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Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.

Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM.

J Med Chem. 2020 Jan 6. doi: 10.1021/acs.jmedchem.9b01876. [Epub ahead of print]


Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites.

Kalel VC, Li M, Gaussmann S, Delhommel F, Schäfer AB, Tippler B, Jung M, Maier R, Oeljeklaus S, Schliebs W, Warscheid B, Sattler M, Erdmann R.

Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118520. doi: 10.1016/j.bbamcr.2019.07.015. Epub 2019 Jul 29.


Using Pull Down Strategies to Analyze the Interactome of Peroxisomal Membrane Proteins in Human Cells.

Klümper J, Oeljeklaus S, Warscheid B, Erdmann R, Schliebs W.

Subcell Biochem. 2018;89:261-285. doi: 10.1007/978-981-13-2233-4_11.


Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii.

Mbekeani AJ, Stanley WA, Kalel VC, Dahan N, Zalckvar E, Sheiner L, Schliebs W, Erdmann R, Pohl E, Denny PW.

Genes (Basel). 2018 Aug 29;9(9). pii: E434. doi: 10.3390/genes9090434.


Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19.

Schrul B, Schliebs W.

Biol Chem. 2018 Jun 27;399(7):741-749. doi: 10.1515/hsz-2018-0125. Review.


Inhibitors of glycosomal protein import provide new leads against trypanosomiasis.

Kalel VC, Emmanouilidis L, Dawidowski M, Schliebs W, Sattler M, Popowicz GM, Erdmann R.

Microb Cell. 2017 Jul 3;4(7):229-232. doi: 10.15698/mic2017.07.581.


Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.

Dawidowski M, Emmanouilidis L, Kalel VC, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz GM.

Science. 2017 Mar 31;355(6332):1416-1420. doi: 10.1126/science.aal1807.


Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.

Emmanouilidis L, Schütz U, Tripsianes K, Madl T, Radke J, Rucktäschel R, Wilmanns M, Schliebs W, Erdmann R, Sattler M.

Nat Commun. 2017 Mar 10;8:14635. doi: 10.1038/ncomms14635.


Pex9p is a new yeast peroxisomal import receptor for PTS1-containing proteins.

Effelsberg D, Cruz-Zaragoza LD, Schliebs W, Erdmann R.

J Cell Sci. 2016 Nov 1;129(21):4057-4066. Epub 2016 Sep 27.


Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins.

Galiani S, Waithe D, Reglinski K, Cruz-Zaragoza LD, Garcia E, Clausen MP, Schliebs W, Erdmann R, Eggeling C.

J Biol Chem. 2016 Aug 12;291(33):16948-62. doi: 10.1074/jbc.M116.734038. Epub 2016 Jun 16.


Distinct Pores for Peroxisomal Import of PTS1 and PTS2 Proteins.

Montilla-Martinez M, Beck S, Klümper J, Meinecke M, Schliebs W, Wagner R, Erdmann R.

Cell Rep. 2015 Dec 15;13(10):2126-34. doi: 10.1016/j.celrep.2015.11.016. Epub 2015 Dec 7.


Why do peroxisomes associate with the cytoskeleton?

Neuhaus A, Eggeling C, Erdmann R, Schliebs W.

Biochim Biophys Acta. 2016 May;1863(5):1019-26. doi: 10.1016/j.bbamcr.2015.11.022. Epub 2015 Nov 23. Review.


Peroxisomal Import Reduces the Proapoptotic Activity of Deubiquitinating Enzyme USP2.

Reglinski K, Keil M, Altendorf S, Waithe D, Eggeling C, Schliebs W, Erdmann R.

PLoS One. 2015 Oct 20;10(10):e0140685. doi: 10.1371/journal.pone.0140685. eCollection 2015.


Structural insights into cargo recognition by the yeast PTS1 receptor.

Hagen S, Drepper F, Fischer S, Fodor K, Passon D, Platta HW, Zenn M, Schliebs W, Girzalsky W, Wilmanns M, Warscheid B, Erdmann R.

J Biol Chem. 2015 Oct 30;290(44):26610-26. doi: 10.1074/jbc.M115.657973. Epub 2015 Sep 10.


Role of Pex21p for Piggyback Import of Gpd1p and Pnc1p into Peroxisomes of Saccharomyces cerevisiae.

Effelsberg D, Cruz-Zaragoza LD, Tonillo J, Schliebs W, Erdmann R.

J Biol Chem. 2015 Oct 16;290(42):25333-42. doi: 10.1074/jbc.M115.653451. Epub 2015 Aug 15.


Identification and functional characterization of Trypanosoma brucei peroxin 16.

Kalel VC, Schliebs W, Erdmann R.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2326-37. doi: 10.1016/j.bbamcr.2015.05.024. Epub 2015 May 27.


Ligand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomes.

Fodor K, Wolf J, Reglinski K, Passon DM, Lou Y, Schliebs W, Erdmann R, Wilmanns M.

Traffic. 2015 Jan;16(1):85-98. doi: 10.1111/tra.12238. Epub 2014 Dec 2.


A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.

Neuhaus A, Kooshapur H, Wolf J, Meyer NH, Madl T, Saidowsky J, Hambruch E, Lazam A, Jung M, Sattler M, Schliebs W, Erdmann R.

J Biol Chem. 2014 Jan 3;289(1):437-48. doi: 10.1074/jbc.M113.499707. Epub 2013 Nov 14.


TubStain: a universal peptide-tool to label microtubules.

Theiss C, Neuhaus A, Schliebs W, Erdmann R.

Histochem Cell Biol. 2012 Sep;138(3):531-40. doi: 10.1007/s00418-012-0992-6. Epub 2012 Jul 6.


Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1.

Fodor K, Wolf J, Erdmann R, Schliebs W, Wilmanns M.

PLoS Biol. 2012;10(4):e1001309. doi: 10.1371/journal.pbio.1001309. Epub 2012 Apr 17.


Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis.

Oeljeklaus S, Reinartz BS, Wolf J, Wiese S, Tonillo J, Podwojski K, Kuhlmann K, Stephan C, Meyer HE, Schliebs W, Brocard C, Erdmann R, Warscheid B.

J Proteome Res. 2012 Apr 6;11(4):2567-80. doi: 10.1021/pr3000333. Epub 2012 Mar 23.


MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.

Alkhaja AK, Jans DC, Nikolov M, Vukotic M, Lytovchenko O, Ludewig F, Schliebs W, Riedel D, Urlaub H, Jakobs S, Deckers M.

Mol Biol Cell. 2012 Jan;23(2):247-57. doi: 10.1091/mbc.E11-09-0774. Epub 2011 Nov 23.


A monoclonal antibody for in vivo detection of peroxisome-associated PTS1 receptor.

Cizmowski C, Jung M, Erdmann R, Schliebs W.

Hybridoma (Larchmt). 2011 Aug;30(4):387-91. doi: 10.1089/hyb.2011.0038.


PEX14 is required for microtubule-based peroxisome motility in human cells.

Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K, Herrmann C, Meyer HE, Wiese S, Warscheid B, Theiss C, Erdmann R.

J Cell Sci. 2011 May 15;124(Pt 10):1759-68. doi: 10.1242/jcs.079368. Epub 2011 Apr 26.


The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition.

Williams CP, Schueller N, Thompson CA, van den Berg M, Van Haren SD, Erdmann R, Bond CS, Distel B, Schliebs W, Wilmanns M, Stanley WA.

BMC Biochem. 2011 Mar 4;12:12. doi: 10.1186/1471-2091-12-12.


Peroxisomal protein import and ERAD: variations on a common theme.

Schliebs W, Girzalsky W, Erdmann R.

Nat Rev Mol Cell Biol. 2010 Dec;11(12):885-90. doi: 10.1038/nrm3008. Epub 2010 Nov 17. Review.


Peroxisomes as dynamic organelles: peroxisomal matrix protein import.

Wolf J, Schliebs W, Erdmann R.

FEBS J. 2010 Aug;277(16):3268-78. doi: 10.1111/j.1742-4658.2010.07739.x. Epub 2010 Jul 12. Review.


The peroxisomal receptor Pex19p forms a helical mPTS recognition domain.

Schueller N, Holton SJ, Fodor K, Milewski M, Konarev P, Stanley WA, Wolf J, Erdmann R, Schliebs W, Song YH, Wilmanns M.

EMBO J. 2010 Aug 4;29(15):2491-500. doi: 10.1038/emboj.2010.115. Epub 2010 Jun 8.


The peroxisomal importomer constitutes a large and highly dynamic pore.

Meinecke M, Cizmowski C, Schliebs W, Krüger V, Beck S, Wagner R, Erdmann R.

Nat Cell Biol. 2010 Mar;12(3):273-7. doi: 10.1038/ncb2027. Epub 2010 Feb 14.


Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.

Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M.

EMBO J. 2009 Mar 18;28(6):745-54. doi: 10.1038/emboj.2009.7. Epub 2009 Feb 5.


Peroxisomal targeting of PTS2 pre-import complexes in the yeast Saccharomyces cerevisiae.

Grunau S, Schliebs W, Linnepe R, Neufeld C, Cizmowski C, Reinartz B, Meyer HE, Warscheid B, Girzalsky W, Erdmann R.

Traffic. 2009 Apr;10(4):451-60. doi: 10.1111/j.1600-0854.2009.00876.x.


Dynamin-like protein-dependent formation of Woronin bodies in Saccharomyces cerevisiae upon heterologous expression of a single protein.

Würtz C, Schliebs W, Erdmann R, Rottensteiner H.

FEBS J. 2008 Jun;275(11):2932-41. doi: 10.1111/j.1742-4658.2008.06430.x. Epub 2008 Apr 23.


Protein translocation into peroxisomes by ring-shaped import receptors.

Stanley WA, Fodor K, Marti-Renom MA, Schliebs W, Wilmanns M.

FEBS Lett. 2007 Oct 16;581(25):4795-802. Epub 2007 Sep 11. Review.


Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling.

Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, Almeida JA, Eisenacher M, Stephan C, Hayen H, Schollenberger L, Korosec T, Waterham HR, Schliebs W, Erdmann R, Berger J, Meyer HE, Just W, Azevedo JE, Wanders RJ, Warscheid B.

Mol Cell Proteomics. 2007 Dec;6(12):2045-57. Epub 2007 Sep 2.


Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p.

Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M.

Mol Cell. 2006 Dec 8;24(5):653-663. doi: 10.1016/j.molcel.2006.10.024.


Pex14p, more than just a docking protein.

Azevedo JE, Schliebs W.

Biochim Biophys Acta. 2006 Dec;1763(12):1574-84. Epub 2006 Sep 14. Review.


PTS2 co-receptors: diverse proteins with common features.

Schliebs W, Kunau WH.

Biochim Biophys Acta. 2006 Dec;1763(12):1605-12. Epub 2006 Sep 5. Review.


A eukaryote without catalase-containing microbodies: Neurospora crassa exhibits a unique cellular distribution of its four catalases.

Schliebs W, Würtz C, Kunau WH, Veenhuis M, Rottensteiner H.

Eukaryot Cell. 2006 Sep;5(9):1490-502.


Membrane association of the cycling peroxisome import receptor Pex5p.

Kerssen D, Hambruch E, Klaas W, Platta HW, de Kruijff B, Erdmann R, Kunau WH, Schliebs W.

J Biol Chem. 2006 Sep 15;281(37):27003-15. Epub 2006 Jul 17.


Sleeping sickness: PEX and drugs.

Schliebs W.

Biochim Biophys Acta. 2006 Jan;1763(1):4-5. Epub 2006 Jan 5. Review.


Yeast Pex14p possesses two functionally distinct Pex5p and one Pex7p binding sites.

Niederhoff K, Meindl-Beinker NM, Kerssen D, Perband U, Schäfer A, Schliebs W, Kunau WH.

J Biol Chem. 2005 Oct 21;280(42):35571-8. Epub 2005 Aug 17.


Peroxisomal matrix protein import: the transient pore model.

Erdmann R, Schliebs W.

Nat Rev Mol Cell Biol. 2005 Sep;6(9):738-42. doi: 10.1038/nrm1710.


Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein.

Costa-Rodrigues J, Carvalho AF, Fransen M, Hambruch E, Schliebs W, Sá-Miranda C, Azevedo JE.

J Biol Chem. 2005 Jul 1;280(26):24404-11. Epub 2005 May 2.


Functional similarity between the peroxisomal PTS2 receptor binding protein Pex18p and the N-terminal half of the PTS1 receptor Pex5p.

Schäfer A, Kerssen D, Veenhuis M, Kunau WH, Schliebs W.

Mol Cell Biol. 2004 Oct;24(20):8895-906.


Peroxisome membrane biogenesis: the stage is set.

Schliebs W, Kunau WH.

Curr Biol. 2004 May 25;14(10):R397-9. Review.


Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction.

Oliveira ME, Reguenga C, Gouveia AM, Guimarães CP, Schliebs W, Kunau WH, Silva MT, Sá-Miranda C, Azevedo JE.

Biochim Biophys Acta. 2002 Dec 23;1567(1-2):13-22.


The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14.

Saidowsky J, Dodt G, Kirchberg K, Wegner A, Nastainczyk W, Kunau WH, Schliebs W.

J Biol Chem. 2001 Sep 14;276(37):34524-9. Epub 2001 Jul 3.


Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14.

Schliebs W, Saidowsky J, Agianian B, Dodt G, Herberg FW, Kunau WH.

J Biol Chem. 1999 Feb 26;274(9):5666-73.


A double mutation at the tip of the dimer interface loop of triosephosphate isomerase generates active monomers with reduced stability.

Schliebs W, Thanki N, Jaenicke R, Wierenga RK.

Biochemistry. 1997 Aug 12;36(32):9655-62.


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