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Items: 49


Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation.

Plote D, Choi W, Mokkapati S, Sundi D, Ferguson JE 3rd, Duplisea J, Parker NR, Yla-Herttuala S, Committee SCB, McConkey D, Schluns KS, Dinney CP.

Oncoimmunology. 2019 Feb 20;8(5):e1577125. doi: 10.1080/2162402X.2019.1577125. eCollection 2019.


IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses.

Santana Carrero RM, Beceren-Braun F, Rivas SC, Hegde SM, Gangadharan A, Plote D, Pham G, Anthony SM, Schluns KS.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):599-608. doi: 10.1073/pnas.1814642116. Epub 2018 Dec 26.


The development of interferon-based gene therapy for BCG unresponsive bladder cancer: from bench to bedside.

Duplisea JJ, Mokkapati S, Plote D, Schluns KS, McConkey DJ, Yla-Herttuala S, Parker NR, Dinney CP.

World J Urol. 2019 Oct;37(10):2041-2049. doi: 10.1007/s00345-018-2553-7. Epub 2018 Nov 11. Review.


Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.

Hailemichael Y, Woods A, Fu T, He Q, Nielsen MC, Hasan F, Roszik J, Xiao Z, Vianden C, Khong H, Singh M, Sharma M, Faak F, Moore D, Dai Z, Anthony SM, Schluns KS, Sharma P, Engelhard VH, Overwijk WW.

J Clin Invest. 2018 Apr 2;128(4):1338-1354. doi: 10.1172/JCI93303. Epub 2018 Feb 26.


The potential and promise of IL-15 in immuno-oncogenic therapies.

Robinson TO, Schluns KS.

Immunol Lett. 2017 Oct;190:159-168. doi: 10.1016/j.imlet.2017.08.010. Epub 2017 Aug 16. Review.


Absence of Grail promotes CD8+ T cell anti-tumour activity.

Haymaker C, Yang Y, Wang J, Zou Q, Sahoo A, Alekseev A, Singh D, Ritthipichai K, Hailemichael Y, Hoang ON, Qin H, Schluns KS, Wang T, Overwijk WW, Sun SC, Bernatchez C, Kwak LW, Neelapu SS, Nurieva R.

Nat Commun. 2017 Aug 10;8(1):239. doi: 10.1038/s41467-017-00252-w.


Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion.

Anthony SM, Rivas SC, Colpitts SL, Howard ME, Stonier SW, Schluns KS.

J Immunol. 2016 Jun 1;196(11):4544-52. doi: 10.4049/jimmunol.1600219. Epub 2016 Apr 22.


Intranasal Vaccination Affords Localization and Persistence of Antigen-Specific CD8⁺ T Lymphocytes in the Female Reproductive Tract.

Singh S, Schluns KS, Yang G, Anthony SM, Barry MA, Sastry KJ.

Vaccines (Basel). 2016 Mar 17;4(1). pii: E7. doi: 10.3390/vaccines4010007.


Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.

Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier LL, Cao W.

Cell Rep. 2015 Aug 18;12(7):1120-32. doi: 10.1016/j.celrep.2015.07.021. Epub 2015 Aug 6.


Protecting the borders: tissue-resident memory T cells on the front line.

Schluns KS, Klonowski KD.

Front Immunol. 2015 Mar 3;6:90. doi: 10.3389/fimmu.2015.00090. eCollection 2015. No abstract available.


Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways.

Anthony SM, Howard ME, Hailemichael Y, Overwijk WW, Schluns KS.

PLoS One. 2015 Mar 10;10(3):e0120274. doi: 10.1371/journal.pone.0120274. eCollection 2015.


Procedures for mucosal immunization and analyses of cellular immune response to candidate HIV vaccines in murine and nonhuman primate models.

Singh S, Nehete P, Hanley P, Nehete B, Yang G, He H, Anthony SM, Schluns KS, Sastry KJ.

Methods Mol Biol. 2014;1184:417-55. doi: 10.1007/978-1-4939-1115-8_24.


Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge.

Singh S, Yang G, Schluns KS, Anthony SM, Sastry KJ.

PLoS One. 2014 Mar 5;9(3):e90001. doi: 10.1371/journal.pone.0090001. eCollection 2014.


Nfil3-independent lineage maintenance and antiviral response of natural killer cells.

Firth MA, Madera S, Beaulieu AM, Gasteiger G, Castillo EF, Schluns KS, Kubo M, Rothman PB, Vivier E, Sun JC.

J Exp Med. 2013 Dec 16;210(13):2981-90. doi: 10.1084/jem.20130417. Epub 2013 Nov 25.


The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.

Lee PH, Puppi M, Schluns KS, Yu-Lee LY, Dong C, Lacorazza HD.

J Immunol. 2014 Jan 1;192(1):178-88. doi: 10.4049/jimmunol.1301372. Epub 2013 Nov 20.


Transcriptional regulation of IL-15 expression during hematopoiesis.

Colpitts SL, Stonier SW, Stoklasek TA, Root SH, Aguila HL, Schluns KS, Lefrançois L.

J Immunol. 2013 Sep 15;191(6):3017-24. doi: 10.4049/jimmunol.1301389. Epub 2013 Aug 21.


A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining.

Puebla-Osorio N, Kim J, Ojeda S, Zhang H, Tavana O, Li S, Wang Y, Ma Q, Schluns KS, Zhu C.

Oncogene. 2014 May 22;33(21):2748-57. doi: 10.1038/onc.2013.234. Epub 2013 Jun 10.


Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion.

Hailemichael Y, Dai Z, Jaffarzad N, Ye Y, Medina MA, Huang XF, Dorta-Estremera SM, Greeley NR, Nitti G, Peng W, Liu C, Lou Y, Wang Z, Ma W, Rabinovich B, Sowell RT, Schluns KS, Davis RE, Hwu P, Overwijk WW.

Nat Med. 2013 Apr;19(4):465-72. doi: 10.1038/nm.3105. Epub 2013 Mar 3.


Regulating the immune system via IL-15 transpresentation.

Castillo EF, Schluns KS.

Cytokine. 2012 Sep;59(3):479-90. doi: 10.1016/j.cyto.2012.06.017. Epub 2012 Jul 12. Review.


Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2.

Wang X, Zhang Y, Yang XO, Nurieva RI, Chang SH, Ojeda SS, Kang HS, Schluns KS, Gui J, Jetten AM, Dong C.

Immunity. 2012 Jan 27;36(1):23-31. doi: 10.1016/j.immuni.2011.10.019. Epub 2012 Jan 12.


Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.

Ma W, Ortiz-Quintero B, Rangel R, McKeller MR, Herrera-Rodriguez S, Castillo EF, Schluns KS, Hall M, Zhang H, Suh WK, Okada H, Mak TW, Zhou Y, Blackburn MR, Martinez-Valdez H.

Cell Res. 2011 Nov;21(11):1564-77. doi: 10.1038/cr.2011.84. Epub 2011 May 24.


Window of opportunity for daclizumab.

Schluns KS.

Nat Med. 2011 May;17(5):545-7. doi: 10.1038/nm0511-545. No abstract available.


Induction of TLR4-dependent CD8+ T cell immunity by murine β-defensin2 fusion protein vaccines.

Park HJ, Qin H, Cha SC, Sharma R, Chung Y, Schluns KS, Neelapu SS, Overwijk WW, Hwu P, Kwak LW.

Vaccine. 2011 Apr 18;29(18):3476-82. doi: 10.1016/j.vaccine.2011.02.061. Epub 2011 Mar 5.


Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation.

Castillo EF, Acero LF, Stonier SW, Zhou D, Schluns KS.

Blood. 2010 Oct 7;116(14):2494-503. doi: 10.1182/blood-2010-03-277103. Epub 2010 Jun 25.


Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types.

Frasca L, Stonier SW, Overwijk WW, Schluns KS.

J Leukoc Biol. 2010 Jul;88(1):69-78. doi: 10.1189/jlb.1209816. Epub 2010 Mar 30.


Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.

Stonier SW, Schluns KS.

Immunol Lett. 2010 Jan 4;127(2):85-92. doi: 10.1016/j.imlet.2009.09.009. Epub 2009 Oct 7. Review.


Dendritic cells support the in vivo development and maintenance of NK cells via IL-15 trans-presentation.

Castillo EF, Stonier SW, Frasca L, Schluns KS.

J Immunol. 2009 Oct 15;183(8):4948-56. doi: 10.4049/jimmunol.0900719. Epub 2009 Sep 28.


Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs.

Ma LJ, Acero LF, Zal T, Schluns KS.

J Immunol. 2009 Jul 15;183(2):1044-54. doi: 10.4049/jimmunol.0900420. Epub 2009 Jun 24.


IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.

Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW.

J Immunol. 2009 Jun 15;182(12):7398-407. doi: 10.4049/jimmunol.0802982.


Functions of γC cytokines in immune homeostasis: current and potential clinical applications.

Overwijk WW, Schluns KS.

Clin Immunol. 2009 Aug;132(2):153-65. doi: 10.1016/j.clim.2009.03.512. Epub 2009 May 9. Review.


Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation.

Stonier SW, Ma LJ, Castillo EF, Schluns KS.

Blood. 2008 Dec 1;112(12):4546-54. doi: 10.1182/blood-2008-05-156307. Epub 2008 Sep 23.


Molecular antagonism and plasticity of regulatory and inflammatory T cell programs.

Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C.

Immunity. 2008 Jul 18;29(1):44-56. doi: 10.1016/j.immuni.2008.05.007. Epub 2008 Jun 26.


Regulation of inflammatory responses by IL-17F.

Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C.

J Exp Med. 2008 May 12;205(5):1063-75. doi: 10.1084/jem.20071978. Epub 2008 Apr 14.


T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.

Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C.

Immunity. 2008 Jan;28(1):29-39. doi: 10.1016/j.immuni.2007.11.016. Epub 2007 Dec 27.


Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo.

Stoklasek TA, Schluns KS, Lefrançois L.

J Immunol. 2006 Nov 1;177(9):6072-80.


The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both?

Schluns KS, Stoklasek T, Lefrançois L.

Int J Biochem Cell Biol. 2005 Aug;37(8):1567-71. Epub 2005 Mar 5. Review.


Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression.

Schluns KS, Nowak EC, Cabrera-Hernandez A, Puddington L, Lefrançois L, Aguila HL.

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5616-21. Epub 2004 Apr 1.


Transregulation of memory CD8 T-cell proliferation by IL-15Ralpha+ bone marrow-derived cells.

Schluns KS, Klonowski KD, Lefrançois L.

Blood. 2004 Feb 1;103(3):988-94. Epub 2003 Sep 25.


Cytokine control of memory T-cell development and survival.

Schluns KS, Lefrançois L.

Nat Rev Immunol. 2003 Apr;3(4):269-79. Review.


Migration of primary and memory CD8 T cells.

Lefrançois L, Marzo AL, Masopust D, Schluns KS, Vezy V.

Adv Exp Med Biol. 2002;512:141-6. Review.


Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses.

D'Souza WN, Schluns KS, Masopust D, Lefrançois L.

J Immunol. 2002 Jun 1;168(11):5566-72.


Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells.

Schluns KS, Williams K, Ma A, Zheng XX, Lefrançois L.

J Immunol. 2002 May 15;168(10):4827-31.


TGF-beta1 and IL-6 expression in rat pineal gland is regulated by norepinephrine and interleukin-1beta.

Tsai SY, Schluns KS, Le PT, McNulty JA.

Histol Histopathol. 2001 Oct;16(4):1135-41. doi: 10.14670/HH-16.1135.


Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo.

Schluns KS, Kieper WC, Jameson SC, Lefrançois L.

Nat Immunol. 2000 Nov;1(5):426-32.


Induction and visualization of mucosal memory CD8 T cells following systemic virus infection.

Kim SK, Schluns KS, Lefrançois L.

J Immunol. 1999 Oct 15;163(8):4125-32.


Human thymic epithelial cells produce TGF-beta 3 and express TGF-beta receptors.

Schluns KS, Grutkoski PS, Cook JE, Engelmann GL, Le PT.

Int Immunol. 1995 Oct;7(10):1681-90.


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