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Items: 3

1.

Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.

Meyers K, Cogan DA, Burke J, Arenas R, Balestra M, Brown NF, Chen Z, Cerny MA, Clifford HE, Colombo F, Fader L, Frederick KS, Guo X, Goldberg D, Hornberger KR, Kugler S, Lord J, Marshall DR, Moss N, Parmentier JH, Richman JR, Schmenk J, Weldon SM, Yu M, Zhang M.

Bioorg Med Chem Lett. 2018 Mar 1;28(5):979-984. doi: 10.1016/j.bmcl.2017.12.015. Epub 2017 Dec 8.

PMID:
29254646
2.

Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.

Cerny MA, Csengery A, Schmenk J, Frederick K.

J Steroid Biochem Mol Biol. 2015 Nov;154:197-205. doi: 10.1016/j.jsbmb.2015.08.004. Epub 2015 Aug 21.

PMID:
26303746
3.

Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes.

Hutzler JM, Yang YS, Albaugh D, Fullenwider CL, Schmenk J, Fisher MB.

Drug Metab Dispos. 2012 Feb;40(2):267-75. doi: 10.1124/dmd.111.042861. Epub 2011 Oct 26.

PMID:
22031625

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