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Secondary Metabolites of Onygenales Fungi Exemplified by Aioliomyces pyridodomos.

Lin Z, Kakule TB, Reilly CA, Beyhan S, Schmidt EW.

J Nat Prod. 2019 Jun 28;82(6):1616-1626. doi: 10.1021/acs.jnatprod.9b00121. Epub 2019 Jun 3.


Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium.

Lacerna NM 2nd, Miller BW, Lim AL, Tun JO, Robes JMD, Cleofas MJB, Lin Z, Salvador-Reyes LA, Haygood MG, Schmidt EW, Concepcion GP.

J Nat Prod. 2019 Apr 26;82(4):1024-1028. doi: 10.1021/acs.jnatprod.8b00979. Epub 2019 Feb 22.


Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity.

Lin Z, Phadke S, Lu Z, Beyhan S, Abdel Aziz MH, Reilly C, Schmidt EW.

J Nat Prod. 2018 Dec 28;81(12):2605-2611. doi: 10.1021/acs.jnatprod.7b01067. Epub 2018 Dec 3.


Roads to Rome: Role of Multiple Cassettes in Cyanobactin RiPP Biosynthesis.

Gu W, Sardar D, Pierce E, Schmidt EW.

J Am Chem Soc. 2018 Nov 28;140(47):16213-16221. doi: 10.1021/jacs.8b09328. Epub 2018 Nov 14.


A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases.

Estrada P, Morita M, Hao Y, Schmidt EW, Nair SK.

J Am Chem Soc. 2018 Jul 5;140(26):8124-8127. doi: 10.1021/jacs.8b05187. Epub 2018 Jun 26.


Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene.

Wozniak CE, Lin Z, Schmidt EW, Hughes KT, Liou TG.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00463-18. doi: 10.1128/AAC.00463-18. Print 2018 Sep.


The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis.

Gu W, Dong SH, Sarkar S, Nair SK, Schmidt EW.

Methods Enzymol. 2018;604:113-163. doi: 10.1016/bs.mie.2018.03.002. Epub 2018 May 4. Review.


Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis.

Morita M, Hao Y, Jokela JK, Sardar D, Lin Z, Sivonen K, Nair SK, Schmidt EW.

J Am Chem Soc. 2018 May 16;140(19):6044-6048. doi: 10.1021/jacs.8b03137. Epub 2018 May 1.


Parallel lives of symbionts and hosts: chemical mutualism in marine animals.

Morita M, Schmidt EW.

Nat Prod Rep. 2018 Apr 25;35(4):357-378. doi: 10.1039/c7np00053g. Review.


Accessing chemical diversity from the uncultivated symbionts of small marine animals.

Smith TE, Pond CD, Pierce E, Harmer ZP, Kwan J, Zachariah MM, Harper MK, Wyche TP, Matainaho TK, Bugni TS, Barrows LR, Ireland CM, Schmidt EW.

Nat Chem Biol. 2018 Feb;14(2):179-185. doi: 10.1038/nchembio.2537. Epub 2018 Jan 1.


Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts.

Torres JP, Tianero MD, Robes JMD, Kwan JC, Biggs JS, Concepcion GP, Olivera BM, Haygood MG, Schmidt EW.

Appl Environ Microbiol. 2017 Nov 16;83(23). pii: e01418-17. doi: 10.1128/AEM.01418-17. Print 2017 Dec 1.


Three Principles of Diversity-Generating Biosynthesis.

Gu W, Schmidt EW.

Acc Chem Res. 2017 Oct 17;50(10):2569-2576. doi: 10.1021/acs.accounts.7b00330. Epub 2017 Sep 11.


Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products.

Lin Z, Smith MD, Concepcion GP, Haygood MG, Olivera BM, Light A, Schmidt EW.

J Nat Prod. 2017 Aug 25;80(8):2360-2370. doi: 10.1021/acs.jnatprod.7b00317. Epub 2017 Jul 26.


Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study.

Olivera BM, Raghuraman S, Schmidt EW, Safavi-Hemami H.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Sep;203(9):717-735. doi: 10.1007/s00359-017-1183-7. Epub 2017 May 27. Review.


Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory.

Distel DL, Altamia MA, Lin Z, Shipway JR, Han A, Forteza I, Antemano R, Limbaco MGJP, Tebo AG, Dechavez R, Albano J, Rosenberg G, Concepcion GP, Schmidt EW, Haygood MG.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3652-E3658. doi: 10.1073/pnas.1620470114. Epub 2017 Apr 17.


Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges.

Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore BS.

Nat Chem Biol. 2017 May;13(5):537-543. doi: 10.1038/nchembio.2330. Epub 2017 Mar 20.


Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products.

Sardar D, Hao Y, Lin Z, Morita M, Nair SK, Schmidt EW.

J Am Chem Soc. 2017 Mar 1;139(8):2884-2887. doi: 10.1021/jacs.6b12872. Epub 2017 Feb 15.


Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis.

Zhang S, Qiu Y, Kakule TB, Lu Z, Xu F, Lamb JG, Reilly CA, Zheng Y, Sham SW, Wang W, Xuan L, Schmidt EW, Zhan J.

J Nat Prod. 2017 Feb 24;80(2):363-370. doi: 10.1021/acs.jnatprod.6b00808. Epub 2017 Jan 20.


Molecular basis for the broad substrate selectivity of a peptide prenyltransferase.

Hao Y, Pierce E, Roe D, Morita M, McIntosh JA, Agarwal V, Cheatham TE 3rd, Schmidt EW, Nair SK.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14037-14042. Epub 2016 Nov 21.


Directing Biosynthesis: Practical Supply of Natural and Unnatural Cyanobactins.

Sardar D, Tianero MD, Schmidt EW.

Methods Enzymol. 2016;575:1-20. doi: 10.1016/bs.mie.2016.02.012. Epub 2016 Mar 16.


Origin of Chemical Diversity in Prochloron-Tunicate Symbiosis.

Lin Z, Torres JP, Tianero MD, Kwan JC, Schmidt EW.

Appl Environ Microbiol. 2016 May 31;82(12):3450-60. doi: 10.1128/AEM.00860-16. Print 2016 Jun 15.


Metabolic model for diversity-generating biosynthesis.

Tianero MD, Pierce E, Raghuraman S, Sardar D, McIntosh JA, Heemstra JR, Schonrock Z, Covington BC, Maschek JA, Cox JE, Bachmann BO, Olivera BM, Ruffner DE, Schmidt EW.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1772-7. doi: 10.1073/pnas.1525438113. Epub 2016 Feb 1.


Combinatorial biosynthesis of RiPPs: docking with marine life.

Sardar D, Schmidt EW.

Curr Opin Chem Biol. 2016 Apr;31:15-21. doi: 10.1016/j.cbpa.2015.11.016. Epub 2015 Dec 19. Review.


Small Molecules in the Cone Snail Arsenal.

Neves JL, Lin Z, Imperial JS, Antunes A, Vasconcelos V, Olivera BM, Schmidt EW.

Org Lett. 2015 Oct 16;17(20):4933-5. doi: 10.1021/acs.orglett.5b02389. Epub 2015 Sep 30.


Modularity of RiPP Enzymes Enables Designed Synthesis of Decorated Peptides.

Sardar D, Lin Z, Schmidt EW.

Chem Biol. 2015 Jul 23;22(7):907-16. doi: 10.1016/j.chembiol.2015.06.014. Epub 2015 Jul 9.


Natural products: Hunting microbial metabolites.

Schmidt EW.

Nat Chem. 2015 May;7(5):375-6. doi: 10.1038/nchem.2252. No abstract available.


Biosynthesis of the tetramic acids Sch210971 and Sch210972.

Kakule TB, Zhang S, Zhan J, Schmidt EW.

Org Lett. 2015 May 15;17(10):2295-7. doi: 10.1021/acs.orglett.5b00715. Epub 2015 Apr 17.


Constellation pharmacology: a new paradigm for drug discovery.

Teichert RW, Schmidt EW, Olivera BM.

Annu Rev Pharmacol Toxicol. 2015;55:573-89. doi: 10.1146/annurev-pharmtox-010814-124551. Review.


Combinatorialization of fungal polyketide synthase-peptide synthetase hybrid proteins.

Kakule TB, Lin Z, Schmidt EW.

J Am Chem Soc. 2014 Dec 24;136(51):17882-90. doi: 10.1021/ja511087p. Epub 2014 Dec 8.


Isolation of pyrrolocins A-C: cis- and trans-decalin tetramic acid antibiotics from an endophytic fungal-derived pathway.

Jadulco RC, Koch M, Kakule TB, Schmidt EW, Orendt A, He H, Janso JE, Carter GT, Larson EC, Pond C, Matainaho TK, Barrows LR.

J Nat Prod. 2014 Nov 26;77(11):2537-44. doi: 10.1021/np500617u. Epub 2014 Oct 29.


Native promoter strategy for high-yielding synthesis and engineering of fungal secondary metabolites.

Kakule TB, Jadulco RC, Koch M, Janso JE, Barrows LR, Schmidt EW.

ACS Synth Biol. 2015 May 15;4(5):625-33. doi: 10.1021/sb500296p. Epub 2014 Sep 26.


Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.

Lin Z, Koch M, Abdel Aziz MH, Galindo-Murillo R, Tianero MD, Cheatham TE, Barrows LR, Reilly CA, Schmidt EW.

Org Lett. 2014 Sep 19;16(18):4774-7. doi: 10.1021/ol502227x. Epub 2014 Sep 4.


Species specificity of symbiosis and secondary metabolism in ascidians.

Tianero MD, Kwan JC, Wyche TP, Presson AP, Koch M, Barrows LR, Bugni TS, Schmidt EW.

ISME J. 2015 Mar;9(3):615-28. doi: 10.1038/ismej.2014.152. Epub 2014 Aug 29.


Assessing the combinatorial potential of the RiPP cyanobactin tru pathway.

Ruffner DE, Schmidt EW, Heemstra JR.

ACS Synth Biol. 2015 Apr 17;4(4):482-92. doi: 10.1021/sb500267d. Epub 2014 Sep 2.


Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella.

Kwan JC, Tianero MD, Donia MS, Wyche TP, Bugni TS, Schmidt EW.

PLoS One. 2014 May 2;9(5):e95850. doi: 10.1371/journal.pone.0095850. eCollection 2014.


Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis.

Lin Z, Zachariah MM, Marett L, Hughen RW, Teichert RW, Concepcion GP, Haygood MG, Olivera BM, Light AR, Schmidt EW.

J Nat Prod. 2014 May 23;77(5):1224-30. doi: 10.1021/np500155d. Epub 2014 May 1.


Recognition sequences and substrate evolution in cyanobactin biosynthesis.

Sardar D, Pierce E, McIntosh JA, Schmidt EW.

ACS Synth Biol. 2015 Feb 20;4(2):167-76. doi: 10.1021/sb500019b. Epub 2014 Mar 26.


Synthesis and bioactivity of nobilamide B.

Jacinto MP, Flores MS, Lin Z, Concepcion GP, Schmidt EW, Faulkner S, Villaraza AJ.

RSC Adv. 2014;4(71):37609-37612.


Bacterial endosymbiosis in a chordate host: long-term co-evolution and conservation of secondary metabolism.

Kwan JC, Schmidt EW.

PLoS One. 2013 Dec 4;8(12):e80822. doi: 10.1371/journal.pone.0080822. eCollection 2013.


Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp.

Lin Z, Koch M, Pond CD, Mabeza G, Seronay RA, Concepcion GP, Barrows LR, Olivera BM, Schmidt EW.

J Antibiot (Tokyo). 2014 Jan;67(1):121-6. doi: 10.1038/ja.2013.115. Epub 2013 Nov 13.


Neuroactive diol and acyloin metabolites from cone snail-associated bacteria.

Lin Z, Marett L, Hughen RW, Flores M, Forteza I, Ammon MA, Concepcion GP, Espino S, Olivera BM, Rosenberg G, Haygood MG, Light AR, Schmidt EW.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4867-9. doi: 10.1016/j.bmcl.2013.06.088. Epub 2013 Jul 8.


Two related pyrrolidinedione synthetase loci in Fusarium heterosporum ATCC 74349 produce divergent metabolites.

Kakule TB, Sardar D, Lin Z, Schmidt EW.

ACS Chem Biol. 2013 Jul 19;8(7):1549-57. doi: 10.1021/cb400159f. Epub 2013 May 6.


Linear and nonlinear optical characterization of aluminum nanoantennas.

Schwab PM, Moosmann C, Wissert MD, Schmidt EW, Ilin KS, Siegel M, Lemmer U, Eisler HJ.

Nano Lett. 2013 Apr 10;13(4):1535-40. doi: 10.1021/nl304692p. Epub 2013 Mar 12.


Aestuaramides, a natural library of cyanobactin cyclic peptides resulting from isoprene-derived Claisen rearrangements.

McIntosh JA, Lin Z, Tianero MD, Schmidt EW.

ACS Chem Biol. 2013 May 17;8(5):877-83. doi: 10.1021/cb300614c. Epub 2013 Feb 22.


A bacterial source for mollusk pyrone polyketides.

Lin Z, Torres JP, Ammon MA, Marett L, Teichert RW, Reilly CA, Kwan JC, Hughen RW, Flores M, Tianero MD, Peraud O, Cox JE, Light AR, Villaraza AJ, Haygood MG, Concepcion GP, Olivera BM, Schmidt EW.

Chem Biol. 2013 Jan 24;20(1):73-81. doi: 10.1016/j.chembiol.2012.10.019.


Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills.

Elshahawi SI, Trindade-Silva AE, Hanora A, Han AW, Flores MS, Vizzoni V, Schrago CG, Soares CA, Concepcion GP, Distel DL, Schmidt EW, Haygood MG.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):E295-304. doi: 10.1073/pnas.1213892110. Epub 2013 Jan 3.


Decoding and recoding the ribosomal peptide universe.

Schmidt EW.

Chem Biol. 2012 Dec 21;19(12):1501-2. doi: 10.1016/j.chembiol.2012.12.002.


Genome streamlining and chemical defense in a coral reef symbiosis.

Kwan JC, Donia MS, Han AW, Hirose E, Haygood MG, Schmidt EW.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20655-60. doi: 10.1073/pnas.1213820109. Epub 2012 Nov 26.


Structures of cyanobactin maturation enzymes define a family of transamidating proteases.

Agarwal V, Pierce E, McIntosh J, Schmidt EW, Nair SK.

Chem Biol. 2012 Nov 21;19(11):1411-22. doi: 10.1016/j.chembiol.2012.09.012.

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