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Items: 42

1.

Development of a Clinically Viable Heroin Vaccine.

Bremer PT, Schlosburg JE, Banks ML, Steele FF, Zhou B, Poklis JL, Janda KD.

J Am Chem Soc. 2017 Jun 28;139(25):8601-8611. doi: 10.1021/jacs.7b03334. Epub 2017 Jun 20.

2.

Methamphetamine Vaccines: Improvement through Hapten Design.

Collins KC, Schlosburg JE, Bremer PT, Janda KD.

J Med Chem. 2016 Apr 28;59(8):3878-85. doi: 10.1021/acs.jmedchem.6b00084. Epub 2016 Apr 19.

3.

Investigations of Enantiopure Nicotine Haptens Using an Adjuvanting Carrier in Anti-Nicotine Vaccine Development.

Jacob NT, Lockner JW, Schlosburg JE, Ellis BA, Eubanks LM, Janda KD.

J Med Chem. 2016 Mar 24;59(6):2523-9. doi: 10.1021/acs.jmedchem.5b01676. Epub 2016 Mar 7.

PMID:
26918428
4.

Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs.

Bremer PT, Kimishima A, Schlosburg JE, Zhou B, Collins KC, Janda KD.

Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3772-5. doi: 10.1002/anie.201511654. Epub 2016 Feb 16.

5.

A New Strategy for Smoking Cessation: Characterization of a Bacterial Enzyme for the Degradation of Nicotine.

Xue S, Schlosburg JE, Janda KD.

J Am Chem Soc. 2015 Aug 19;137(32):10136-9. doi: 10.1021/jacs.5b06605. Epub 2015 Aug 6.

PMID:
26237398
6.

Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.

Viader A, Blankman JL, Zhong P, Liu X, Schlosburg JE, Joslyn CM, Liu QS, Tomarchio AJ, Lichtman AH, Selley DE, Sim-Selley LJ, Cravatt BF.

Cell Rep. 2015 Aug 4;12(5):798-808. doi: 10.1016/j.celrep.2015.06.075. Epub 2015 Jul 23.

7.

Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals.

Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ.

J Clin Invest. 2015 Aug 3;125(8):3193-7. doi: 10.1172/JCI79828. Epub 2015 Jun 29.

8.

Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks.

Repunte-Canonigo V, Shin W, Vendruscolo LF, Lefebvre C, van der Stap L, Kawamura T, Schlosburg JE, Alvarez M, Koob GF, Califano A, Sanna PP.

Genome Biol. 2015 Feb 2;16:68. doi: 10.1186/s13059-015-0593-5.

9.

κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake.

Whitfield TW Jr, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF.

J Neurosci. 2015 Mar 11;35(10):4296-305. doi: 10.1523/JNEUROSCI.1978-13.2015.

10.

Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge.

Nass SR, Long JZ, Schlosburg JE, Cravatt BF, Lichtman AH, Kinsey SG.

J Neuroimmune Pharmacol. 2015 Jun;10(2):364-70. doi: 10.1007/s11481-015-9593-1. Epub 2015 Feb 27.

11.

Flagellin as carrier and adjuvant in cocaine vaccine development.

Lockner JW, Eubanks LM, Choi JL, Lively JM, Schlosburg JE, Collins KC, Globisch D, Rosenfeld-Gunn RJ, Wilson IA, Janda KD.

Mol Pharm. 2015 Feb 2;12(2):653-62. doi: 10.1021/mp500520r. Epub 2015 Jan 7.

12.

VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation.

Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O.

Nat Neurosci. 2014 Dec;17(12):1751-8. doi: 10.1038/nn.3872. Epub 2014 Nov 17.

13.

Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats.

Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF.

Neuropsychopharmacology. 2015 Mar 13;40(5):1123-9. doi: 10.1038/npp.2014.293.

14.

A human recombinant monoclonal antibody to cocaine: Preparation, characterization and behavioral studies.

Eubanks LM, Ellis BA, Cai X, Schlosburg JE, Janda KD.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4664-4666. doi: 10.1016/j.bmcl.2014.08.035. Epub 2014 Aug 21.

15.

Compulsive-like responding for opioid analgesics in rats with extended access.

Wade CL, Vendruscolo LF, Schlosburg JE, Hernandez DO, Koob GF.

Neuropsychopharmacology. 2015 Jan;40(2):421-8. doi: 10.1038/npp.2014.188. Epub 2014 Jul 25.

16.

Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice.

Schlosburg JE, Kinsey SG, Ignatowska-Jankowska B, Ramesh D, Abdullah RA, Tao Q, Booker L, Long JZ, Selley DE, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2014 Aug;350(2):196-204. doi: 10.1124/jpet.114.212753. Epub 2014 May 21.

17.

Lipid tucaresol as an adjuvant for methamphetamine vaccine development.

Collins KC, Schlosburg JE, Lockner JW, Bremer PT, Ellis BA, Janda KD.

Chem Commun (Camb). 2014 Apr 21;50(31):4079-81. doi: 10.1039/c4cc00682h.

18.

Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats.

Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP.

Neuropsychopharmacology. 2014 Jun;39(7):1722-31. doi: 10.1038/npp.2014.20. Epub 2014 Jan 29.

19.

Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy.

Bremer PT, Schlosburg JE, Lively JM, Janda KD.

Mol Pharm. 2014 Mar 3;11(3):1075-80. doi: 10.1021/mp400631w. Epub 2014 Feb 19.

20.

Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.

Park PE, Schlosburg JE, Vendruscolo LF, Schulteis G, Edwards S, Koob GF.

Addict Biol. 2015 Mar;20(2):275-84. doi: 10.1111/adb.12120. Epub 2013 Dec 13.

21.

Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake.

Schlosburg JE, Whitfield TW Jr, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF.

J Neurosci. 2013 Dec 4;33(49):19384-92. doi: 10.1523/JNEUROSCI.1979-13.2013.

22.

Addiction as a stress surfeit disorder.

Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW Jr, George O.

Neuropharmacology. 2014 Jan;76 Pt B:370-82. doi: 10.1016/j.neuropharm.2013.05.024. Epub 2013 Jun 6. Review.

23.

Dynamic vaccine blocks relapse to compulsive intake of heroin.

Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):9036-41. doi: 10.1073/pnas.1219159110. Epub 2013 May 6.

24.

Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats.

Park PE, Vendruscolo LF, Schlosburg JE, Edwards S, Schulteis G, Koob GF.

Int J Neuropsychopharmacol. 2013 Sep;16(8):1867-75. doi: 10.1017/S1461145713000308. Epub 2013 Apr 16.

25.

The NK1 receptor antagonist L822429 reduces heroin reinforcement.

Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M.

Neuropsychopharmacology. 2013 May;38(6):976-84. doi: 10.1038/npp.2012.261. Epub 2012 Dec 18.

26.

Hippocampal neurogenesis protects against cocaine-primed relapse.

Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD.

Addict Biol. 2014 Jul;19(4):562-74. doi: 10.1111/adb.12019. Epub 2012 Dec 24.

27.

Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice.

Schlosburg JE, Radanova L, Di Marzo V, Imming P, Lichtman AH.

Behav Pharmacol. 2012 Oct;23(7):722-6. doi: 10.1097/FBP.0b013e3283584794.

28.

A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.

Wee S, Vendruscolo LF, Misra KK, Schlosburg JE, Koob GF.

Sci Transl Med. 2012 Aug 8;4(146):146ra110. doi: 10.1126/scitranslmed.3003948.

29.

Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats.

Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW Jr, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF.

J Neurosci. 2012 May 30;32(22):7563-71. doi: 10.1523/JNEUROSCI.0069-12.2012.

30.

Developing a vaccine against multiple psychoactive targets: a case study of heroin.

Stowe GN, Schlosburg JE, Vendruscolo LF, Edwards S, Misra KK, Schulteis G, Zakhari JS, Koob GF, Janda KD.

CNS Neurol Disord Drug Targets. 2011 Dec;10(8):865-75. Review.

31.

Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism.

Edwards S, Vendruscolo LF, Schlosburg JE, Misra KK, Wee S, Park PE, Schulteis G, Koob GF.

Neuropharmacology. 2012 Feb;62(2):1142-51. doi: 10.1016/j.neuropharm.2011.11.006. Epub 2011 Nov 23.

32.

Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice.

Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF, Akbarali HI, Lichtman AH.

J Pharmacol Exp Ther. 2011 Oct;339(1):173-85. doi: 10.1124/jpet.111.181370. Epub 2011 Jun 30.

33.

A vaccine strategy that induces protective immunity against heroin.

Stowe GN, Vendruscolo LF, Edwards S, Schlosburg JE, Misra KK, Schulteis G, Mayorov AV, Zakhari JS, Koob GF, Janda KD.

J Med Chem. 2011 Jul 28;54(14):5195-204. doi: 10.1021/jm200461m. Epub 2011 Jun 30.

34.

Escalation patterns of varying periods of heroin access.

Vendruscolo LF, Schlosburg JE, Misra KK, Chen SA, Greenwell TN, Koob GF.

Pharmacol Biochem Behav. 2011 Jun;98(4):570-4. doi: 10.1016/j.pbb.2011.03.004. Epub 2011 Mar 23.

35.

CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action.

Schlosburg JE, O'Neal ST, Conrad DH, Lichtman AH.

Psychopharmacology (Berl). 2011 Aug;216(3):323-31. doi: 10.1007/s00213-011-2224-5. Epub 2011 Feb 22.

36.

Marijuana dependence: not just smoke and mirrors.

Ramesh D, Schlosburg JE, Wiebelhaus JM, Lichtman AH.

ILAR J. 2011;52(3):295-308. doi: 10.1093/ilar.52.3.295. Review.

37.

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.

Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF.

Nat Neurosci. 2010 Sep;13(9):1113-9. doi: 10.1038/nn.2616. Epub 2010 Aug 22.

38.

FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration.

Falenski KW, Thorpe AJ, Schlosburg JE, Cravatt BF, Abdullah RA, Smith TH, Selley DE, Lichtman AH, Sim-Selley LJ.

Neuropsychopharmacology. 2010 Jul;35(8):1775-87. doi: 10.1038/npp.2010.44. Epub 2010 Mar 31.

39.

Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice.

Schlosburg JE, Carlson BL, Ramesh D, Abdullah RA, Long JZ, Cravatt BF, Lichtman AH.

AAPS J. 2009 Jun;11(2):342-52. doi: 10.1208/s12248-009-9110-7. Epub 2009 May 9.

40.

Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation.

Schlosburg JE, Kinsey SG, Lichtman AH.

AAPS J. 2009 Mar;11(1):39-44. doi: 10.1208/s12248-008-9075-y. Epub 2009 Jan 29. Review.

41.

Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus.

Schlosburg JE, Boger DL, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2009 Apr;329(1):314-23. doi: 10.1124/jpet.108.150136. Epub 2009 Jan 23.

42.

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.

Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, Pavón FJ, Serrano AM, Selley DE, Parsons LH, Lichtman AH, Cravatt BF.

Nat Chem Biol. 2009 Jan;5(1):37-44. doi: 10.1038/nchembio.129. Epub 2008 Nov 23.

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