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Items: 1 to 50 of 306

1.

Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance.

Kuo CS, Chen JS, Lin LY, Schmid-Schönbein GW, Chien S, Huang PH, Chen JW, Lin SJ.

Sci Rep. 2020 Feb 3;10(1):1725. doi: 10.1038/s41598-020-58361-4.

PMID:
32015418
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2.

A Lifetime Achievement in Bioengineering: Professor Shu Chien.

Weinbaum S, Li YJ, Schmid-Schönbein GW.

Ann Biomed Eng. 2019 Nov;47(11):2147-2150. doi: 10.1007/s10439-019-02390-2. No abstract available.

PMID:
31650299
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3.

Elevated Resting and Postprandial Digestive Proteolytic Activity in Peripheral Blood of Individuals With Type-2 Diabetes Mellitus, With Uncontrolled Cleavage of Insulin Receptors.

Modestino AE, Skowronski EA, Pruitt C, Taub PR, Herbst K, Schmid-Schönbein GW, Heller MJ, Mills PJ.

J Am Coll Nutr. 2019 Aug;38(6):485-492. doi: 10.1080/07315724.2018.1545611. Epub 2019 Apr 9.

PMID:
30964398
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4.

Pancreatic source of protease activity in the spontaneously hypertensive rat and its reduction during temporary food restriction.

Chan AHW, Schmid-Schönbein GW.

Microcirculation. 2019 Aug;26(6):e12548. doi: 10.1111/micc.12548. Epub 2019 May 3.

PMID:
30946505

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5.

Proteolysis in septic shock patients: plasma peptidomic patterns are associated with mortality.

Bauzá-Martinez J, Aletti F, Pinto BB, Ribas V, Odena MA, Díaz R, Romay E, Ferrer R, Kistler EB, Tedeschi G, Schmid-Schönbein GW, Herpain A, Bendjelid K, de Oliveira E.

Br J Anaesth. 2018 Nov;121(5):1065-1074. doi: 10.1016/j.bja.2018.05.072. Epub 2018 Jul 26.

PMID:
30336851
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6.

Cleavage of the leptin receptor by matrix metalloproteinase-2 promotes leptin resistance and obesity in mice.

Mazor R, Friedmann-Morvinski D, Alsaigh T, Kleifeld O, Kistler EB, Rousso-Noori L, Huang C, Li JB, Verma IM, Schmid-Schönbein GW.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaah6324. doi: 10.1126/scitranslmed.aah6324.

PMID:
30135249

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7.

Fine control of endothelial VEGFR-2 activation: caveolae as fluid shear stress shelters for membrane receptors.

Shin H, Haga JH, Kosawada T, Kimura K, Li YS, Chien S, Schmid-Schönbein GW.

Biomech Model Mechanobiol. 2019 Feb;18(1):5-16. doi: 10.1007/s10237-018-1063-2. Epub 2018 Aug 7.

PMID:
30088112
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8.

IGF-1 receptor cleavage in hypertension.

Cirrik S, Schmid-Schönbein GW.

Hypertens Res. 2018 Jun;41(6):406-413. doi: 10.1038/s41440-018-0023-7. Epub 2018 Mar 19.

PMID:
29556095

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9.

Preliminary profiling of blood transcriptome in a rat model of hemorrhagic shock.

Braga D, Barcella M, D'Avila F, Lupoli S, Tagliaferri F, Santamaria MH, DeLano FA, Baselli G, Schmid-Schönbein GW, Kistler EB, Aletti F, Barlassina C.

Exp Biol Med (Maywood). 2017 Aug;242(14):1462-1470. doi: 10.1177/1535370217717978. Epub 2017 Jun 29.

PMID:
28661205
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10.

Volatile Decay Products in Breath During Peritonitis Shock are Attenuated by Enteral Blockade of Pancreatic Digestive Proteases.

DeLano FA, Chow J, Schmid-Schönbein GW.

Shock. 2017 Nov;48(5):571-575. doi: 10.1097/SHK.0000000000000888.

PMID:
28498300
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11.

Enteral tranexamic acid attenuates vasopressor resistance and changes in α1-adrenergic receptor expression in hemorrhagic shock.

Santamaria MH, Aletti F, Li JB, Tan A, Chang M, Leon J, Schmid-Schönbein GW, Kistler EB.

J Trauma Acute Care Surg. 2017 Aug;83(2):263-270. doi: 10.1097/TA.0000000000001513.

PMID:
28422915
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12.

Fluid shear-induced cathepsin B release in the control of Mac1-dependent neutrophil adhesion.

Akenhead ML, Fukuda S, Schmid-Schönbein GW, Shin HY.

J Leukoc Biol. 2017 Jul;102(1):117-126. doi: 10.1189/jlb.3A0716-317RR. Epub 2017 Apr 7.

PMID:
28389621
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13.

The autodigestion hypothesis: Proteolytic receptor cleavage in rheological and cardiovascular cell dysfunction1.

Schmid-Schönbein GW.

Biorheology. 2016;53(5-6):179-191. doi: 10.3233/BIR-17131.

PMID:
28269737
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14.

Identification of novel loci affecting circulating chromogranins and related peptides.

Benyamin B, Maihofer AX, Schork AJ, Hamilton BA, Rao F, Schmid-Schönbein GW, Zhang K, Mahata M, Stridsberg M, Schork NJ, Biswas N, Hook VY, Wei Z, Montgomery GW, Martin NG, Nievergelt CM, Whitfield JB, O'Connor DT.

Hum Mol Genet. 2017 Jan 1;26(1):233-242. doi: 10.1093/hmg/ddw380.

PMID:
28011710
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15.

Control of overweight and obesity in childhood through education in meal time habits. The 'good manners for a healthy future' programme.

Salazar Vázquez BY, Salazar Vázquez MA, López Gutiérrez G, Acosta Rosales K, Cabrales P, Vadillo-Ortega F, Intaglietta M, Pérez Tamayo R, Schmid-Schönbein GW.

Pediatr Obes. 2016 Dec;11(6):484-490. doi: 10.1111/ijpo.12091. Epub 2015 Dec 15.

PMID:
26667210
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16.

Thrombin generation assay in untreated whole human blood.

Modestino A, Tyndall M, Yu J, Lefkowitz RB, Schmid-Schönbein GW, Heller MJ.

Electrophoresis. 2016 Aug;37(15-16):2248-56. doi: 10.1002/elps.201600061.

PMID:
27271700

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17.

Can Fishy Odor Be a Risk Factor for Coronary Artery Disease?

Schmid-Schönbein GW.

J Am Coll Cardiol. 2016 Jun 7;67(22):2629-30. doi: 10.1016/j.jacc.2016.03.550. No abstract available.

PMID:
27256834
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18.

Set up of a protocol for rat plasma peptidomics in hemorrhagic shock model in presence of heparin.

Maffioli E, Aletti F, Santagata F, Negri A, Santamaria MH, De Lano FA, Kistler EB, Schmid-Schönbein GW, Tedeschi G.

EuPA Open Proteom. 2016 Mar 16;12:1-3. doi: 10.1016/j.euprot.2016.03.004. eCollection 2016 Sep.

PMID:
29900112
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19.

Is Matrix Metalloproteinase-8 Activity in the Mucosal Barrier a Requirement for Leakage of Cecal Material in Peritonitis?

Schmid-Schönbein GW.

Crit Care Med. 2016 Apr;44(4):854-5. doi: 10.1097/CCM.0000000000001500. No abstract available.

PMID:
26974453
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20.

Peptidomic Analysis of Rat Plasma: Proteolysis in Hemorrhagic Shock.

Aletti F, Maffioli E, Negri A, Santamaria MH, DeLano FA, Kistler EB, Schmid-Schönbein GW, Tedeschi G.

Shock. 2016 May;45(5):540-54. doi: 10.1097/SHK.0000000000000532.

PMID:
26863123
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21.

ShockOmics: multiscale approach to the identification of molecular biomarkers in acute heart failure induced by shock.

Aletti F, Conti C, Ferrario M, Ribas V, Bollen Pinto B, Herpain A, Post E, Romay Medina E, Barlassina C, de Oliveira E, Pastorelli R, Tedeschi G, Ristagno G, Taccone FS, Schmid-Schönbein GW, Ferrer R, De Backer D, Bendjelid K, Baselli G.

Scand J Trauma Resusc Emerg Med. 2016 Jan 28;24:9. doi: 10.1186/s13049-016-0197-4.

PMID:
26822963
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22.

Autodigestion: Proteolytic Degradation and Multiple Organ Failure in Shock.

Altshuler AE, Kistler EB, Schmid-Schönbein GW.

Shock. 2016 May;45(5):483-9. doi: 10.1097/SHK.0000000000000544. Review.

PMID:
26717111
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23.

Heart period and blood pressure characteristics in splanchnic arterial occlusion shock-induced collapse.

Aletti F, Gambarotta N, Penn AH, Ferrario M, Schmid-Schönbein GW.

J Clin Monit Comput. 2017 Feb;31(1):167-175. doi: 10.1007/s10877-015-9813-5. Epub 2015 Dec 19.

PMID:
26686691
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24.

Proteolytic receptor cleavage in the pathogenesis of blood rheology and co-morbidities in metabolic syndrome. Early forms of autodigestion.

Mazor R, Schmid-Schönbein GW.

Biorheology. 2015;52(5-6):337-52. doi: 10.3233/BIR-15045. Review.

PMID:
26600265
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25.

Breast Milk Protects Against Gastrointestinal Symptoms in Infants at High Risk for Autism During Early Development.

Penn AH, Carver LJ, Herbert CA, Lai TS, McIntire MJ, Howard JT, Taylor SF, Schmid-Schönbein GW, Dobkins KR.

J Pediatr Gastroenterol Nutr. 2016 Feb;62(2):317-27. doi: 10.1097/MPG.0000000000000907.

PMID:
26230900
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26.

Four-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in Diabetic Kidney Disease.

Li SY, Huang PH, Tarng DC, Lin TP, Yang WC, Chang YH, Yang AH, Lin CC, Yang MH, Chen JW, Schmid-Schönbein GW, Chien S, Chu PH, Lin SJ.

J Am Soc Nephrol. 2015 Dec;26(12):3072-84. doi: 10.1681/ASN.2014100989. Epub 2015 Apr 8.

PMID:
25855776
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27.

Cellular and molecular basis of Venous insufficiency.

Pocock ES, Alsaigh T, Mazor R, Schmid-Schönbein GW.

Vasc Cell. 2014 Dec 12;6(1):24. doi: 10.1186/s13221-014-0024-5. eCollection 2014.

PMID:
25520775
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28.

Cleavage and reduced CD36 ectodomain density on heart and spleen macrophages in the spontaneously hypertensive rat.

Santamaria MH, Chen AY, Chow J, Muñoz DC, Schmid-Schönbein GW.

Microvasc Res. 2014 Sep;95:131-42. doi: 10.1016/j.mvr.2014.08.004. Epub 2014 Aug 27.

PMID:
25172177
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29.

Effect of digestion and storage of human milk on free fatty acid concentration and cytotoxicity.

Penn AH, Altshuler AE, Small JW, Taylor SF, Dobkins KR, Schmid-Schönbein GW.

J Pediatr Gastroenterol Nutr. 2014 Sep;59(3):365-73. doi: 10.1097/MPG.0000000000000441.

PMID:
24840512
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30.

Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition.

Altshuler AE, Lamadrid I, Li D, Ma SR, Kurre L, Schmid-Schönbein GW, Penn AH.

PLoS One. 2014 May 7;9(5):e96655. doi: 10.1371/journal.pone.0096655. eCollection 2014.

PMID:
24805256
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31.

Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury.

Altshuler AE, Richter MD, Modestino AE, Penn AH, Heller MJ, Schmid-Schönbein GW.

Physiol Rep. 2013 Oct;1(5):e00109. doi: 10.1002/phy2.109. Epub 2013 Oct 20.

PMID:
24303180
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32.

Pancreatic digestive enzyme blockade in the small intestine prevents insulin resistance in hemorrhagic shock.

DeLano FA, Schmid-Schönbein GW.

Shock. 2014 Jan;41(1):55-61. doi: 10.1097/SHK.0000000000000048.

PMID:
24088998
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33.

The oxygen free radicals control MMP-9 and transcription factors expression in the spontaneously hypertensive rat.

Duansak N, Schmid-Schönbein GW.

Microvasc Res. 2013 Nov;90:154-61. doi: 10.1016/j.mvr.2013.09.003. Epub 2013 Sep 21.

PMID:
24060804
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34.

The autodigestion hypothesis for shock and multi-organ failure.

Schmid-Schönbein GW, Chang M.

Ann Biomed Eng. 2014 Feb;42(2):405-14. doi: 10.1007/s10439-013-0891-6. Epub 2013 Aug 30. Review.

PMID:
23989761
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35.

MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension.

Friese RS, Altshuler AE, Zhang K, Miramontes-Gonzalez JP, Hightower CM, Jirout ML, Salem RM, Gayen JR, Mahapatra NR, Biswas N, Cale M, Vaingankar SM, Kim HS, Courel M, Taupenot L, Ziegler MG, Schork NJ, Pravenec M, Mahata SK, Schmid-Schönbein GW, O'Connor DT.

Hum Mol Genet. 2013 Sep 15;22(18):3624-40. doi: 10.1093/hmg/ddt213. Epub 2013 May 13.

PMID:
23674521
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36.

An elementary analysis of physiologic shock and multi-organ failure: the autodigestion hypothesis.

Schmid-Schonbein GW, DeLano FA, Penn AH, Kistler E.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:3114-5. doi: 10.1109/EMBC.2012.6346623.

PMID:
23366584

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37.

Pancreatic digestive enzyme blockade in the intestine increases survival after experimental shock.

DeLano FA, Hoyt DB, Schmid-Schönbein GW.

Sci Transl Med. 2013 Jan 23;5(169):169ra11. doi: 10.1126/scitranslmed.3005046.

PMID:
23345609
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38.

Cellular and Molecular Bioengineering: A Tipping Point.

Brown G, Butler PJ, Chang DW, Chien S, Clegg RM, Dewey CF, Dong C, Guo XE, Helmke BP, Hess H, Jacobs CR, Kaunas RR, Kumar S, Lu HH, Mathur AB, Mow VC, Schmid-Schönbein GW, Skoracki R, Wang N, Wang Y, Zhu C.

Cell Mol Bioeng. 2012 Sep 1;5(3):239-253. Epub 2012 Aug 24.

PMID:
23264805
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39.

Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.

Mazor R, Alsaigh T, Shaked H, Altshuler AE, Pocock ES, Kistler EB, Karin M, Schmid-Schönbein GW.

J Biol Chem. 2013 Jan 4;288(1):598-607. doi: 10.1074/jbc.M112.417451. Epub 2012 Nov 15.

PMID:
23155052
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40.

Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes.

Frankwich K, Tibble C, Torres-Gonzalez M, Bonner M, Lefkowitz R, Tyndall M, Schmid-Schönbein GW, Villarreal F, Heller M, Herbst K.

J Inflamm (Lond). 2012 Oct 1;9(1):35. doi: 10.1186/1476-9255-9-35.

PMID:
23025537
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41.

Digested formula but not digested fresh human milk causes death of intestinal cells in vitro: implications for necrotizing enterocolitis.

Penn AH, Altshuler AE, Small JW, Taylor SF, Dobkins KR, Schmid-Schönbein GW.

Pediatr Res. 2012 Dec;72(6):560-7. doi: 10.1038/pr.2012.125. Epub 2012 Sep 24.

PMID:
23007028
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42.

The integrin-cortex complex under control of GPCRs.

Schmid-Schönbein GW.

Cardiovasc Res. 2012 Oct 1;96(1):7-8. doi: 10.1093/cvr/cvs269. Epub 2012 Aug 16. No abstract available.

PMID:
22899701

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43.

Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine.

Chang M, Alsaigh T, Kistler EB, Schmid-Schönbein GW.

PLoS One. 2012;7(6):e40087. doi: 10.1371/journal.pone.0040087. Epub 2012 Jun 29.

PMID:
22768227
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44.

Cell proliferation along vascular islands during microvascular network growth.

Kelly-Goss MR, Winterer ER, Stapor PC, Yang M, Sweat RS, Stallcup WB, Schmid-Schönbein GW, Murfee WL.

BMC Physiol. 2012 Jun 21;12:7. doi: 10.1186/1472-6793-12-7.

PMID:
22720777
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45.

Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome.

Friese RS, Ye C, Nievergelt CM, Schork AJ, Mahapatra NR, Rao F, Napolitan PS, Waalen J, Ehret GB, Munroe PB, Schmid-Schönbein GW, Eskin E, O'Connor DT.

Circ Cardiovasc Genet. 2012 Aug 1;5(4):430-40. doi: 10.1161/CIRCGENETICS.111.962415. Epub 2012 Jun 5.

PMID:
22670052
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46.

Impaired small-bowel barrier integrity in the presence of lumenal pancreatic digestive enzymes leads to circulatory shock.

Kistler EB, Alsaigh T, Chang M, Schmid-Schönbein GW.

Shock. 2012 Aug;38(3):262-7. doi: 10.1097/SHK.0b013e31825b1717.

PMID:
22576000
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47.

Receptor cleavage and P-selectin-dependent reduction of leukocyte adhesion in the spontaneously hypertensive rat.

Chen AY, Ha JN, Delano FA, Schmid-Schönbein GW.

J Leukoc Biol. 2012 Jul;92(1):183-94. doi: 10.1189/jlb.0112010. Epub 2012 May 7.

PMID:
22566571
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48.

Proteolytic Activity Attenuates the Response of Endothelial Cells to Fluid Shear Stress.

Altshuler AE, Morgan MJ, Chien S, Schmid-Schönbein GW.

Cell Mol Bioeng. 2012 Mar;5(1):82-91.

PMID:
22545072
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49.

Successful treatment with continuous enteral protease inhibitor in a patient with severe septic shock.

Lee YT, Wei J, Chuang YC, Chang CY, Chen IC, Weng CF, Schmid-Schönbein GW.

Transplant Proc. 2012 Apr;44(3):817-9. doi: 10.1016/j.transproceed.2012.03.032.

PMID:
22483504

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50.

Protease activity increases in plasma, peritoneal fluid, and vital organs after hemorrhagic shock in rats.

Altshuler AE, Penn AH, Yang JA, Kim GR, Schmid-Schönbein GW.

PLoS One. 2012;7(3):e32672. doi: 10.1371/journal.pone.0032672. Epub 2012 Mar 27.

PMID:
22479334
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