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Items: 1 to 50 of 89

1.

Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers.

Baxter NT, Schmidt AW, Venkataraman A, Kim KS, Waldron C, Schmidt TM.

MBio. 2019 Jan 29;10(1). pii: e02566-18. doi: 10.1128/mBio.02566-18.

2.

Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.

Helal CJ, Arnold EP, Boyden TL, Chang C, Chappie TA, Fennell KF, Forman MD, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Kang Z, Kleiman RJ, Kormos BL, LaChapelle EA, Lee CW, Lu J, Maklad N, McDowell L, Mente S, O'Connor RE, Pandit J, Piotrowski M, Schmidt AW, Schmidt CJ, Ueno H, Verhoest PR, Yang EX.

J Med Chem. 2018 Apr 26;61(8):3753. doi: 10.1021/acs.jmedchem.8b00475. Epub 2018 Apr 6. No abstract available.

PMID:
29624389
3.

Synthesis of 1,1'- and 2,2'-Bicarbazole Alkaloids by Iron(III)-Catalyzed Oxidative Coupling of 2- and 1-Hydroxycarbazoles.

Brütting C, Fritsche RF, Kutz SK, Börger C, Schmidt AW, Kataeva O, Knölker HJ.

Chemistry. 2018 Jan 9;24(2):458-470. doi: 10.1002/chem.201704554. Epub 2017 Dec 4.

PMID:
29024097
4.

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.

Helal CJ, Arnold EP, Boyden TL, Chang C, Chappie TA, Fennell KF, Forman MD, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Kang Z, Kleiman RJ, Kormos BL, Lee CW, Lu J, Maklad N, McDowell L, Mente S, O'Connor RE, Pandit J, Piotrowski M, Schmidt AW, Schmidt CJ, Ueno H, Verhoest PR, Yang EX.

J Med Chem. 2017 Jul 13;60(13):5673-5698. doi: 10.1021/acs.jmedchem.7b00397. Epub 2017 Jun 16. Erratum in: J Med Chem. 2018 Apr 26;61(8):3753.

PMID:
28574706
5.

Synthesis of Glycoborine, Glybomine A and B, the Phytoalexin Carbalexin A and the β-Adrenoreceptor Antagonists Carazolol and Carvedilol.

Brütting C, Hesse R, Jäger A, Kataeva O, Schmidt AW, Knölker HJ.

Chemistry. 2016 Nov 14;22(47):16897-16911. doi: 10.1002/chem.201604002. Epub 2016 Oct 25.

PMID:
27778384
6.

Variable responses of human microbiomes to dietary supplementation with resistant starch.

Venkataraman A, Sieber JR, Schmidt AW, Waldron C, Theis KR, Schmidt TM.

Microbiome. 2016 Jun 29;4(1):33. doi: 10.1186/s40168-016-0178-x.

7.

Determination of receptor occupancy in the presence of mass dose: [11C]GSK189254 PET imaging of histamine H3 receptor occupancy by PF-03654746.

Gallezot JD, Planeta B, Nabulsi N, Palumbo D, Li X, Liu J, Rowinski C, Chidsey K, Labaree D, Ropchan J, Lin SF, Sawant-Basak A, McCarthy TJ, Schmidt AW, Huang Y, Carson RE.

J Cereb Blood Flow Metab. 2017 Mar;37(3):1095-1107. doi: 10.1177/0271678X16650697. Epub 2016 Jul 20.

8.

Chemical constituents isolated from Zygophyllum melongena Bunge growing in Mongolia.

Ganbaatar C, Gruner M, Tunsag J, Batsuren D, Ganpurev B, Chuluunnyam L, Sodbayar B, Schmidt AW, Knölker HJ.

Nat Prod Res. 2016 Jul;30(14):1661-4. doi: 10.1080/14786419.2015.1118630. Epub 2016 Jan 11.

PMID:
26795069
9.

Synthesis of Methylene-Bridged Biscarbazole Alkaloids by using an Ullmann-type Coupling: First Total Synthesis of Murrastifoline-C and Murrafoline-E.

Kutz SK, Börger C, Schmidt AW, Knölker HJ.

Chemistry. 2016 Feb 12;22(7):2487-500. doi: 10.1002/chem.201504680. Epub 2016 Jan 20.

PMID:
26787133
10.

Total syntheses of murrayamine E, I, and K.

Schuster C, Julich-Gruner KK, Schnitzler H, Hesse R, Jäger A, Schmidt AW, Knölker HJ.

J Org Chem. 2015 Jun 5;80(11):5666-73. doi: 10.1021/acs.joc.5b00630. Epub 2015 May 12.

PMID:
25915067
11.

Risk for cardiovascular disease among Seventh-day Adventists and Baptists in Denmark, 1977-2009.

Christiansen NS, Schmidt AW, Johansen C, Ross L, Hvidt NC, Thygesen LC.

Int J Cardiol. 2015 Apr 15;185:133-5. doi: 10.1016/j.ijcard.2015.03.131. Epub 2015 Mar 10. No abstract available.

PMID:
25791113
12.

Synthesis of prenyl- and geranyl-substituted carbazole alkaloids by DIBAL-H promoted reductive pyran ring opening of dialkylpyrano[3,2-a]carbazoles.

Hesse R, Kataeva O, Schmidt AW, Knölker HJ.

Chemistry. 2014 Jul 28;20(31):9504-9. doi: 10.1002/chem.201403645. Epub 2014 Jul 9.

PMID:
25042058
13.

Total synthesis of the cyclic monoterpenoid pyrano[3,2-a]carbazole alkaloids derived from 2-hydroxy-6-methylcarbazole.

Gassner C, Hesse R, Schmidt AW, Knölker HJ.

Org Biomol Chem. 2014 Sep 7;12(33):6490-9. doi: 10.1039/c4ob01151a.

PMID:
25023897
14.

Total synthesis of 7- and 8-oxygenated pyrano[3,2-a]carbazole and pyrano[2,3-a]carbazole alkaloids via boronic acid-catalyzed annulation of the pyran ring.

Julich-Gruner KK, Kataeva O, Schmidt AW, Knölker HJ.

Chemistry. 2014 Jul 7;20(28):8536-40. doi: 10.1002/chem.201403143. Epub 2014 May 30.

PMID:
24889600
15.

First total syntheses of chrestifoline-B and (±)-chrestifoline-C, and improved synthetic routes to bismurrayafoline-A, bismurrayafolinol and chrestifoline-D.

Börger C, Schmidt AW, Knölker HJ.

Org Biomol Chem. 2014 Jun 21;12(23):3831-5. doi: 10.1039/c4ob00609g.

PMID:
24806196
16.

Palladium(II)-catalysed total synthesis of naturally occurring pyrano[3,2-a]carbazole and pyrano[2,3-b]carbazole alkaloids.

Hesse R, Jäger A, Schmidt AW, Knölker HJ.

Org Biomol Chem. 2014 Jun 21;12(23):3866-76. doi: 10.1039/c4ob00367e.

PMID:
24788002
17.

Bacterial communities in Malagasy soils with differing levels of disturbance affecting botanical diversity.

Blasiak LC, Schmidt AW, Andriamiarinoro H, Mulaw T, Rasolomampianina R, Applequist WL, Birkinshaw C, Rejo-Fienena F, Lowry PP 2nd, Schmidt TM, Hill RT.

PLoS One. 2014 Jan 20;9(1):e85097. doi: 10.1371/journal.pone.0085097. eCollection 2014.

18.

Regioselective prenylation of bromocarbazoles by palladium(0)-catalysed cross coupling--synthesis of O-methylsiamenol, O-methylmicromeline and carquinostatin A.

Thomas C, Kataeva O, Schmidt AW, Knölker HJ.

Org Biomol Chem. 2014 Feb 14;12(6):872-5. doi: 10.1039/c3ob42297f.

PMID:
24336906
19.

Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis.

Schmidt AW, Choi TA, Theumer G, Franzblau SG, Knölker HJ.

Bioorg Med Chem Lett. 2013 Nov 15;23(22):6111-3. doi: 10.1016/j.bmcl.2013.09.013. Epub 2013 Sep 14.

PMID:
24084159
20.

Efficient construction of pyrano[3,2-a]carbazoles: application to a biomimetic total synthesis of cyclized monoterpenoid pyrano[3,2-a]carbazole alkaloids.

Hesse R, Gruner KK, Kataeva O, Schmidt AW, Knölker HJ.

Chemistry. 2013 Oct 11;19(42):14098-111. doi: 10.1002/chem.201301792. Epub 2013 Sep 12.

PMID:
24030919
21.

Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol.

Saini R, Kataeva O, Schmidt AW, Wang Y, Meljon A, Griffiths WJ, Knölker HJ.

Bioorg Med Chem. 2013 Sep 15;21(18):5794-8. doi: 10.1016/j.bmc.2013.07.015. Epub 2013 Jul 17.

PMID:
23910990
22.

Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.

Claffey MM, Helal CJ, Verhoest PR, Kang Z, Fors KS, Jung S, Zhong J, Bundesmann MW, Hou X, Lui S, Kleiman RJ, Vanase-Frawley M, Schmidt AW, Menniti F, Schmidt CJ, Hoffman WE, Hajos M, McDowell L, O'Connor RE, Macdougall-Murphy M, Fonseca KR, Becker SL, Nelson FR, Liras S.

J Med Chem. 2012 Nov 8;55(21):9055-68. doi: 10.1021/jm3009635. Epub 2012 Oct 12.

PMID:
23025719
23.

Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease.

Brodney MA, Johnson DE, Sawant-Basak A, Coffman KJ, Drummond EM, Hudson EL, Fisher KE, Noguchi H, Waizumi N, McDowell LL, Papanikolaou A, Pettersen BA, Schmidt AW, Tseng E, Stutzman-Engwall K, Rubitski DM, Vanase-Frawley MA, Grimwood S.

J Med Chem. 2012 Nov 8;55(21):9240-54. doi: 10.1021/jm300953p. Epub 2012 Oct 5.

PMID:
22974325
24.

Occurrence, biogenesis, and synthesis of biologically active carbazole alkaloids.

Schmidt AW, Reddy KR, Knölker HJ.

Chem Rev. 2012 Jun 13;112(6):3193-328. doi: 10.1021/cr200447s. Epub 2012 Apr 5. Review. No abstract available.

PMID:
22480243
25.

Stereoselective synthesis and hormonal activity of novel dafachronic acids and naturally occurring steroids isolated from corals.

Saini R, Boland S, Kataeva O, Schmidt AW, Kurzchalia TV, Knölker HJ.

Org Biomol Chem. 2012 Jun 7;10(21):4159-63. doi: 10.1039/c2ob25394a. Epub 2012 Mar 21.

PMID:
22434373
26.

Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.

Kleiman RJ, Chapin DS, Christoffersen C, Freeman J, Fonseca KR, Geoghegan KF, Grimwood S, Guanowsky V, Hajós M, Harms JF, Helal CJ, Hoffmann WE, Kocan GP, Majchrzak MJ, McGinnis D, McLean S, Menniti FS, Nelson F, Roof R, Schmidt AW, Seymour PA, Stephenson DT, Tingley FD, Vanase-Frawley M, Verhoest PR, Schmidt CJ.

J Pharmacol Exp Ther. 2012 May;341(2):396-409. doi: 10.1124/jpet.111.191353. Epub 2012 Feb 10.

PMID:
22328573
27.

Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764).

Wager TT, Pettersen BA, Schmidt AW, Spracklin DK, Mente S, Butler TW, Howard H, Lettiere DJ, Rubitski DM, Wong DF, Nedza FM, Nelson FR, Rollema H, Raggon JW, Aubrecht J, Freeman JK, Marcek JM, Cianfrogna J, Cook KW, James LC, Chatman LA, Iredale PA, Banker MJ, Homiski ML, Munzner JB, Chandrasekaran RY.

J Med Chem. 2011 Nov 10;54(21):7602-20. doi: 10.1021/jm200939b. Epub 2011 Oct 7.

PMID:
21928839
28.

Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors.

Grimwood S, Lu Y, Schmidt AW, Vanase-Frawley MA, Sawant-Basak A, Miller E, McLean S, Freeman J, Wong S, McLaughlin JP, Verhoest PR.

J Pharmacol Exp Ther. 2011 Nov;339(2):555-66. doi: 10.1124/jpet.111.185108. Epub 2011 Aug 5.

PMID:
21821697
29.

Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242).

Verhoest PR, Basak AS, Parikh V, Hayward M, Kauffman GW, Paradis V, McHardy SF, McLean S, Grimwood S, Schmidt AW, Vanase-Frawley M, Freeman J, Van Deusen J, Cox L, Wong D, Liras S.

J Med Chem. 2011 Aug 25;54(16):5868-77. doi: 10.1021/jm2006035. Epub 2011 Jul 22.

PMID:
21744827
30.

Organosilicon-mediated total synthesis of the triquinane sesquiterpenes (±)-β-isocomene and (±)-isocomene.

Schmidt AW, Olpp T, Baum E, Stiffel T, Knölker HJ.

Org Biomol Chem. 2010 Oct 21;8(20):4562-8. doi: 10.1039/c0ob00051e. Epub 2010 Jul 28.

PMID:
20664880
31.

Determination of 4-nonylphenol in water samples using 4-(2,6-dimethylhept-3-yl)phenol as new internal standard.

Fischer AR, Lan NT, Wiedemann C, Heide P, Werner P, Schmidt AW, Theumer G, Knölker HJ.

J Chromatogr A. 2010 Apr 23;1217(17):2950-5. doi: 10.1016/j.chroma.2010.02.063. Epub 2010 Mar 3.

PMID:
20299017
32.

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.

O'Donnell CJ, Rogers BN, Bronk BS, Bryce DK, Coe JW, Cook KK, Duplantier AJ, Evrard E, Hajós M, Hoffmann WE, Hurst RS, Maklad N, Mather RJ, McLean S, Nedza FM, O'Neill BT, Peng L, Qian W, Rottas MM, Sands SB, Schmidt AW, Shrikhande AV, Spracklin DK, Wong DF, Zhang A, Zhang L.

J Med Chem. 2010 Feb 11;53(3):1222-37. doi: 10.1021/jm9015075.

PMID:
20043678
33.

Biaryl piperidines as potent and selective delta opioid receptor ligands.

Liras S, McHardy SF, Allen MP, Segelstein BE, Heck SD, Bryce DK, Schmidt AW, Vanase-Frawley M, Callegari E, McLean S.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):503-7. doi: 10.1016/j.bmcl.2009.11.113. Epub 2009 Nov 26.

PMID:
20015649
34.

Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.

Verhoest PR, Proulx-Lafrance C, Corman M, Chenard L, Helal CJ, Hou X, Kleiman R, Liu S, Marr E, Menniti FS, Schmidt CJ, Vanase-Frawley M, Schmidt AW, Williams RD, Nelson FR, Fonseca KR, Liras S.

J Med Chem. 2009 Dec 24;52(24):7946-9. doi: 10.1021/jm9015334.

PMID:
19919087
35.

Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia.

Verhoest PR, Chapin DS, Corman M, Fonseca K, Harms JF, Hou X, Marr ES, Menniti FS, Nelson F, O'Connor R, Pandit J, Proulx-Lafrance C, Schmidt AW, Schmidt CJ, Suiciak JA, Liras S.

J Med Chem. 2009 Aug 27;52(16):5188-96. doi: 10.1021/jm900521k.

PMID:
19630403
36.

Synthesis and biological activity of the (25R)-cholesten-26-oic acids--ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans.

Martin R, Schmidt AW, Theumer G, Krause T, Entchev EV, Kurzchalia TV, Knölker HJ.

Org Biomol Chem. 2009 Mar 7;7(5):909-20. doi: 10.1039/b817358c. Epub 2009 Jan 27.

PMID:
19225674
37.
38.

Membrane domain-disrupting effects of 4-substitued cholesterol derivatives.

Carrer DC, Schmidt AW, Knölker HJ, Schwille P.

Langmuir. 2008 Aug 19;24(16):8807-12. doi: 10.1021/la801471e. Epub 2008 Jul 26.

PMID:
18656973
39.

2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists.

Chen YL, Obach RS, Braselton J, Corman ML, Forman J, Freeman J, Gallaschun RJ, Mansbach R, Schmidt AW, Sprouse JS, Tingley Iii FD, Winston E, Schulz DW.

J Med Chem. 2008 Mar 13;51(5):1385-92. doi: 10.1021/jm070579c. Epub 2008 Feb 21.

PMID:
18288792
40.

Synthesis and SAR of 2-aryloxy-4-alkoxy-pyridines as potent orally active corticotropin-releasing factor 1 receptor antagonists.

Chen YL, Braselton J, Forman J, Gallaschun RJ, Mansbach R, Schmidt AW, Seeger TF, Sprouse JS, Tingley FD 3rd, Winston E, Schulz DW.

J Med Chem. 2008 Mar 13;51(5):1377-84. doi: 10.1021/jm070578k. Epub 2008 Feb 9.

PMID:
18260619
41.

Methylphenidate and atomoxetine increase histamine release in rat prefrontal cortex.

Horner WE, Johnson DE, Schmidt AW, Rollema H.

Eur J Pharmacol. 2007 Mar 8;558(1-3):96-7. Epub 2006 Dec 1.

PMID:
17198700
42.

Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia.

Johnson DE, Yamazaki H, Ward KM, Schmidt AW, Lebel WS, Treadway JL, Gibbs EM, Zawalich WS, Rollema H.

Diabetes. 2005 May;54(5):1552-8.

43.

The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release.

Johnson DE, Nedza FM, Spracklin DK, Ward KM, Schmidt AW, Iredale PA, Godek DM, Rollema H.

Eur J Pharmacol. 2005 Jan 4;506(3):209-19. Epub 2004 Dec 15.

PMID:
15627430
44.

Novel 5-HT7 receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides.

Vermeulen ES, van Smeden M, Schmidt AW, Sprouse JS, Wikström HV, Grol CJ.

J Med Chem. 2004 Oct 21;47(22):5451-66.

PMID:
15481983
45.

Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16.

Matyash V, Entchev EV, Mende F, Wilsch-Bräuninger M, Thiele C, Schmidt AW, Knölker HJ, Ward S, Kurzchalia TV.

PLoS Biol. 2004 Oct;2(10):e280. Epub 2004 Sep 21.

46.

Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species.

Lyles-Eggleston M, Altundas R, Xia J, Sikazwe DM, Fan P, Yang Q, Li S, Zhang W, Zhu X, Schmidt AW, Vanase-Frawley M, Shrihkande A, Villalobos A, Borne RF, Ablordeppey SY.

J Med Chem. 2004 Jan 29;47(3):497-508.

PMID:
14736232
47.
48.

The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review.

Seymour PA, Schmidt AW, Schulz DW.

CNS Drug Rev. 2003 Spring;9(1):57-96. Review.

49.

Discovery of a series of (4,5-dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists.

Parikh V, Welch WM, Schmidt AW.

Bioorg Med Chem Lett. 2003 Jan 20;13(2):269-71.

PMID:
12482437
50.

Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain.

Johnson DE, Rollema H, Schmidt AW, McHarg AD.

Eur J Pharmacol. 2001 Aug 17;425(3):203-10.

PMID:
11513839

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