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Items: 49


Using the Extremes of Human Inflammation to Understand the Transcriptional Control of Interleukin 18.

LaRivière WB, Schmidt EP.

Am J Respir Crit Care Med. 2020 Jan 3. doi: 10.1164/rccm.201912-2322ED. [Epub ahead of print] No abstract available.


Plasma and Urinary Glycosaminoglycans as Evidence for Endotheliopathy in a Swine Burn Model.

Gómez BI, Dubick MA, Schmidt EP, Shupp JW, Burmeister DM.

J Surg Res. 2019 Dec 13;248:28-37. doi: 10.1016/j.jss.2019.11.006. [Epub ahead of print]


Grant Writing for Clinicians in Training: An Important Career Development Exercise.

Files DC, Hume PS, Krall J, Montemayor K, Schmidt EP, King LS.

Chest. 2019 Nov 12. pii: S0012-3692(19)34189-3. doi: 10.1016/j.chest.2019.10.024. [Epub ahead of print] No abstract available.


Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses.

Oshima K, Han X, Ouyang Y, El Masri R, Yang Y, Haeger SM, McMurtry SA, Lane TC, Davizon-Castillo P, Zhang F, Yue X, Vivès RR, Linhardt RJ, Schmidt EP.

Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L667-L677. doi: 10.1152/ajplung.00175.2019. Epub 2019 Aug 28.


Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation.

Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP.

Crit Care. 2019 Jul 23;23(1):259. doi: 10.1186/s13054-019-2534-2.


Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung.

Liao S, Eickelberg O, Schmidt EP, Yang Y.

J Vis Exp. 2019 May 20;(147). doi: 10.3791/59450.


Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade.

Kwiecinski JM, Crosby HA, Valotteau C, Hippensteel JA, Nayak MK, Chauhan AK, Schmidt EP, Dufrêne YF, Horswill AR.

PLoS Pathog. 2019 May 22;15(5):e1007800. doi: 10.1371/journal.ppat.1007800. eCollection 2019 May.


Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions.

Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9208-9213. doi: 10.1073/pnas.1902227116. Epub 2019 Apr 22.


Circulating heparan sulfate fragments mediate septic cognitive dysfunction.

Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP.

J Clin Invest. 2019 Apr 1;129(4):1779-1784. doi: 10.1172/JCI124485. Epub 2019 Mar 18.


The glycocalyx: a novel diagnostic and therapeutic target in sepsis.

Uchimido R, Schmidt EP, Shapiro NI.

Crit Care. 2019 Jan 17;23(1):16. doi: 10.1186/s13054-018-2292-6. Review.


The Pulmonary Endothelial Glycocalyx in ARDS: A Critical Role for Heparan Sulfate.

LaRivière WB, Schmidt EP.

Curr Top Membr. 2018;82:33-52. doi: 10.1016/bs.ctm.2018.08.005. Epub 2018 Sep 27.


Intravital Microscopy in the Mouse Lung.

Yang Y, Hippensteel JA, Schmidt EP.

Methods Mol Biol. 2018;1809:331-339. doi: 10.1007/978-1-4939-8570-8_21. Review.


Challenging Dogma: The Value of Bolus Fluids in the Early Resuscitation of Hyperdynamic Sepsis.

Hippensteel JA, Shapiro NI, Schmidt EP.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):981-983. doi: 10.1164/rccm.201806-1071ED. No abstract available.


Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury.

Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP.

Am J Respir Cell Mol Biol. 2018 Sep;59(3):363-374. doi: 10.1165/rcmb.2017-0428OC.


More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series).

Oshima K, Haeger SM, Hippensteel JA, Herson PS, Schmidt EP.

Pulm Circ. 2018 Jan-Mar;8(1):2045893217745786. doi: 10.1177/2045893217745786.


Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte.

Hippensteel JA, Schmidt EP.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):416-418. doi: 10.1164/rccm.201710-2094ED. No abstract available.


Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice.

Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaah5360. doi: 10.1126/scitranslmed.aah5360.


Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding.

Zhang Y, Haeger SM, Yang Y, Dailey KL, Ford JA, Schmidt EP.

Shock. 2017 Dec;48(6):666-673. doi: 10.1097/SHK.0000000000000907.


A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis.

Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F553-F559. doi: 10.1152/ajprenal.00493.2016. Epub 2017 May 17.


Electronic Cigarettes Are as Toxic to Skin Flap Survival as Tobacco Cigarettes.

Rau AS, Reinikovaite V, Schmidt EP, Taraseviciene-Stewart L, Deleyiannis FW.

Ann Plast Surg. 2017 Jul;79(1):86-91. doi: 10.1097/SAP.0000000000000998.


Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution.

Yang Y, Haeger SM, Suflita MA, Zhang F, Dailey KL, Colbert JF, Ford JA, Picon MA, Stearman RS, Lin L, Liu X, Han X, Linhardt RJ, Schmidt EP.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):727-737. doi: 10.1165/rcmb.2016-0338OC.


Chemoenzymatic synthesis of unmodified heparin oligosaccharides: cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation.

Zhang X, Xu Y, Hsieh PH, Liu J, Lin L, Schmidt EP, Linhardt RJ.

Org Biomol Chem. 2017 Feb 1;15(5):1222-1227. doi: 10.1039/c6ob02603f.


Severe Sepsis Outcomes Among Hospitalizations With Inflammatory Bowel Disease.

Colbert JF, Schmidt EP, Faubel S, Ginde AA.

Shock. 2017 Feb;47(2):128-131. doi: 10.1097/SHK.0000000000000742.


Endothelial and Microcirculatory Function and Dysfunction in Sepsis.

Colbert JF, Schmidt EP.

Clin Chest Med. 2016 Jun;37(2):263-75. doi: 10.1016/j.ccm.2016.01.009. Epub 2016 Mar 4. Review.


Adhesion Molecules: Master Controllers of the Circulatory System.

Schmidt EP, Kuebler WM, Lee WL, Downey GP.

Compr Physiol. 2016 Mar 15;6(2):945-73. doi: 10.1002/cphy.c150020. Review.


Heparan Sulfate in the Developing, Healthy, and Injured Lung.

Haeger SM, Yang Y, Schmidt EP.

Am J Respir Cell Mol Biol. 2016 Jul;55(1):5-11. doi: 10.1165/rcmb.2016-0043TR. Review.


Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome.

Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ.

Am J Respir Crit Care Med. 2016 Aug 15;194(4):439-49. doi: 10.1164/rccm.201511-2281OC.


The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.

Morris A, Wang B, Waern I, Venkatasamy R, Page C, Schmidt EP, Wernersson S, Li JP, Spina D.

PLoS One. 2015 Jun 3;10(6):e0127032. doi: 10.1371/journal.pone.0127032. eCollection 2015.


Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry.

Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ.

Anal Chem. 2015 Jun 16;87(12):6220-7. doi: 10.1021/acs.analchem.5b00913. Epub 2015 Jun 2.


Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung.

Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP.

Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S1-2. doi: 10.1513/AnnalsATS.201411-536MG. No abstract available.


Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation.

Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP.

Am J Pathol. 2014 Sep;184(9):2382-9. doi: 10.1016/j.ajpath.2014.06.002. Epub 2014 Jul 9.


The circulating glycosaminoglycan signature of respiratory failure in critically ill adults.

Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ.

J Biol Chem. 2014 Mar 21;289(12):8194-202. doi: 10.1074/jbc.M113.539452. Epub 2014 Feb 7.


Heparanase mediates renal dysfunction during early sepsis in mice.

Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP.

Physiol Rep. 2013 Nov;1(6):e00153. doi: 10.1002/phy2.153. Epub 2013 Nov 11.


Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3.

Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM.

Am J Respir Cell Mol Biol. 2014 May;50(5):932-41. doi: 10.1165/rcmb.2013-0361OC.


Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-α antibodies.

Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S.

PLoS One. 2013 Nov 12;8(11):e79037. doi: 10.1371/journal.pone.0079037. eCollection 2013.


The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier.

Yang Y, Schmidt EP.

Tissue Barriers. 2013 Jan 1;1(1). pii: 23494.


Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions.

Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP.

Am J Respir Cell Mol Biol. 2013 Jul;49(1):1-5. doi: 10.1165/rcmb.2012-0472TR. Review.


Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling.

Chow K, Fessel JP, Kaoriihida-Stansbury, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH Jr, Nozik-Grayck E, West JD, Klemm DJ, Majka SM.

Pulm Circ. 2013 Jan;3(1):31-49. doi: 10.4103/2045-8932.109912.


In vivo measurement of the mouse pulmonary endothelial surface layer.

Yang Y, Yang G, Schmidt EP.

J Vis Exp. 2013 Feb 22;(72):e50322. doi: 10.3791/50322.


The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.

Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM.

Nat Med. 2012 Aug;18(8):1217-23. doi: 10.1038/nm.2843. Epub 2012 Jul 22.


The expanding appreciation of heparanase in human disease.

Schmidt EP.

Neurosci Lett. 2012 Mar 5;511(1):1-3. doi: 10.1016/j.neulet.2012.01.027. Epub 2012 Jan 25. No abstract available.


On, around, and through: neutrophil-endothelial interactions in innate immunity.

Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP.

Physiology (Bethesda). 2011 Oct;26(5):334-47. doi: 10.1152/physiol.00011.2011. Review.


Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury.

Carpenter TC, Schroeder W, Stenmark KR, Schmidt EP.

Am J Respir Cell Mol Biol. 2012 Jan;46(1):40-7. doi: 10.1165/rcmb.2011-0044OC.


Hyperoxia and apoptosis. Too much of a good thing?

Tuder RM, Hunt JM, Schmidt EP.

Am J Respir Crit Care Med. 2011 Apr 15;183(8):964-5. doi: 10.1164/rccm.201010-1756ED. No abstract available.


Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases.

Schmidt EP, Tuder RM.

J Cell Death. 2010 Jul 22;3:41-53. eCollection 2010. Review.


Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases.

Schmidt EP, Tuder RM.

J Cell Death. 2010 Jul 20;2010(3):41-53.


Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice.

Schmidt EP, Damarla M, Rentsendorj O, Servinsky LE, Zhu B, Moldobaeva A, Gonzalez A, Hassoun PM, Pearse DB.

Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L1056-65. doi: 10.1152/ajplung.90329.2008. Epub 2008 Oct 10.


Pulmonary predictors of survival in amyotrophic lateral sclerosis: use in clinical trial design.

Schmidt EP, Drachman DB, Wiener CM, Clawson L, Kimball R, Lechtzin N.

Muscle Nerve. 2006 Jan;33(1):127-32.


Images in clinical medicine. Toxic neutrophils in Streptococcus pneumoniae sepsis.

Hann CL, Schmidt EP.

N Engl J Med. 2004 Dec 16;351(25):2636. No abstract available.

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