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A new data effort to inform career choices in biomedicine.

Blank R, Daniels RJ, Gilliland G, Gutmann A, Hawgood S, Hrabowski FA, Pollack ME, Price V, Reif LR, Schlissel MS.

Science. 2017 Dec 15;358(6369):1388-1389. doi: 10.1126/science.aar4638. No abstract available.


Dual Mechanism of Rag Gene Repression by c-Myb during Pre-B Cell Proliferation.

Timblin GA, Xie L, Tjian R, Schlissel MS.

Mol Cell Biol. 2017 May 31;37(12). pii: e00437-16. doi: 10.1128/MCB.00437-16. Print 2017 Jun 15.


Pillars Article: Cell Type-Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro. Cell. 1996. 85: 887-897.

Stanhope-Baker P, Hudson KM, Shaffer AL, Constantinescu A, Schlissel MS.

J Immunol. 2015 Dec 1;195(11):5106-16. No abstract available.


The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.

Vettermann C, Timblin GA, Lim V, Lai EC, Schlissel MS.

PLoS One. 2015 Jan 5;10(1):e0113824. doi: 10.1371/journal.pone.0113824. eCollection 2015.


Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro.

Chow KT, Schulz D, McWhirter SM, Schlissel MS.

PLoS One. 2013 Sep 24;8(9):e75891. doi: 10.1371/journal.pone.0075891. eCollection 2013.


Ebf1 and c-Myb repress rag transcription downstream of Stat5 during early B cell development.

Timblin GA, Schlissel MS.

J Immunol. 2013 Nov 1;191(9):4676-87. doi: 10.4049/jimmunol.1301675. Epub 2013 Sep 25.


MK5 activates Rag transcription via Foxo1 in developing B cells.

Chow KT, Timblin GA, McWhirter SM, Schlissel MS.

J Exp Med. 2013 Jul 29;210(8):1621-34. doi: 10.1084/jem.20130498. Epub 2013 Jul 22.


miR290-5p/292-5p activate the immunoglobulin kappa locus in B cell development.

Garcia PB, Cai A, Bates JG, Nolla H, Schlissel MS.

PLoS One. 2012;7(8):e43805. doi: 10.1371/journal.pone.0043805. Epub 2012 Aug 23.


Extensive gene-specific translational reprogramming in a model of B cell differentiation and Abl-dependent transformation.

Bates JG, Salzman J, May D, Garcia PB, Hogan GJ, McIntosh M, Schlissel MS, Brown PO.

PLoS One. 2012;7(5):e37108. doi: 10.1371/journal.pone.0037108. Epub 2012 May 31.


RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.

Bednarski JJ, Nickless A, Bhattacharya D, Amin RH, Schlissel MS, Sleckman BP.

J Exp Med. 2012 Jan 16;209(1):11-7. doi: 10.1084/jem.20112078. Epub 2011 Dec 26.


Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1.

Schulz D, Vassen L, Chow KT, McWhirter SM, Amin RH, Möröy T, Schlissel MS.

J Exp Med. 2012 Jan 16;209(1):187-99. doi: 10.1084/jem.20110645. Epub 2011 Dec 26.


CTCF-binding elements mediate control of V(D)J recombination.

Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, Schlissel MS, Murre C, Busslinger M, Giallourakis CC, Alt FW.

Nature. 2011 Sep 11;477(7365):424-30. doi: 10.1038/nature10495.


CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.

Degner SC, Verma-Gaur J, Wong TP, Bossen C, Iverson GM, Torkamani A, Vettermann C, Lin YC, Ju Z, Schulz D, Murre CS, Birshtein BK, Schork NJ, Schlissel MS, Riblet R, Murre C, Feeney AJ.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9566-71. doi: 10.1073/pnas.1019391108. Epub 2011 May 23.


Forced expression of cyclin-dependent kinase 6 confers resistance of pro-B acute lymphocytic leukemia to Gleevec treatment.

Kuo TC, Chavarria-Smith JE, Huang D, Schlissel MS.

Mol Cell Biol. 2011 Jul;31(13):2566-76. doi: 10.1128/MCB.01349-10. Epub 2011 May 2.


Receptor editing as a mechanism of B cell tolerance.

Sukumar S, Schlissel MS.

J Immunol. 2011 Feb 1;186(3):1301-2. doi: 10.4049/jimmunol.1090129. No abstract available.


Allelic exclusion of immunoglobulin genes: models and mechanisms.

Vettermann C, Schlissel MS.

Immunol Rev. 2010 Sep;237(1):22-42. doi: 10.1111/j.1600-065X.2010.00935.x. Review.


Epigenetics drives RAGs to recombination riches.

Schlissel MS.

Cell. 2010 Apr 30;141(3):400-2. doi: 10.1016/j.cell.2010.04.014.


Abelson virus transformation prevents TRAIL expression by inhibiting FoxO3a and NF-kappaB.

Wilson MK, McWhirter SM, Amin RH, Huang D, Schlissel MS.

Mol Cells. 2010 Apr;29(4):333-41. doi: 10.1007/s10059-010-0029-8. Epub 2010 Mar 4.


NF-kappaB activity marks cells engaged in receptor editing.

Cadera EJ, Wan F, Amin RH, Nolla H, Lenardo MJ, Schlissel MS.

J Exp Med. 2009 Aug 3;206(8):1803-16. doi: 10.1084/jem.20082815. Epub 2009 Jul 6.


A histone code for regulating V(D)J recombination.

Schlissel MS, Schulz D, Vettermann C.

Mol Cell. 2009 Jun 26;34(6):639-40. doi: 10.1016/j.molcel.2009.06.004.


Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.

Derudder E, Cadera EJ, Vahl JC, Wang J, Fox CJ, Zha S, van Loo G, Pasparakis M, Schlissel MS, Schmidt-Supprian M, Rajewsky K.

Nat Immunol. 2009 Jun;10(6):647-54. doi: 10.1038/ni.1732. Epub 2009 May 3.


Mechanisms controlling expression of the RAG locus during lymphocyte development.

Kuo TC, Schlissel MS.

Curr Opin Immunol. 2009 Apr;21(2):173-8. doi: 10.1016/j.coi.2009.03.008. Epub 2009 Apr 7. Review.


The effects of c-Abl mutation on developing B cell differentiation and survival.

Brightbill H, Schlissel MS.

Int Immunol. 2009 May;21(5):575-85. doi: 10.1093/intimm/dxp027. Epub 2009 Mar 19.


Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.

Amin RH, Cado D, Nolla H, Huang D, Shinton SA, Zhou Y, Hardy RR, Schlissel MS.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):522-7. doi: 10.1073/pnas.0808895106. Epub 2008 Dec 30.


RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination.

Curry JD, Schlissel MS.

Nucleic Acids Res. 2008 Oct;36(18):5750-62. doi: 10.1093/nar/gkn553. Epub 2008 Sep 6.


Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.

Amin RH, Schlissel MS.

Nat Immunol. 2008 Jun;9(6):613-22. doi: 10.1038/ni.1612. Epub 2008 May 11.


Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells.

Hewitt SL, Farmer D, Marszalek K, Cadera E, Liang HE, Xu Y, Schlissel MS, Skok JA.

Nat Immunol. 2008 Apr;9(4):396-404. doi: 10.1038/ni1567. Epub 2008 Feb 24.


Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.

Bates JG, Cado D, Nolla H, Schlissel MS.

J Exp Med. 2007 Dec 24;204(13):3247-56. Epub 2007 Dec 3.


Chromosomal reinsertion of broken RSS ends during T cell development.

Curry JD, Schulz D, Guidos CJ, Danska JS, Nutter L, Nussenzweig A, Schlissel MS.

J Exp Med. 2007 Oct 1;204(10):2293-303. Epub 2007 Sep 4.


The regulation of receptor editing.

Schlissel MS.

Adv Exp Med Biol. 2007;596:173-9. Review. No abstract available.


Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins.

Huang F, Kitaura Y, Jang I, Naramura M, Kole HH, Liu L, Qin H, Schlissel MS, Gu H.

Immunity. 2006 Oct;25(4):571-81.


AID for innate immunity to retroviral transformation.

Schlissel MS, Kuo TC.

Immunity. 2006 Jun;24(6):671-2. Review.


Leukemia and lymphoma: a cost of doing business for adaptive immunity.

Schlissel MS, Kaffer CR, Curry JD.

Genes Dev. 2006 Jun 15;20(12):1539-44. No abstract available.


Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint.

Pedraza-Alva G, Koulnis M, Charland C, Thornton T, Clements JL, Schlissel MS, Rincón M.

EMBO J. 2006 Feb 22;25(4):763-73. Epub 2006 Feb 2.


Pre-BCR signals and the control of Ig gene rearrangements.

Geier JK, Schlissel MS.

Semin Immunol. 2006 Feb;18(1):31-9. Epub 2006 Jan 18. Review.


Single-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsis.

Curry JD, Geier JK, Schlissel MS.

Nat Immunol. 2005 Dec;6(12):1272-9. Epub 2005 Nov 13.


NF-kappa B comes home.

Amin RH, Schlissel MS.

Immunity. 2005 Apr;22(4):401-2.


Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.

Tze LE, Schram BR, Lam KP, Hogquist KA, Hippen KL, Liu J, Shinton SA, Otipoby KL, Rodine PR, Vegoe AL, Kraus M, Hardy RR, Schlissel MS, Rajewsky K, Behrens TW.

PLoS Biol. 2005 Mar;3(3):e82. Epub 2005 Mar 8.


Quantification of Jkappa signal end breaks in developing B cells by blunt-end linker ligation and qPCR.

Curry JD, Li L, Schlissel MS.

J Immunol Methods. 2005 Jan;296(1-2):19-30. Epub 2004 Nov 23.


Regulation of activation and recombination of the murine Igkappa locus.

Schlissel MS.

Immunol Rev. 2004 Aug;200:215-23. Review.


Pax5 activates immunoglobulin heavy chain V to DJ rearrangement in transgenic thymocytes.

Hsu LY, Liang HE, Johnson K, Kang C, Schlissel MS.

J Exp Med. 2004 Mar 15;199(6):825-30. Epub 2004 Mar 8.


B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors.

Borghesi L, Hsu LY, Miller JP, Anderson M, Herzenberg L, Herzenberg L, Schlissel MS, Allman D, Gerstein RM.

J Exp Med. 2004 Feb 16;199(4):491-502. Epub 2004 Feb 9.


Regulating antigen-receptor gene assembly.

Schlissel MS.

Nat Rev Immunol. 2003 Nov;3(11):890-9. Review. No abstract available.


A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

Hsu LY, Lauring J, Liang HE, Greenbaum S, Cado D, Zhuang Y, Schlissel MS.

Immunity. 2003 Jul;19(1):105-17.


A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines.

Muljo SA, Schlissel MS.

Nat Immunol. 2003 Jan;4(1):31-7. Epub 2002 Dec 2.


The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development.

Liang HE, Hsu LY, Cado D, Cowell LG, Kelsoe G, Schlissel MS.

Immunity. 2002 Nov;17(5):639-51.


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