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Items: 25


PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.

McNeill RS, Stroobant EE, Smithberger E, Canoutas DA, Butler MK, Shelton AK, Patel SD, Limas JC, Skinner KR, Bash RE, Schmid RS, Miller CR.

PLoS One. 2018 Jul 5;13(7):e0200014. doi: 10.1371/journal.pone.0200014. eCollection 2018.


Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.

Vitucci M, Irvin DM, McNeill RS, Schmid RS, Simon JM, Dhruv HD, Siegel MB, Werneke AM, Bash RE, Kim S, Berens ME, Miller CR.

Neuro Oncol. 2017 Sep 1;19(9):1237-1247. doi: 10.1093/neuonc/nox050.


Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.

McNeill RS, Canoutas DA, Stuhlmiller TJ, Dhruv HD, Irvin DM, Bash RE, Angus SP, Herring LE, Simon JM, Skinner KR, Limas JC, Chen X, Schmid RS, Siegel MB, Van Swearingen AED, Hadler MJ, Sulman EP, Sarkaria JN, Anders CK, Graves LM, Berens ME, Johnson GL, Miller CR.

Neuro Oncol. 2017 Oct 19;19(11):1469-1480. doi: 10.1093/neuonc/nox044.


Tumor-homing cytotoxic human induced neural stem cells for cancer therapy.

Bagó JR, Okolie O, Dumitru R, Ewend MG, Parker JS, Werff RV, Underhill TM, Schmid RS, Miller CR, Hingtgen SD.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaah6510. doi: 10.1126/scitranslmed.aah6510.


Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model.

Okolie O, Bago JR, Schmid RS, Irvin DM, Bash RE, Miller CR, Hingtgen SD.

Neuro Oncol. 2016 Dec;18(12):1622-1633. Epub 2016 Jun 13.


Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.

Schmid RS, Simon JM, Vitucci M, McNeill RS, Bash RE, Werneke AM, Huey L, White KK, Ewend MG, Wu J, Miller CR.

Neuro Oncol. 2016 Jul;18(7):962-73. doi: 10.1093/neuonc/nov321. Epub 2016 Jan 28.


Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice.

McNeill RS, Schmid RS, Bash RE, Vitucci M, White KK, Werneke AM, Constance BH, Huff B, Miller CR.

J Vis Exp. 2014 Aug 12;(90):e51763. doi: 10.3791/51763.


Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis.

Vitucci M, Karpinich NO, Bash RE, Werneke AM, Schmid RS, White KK, McNeill RS, Huff B, Wang S, Van Dyke T, Miller CR.

Neuro Oncol. 2013 Oct;15(10):1317-29. doi: 10.1093/neuonc/not084. Epub 2013 Jun 27.


Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L.

J Med Chem. 2012 Nov 8;55(21):9312-30. doi: 10.1021/jm301034u. Epub 2012 Oct 8.


Genetically engineered mouse models of diffuse gliomas.

Schmid RS, Vitucci M, Miller CR.

Brain Res Bull. 2012 May 1;88(1):72-9. doi: 10.1016/j.brainresbull.2011.06.002. Epub 2011 Jun 13. Review.


Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.

Hoffstrom BG, Kaplan A, Letso R, Schmid RS, Turmel GJ, Lo DC, Stockwell BR.

Nat Chem Biol. 2010 Dec;6(12):900-6. doi: 10.1038/nchembio.467. Epub 2010 Oct 31.


Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.

Braithwaite SP, Schmid RS, He DN, Sung ML, Cho S, Resnick L, Monaghan MM, Hirst WD, Essrich C, Reinhart PH, Lo DC.

Neurobiol Dis. 2010 Sep;39(3):311-7. doi: 10.1016/j.nbd.2010.04.015. Epub 2010 May 6.


L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth.

Schmid RS, Maness PF.

Curr Opin Neurobiol. 2008 Jun;18(3):245-50. doi: 10.1016/j.conb.2008.07.015. Review.


A methyl-CpG-binding protein 2-enhanced green fluorescent protein reporter mouse model provides a new tool for studying the neuronal basis of Rett syndrome.

Schmid RS, Tsujimoto N, Qu Q, Lei H, Li E, Chen T, Blaustein CS.

Neuroreport. 2008 Mar 5;19(4):393-8. doi: 10.1097/WNR.0b013e3282f5661c.


Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex.

Ghashghaei HT, Weimer JM, Schmid RS, Yokota Y, McCarthy KD, Popko B, Anton ES.

Genes Dev. 2007 Dec 15;21(24):3258-71.


Reelin, integrin and DAB1 interactions during embryonic cerebral cortical development.

Schmid RS, Jo R, Shelton S, Kreidberg JA, Anton ES.

Cereb Cortex. 2005 Oct;15(10):1632-6. Epub 2005 Feb 9.


Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling.

Schmid RS, Midkiff BR, Kedar VP, Maness PF.

Neuroreport. 2004 Dec 22;15(18):2791-4.


alpha3beta1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development.

Schmid RS, Shelton S, Stanco A, Yokota Y, Kreidberg JA, Anton ES.

Development. 2004 Dec;131(24):6023-31. Epub 2004 Nov 10.


Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex.

Schmid RS, McGrath B, Berechid BE, Boyles B, Marchionni M, Sestan N, Anton ES.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4251-6. Epub 2003 Mar 20.


Role of integrins in the development of the cerebral cortex.

Schmid RS, Anton ES.

Cereb Cortex. 2003 Mar;13(3):219-24. Review.


The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins.

Thelen K, Kedar V, Panicker AK, Schmid RS, Midkiff BR, Maness PF.

J Neurosci. 2002 Jun 15;22(12):4918-31.


NGF enhances sensory axon growth induced by laminin but not by the L1 cell adhesion molecule.

Liu RY, Schmid RS, Snider WD, Maness PF.

Mol Cell Neurosci. 2002 May;20(1):2-12.


NCAM stimulates the Ras-MAPK pathway and CREB phosphorylation in neuronal cells.

Schmid RS, Graff RD, Schaller MD, Chen S, Schachner M, Hemperly JJ, Maness PF.

J Neurobiol. 1999 Mar;38(4):542-58.


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