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Items: 37

1.

Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance.

Quanz M, Bender E, Kopitz C, Grünewald S, Schlicker A, Schwede W, Eheim A, Toschi L, Neuhaus R, Richter C, Toedling J, Merz C, Lesche R, Kamburov A, Siebeneicher H, Bauser M, Hägebarth A.

Mol Cancer Ther. 2018 Nov;17(11):2285-2296. doi: 10.1158/1535-7163.MCT-17-1253. Epub 2018 Aug 16.

PMID:
30115664
2.

Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death.

Klutzny S, Lesche R, Keck M, Kaulfuss S, Schlicker A, Christian S, Sperl C, Neuhaus R, Mowat J, Steckel M, Riefke B, Prechtl S, Parczyk K, Steigemann P.

Cell Death Dis. 2017 Mar 30;8(3):e2709. doi: 10.1038/cddis.2017.130.

3.

OncoScape: Exploring the cancer aberration landscape by genomic data fusion.

Schlicker A, Michaut M, Rahman R, Wessels LF.

Sci Rep. 2016 Jun 20;6:28103. doi: 10.1038/srep28103.

4.

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

Vecchione L, Gambino V, Raaijmakers J, Schlicker A, Fumagalli A, Russo M, Villanueva A, Beerling E, Bartolini A, Mollevi DG, El-Murr N, Chiron M, Calvet L, Nicolazzi C, Combeau C, Henry C, Simon IM, Tian S, in 't Veld S, D'ario G, Mainardi S, Beijersbergen RL, Lieftink C, Linn S, Rumpf-Kienzl C, Delorenzi M, Wessels L, Salazar R, Di Nicolantonio F, Bardelli A, van Rheenen J, Medema RH, Tejpar S, Bernards R.

Cell. 2016 Apr 7;165(2):317-30. doi: 10.1016/j.cell.2016.02.059.

5.

Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma.

Heynen GJ, Nevedomskaya E, Palit S, Jagalur Basheer N, Lieftink C, Schlicker A, Zwart W, Bernards R, Bajpe PK.

Mol Cancer Res. 2016 May;14(5):411-22. doi: 10.1158/1541-7786.MCR-15-0291-T. Epub 2016 Jan 19.

6.

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.

Michaut M, Chin SF, Majewski I, Severson TM, Bismeijer T, de Koning L, Peeters JK, Schouten PC, Rueda OM, Bosma AJ, Tarrant F, Fan Y, He B, Xue Z, Mittempergher L, Kluin RJ, Heijmans J, Snel M, Pereira B, Schlicker A, Provenzano E, Ali HR, Gaber A, O'Hurley G, Lehn S, Muris JJ, Wesseling J, Kay E, Sammut SJ, Bardwell HA, Barbet AS, Bard F, Lecerf C, O'Connor DP, Vis DJ, Benes CH, McDermott U, Garnett MJ, Simon IM, Jirström K, Dubois T, Linn SC, Gallagher WM, Wessels LF, Caldas C, Bernards R.

Sci Rep. 2016 Jan 5;6:18517. doi: 10.1038/srep18517.

7.

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival.

Iskit S, Schlicker A, Wessels L, Peeper DS.

Oncotarget. 2015 Dec 22;6(41):43146-61. doi: 10.18632/oncotarget.6454.

8.

The consensus molecular subtypes of colorectal cancer.

Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, De Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S.

Nat Med. 2015 Nov;21(11):1350-6. doi: 10.1038/nm.3967. Epub 2015 Oct 12.

9.

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.

Henneman L, van Miltenburg MH, Michalak EM, Braumuller TM, Jaspers JE, Drenth AP, de Korte-Grimmerink R, Gogola E, Szuhai K, Schlicker A, Bin Ali R, Pritchard C, Huijbers IJ, Berns A, Rottenberg S, Jonkers J.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8409-14. doi: 10.1073/pnas.1500223112. Epub 2015 Jun 22.

10.

ERBB2 Mutations Characterize a Subgroup of Muscle-invasive Bladder Cancers with Excellent Response to Neoadjuvant Chemotherapy.

Groenendijk FH, de Jong J, Fransen van de Putte EE, Michaut M, Schlicker A, Peters D, Velds A, Nieuwland M, van den Heuvel MM, Kerkhoven RM, Wessels LF, Broeks A, van Rhijn BW, Bernards R, van der Heijden MS.

Eur Urol. 2016 Mar;69(3):384-8. doi: 10.1016/j.eururo.2015.01.014. Epub 2015 Jan 27.

PMID:
25636205
11.

BRCA2-deficient sarcomatoid mammary tumors exhibit multidrug resistance.

Jaspers JE, Sol W, Kersbergen A, Schlicker A, Guyader C, Xu G, Wessels L, Borst P, Jonkers J, Rottenberg S.

Cancer Res. 2015 Feb 15;75(4):732-41. doi: 10.1158/0008-5472.CAN-14-0839. Epub 2014 Dec 15.

12.

Inflammatory response of lung macrophages and epithelial cells after exposure to redox active nanoparticles: effect of solubility and antioxidant treatment.

Urner M, Schlicker A, Z'graggen BR, Stepuk A, Booy C, Buehler KP, Limbach L, Chmiel C, Stark WJ, Beck-Schimmer B.

Environ Sci Technol. 2014 Dec 2;48(23):13960-8. doi: 10.1021/es504011m. Epub 2014 Nov 13.

PMID:
25343230
13.

Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers.

Sieuwerts AM, Willis S, Burns MB, Look MP, Meijer-Van Gelder ME, Schlicker A, Heideman MR, Jacobs H, Wessels L, Leyland-Jones B, Gray KP, Foekens JA, Harris RS, Martens JW.

Horm Cancer. 2014 Dec;5(6):405-13. doi: 10.1007/s12672-014-0196-8. Epub 2014 Aug 15.

14.

Volatile anaesthetics reduce neutrophil inflammatory response by interfering with CXC receptor-2 signalling.

Müller-Edenborn B, Frick R, Piegeler T, Schläpfer M, Roth-Z'graggen B, Schlicker A, Beck-Schimmer B.

Br J Anaesth. 2015 Jan;114(1):143-9. doi: 10.1093/bja/aeu189. Epub 2014 Jul 2.

15.

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

Sun C, Hobor S, Bertotti A, Zecchin D, Huang S, Galimi F, Cottino F, Prahallad A, Grernrum W, Tzani A, Schlicker A, Wessels LF, Smit EF, Thunnissen E, Halonen P, Lieftink C, Beijersbergen RL, Di Nicolantonio F, Bardelli A, Trusolino L, Bernards R.

Cell Rep. 2014 Apr 10;7(1):86-93. doi: 10.1016/j.celrep.2014.02.045. Epub 2014 Mar 27.

16.

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma.

Sun C, Wang L, Huang S, Heynen GJ, Prahallad A, Robert C, Haanen J, Blank C, Wesseling J, Willems SM, Zecchin D, Hobor S, Bajpe PK, Lieftink C, Mateus C, Vagner S, Grernrum W, Hofland I, Schlicker A, Wessels LF, Beijersbergen RL, Bardelli A, Di Nicolantonio F, Eggermont AM, Bernards R.

Nature. 2014 Apr 3;508(7494):118-22. doi: 10.1038/nature13121. Epub 2014 Mar 26.

17.

Dabigatran anticoagulation and Stanford type A aortic dissection: lethal coincidence: Case report with literature review.

Stein P, Bosshart M, Brand B, Schlicker A, Spahn DR, Bettex D.

Acta Anaesthesiol Scand. 2014 May;58(5):630-7. doi: 10.1111/aas.12303. Epub 2014 Mar 6.

PMID:
24601892
18.

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition.

Roepman P, Schlicker A, Tabernero J, Majewski I, Tian S, Moreno V, Snel MH, Chresta CM, Rosenberg R, Nitsche U, Macarulla T, Capella G, Salazar R, Orphanides G, Wessels LF, Bernards R, Simon IM.

Int J Cancer. 2014 Feb 1;134(3):552-62. doi: 10.1002/ijc.28387. Epub 2013 Sep 13.

19.

Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.

Schlicker A, Beran G, Chresta CM, McWalter G, Pritchard A, Weston S, Runswick S, Davenport S, Heathcote K, Castro DA, Orphanides G, French T, Wessels LF.

BMC Med Genomics. 2012 Dec 31;5:66. doi: 10.1186/1755-8794-5-66.

20.

MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.

Huang S, Hölzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U, Garnett M, Grernrum W, Sun C, Prahallad A, Groenendijk FH, Mittempergher L, Nijkamp W, Neefjes J, Salazar R, Ten Dijke P, Uramoto H, Tanaka F, Beijersbergen RL, Wessels LF, Bernards R.

Cell. 2012 Nov 21;151(5):937-50. doi: 10.1016/j.cell.2012.10.035.

21.

Mining GO annotations for improving annotation consistency.

Faria D, Schlicker A, Pesquita C, Bastos H, Ferreira AE, Albrecht M, Falcão AO.

PLoS One. 2012;7(7):e40519. doi: 10.1371/journal.pone.0040519. Epub 2012 Jul 25.

22.

Comparison of manganese oxide nanoparticles and manganese sulfate with regard to oxidative stress, uptake and apoptosis in alveolar epithelial cells.

Frick R, Müller-Edenborn B, Schlicker A, Rothen-Rutishauser B, Raemy DO, Günther D, Hattendorf B, Stark W, Beck-Schimmer B.

Toxicol Lett. 2011 Aug 28;205(2):163-72. doi: 10.1016/j.toxlet.2011.05.1037. Epub 2011 Jun 2.

23.

Fluorinated groups mediate the immunomodulatory effects of volatile anesthetics in acute cell injury.

Urner M, Limbach LK, Herrmann IK, Müller-Edenborn B, Roth-Z'Graggen B, Schlicker A, Reyes L, Booy C, Hasler M, Stark WJ, Beck-Schimmer B.

Am J Respir Cell Mol Biol. 2011 Sep;45(3):617-24. doi: 10.1165/rcmb.2010-0451OC. Epub 2011 Jan 14.

PMID:
21239603
24.

Improving disease gene prioritization using the semantic similarity of Gene Ontology terms.

Schlicker A, Lengauer T, Albrecht M.

Bioinformatics. 2010 Sep 15;26(18):i561-7. doi: 10.1093/bioinformatics/btq384.

25.

In vitro exposure of human fibroblasts to local anaesthetics impairs cell growth.

Fedder C, Beck-Schimmer B, Aguirre J, Hasler M, Roth-Z'graggen B, Urner M, Kalberer S, Schlicker A, Votta-Velis G, Bonvini JM, Graetz K, Borgeat A.

Clin Exp Immunol. 2010 Nov;162(2):280-8. doi: 10.1111/j.1365-2249.2010.04252.x. Epub 2010 Sep 1.

26.

FunSimMat update: new features for exploring functional similarity.

Schlicker A, Albrecht M.

Nucleic Acids Res. 2010 Jan;38(Database issue):D244-8. doi: 10.1093/nar/gkp979. Epub 2009 Nov 18.

27.

Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus.

Welsch C, Domingues FS, Susser S, Antes I, Hartmann C, Mayr G, Schlicker A, Sarrazin C, Albrecht M, Zeuzem S, Lengauer T.

Genome Biol. 2008 Jan 23;9(1):R16. doi: 10.1186/gb-2008-9-1-r16.

28.

FunSimMat: a comprehensive functional similarity database.

Schlicker A, Albrecht M.

Nucleic Acids Res. 2008 Jan;36(Database issue):D434-9. Epub 2007 Oct 11.

29.

Computational analysis of human protein interaction networks.

Ramírez F, Schlicker A, Assenov Y, Lengauer T, Albrecht M.

Proteomics. 2007 Aug;7(15):2541-52.

PMID:
17647236
30.

Functional evaluation of domain-domain interactions and human protein interaction networks.

Schlicker A, Huthmacher C, Ramírez F, Lengauer T, Albrecht M.

Bioinformatics. 2007 Apr 1;23(7):859-65.

PMID:
17456608
31.

The implications of alternative splicing in the ENCODE protein complement.

Tress ML, Martelli PL, Frankish A, Reeves GA, Wesselink JJ, Yeats C, Olason PI, Albrecht M, Hegyi H, Giorgetti A, Raimondo D, Lagarde J, Laskowski RA, López G, Sadowski MI, Watson JD, Fariselli P, Rossi I, Nagy A, Kai W, Størling Z, Orsini M, Assenov Y, Blankenburg H, Huthmacher C, Ramírez F, Schlicker A, Denoeud F, Jones P, Kerrien S, Orchard S, Antonarakis SE, Reymond A, Birney E, Brunak S, Casadio R, Guigo R, Harrow J, Hermjakob H, Jones DT, Lengauer T, Orengo CA, Patthy L, Thornton JM, Tramontano A, Valencia A.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5495-500. Epub 2007 Mar 19.

32.

GOTax: investigating biological processes and biochemical activities along the taxonomic tree.

Schlicker A, Rahnenführer J, Albrecht M, Lengauer T, Domingues FS.

Genome Biol. 2007;8(3):R33.

33.

A new measure for functional similarity of gene products based on Gene Ontology.

Schlicker A, Domingues FS, Rahnenführer J, Lengauer T.

BMC Bioinformatics. 2006 Jun 15;7:302.

34.

Biodistribution and pharmacokinetics of the (19)F-labeled radiosensitizer 3-aminobenzamide: assessment by (19)F MR imaging.

Brix G, Schlicker A, Mier W, Peschke P, Bellemann ME.

Magn Reson Imaging. 2005 Nov;23(9):967-76. Epub 2005 Oct 26.

PMID:
16310113
35.

Neutral and ionic aluminum, gallium, and indium compounds carrying two or three terminal ethynyl groups.

Schiefer M, Reddy ND, Ahn HJ, Stasch A, Roesky HW, Schlicker AC, Schmidt HG, Noltemeyer M, Vidovic D.

Inorg Chem. 2003 Aug 11;42(16):4970-6.

PMID:
12895122
36.

Albumin as a carrier system for delivering drugs to solid tumors.

Schlicker A, Peschke P, Sinn H, Hahn EW.

PDA J Pharm Sci Technol. 2000 Nov-Dec;54(6):442-8. No abstract available.

PMID:
11107836
37.

4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer.

Schlicker A, Peschke P, Bürkle A, Hahn EW, Kim JH.

Int J Radiat Biol. 1999 Jan;75(1):91-100.

PMID:
9972795

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