog. 2017 Jul 17;13(7):e1006498. doi: 10.1371/journal.ppat.1006498. eCollection 2017 Jul.


Impact of HSCT Conditioning and Glucocorticoid Dose on Exercise Adherence and Response.

Wiskemann J, Herzog B, Kuehl R, Schmidt ME, Steindorf K, Schwerdtfeger R, Dreger P, Bohus M.

Med Sci Sports Exerc. 2017 Nov;49(11):2143-2150. doi: 10.1249/MSS.0000000000001357.


Dissociation of Down syndrome and Alzheimer's disease effects with imaging.

Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS.

Alzheimers Dement (N Y). 2016 Jun;2(2):69-81. doi: 10.1016/j.trci.2016.02.004.


Redox stratification of an ancient lake in Gale crater, Mars.

Hurowitz JA, Grotzinger JP, Fischer WW, McLennan SM, Milliken RE, Stein N, Vasavada AR, Blake DF, Dehouck E, Eigenbrode JL, Fairén AG, Frydenvang J, Gellert R, Grant JA, Gupta S, Herkenhoff KE, Ming DW, Rampe EB, Schmidt ME, Siebach KL, Stack-Morgan K, Sumner DY, Wiens RC.

Science. 2017 Jun 2;356(6341). pii: eaah6849. doi: 10.1126/science.aah6849. Epub 2017 Jun 1.


Nitrogen Gas Field Ion Source (GFIS) Focused Ion Beam (FIB) Secondary Electron Imaging: A First Look.

Schmidt ME, Yasaka A, Akabori M, Mizuta H.

Microsc Microanal. 2017 Aug;23(4):758-768. doi: 10.1017/S1431927617000502. Epub 2017 May 10.


The value of PET ligand discovery to CNS drug development.

Schmidt ME, Andrés JI.

Future Med Chem. 2017 Mar;9(4):351-356. doi: 10.4155/fmc-2017-0018. Epub 2017 Mar 6. No abstract available.


Modulation of the host immune response by respiratory syncytial virus proteins.

Schmidt ME, Varga SM.

J Microbiol. 2017 Mar;55(3):161-171. doi: 10.1007/s12275-017-7045-8. Epub 2017 Feb 28. Review.


The epidemiologic characteristics, temporal trends, predictors of death, and discharge disposition in patients with a diagnosis of sepsis: A cross-sectional retrospective cohort study.

Elfeky S, Golabi P, Otgonsuren M, Djurkovic S, Schmidt ME, Younossi ZM.

J Crit Care. 2017 Jun;39:48-55. doi: 10.1016/j.jcrc.2017.01.006. Epub 2017 Jan 20.


Effects of exercise on sleep problems in breast cancer patients receiving radiotherapy: a randomized clinical trial.

Steindorf K, Wiskemann J, Ulrich CM, Schmidt ME.

Breast Cancer Res Treat. 2017 Apr;162(3):489-499. doi: 10.1007/s10549-017-4141-8. Epub 2017 Feb 8.


Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease.

Rombouts FJ, Andrés JI, Ariza M, Alonso JM, Austin N, Bottelbergs A, Chen L, Chupakhin V, Cleiren E, Fierens K, Fontana A, Langlois X, Leenaerts JE, Mariën J, Martínez Lamenca C, Salter R, Schmidt ME, Te Riele P, Wintmolders C, Trabanco AA, Zhang W, Macdonald G, Moechars D.

J Med Chem. 2017 Feb 23;60(4):1272-1291. doi: 10.1021/acs.jmedchem.6b01173. Epub 2017 Feb 10.


Self-reported physical activity behavior of breast cancer survivors during and after adjuvant therapy: 12 months follow-up of two randomized exercise intervention trials.

Schmidt ME, Wiskemann J, Ulrich CM, Schneeweiss A, Steindorf K.

Acta Oncol. 2017 Apr;56(4):618-627. doi: 10.1080/0284186X.2016.1275776. Epub 2017 Jan 13.


Partial hydrogenation induced interaction in a graphene-SiO2 interface: irreversible modulation of device characteristics.

Iwasaki T, Muruganathan M, Schmidt ME, Mizuta H.

Nanoscale. 2017 Jan 26;9(4):1662-1669. doi: 10.1039/c6nr08117g.


Effects and moderators of exercise on quality of life and physical function in patients with cancer: An individual patient data meta-analysis of 34 RCTs.

Buffart LM, Kalter J, Sweegers MG, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, May AM, Galvão DA, Chinapaw MJ, Steindorf K, Irwin ML, Stuiver MM, Hayes S, Griffith KA, Lucia A, Mesters I, van Weert E, Knoop H, Goedendorp MM, Mutrie N, Daley AJ, McConnachie A, Bohus M, Thorsen L, Schulz KH, Short CE, James EL, Plotnikoff RC, Arbane G, Schmidt ME, Potthoff K, van Beurden M, Oldenburg HS, Sonke GS, van Harten WH, Garrod R, Schmitz KH, Winters-Stone KM, Velthuis MJ, Taaffe DR, van Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-de Leeuw IM, Brug J.

Cancer Treat Rev. 2017 Jan;52:91-104. doi: 10.1016/j.ctrv.2016.11.010. Epub 2016 Dec 5. Review.

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