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Inflammation-mediated deacetylation of the ribonuclease 1 promoter via histone deacetylase 2 in endothelial cells.

Bedenbender K, Scheller N, Fischer S, Leiting S, Preissner KT, Schmeck BT, Vollmeister E.

FASEB J. 2019 Apr 30:fj201900451R. doi: 10.1096/fj.201900451R. [Epub ahead of print]


Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells.

Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U.

J Clin Invest. 2019 Apr 2;130:1972-1983. doi: 10.1172/JCI98929. eCollection 2019 Apr 2.


Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.

Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR.

Nat Microbiol. 2019 Apr;4(4):701-713. doi: 10.1038/s41564-019-0367-z. Epub 2019 Feb 25.


ncRNAs in Inflammatory and Infectious Diseases.

Schulte LN, Bertrams W, Stielow C, Schmeck B.

Methods Mol Biol. 2019;1912:3-32. doi: 10.1007/978-1-4939-8982-9_1. Review.


Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome.

Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B.

J Infect Dis. 2019 Jan 29;219(4):540-543. doi: 10.1093/infdis/jiy554.


A Far-Red Fluorescent DNA Binder for Interaction Studies of Live Multidrug-Resistant Pathogens and Host Cells.

Schulte LN, Heinrich B, Janga H, Schmeck BT, Vázquez O.

Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11564-11568. doi: 10.1002/anie.201804090. Epub 2018 Aug 6.


Whither systems medicine?

Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O.

Exp Mol Med. 2018 Mar 2;50(3):e453. doi: 10.1038/emm.2017.290. Review.


Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group.

Crit Care Med. 2018 Mar;46(3):e258-e267. doi: 10.1097/CCM.0000000000002916.


THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B.

Sci Rep. 2017 Sep 20;7(1):11988. doi: 10.1038/s41598-017-12154-4.


Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles.

Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B.

Sci Rep. 2017 Jul 24;7(1):6301. doi: 10.1038/s41598-017-06443-1.


microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1.

Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W.

PLoS One. 2017 Apr 26;12(4):e0176204. doi: 10.1371/journal.pone.0176204. eCollection 2017.


Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages.

Jung AL, Hoffmann K, Herkt CE, Schulz C, Bertrams W, Schmeck B.

J Vis Exp. 2017 Feb 22;(120). doi: 10.3791/55146.


An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data.

Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J.

J Immunol. 2017 Mar 1;198(5):2191-2201. doi: 10.4049/jimmunol.1502513. Epub 2017 Jan 30.


Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.

Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H.

J Allergy Clin Immunol. 2016 Jul;138(1):47-56. doi: 10.1016/j.jaci.2016.02.046. Review.


Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2.

Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck BT.

J Infect Dis. 2016 Aug 1;214(3):454-63. doi: 10.1093/infdis/jiw171. Epub 2016 Apr 29.


Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages.

Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B.

PLoS Pathog. 2016 Apr 22;12(4):e1005592. doi: 10.1371/journal.ppat.1005592. eCollection 2016 Apr.


MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation.

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B.

J Infect Dis. 2016 Jul 15;214(2):288-99. doi: 10.1093/infdis/jiw109. Epub 2016 Mar 16.


Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.

Rohwer N, Bindel F, Grimm C, Lin SJ, Wappler J, Klinger B, Blüthgen N, Du Bois I, Schmeck B, Lehrach H, de Graauw M, Goncalves E, Saez-Rodriguez J, Tan P, Grabsch HI, Prigione A, Kempa S, Cramer T.

Oncotarget. 2016 Feb 9;7(6):6693-710. doi: 10.18632/oncotarget.6793.


Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive.

Eberhardt M, Lai X, Tomar N, Gupta S, Schmeck B, Steinkasserer A, Schuler G, Vera J.

Methods Mol Biol. 2016;1386:135-79. doi: 10.1007/978-1-4939-3283-2_9. Review.


Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy.

Schmeck B, Bertrams W, Lai X, Vera J.

Methods Mol Biol. 2016;1386:119-33. doi: 10.1007/978-1-4939-3283-2_8. Review.


Training in Systems Approaches for the Next Generation of Life Scientists and Medical Doctors.

Rozman D, Acimovic J, Schmeck B.

Methods Mol Biol. 2016;1386:73-86. doi: 10.1007/978-1-4939-3283-2_5. Review.


[COPD Update 2015: Cell Biology goes Clinic? - Important Research Findings for Clinicians].

Schmeck B, Jerrentrup L, Bals R.

Pneumologie. 2015 Dec;69(12):704-710. Epub 2015 Dec 9. German.


Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO.

Koepke J, Dresel M, Schmid S, Greulich T, Beutel B, Schmeck B, Vogelmeier CF, Janciauskiene S, Koczulla AR.

PLoS One. 2015 Jan 30;10(1):e0117497. doi: 10.1371/journal.pone.0117497. eCollection 2015.


Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro.

Chillappagari S, Venkatesan S, Garapati V, Mahavadi P, Munder A, Seubert A, Sarode G, Guenther A, Schmeck BT, Tümmler B, Henke MO.

Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L791-9. doi: 10.1152/ajplung.00167.2014. Epub 2014 Sep 19.


Malignancy Associated MicroRNA Expression Changes in Canine Mammary Cancer of Different Malignancies.

von Deetzen MC, Schmeck BT, Gruber AD, Klopfleisch R.

ISRN Vet Sci. 2014 Apr 2;2014:148597. doi: 10.1155/2014/148597. eCollection 2014.


Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial.

Greulich T, Nell C, Koepke J, Fechtel J, Franke M, Schmeck B, Haid D, Apelt S, Filipovic S, Kenn K, Janciauskiene S, Vogelmeier C, Koczulla AR.

BMC Pulm Med. 2014 Apr 11;14:60. doi: 10.1186/1471-2466-14-60.


Molecular quantification of canine specific microRNA species.

von Deetzen MC, Schmeck B, Gruber AD, Klopfleisch R.

Res Vet Sci. 2013 Oct;95(2):562-8. doi: 10.1016/j.rvsc.2013.06.012. Epub 2013 Jul 22.


MicroRNAs in the lung.

Sittka A, Schmeck B.

Adv Exp Med Biol. 2013;774:121-34. doi: 10.1007/978-94-007-5590-1_7. Review.


Asthma phenotyping, therapy, and prevention: what can we learn from systems biology?

Sittka A, Vera J, Lai X, Schmeck BT.

Pediatr Res. 2013 Apr;73(4 Pt 2):543-52. doi: 10.1038/pr.2013.8. Epub 2013 Jan 11. Review.


Systems biology and bioinformatics in aging research: a workshop report.

Fuellen G, Dengjel J, Hoeflich A, Hoeijemakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmitz U, Stolzing A, Sühnel J, Wuttke D, Vera J.

Rejuvenation Res. 2012 Dec;15(6):631-41. doi: 10.1089/rej.2012.1360. Epub 2012 Nov 19.


TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.

Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.

Eur Respir J. 2013 Feb;41(2):384-91. doi: 10.1183/09031936.00196311. Epub 2012 May 31.


Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N'Guessan PD, Suttorp N, Opitz B.

PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.


Encouraging experience with intracardiac transplantation of unselected autologous bone marrow cells concomitant with coronary artery bypass surgery after myocardial infarction.

Holinski S, Schmeck B, Claus B, Radtke H, Elgeti T, Holzhausen M, Konertz W.

Ann Thorac Cardiovasc Surg. 2011;17(4):383-9.


Simvastatin attenuates ventilator-induced lung injury in mice.

Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

Crit Care. 2010;14(4):R143. doi: 10.1186/cc9209. Epub 2010 Jul 30.


Legionella pneumophila-induced IκBζ-dependent expression of interleukin-6 in lung epithelium.

Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N'Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.

Eur Respir J. 2011 Mar;37(3):648-57. doi: 10.1183/09031936.00200009. Epub 2010 Jul 22.


Legionella pneumophila induces human beta defensin-3 in pulmonary cells.

Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N'Guessan PD.

Respir Res. 2010 Jul 8;11:93. doi: 10.1186/1465-9921-11-93.


TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

Zahlten J, Steinicke R, Opitz B, Eitel J, N'guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.

J Immunol. 2010 Jul 1;185(1):597-604. doi: 10.4049/jimmunol.0901798. Epub 2010 Jun 4.


Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3.

Meixenberger K, Pache F, Eitel J, Schmeck B, Hippenstiel S, Slevogt H, N'Guessan P, Witzenrath M, Netea MG, Chakraborty T, Suttorp N, Opitz B.

J Immunol. 2010 Jan 15;184(2):922-30. doi: 10.4049/jimmunol.0901346. Epub 2009 Dec 11.


PKC(alpha) and PKC(epsilon) differentially regulate Legionella pneumophila-induced GM-CSF.

Vardarova K, Scharf S, Lang F, Schmeck B, Opitz B, Eitel J, Hocke AC, Slevogt H, Flieger A, Hippenstiel S, Suttorp N, N'guessan PD.

Eur Respir J. 2009 Nov;34(5):1171-9. doi: 10.1183/09031936.00171908. Epub 2009 Mar 26.


Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells.

Dje N'Guessan P, Riediger F, Vardarova K, Scharf S, Eitel J, Opitz B, Slevogt H, Weichert W, Hocke AC, Schmeck B, Suttorp N, Hippenstiel S.

Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):380-6. doi: 10.1161/ATVBAHA.108.178319. Epub 2009 Jan 2.


Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia.

Witzenrath M, Gutbier B, Schmeck B, Tenor H, Seybold J, Kuelzer R, Grentzmann G, Hatzelmann A, van Laak V, Tschernig T, Mitchell TJ, Schudt C, Rosseau S, Suttorp N, Schütte H.

Crit Care Med. 2009 Feb;37(2):584-90. doi: 10.1097/CCM.0b013e3181959814.


Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.

Witzenrath M, Schmeck B, Doehn JM, Tschernig T, Zahlten J, Loeffler JM, Zemlin M, Müller H, Gutbier B, Schütte H, Hippenstiel S, Fischetti VA, Suttorp N, Rosseau S.

Crit Care Med. 2009 Feb;37(2):642-9. doi: 10.1097/CCM.0b013e31819586a6.


Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2.

Eitel J, Krüll M, Hocke AC, N'Guessan PD, Zahlten J, Schmeck B, Slevogt H, Hippenstiel S, Suttorp N, Opitz B.

J Immunol. 2008 Aug 15;181(4):2664-71.


Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression.

Schmeck B, Lorenz J, N'guessan PD, Opitz B, van Laak V, Zahlten J, Slevogt H, Witzenrath M, Flieger A, Suttorp N, Hippenstiel S.

J Immunol. 2008 Jul 15;181(2):940-7.


NAIP and Ipaf control Legionella pneumophila replication in human cells.

Vinzing M, Eitel J, Lippmann J, Hocke AC, Zahlten J, Slevogt H, N'guessan PD, Günther S, Schmeck B, Hippenstiel S, Flieger A, Suttorp N, Opitz B.

J Immunol. 2008 May 15;180(10):6808-15.


Rho-kinase and contractile apparatus proteins in murine airway hyperresponsiveness.

Witzenrath M, Ahrens B, Schmeck B, Kube SM, Hippenstiel S, Rosseau S, Hamelmann E, Suttorp N, Schütte H.

Exp Toxicol Pathol. 2008 Jun;60(1):9-15. doi: 10.1016/j.etp.2008.03.002. Epub 2008 Apr 22.


Simvastatin reduces Chlamydophila pneumoniae-mediated histone modifications and gene expression in cultured human endothelial cells.

Schmeck B, Beermann W, N'Guessan PD, Hocke AC, Opitz B, Eitel J, Dinh QT, Witzenrath M, Krüll M, Suttorp N, Hippenstiel S.

Circ Res. 2008 Apr 25;102(8):888-95. doi: 10.1161/CIRCRESAHA.107.161307. Epub 2008 Feb 28.


Trigeminal nasal-specific neurons respond to nerve growth factor with substance-P biosynthesis.

Mingomataj E, Dinh QT, Groneberg D, Feleszko W, Schmeck B, Joachim R, Noga O, Nagel S, Klapp BF, Fischer A.

Clin Exp Allergy. 2008 Jul;38(7):1203-11. doi: 10.1111/j.1365-2222.2008.02957.x. Epub 2008 Feb 26.


Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles.

Galka F, Wai SN, Kusch H, Engelmann S, Hecker M, Schmeck B, Hippenstiel S, Uhlin BE, Steinert M.

Infect Immun. 2008 May;76(5):1825-36. doi: 10.1128/IAI.01396-07. Epub 2008 Feb 4.


Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms.

Slevogt H, Maqami L, Vardarowa K, Beermann W, Hocke AC, Eitel J, Schmeck B, Weimann A, Opitz B, Hippenstiel S, Suttorp N, N'Guessan PD.

Eur Respir J. 2008 Apr;31(4):725-35. doi: 10.1183/09031936.00103507. Epub 2008 Jan 9.

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