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Items: 50

1.

Signature maps for automatic identification of prostate cancer from colorimetric analysis of H&E- and IHC-stained histopathological specimens.

Leng E, Henriksen JC, Rizzardi AE, Jin J, Nam JW, Brassuer BM, Johnson AD, Reder NP, Koopmeiners JS, Schmechel SC, Metzger GJ.

Sci Rep. 2019 May 6;9(1):6992. doi: 10.1038/s41598-019-43486-y.

2.

Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors.

Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, Picard D, Wu X, Rodriguez FJ, Rosemarie Q, Krebs RD, Molan AM, Demer AM, Frees MM, Rizzardi AE, Schmechel SC, Eberhart CG, Jenkins RB, Wechsler-Reya RJ, Odde DJ, Huang A, Taylor MD, Sarver AL, Largaespada DA.

Cancer Res. 2019 Mar 1;79(5):905-917. doi: 10.1158/0008-5472.CAN-18-1261. Epub 2019 Jan 23.

PMID:
30674530
3.

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.

Borgatti A, Koopmeiners JS, Sarver AL, Winter AL, Stuebner K, Todhunter D, Rizzardi AE, Henriksen JC, Schmechel S, Forster CL, Kim JH, Froelich J, Walz J, Henson MS, Breen M, Lindblad-Toh K, Oh F, Pilbeam K, Modiano JF, Vallera DA.

Mol Cancer Ther. 2017 May;16(5):956-965. doi: 10.1158/1535-7163.MCT-16-0637. Epub 2017 Feb 13.

4.

Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies.

Seelig DM, Ito D, Forster CL, Yoon UA, Breen M, Burns LJ, Bachanova V, Lindblad-Toh K, O'Brien TD, Schmechel SC, Rizzardi AE, Modiano JF, Linden MA.

Leuk Lymphoma. 2017 Jul;58(7):1702-1710. doi: 10.1080/10428194.2016.1260122. Epub 2016 Dec 8.

5.

Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor β2 immunohistochemistry in prostate cancer.

Rizzardi AE, Zhang X, Vogel RI, Kolb S, Geybels MS, Leung YK, Henriksen JC, Ho SM, Kwak J, Stanford JL, Schmechel SC.

Diagn Pathol. 2016 Jul 11;11(1):63. doi: 10.1186/s13000-016-0511-5.

6.

Detection of Prostate Cancer: Quantitative Multiparametric MR Imaging Models Developed Using Registered Correlative Histopathology.

Metzger GJ, Kalavagunta C, Spilseth B, Bolan PJ, Li X, Hutter D, Nam JW, Johnson AD, Henriksen JC, Moench L, Konety B, Warlick CA, Schmechel SC, Koopmeiners JS.

Radiology. 2016 Jun;279(3):805-16. doi: 10.1148/radiol.2015151089. Epub 2016 Jan 29.

7.

A Distributed Network for Intensive Longitudinal Monitoring in Metastatic Triple-Negative Breast Cancer.

Blau CA, Ramirez AB, Blau S, Pritchard CC, Dorschner MO, Schmechel SC, Martins TJ, Mahen EM, Burton KA, Komashko VM, Radenbaugh AJ, Dougherty K, Thomas A, Miller CP, Annis J, Fromm JR, Song C, Chang E, Howard K, Austin S, Schmidt RA, Linenberger ML, Becker PS, Senecal FM, Mecham BH, Lee SI, Madan A, Ronen R, Dutkowski J, Heimfeld S, Wood BL, Stilwell JL, Kaldjian EP, Haussler D, Zhu J.

J Natl Compr Canc Netw. 2016 Jan;14(1):8-17.

8.

Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.

Rahrmann EP, Moriarity BS, Otto GM, Watson AL, Choi K, Collins MH, Wallace M, Webber BR, Forster CL, Rizzardi AE, Schmechel SC, Ratner N, Largaespada DA.

Am J Pathol. 2014 Jul;184(7):2082-98. doi: 10.1016/j.ajpath.2014.04.006. Epub 2014 May 13.

9.

Evaluation of protein biomarkers of prostate cancer aggressiveness.

Rizzardi AE, Rosener NK, Koopmeiners JS, Isaksson Vogel R, Metzger GJ, Forster CL, Marston LO, Tiffany JR, McCarthy JB, Turley EA, Warlick CA, Henriksen JC, Schmechel SC.

BMC Cancer. 2014 Apr 5;14:244. doi: 10.1186/1471-2407-14-244.

10.

Registration of in vivo prostate MRI and pseudo-whole mount histology using Local Affine Transformations guided by Internal Structures (LATIS).

Kalavagunta C, Zhou X, Schmechel SC, Metzger GJ.

J Magn Reson Imaging. 2015 Apr;41(4):1104-14. doi: 10.1002/jmri.24629. Epub 2014 Apr 4.

11.

Elevated hyaluronan and hyaluronan-mediated motility receptor are associated with biochemical failure in patients with intermediate-grade prostate tumors.

Rizzardi AE, Vogel RI, Koopmeiners JS, Forster CL, Marston LO, Rosener NK, Akentieva N, Price MA, Metzger GJ, Warlick CA, Henriksen JC, Turley EA, McCarthy JB, Schmechel SC.

Cancer. 2014 Jun 15;120(12):1800-9. doi: 10.1002/cncr.28646. Epub 2014 Mar 25.

12.

CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy.

Ding L, Chen S, Liu P, Pan Y, Zhong J, Regan KM, Wang L, Yu C, Rizzardi A, Cheng L, Zhang J, Schmechel SC, Cheville JC, Van Deursen J, Tindall DJ, Huang H.

Cancer Res. 2014 Apr 1;74(7):2050-61. doi: 10.1158/0008-5472.CAN-13-1659. Epub 2014 Feb 3.

13.

Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.

Misemer BS, Skubitz AP, Carlos Manivel J, Schmechel SC, Cheng EY, Henriksen JC, Koopmeiners JS, Corless CL, Skubitz KM.

Cancer Med. 2014 Feb;3(1):81-90. doi: 10.1002/cam4.160. Epub 2013 Nov 26.

14.

A large juvenile xanthogranuloma within the tongue.

Baik FM, Andeen NK, Schmechel SC, Futran ND.

Otolaryngol Head Neck Surg. 2014 Feb;150(2):332-3. doi: 10.1177/0194599813514534. Epub 2013 Dec 10. No abstract available.

PMID:
24326868
15.

Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation.

Bohrer LR, Chuntova P, Bade LK, Beadnell TC, Leon RP, Brady NJ, Ryu Y, Goldberg JE, Schmechel SC, Koopmeiners JS, McCarthy JB, Schwertfeger KL.

Cancer Res. 2014 Jan 1;74(1):374-86. doi: 10.1158/0008-5472.CAN-13-2469. Epub 2013 Nov 6.

16.

Hemophagocytosis in an adrenal aspirate: histiocytic sarcoma.

Singh C, Schmechel SC, Cioc AM, Jessurun J, Pambuccian SE, Pambuccian SE.

Diagn Cytopathol. 2014 Oct;42(10):863-7. doi: 10.1002/dc.22974. Epub 2013 Jun 27. No abstract available.

PMID:
23813724
17.

Effects of topical copper tripeptide complex on wound healing in an irradiated rat model.

Parker NP, Ardeshirpour F, Schmechel SC, Lassig AA.

Otolaryngol Head Neck Surg. 2013 Sep;149(3):384-9. doi: 10.1177/0194599813492644. Epub 2013 Jun 6.

PMID:
23744835
18.

Expression of FGFR3 and FGFR4 and clinical risk factors associated with progression-free survival in synovial sarcoma.

Charbonneau B, Vogel RI, Manivel JC, Rizzardi A, Schmechel SC, Ognjanovic S, Subramanian S, Largaespada D, Weigel B.

Hum Pathol. 2013 Sep;44(9):1918-26. doi: 10.1016/j.humpath.2013.03.001. Epub 2013 May 10.

19.

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.

Watson AL, Rahrmann EP, Moriarity BS, Choi K, Conboy CB, Greeley AD, Halfond AL, Anderson LK, Wahl BR, Keng VW, Rizzardi AE, Forster CL, Collins MH, Sarver AL, Wallace MR, Schmechel SC, Ratner N, Largaespada DA.

Cancer Discov. 2013 Jun;3(6):674-89. doi: 10.1158/2159-8290.CD-13-0081. Epub 2013 Mar 27.

20.

Histiocytic sarcoma in the bronchoalveolar lavage fluid.

Dvorak LA, Hart MK, Cioc AM, Schmechel SC, Jessurun J, Pambuccian SE.

Diagn Cytopathol. 2013 Nov;41(11):965-70. doi: 10.1002/dc.22876. Epub 2012 Sep 25. No abstract available.

PMID:
23008273
21.

Evaluating tumor heterogeneity in immunohistochemistry-stained breast cancer tissue.

Potts SJ, Krueger JS, Landis ND, Eberhard DA, Young GD, Schmechel SC, Lange H.

Lab Invest. 2012 Sep;92(9):1342-57. doi: 10.1038/labinvest.2012.91. Epub 2012 Jul 16.

22.

Follicular lymphoma transformed to "double-hit" B lymphoblastic lymphoma presenting in the peritoneal fluid.

Kaplan A, Samad A, Dolan MM, Cioc AM, Holman CJ, Schmechel SC, Pambuccian SE.

Diagn Cytopathol. 2013 Nov;41(11):986-90. doi: 10.1002/dc.22871. Epub 2012 May 24.

PMID:
22623514
23.

Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring.

Rizzardi AE, Johnson AT, Vogel RI, Pambuccian SE, Henriksen J, Skubitz AP, Metzger GJ, Schmechel SC.

Diagn Pathol. 2012 Jun 20;7:42. doi: 10.1186/1746-1596-7-42.

24.

Development of multigene expression signature maps at the protein level from digitized immunohistochemistry slides.

Metzger GJ, Dankbar SC, Henriksen J, Rizzardi AE, Rosener NK, Schmechel SC.

PLoS One. 2012;7(3):e33520. doi: 10.1371/journal.pone.0033520. Epub 2012 Mar 15.

25.

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression.

Li Y, Hwang TH, Oseth LA, Hauge A, Vessella RL, Schmechel SC, Hirsch B, Beckman KB, Silverstein KA, Dehm SM.

Oncogene. 2012 Nov 8;31(45):4759-67. doi: 10.1038/onc.2011.637. Epub 2012 Jan 23.

26.

Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group.

Malempati S, Weigel B, Ingle AM, Ahern CH, Carroll JM, Roberts CT, Reid JM, Schmechel S, Voss SD, Cho SY, Chen HX, Krailo MD, Adamson PC, Blaney SM.

J Clin Oncol. 2012 Jan 20;30(3):256-62. doi: 10.1200/JCO.2011.37.4355. Epub 2011 Dec 19.

27.

Herpes simplex virus-induced epithelial damage and susceptibility to human immunodeficiency virus type 1 infection in human cervical organ culture.

Horbul JE, Schmechel SC, Miller BR, Rice SA, Southern PJ.

PLoS One. 2011;6(7):e22638. doi: 10.1371/journal.pone.0022638. Epub 2011 Jul 27.

28.

Epithelioid angiosarcoma of the kidney: a diagnostic dilemma in fine-needle aspiration cytology.

Singh C, Xie L, Schmechel SC, Manivel JC, Pambuccian SE.

Diagn Cytopathol. 2012 Aug;40 Suppl 2:E131-9. doi: 10.1002/dc.21762. Epub 2011 Jun 22.

PMID:
21698784
29.

Tigroid background in an endoscopic ultrasound-guided fine-needle aspirate of a mediastinal lymph node metastasis of pulmonary squamous-cell carcinoma.

Xie L, Schmechel SC, Pambuccian SE.

Diagn Cytopathol. 2012 May;40(5):430-2. doi: 10.1002/dc.21682. Epub 2011 Apr 6. No abstract available.

PMID:
21472875
30.

The human immunodeficiency virus protease inhibitor ritonavir inhibits lung cancer cells, in part, by inhibition of survivin.

Srirangam A, Milani M, Mitra R, Guo Z, Rodriguez M, Kathuria H, Fukuda S, Rizzardi A, Schmechel S, Skalnik DG, Pelus LM, Potter DA.

J Thorac Oncol. 2011 Apr;6(4):661-70. doi: 10.1097/JTO.0b013e31820c9e3c.

31.

Non-ATG-initiated translation directed by microsatellite expansions.

Zu T, Gibbens B, Doty NS, Gomes-Pereira M, Huguet A, Stone MD, Margolis J, Peterson M, Markowski TW, Ingram MA, Nan Z, Forster C, Low WC, Schoser B, Somia NV, Clark HB, Schmechel S, Bitterman PB, Gourdon G, Swanson MS, Moseley M, Ranum LP.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):260-5. doi: 10.1073/pnas.1013343108. Epub 2010 Dec 20.

32.

Pre-conditioning cryosurgery: cellular and molecular mechanisms and dynamics of TNF-α enhanced cryotherapy in an in vivo prostate cancer model system.

Jiang J, Goel R, Schmechel S, Vercellotti G, Forster C, Bischof J.

Cryobiology. 2010 Dec;61(3):280-8. doi: 10.1016/j.cryobiol.2010.09.006. Epub 2010 Oct 20.

33.

Use of tumor necrosis factor-alpha-coated gold nanoparticles to enhance radiofrequency ablation in a translational model of renal tumors.

Pedro RN, Thekke-Adiyat T, Goel R, Shenoi M, Slaton J, Schmechel S, Bischof J, Anderson JK.

Urology. 2010 Aug;76(2):494-8. doi: 10.1016/j.urology.2010.01.085. Epub 2010 May 8.

PMID:
20451965
34.

Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation.

Messlik A, Schmechel S, Kisling S, Bereswill S, Heimesaat MM, Fischer A, Göbel U, Haller D.

J Proteome Res. 2009 Oct;8(10):4406-17. doi: 10.1021/pr9000465.

PMID:
19681597
35.

rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population.

Glas J, Seiderer J, Pasciuto G, Tillack C, Diegelmann J, Pfennig S, Konrad A, Schmechel S, Wetzke M, Török HP, Stallhofer J, Jürgens M, Griga T, Klein W, Epplen JT, Schiemann U, Mussack T, Lohse P, Göke B, Ochsenkühn T, Folwaczny M, Müller-Myhsok B, Brand S.

Am J Gastroenterol. 2009 Mar;104(3):665-72. doi: 10.1038/ajg.2008.65. Epub 2009 Feb 3.

PMID:
19262523
36.

Endoscopic ultrasound-guided fine-needle aspiration diagnosis of clear-cell pancreatic endocrine neoplasm in a patient with von Hippel-Lindau disease: a case report.

Safo AO, Li RW, Vickers SM, Schmechel SC, Pambuccian SE.

Diagn Cytopathol. 2009 May;37(5):365-72. doi: 10.1002/dc.21032.

PMID:
19217049
37.

The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.

Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, Schroff F, Wetzke M, Roeske D, Török HP, Tonenchi L, Pfennig S, Haller D, Griga T, Klein W, Epplen JT, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Mussack T, Folwaczny M, Müller-Myhsok B, Brand S.

Am J Gastroenterol. 2008 Mar;103(3):682-91. Epub 2007 Dec 20.

PMID:
18162085
38.

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD.

Seiderer J, Elben I, Diegelmann J, Glas J, Stallhofer J, Tillack C, Pfennig S, Jürgens M, Schmechel S, Konrad A, Göke B, Ochsenkühn T, Müller-Myhsok B, Lohse P, Brand S.

Inflamm Bowel Dis. 2008 Apr;14(4):437-45.

PMID:
18088064
39.

Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status.

Schmechel S, Konrad A, Diegelmann J, Glas J, Wetzke M, Paschos E, Lohse P, Göke B, Brand S.

Inflamm Bowel Dis. 2008 Feb;14(2):204-12.

PMID:
18022867
40.

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.

Glas J, Seiderer J, Wetzke M, Konrad A, Török HP, Schmechel S, Tonenchi L, Grassl C, Dambacher J, Pfennig S, Maier K, Griga T, Klein W, Epplen JT, Schiemann U, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Müller-Myhsok B, Folwaczny M, Mussack T, Brand S.

PLoS One. 2007 Sep 5;2(9):e819.

41.

Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman.

Czartoski T, Liu C, Koelle DM, Schmechel S, Kalus A, Wald A.

J Clin Microbiol. 2006 Apr;44(4):1584-6.

42.

Reovirus induces and benefits from an integrated cellular stress response.

Smith JA, Schmechel SC, Raghavan A, Abelson M, Reilly C, Katze MG, Kaufman RJ, Bohjanen PR, Schiff LA.

J Virol. 2006 Feb;80(4):2019-33.

43.

Involvement of the interferon-regulated antiviral proteins PKR and RNase L in reovirus-induced shutoff of cellular translation.

Smith JA, Schmechel SC, Williams BR, Silverman RH, Schiff LA.

J Virol. 2005 Feb;79(4):2240-50.

44.

Identification of genes whose expression patterns differ in benign lymphoid tissue and follicular, mantle cell, and small lymphocytic lymphoma.

Schmechel SC, LeVasseur RJ, Yang KH, Koehler KM, Kussick SJ, Sabath DE.

Leukemia. 2004 Apr;18(4):841-55.

PMID:
14961037
45.

Most highly exposed seronegative men lack HIV-1-specific, IFN-gamma-secreting T cells.

Hladik F, Desbien A, Lang J, Wang L, Ding Y, Holte S, Wilson A, Xu Y, Moerbe M, Schmechel S, McElrath MJ.

J Immunol. 2003 Sep 1;171(5):2671-83.

46.

Addition of exogenous protease facilitates reovirus infection in many restrictive cells.

Golden JW, Linke J, Schmechel S, Thoemke K, Schiff LA.

J Virol. 2002 Aug;76(15):7430-43.

47.

Immune defence against HIV-1 infection in HIV-1-exposed seronegative persons.

Schmechel SC, Russell N, Hladik F, Lang J, Wilson A, Ha R, Desbien A, McElrath MJ.

Immunol Lett. 2001 Nov 1;79(1-2):21-7.

PMID:
11595286
48.
49.

Preferential translation of reovirus mRNA by a sigma3-dependent mechanism.

Schmechel S, Chute M, Skinner P, Anderson R, Schiff L.

Virology. 1997 May 26;232(1):62-73.

50.

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