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Items: 1 to 50 of 136

1.

DNA damage in human whole blood caused by radiopharmaceuticals evaluated by the comet assay.

Schmeiser HH, Muehlbauer KR, Mier W, Baranski AC, Neels O, Dimitrakopoulou-Strauss A, Schmezer P, Kratochwil C, Bruchertseifer F, Morgenstern A, Kopka K.

Mutagenesis. 2019 Sep 20;34(3):239-244. doi: 10.1093/mutage/gez007.

2.

DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.

Weigel C, Chaisaingmongkol J, Assenov Y, Kuhmann C, Winkler V, Santi I, Bogatyrova O, Kaucher S, Bermejo JL, Leung SY, Chan TL, Lasitschka F, Bohrer MH, Marx A, Haußen RH, Herold-Mende C, Dyckhoff G, Boukamp P, Delank KW, Hörmann K, Lippert BM, Baier G, Dietz A, Oakes CC, Plass C, Becher H, Schmezer P, Ramroth H, Popanda O.

Clin Epigenetics. 2019 May 3;11(1):67. doi: 10.1186/s13148-019-0666-5.

3.

DNA damage response of clinical carbon ion versus photon radiation in human glioblastoma cells.

Lopez Perez R, Nicolay NH, Wolf JC, Frister M, Schmezer P, Weber KJ, Huber PE.

Radiother Oncol. 2019 Apr;133:77-86. doi: 10.1016/j.radonc.2018.12.028. Epub 2019 Jan 17.

PMID:
30935585
4.

Genome-wide DNA methylation differences according to oestrogen receptor beta status in colorectal cancer.

Neumeyer S, Popanda O, Edelmann D, Butterbach K, Toth C, Roth W, Bläker H, Jiang R, Herpel E, Jäkel C, Schmezer P, Jansen L, Alwers E, Benner A, Burwinkel B, Hoffmeister M, Brenner H, Chang-Claude J.

Epigenetics. 2019 May;14(5):477-493. doi: 10.1080/15592294.2019.1595998. Epub 2019 Mar 30.

PMID:
30931802
5.

Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain.

Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A.

Cell. 2019 Mar 7;176(6):1407-1419.e14. doi: 10.1016/j.cell.2019.01.040. Epub 2019 Feb 28.

PMID:
30827680
6.

Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.

Ridinger J, Koeneke E, Kolbinger FR, Koerholz K, Mahboobi S, Hellweg L, Gunkel N, Miller AK, Peterziel H, Schmezer P, Hamacher-Brady A, Witt O, Oehme I.

Sci Rep. 2018 Jul 3;8(1):10039. doi: 10.1038/s41598-018-28265-5.

7.

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.

Jäkel C, Bergmann F, Toth R, Assenov Y, van der Duin D, Strobel O, Hank T, Klöppel G, Dorrell C, Grompe M, Moss J, Dor Y, Schirmacher P, Plass C, Popanda O, Schmezer P.

Nat Commun. 2017 Nov 6;8(1):1323. doi: 10.1038/s41467-017-01118-x.

8.

BET-bromodomain inhibitors modulate epigenetic patterns at the diacylglycerol kinase alpha enhancer associated with radiation-induced fibrosis.

Valinciute G, Weigel C, Veldwijk MR, Oakes CC, Herskind C, Wenz F, Plass C, Schmezer P, Popanda O.

Radiother Oncol. 2017 Oct;125(1):168-174. doi: 10.1016/j.radonc.2017.08.028. Epub 2017 Sep 12.

PMID:
28916223
9.

Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas.

Henrich KO, Bender S, Saadati M, Dreidax D, Gartlgruber M, Shao C, Herrmann C, Wiesenfarth M, Parzonka M, Wehrmann L, Fischer M, Duffy DJ, Bell E, Torkov A, Schmezer P, Plass C, Höfer T, Benner A, Pfister SM, Westermann F.

Cancer Res. 2016 Sep 15;76(18):5523-37. doi: 10.1158/0008-5472.CAN-15-2507. Epub 2016 Sep 7.

10.

Combined Treatment of ATRA with Epigenetic Drugs Increases Aggressiveness of Glioma Xenografts.

Schmoch T, Gal Z, Mock A, Mossemann J, Lahrmann B, Grabe N, Schmezer P, Lasitschka F, Beckhove P, Unterberg A, Herold-Mende C.

Anticancer Res. 2016 Apr;36(4):1489-96.

PMID:
27069124
11.

Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis.

Weigel C, Veldwijk MR, Oakes CC, Seibold P, Slynko A, Liesenfeld DB, Rabionet M, Hanke SA, Wenz F, Sperk E, Benner A, Rösli C, Sandhoff R, Assenov Y, Plass C, Herskind C, Chang-Claude J, Schmezer P, Popanda O.

Nat Commun. 2016 Mar 11;7:10893. doi: 10.1038/ncomms10893.

12.

LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients.

Mock A, Geisenberger C, Orlik C, Warta R, Schwager C, Jungk C, Dutruel C, Geiselhart L, Weichenhan D, Zucknick M, Nied AK, Friauf S, Exner J, Capper D, Hartmann C, Lahrmann B, Grabe N, Debus J, von Deimling A, Popanda O, Plass C, Unterberg A, Abdollahi A, Schmezer P, Herold-Mende C.

Int J Cancer. 2016 Jul 15;139(2):424-32. doi: 10.1002/ijc.30069. Epub 2016 Mar 18.

13.

Mesenchymal stem cells exhibit resistance to topoisomerase inhibition.

Nicolay NH, Rühle A, Perez RL, Trinh T, Sisombath S, Weber KJ, Schmezer P, Ho AD, Debus J, Saffrich R, Huber PE.

Cancer Lett. 2016 Apr 28;374(1):75-84. doi: 10.1016/j.canlet.2016.02.007. Epub 2016 Feb 11.

PMID:
26876302
14.

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients.

Seibold P, Schmezer P, Behrens S, Michailidou K, Bolla MK, Wang Q, Flesch-Janys D, Nevanlinna H, Fagerholm R, Aittomäki K, Blomqvist C, Margolin S, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Lambrechts D, Wildiers H, Kristensen V, Alnæs GG, Nord S, Borresen-Dale AL, Hooning MJ, Hollestelle A, Jager A, Seynaeve C, Li J, Liu J, Humphreys K, Dunning AM, Rhenius V, Shah M, Kabisch M, Torres D, Ulmer HU, Hamann U, Schildkraut JM, Purrington KS, Couch FJ, Hall P, Pharoah P, Easton DF, Schmidt MK, Chang-Claude J, Popanda O.

BMC Cancer. 2015 Dec 16;15:978. doi: 10.1186/s12885-015-1957-7.

15.

Mutational dynamics between primary and relapse neuroblastomas.

Schramm A, Köster J, Assenov Y, Althoff K, Peifer M, Mahlow E, Odersky A, Beisser D, Ernst C, Henssen AG, Stephan H, Schröder C, Heukamp L, Engesser A, Kahlert Y, Theissen J, Hero B, Roels F, Altmüller J, Nürnberg P, Astrahantseff K, Gloeckner C, De Preter K, Plass C, Lee S, Lode HN, Henrich KO, Gartlgruber M, Speleman F, Schmezer P, Westermann F, Rahmann S, Fischer M, Eggert A, Schulte JH.

Nat Genet. 2015 Aug;47(8):872-7. doi: 10.1038/ng.3349. Epub 2015 Jun 29.

PMID:
26121086
16.

XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients.

Seibold P, Behrens S, Schmezer P, Helmbold I, Barnett G, Coles C, Yarnold J, Talbot CJ, Imai T, Azria D, Koch CA, Dunning AM, Burnet N, Bliss JM, Symonds RP, Rattay T, Suga T, Kerns SL, Bourgier C, Vallis KA, Sautter-Bihl ML, Claßen J, Debus J, Schnabel T, Rosenstein BS, Wenz F, West CM, Popanda O, Chang-Claude J.

Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):1084-1092. doi: 10.1016/j.ijrobp.2015.04.011. Epub 2015 Apr 11.

PMID:
26072091
17.

Retinoid resistance and multifaceted impairment of retinoic acid synthesis in glioblastoma.

Campos B, Weisang S, Osswald F, Ali R, Sedlmeier G, Bageritz J, Mallm JP, Hartmann C, von Deimling A, Popanda O, Goidts V, Plass C, Unterberg A, Schmezer P, Burhenne J, Herold-Mende C.

Glia. 2015 Oct;63(10):1850-9. doi: 10.1002/glia.22849. Epub 2015 May 6.

PMID:
25944104
18.

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD.

Nature. 2015 Apr 23;520(7548):549-52. doi: 10.1038/nature14131. Epub 2015 Feb 18.

PMID:
25707806
19.

Epigenetics in radiation-induced fibrosis.

Weigel C, Schmezer P, Plass C, Popanda O.

Oncogene. 2015 Apr 23;34(17):2145-55. doi: 10.1038/onc.2014.145. Epub 2014 Jun 9. Review.

PMID:
24909163
20.

Reduced promoter methylation and increased expression of CSPG4 negatively influences survival of HNSCC patients.

Warta R, Herold-Mende C, Chaisaingmongkol J, Popanda O, Mock A, Mogler C, Osswald F, Herpel E, Küstner S, Eckstein V, Plass C, Plinkert P, Schmezer P, Dyckhoff G.

Int J Cancer. 2014 Dec 1;135(11):2727-34. doi: 10.1002/ijc.28906. Epub 2014 Apr 26.

21.

The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.

Becker MS, Schmezer P, Breuer R, Haas SF, Essers MA, Krammer PH, Li-Weber M.

Cell Death Dis. 2014 Jan 16;5:e1000. doi: 10.1038/cddis.2013.528.

22.

LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis.

Lehle S, Hildebrand DG, Merz B, Malak PN, Becker MS, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O.

Nucleic Acids Res. 2014 Apr;42(6):e41. doi: 10.1093/nar/gkt1349. Epub 2013 Dec 26.

23.

Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer.

Kuhmann C, Li C, Kloor M, Salou M, Weigel C, Schmidt CR, Ng LW, Tsui WW, Leung SY, Yuen ST, Becker N, Weichenhan D, Plass C, Schmezer P, Chan TL, Popanda O.

Hum Mol Genet. 2014 Apr 15;23(8):2043-54. doi: 10.1093/hmg/ddt599. Epub 2013 Nov 26.

PMID:
24282031
24.

Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation.

Goeppert B, Schmidt CR, Geiselhart L, Dutruel C, Capper D, Renner M, Vogel MN, Zachskorn C, Zinke J, Campos B, Schmezer P, Popanda O, Wick W, Weller M, Meyermann R, Schittenhelm J, Harter PN, Simon P, Weichert W, Schirmacher P, Plass C, Mittelbronn M.

J Neuropathol Exp Neurol. 2013 Oct;72(10):933-41. doi: 10.1097/NEN.0b013e3182a59a88.

25.

Specialty supplement use and biologic measures of oxidative stress and DNA damage.

Kantor ED, Ulrich CM, Owen RW, Schmezer P, Neuhouser ML, Lampe JW, Peters U, Shen DD, Vaughan TL, White E.

Cancer Epidemiol Biomarkers Prev. 2013 Dec;22(12):2312-22. doi: 10.1158/1055-9965.EPI-13-0470. Epub 2013 Aug 5.

26.

Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development.

Dutruel C, Bergmann F, Rooman I, Zucknick M, Weichenhan D, Geiselhart L, Kaffenberger T, Rachakonda PS, Bauer A, Giese N, Hong C, Xie H, Costello JF, Hoheisel J, Kumar R, Rehli M, Schirmacher P, Werner J, Plass C, Popanda O, Schmezer P.

Oncogene. 2014 Jun 26;33(26):3401-10. doi: 10.1038/onc.2013.312. Epub 2013 Aug 5.

PMID:
23912455
27.

Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy?

Seibold P, Hall P, Schoof N, Nevanlinna H, Heikkinen T, Benner A, Liu J, Schmezer P, Popanda O, Flesch-Janys D, Chang-Claude J.

Breast. 2013 Oct;22(5):817-23. doi: 10.1016/j.breast.2013.02.008. Epub 2013 Mar 13.

PMID:
23489758
28.

Evaluation of different biomarkers to predict individual radiosensitivity in an inter-laboratory comparison--lessons for future studies.

Greve B, Bölling T, Amler S, Rössler U, Gomolka M, Mayer C, Popanda O, Dreffke K, Rickinger A, Fritz E, Eckardt-Schupp F, Sauerland C, Braselmann H, Sauter W, Illig T, Riesenbeck D, Könemann S, Willich N, Mörtl S, Eich HT, Schmezer P.

PLoS One. 2012;7(10):e47185. doi: 10.1371/journal.pone.0047185. Epub 2012 Oct 23.

29.

Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk.

Popanda O, Seibold P, Nikolov I, Oakes CC, Burwinkel B, Hausmann S, Flesch-Janys D, Plass C, Chang-Claude J, Schmezer P.

Int J Cancer. 2013 Jan 1;132(1):55-62. doi: 10.1002/ijc.27665. Epub 2012 Jun 26.

30.

Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma.

Chaisaingmongkol J, Popanda O, Warta R, Dyckhoff G, Herpel E, Geiselhart L, Claus R, Lasitschka F, Campos B, Oakes CC, Bermejo JL, Herold-Mende C, Plass C, Schmezer P.

Oncogene. 2012 Dec 6;31(49):5108-16. doi: 10.1038/onc.2011.660. Epub 2012 Jan 30.

PMID:
22286769
31.

The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells.

Abbasi R, Efferth T, Kuhmann C, Opatz T, Hao X, Popanda O, Schmezer P.

Toxicol Appl Pharmacol. 2012 Mar 15;259(3):302-10. doi: 10.1016/j.taap.2012.01.006. Epub 2012 Jan 17.

PMID:
22280988
32.

Epigenetically mediated downregulation of the differentiation-promoting chaperon protein CRABP2 in astrocytic gliomas.

Campos B, Warta R, Chaisaingmongkol J, Geiselhart L, Popanda O, Hartmann C, von Deimling A, Unterberg A, Plass C, Schmezer P, Herold-Mende C.

Int J Cancer. 2012 Oct 15;131(8):1963-8. doi: 10.1002/ijc.27446. Epub 2012 Mar 8.

33.

Suberoylanilide hydroxamic acid affects γH2AX expression in osteosarcoma, atypical teratoid rhabdoid tumor and normal tissue cell lines after irradiation.

Blattmann C, Oertel S, Thiemann M, Weber KJ, Schmezer P, Zelezny O, Lopez Perez R, Kulozik AE, Debus J, Ehemann V.

Strahlenther Onkol. 2012 Feb;188(2):168-76. doi: 10.1007/s00066-011-0028-5. Epub 2012 Jan 18.

PMID:
22249335
34.

Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk.

Seibold P, Hein R, Schmezer P, Hall P, Liu J, Dahmen N, Flesch-Janys D, Popanda O, Chang-Claude J.

Int J Cancer. 2011 Sep 15;129(6):1467-76. doi: 10.1002/ijc.25761. Epub 2011 Jan 6.

35.

DNA methylation changes in cells regrowing after fractioned ionizing radiation.

Kuhmann C, Weichenhan D, Rehli M, Plass C, Schmezer P, Popanda O.

Radiother Oncol. 2011 Oct;101(1):116-21. doi: 10.1016/j.radonc.2011.05.048. Epub 2011 Jun 23.

PMID:
21704414
36.

A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects.

Mayer C, Popanda O, Greve B, Fritz E, Illig T, Eckardt-Schupp F, Gomolka M, Benner A, Schmezer P.

Cancer Lett. 2011 Mar 1;302(1):20-8. doi: 10.1016/j.canlet.2010.12.006. Epub 2011 Jan 13.

PMID:
21236564
37.

Down-regulation of tumor suppressor A kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms.

Goeppert B, Schmezer P, Dutruel C, Oakes C, Renner M, Breinig M, Warth A, Vogel MN, Mittelbronn M, Mehrabi A, Gdynia G, Penzel R, Longerich T, Breuhahn K, Popanda O, Plass C, Schirmacher P, Kern MA.

Hepatology. 2010 Dec;52(6):2023-33. doi: 10.1002/hep.23939. Epub 2010 Oct 26.

PMID:
20979053
38.
39.

Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer.

Chang-Claude J, Ambrosone CB, Lilla C, Kropp S, Helmbold I, von Fournier D, Haase W, Sautter-Bihl ML, Wenz F, Schmezer P, Popanda O.

Br J Cancer. 2009 May 19;100(10):1680-6. doi: 10.1038/sj.bjc.6605036. Epub 2009 Apr 14.

40.

Multicentric investigation of ionising radiation-induced cell death as a predictive parameter of individual radiosensitivity.

Greve B, Dreffke K, Rickinger A, Könemann S, Fritz E, Eckardt-Schupp F, Amler S, Sauerland C, Braselmann H, Sauter W, Illig T, Schmezer P, Gomolka M, Willich N, Bölling T.

Apoptosis. 2009 Feb;14(2):226-35. doi: 10.1007/s10495-008-0294-6.

PMID:
19142732
41.

Genetic variation in normal tissue toxicity induced by ionizing radiation.

Popanda O, Marquardt JU, Chang-Claude J, Schmezer P.

Mutat Res. 2009 Jul 10;667(1-2):58-69. doi: 10.1016/j.mrfmmm.2008.10.014. Epub 2008 Nov 5. Review.

PMID:
19022265
42.

[Epigenetic aspects in carcinomas of the head and neck].

Schmezer P, Plass C.

HNO. 2008 Jun;56(6):594-602. doi: 10.1007/s00106-008-1720-3. Review. German.

43.

UVA radiation causes DNA strand breaks, chromosomal aberrations and tumorigenic transformation in HaCaT skin keratinocytes.

Wischermann K, Popp S, Moshir S, Scharfetter-Kochanek K, Wlaschek M, de Gruijl F, Hartschuh W, Greinert R, Volkmer B, Faust A, Rapp A, Schmezer P, Boukamp P.

Oncogene. 2008 Jul 17;27(31):4269-80. doi: 10.1038/onc.2008.70. Epub 2008 Mar 31. Erratum in: Oncogene. 2008 Dec 4;27(53):6790.

PMID:
18372922
44.

A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients.

Woelfelschneider A, Popanda O, Lilla C, Linseisen J, Mayer C, Celebi O, Debus J, Bartsch H, Chang-Claude J, Schmezer P.

Carcinogenesis. 2008 Sep;29(9):1758-64. doi: 10.1093/carcin/bgn067. Epub 2008 Mar 10.

PMID:
18332046
45.

Genetic predictors of long-term toxicities after radiation therapy for breast cancer.

Kuptsova N, Chang-Claude J, Kropp S, Helmbold I, Schmezer P, von Fournier D, Haase W, Sautter-Bihl ML, Wenz F, Onel K, Ambrosone CB.

Int J Cancer. 2008 Mar 15;122(6):1333-9.

46.

Polymorphisms in three base excision repair genes and breast cancer risk in Thai women.

Sangrajrang S, Schmezer P, Burkholder I, Waas P, Boffetta P, Brennan P, Bartsch H, Wiangnon S, Popanda O.

Breast Cancer Res Treat. 2008 Sep;111(2):279-88. Epub 2007 Oct 6.

PMID:
17922186
47.

The XRCC3 Thr241Met polymorphism and breast cancer risk: a case-control study in a Thai population.

Sangrajrang S, Schmezer P, Burkholder I, Boffetta P, Brennan P, Woelfelschneider A, Bartsch H, Wiangnon S, Cheisilpa A, Popanda O.

Biomarkers. 2007 Sep-Oct;12(5):523-32.

PMID:
17701750
48.

In vitro radiation-induced expression of XPC mRNA as a possible biomarker for developing adverse reactions during radiotherapy.

Wiebalk K, Schmezer P, Kropp S, Chang-Claude J, Celebi O, Debus J, Bartsch H, Popanda O.

Int J Cancer. 2007 Nov 15;121(10):2340-5.

49.

Improved alkaline comet assay protocol for adherent HaCaT keratinocytes to study UVA-induced DNA damage.

Wischermann K, Boukamp P, Schmezer P.

Mutat Res. 2007 Jun 15;630(1-2):122-8. Epub 2007 Apr 21.

PMID:
17509930
50.

Genetic risk profiles for cancer susceptibility and therapy response.

Bartsch H, Dally H, Popanda O, Risch A, Schmezer P.

Recent Results Cancer Res. 2007;174:19-36. Review.

PMID:
17302182

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