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Items: 1 to 50 of 80

1.

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A.

Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K.

J Am Soc Nephrol. 2019 Jan 3. pii: ASN.2018010039. doi: 10.1681/ASN.2018010039. [Epub ahead of print]

PMID:
30606785
2.

A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging.

Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh TL, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N.

ChemMedChem. 2019 Jan 8;14(1):94-99. doi: 10.1002/cmdc.201800483. Epub 2018 Dec 21.

PMID:
30380199
3.

HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease.

Kraus A, Peters DJM, Klanke B, Weidemann A, Willam C, Schley G, Kunzelmann K, Eckardt KU, Buchholz B.

Kidney Int. 2018 Nov;94(5):887-899. doi: 10.1016/j.kint.2018.06.008. Epub 2018 Aug 30.

PMID:
30173898
4.

Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology.

Schley G, Jordan J, Ellmann S, Rosen S, Eckardt KU, Uder M, Willam C, Bäuerle T.

PLoS One. 2018 Jul 16;13(7):e0200259. doi: 10.1371/journal.pone.0200259. eCollection 2018.

5.

Myeloid Cell-Derived HIF-1α Promotes Control of Leishmania major.

Schatz V, Strüssmann Y, Mahnke A, Schley G, Waldner M, Ritter U, Wild J, Willam C, Dehne N, Brüne B, McNiff JM, Colegio OR, Bogdan C, Jantsch J.

J Immunol. 2016 Nov 15;197(10):4034-4041. Epub 2016 Oct 17.

6.

P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells.

Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schödel J, Eckardt KU, Buchholz B.

Purinergic Signal. 2016 Dec;12(4):687-695. Epub 2016 Aug 26.

7.

The impact of hypoxia on nephrogenesis.

Buchholz B, Schley G, Eckardt KU.

Curr Opin Nephrol Hypertens. 2016 May;25(3):180-6. doi: 10.1097/MNH.0000000000000211. Review.

PMID:
27023836
8.

Comparison of Plasma and Urine Biomarker Performance in Acute Kidney Injury.

Schley G, Köberle C, Manuilova E, Rutz S, Forster C, Weyand M, Formentini I, Kientsch-Engel R, Eckardt KU, Willam C.

PLoS One. 2015 Dec 15;10(12):e0145042. doi: 10.1371/journal.pone.0145042. eCollection 2015.

9.

The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3.

Schulz K, Hagos Y, Burckhardt G, Schley G, Burzlaff N, Willam C, Burckhardt BC.

Nephron. 2015;131(4):285-9. doi: 10.1159/000442531. Epub 2015 Dec 8.

PMID:
26640952
10.

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen.

Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J.

Cell Rep. 2015 Dec 15;13(10):2048-55. doi: 10.1016/j.celrep.2015.11.005. Epub 2015 Nov 25.

11.

Glucose promotes secretion-dependent renal cyst growth.

Kraus A, Schley G, Kunzelmann K, Schreiber R, Peters DJ, Stadler R, Eckardt KU, Buchholz B.

J Mol Med (Berl). 2016 Jan;94(1):107-17. doi: 10.1007/s00109-015-1337-4. Epub 2015 Sep 3.

PMID:
26334260
12.

Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis.

Schley G, Scholz H, Kraus A, Hackenbeck T, Klanke B, Willam C, Wiesener MS, Heinze E, Burzlaff N, Eckardt KU, Buchholz B.

Kidney Int. 2015 Dec;88(6):1283-1292. doi: 10.1038/ki.2015.214. Epub 2015 Jul 22.

PMID:
26200943
13.

Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass.

Zacharias HU, Hochrein J, Vogl FC, Schley G, Mayer F, Jeleazcov C, Eckardt KU, Willam C, Oefner PJ, Gronwald W.

J Proteome Res. 2015 Jul 2;14(7):2897-905. doi: 10.1021/acs.jproteome.5b00219. Epub 2015 Jun 12.

PMID:
26036910
14.

Electrochemotherapy in advanced skin tumors and cutaneous metastases - a retrospective multicenter analysis.

Kreuter A, van Eijk T, Lehmann P, Fischer M, Horn T, Assaf C, Schley G, Herbst R, Kellner I, Weisbrich C, Hyun J, Wieland U, Schlaak M, Rübben A, Lommel K.

J Dtsch Dermatol Ges. 2015 Apr;13(4):308-15. doi: 10.1111/ddg.12583.

PMID:
25819239
15.

Kidney injury is independent of endothelial HIF-1α.

Kalucka J, Schley G, Georgescu A, Klanke B, Rössler S, Baumgartl J, Velden J, Amann K, Willam C, Johnson RS, Eckardt KU, Weidemann A.

J Mol Med (Berl). 2015 Aug;93(8):891-904. doi: 10.1007/s00109-015-1264-4. Epub 2015 Mar 11.

PMID:
25754172
16.

Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult.

Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski DM.

Pflugers Arch. 2015 Oct;467(10):2141-9. doi: 10.1007/s00424-014-1667-z. Epub 2015 Jan 13.

PMID:
25578858
17.

The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity.

Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung TL, Laslett AL, Willam C, Qin B, Maxwell PH, Esteban MA.

J Biol Chem. 2014 Feb 7;289(6):3339-51. doi: 10.1074/jbc.M113.538157. Epub 2013 Dec 26.

18.

Hypoxia-inducible factor-1α causes renal cyst expansion through calcium-activated chloride secretion.

Buchholz B, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N, Jantsch J, Kunzelmann K, Eckardt KU.

J Am Soc Nephrol. 2014 Mar;25(3):465-74. doi: 10.1681/ASN.2013030209. Epub 2013 Nov 7.

19.

Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells.

Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K.

Kidney Int. 2014 May;85(5):1058-67. doi: 10.1038/ki.2013.418. Epub 2013 Oct 23.

20.

Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues.

Schley G, Klanke B, Schödel J, Kröning S, Türkoglu G, Beyer A, Hagos Y, Amann K, Burckhardt BC, Burzlaff N, Eckardt KU, Willam C.

Am J Pathol. 2012 Nov;181(5):1595-606. doi: 10.1016/j.ajpath.2012.07.010. Epub 2012 Aug 31.

PMID:
22944601
21.

α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).

Hagos Y, Schley G, Schödel J, Krick W, Burckhardt G, Willam C, Burckhardt BC.

Pflugers Arch. 2012 Oct;464(4):367-74. Epub 2012 Aug 9.

PMID:
22875277
22.

Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.

Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesener MS.

PLoS One. 2012;7(1):e31034. doi: 10.1371/journal.pone.0031034. Epub 2012 Jan 27.

23.

Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.

Schley G, Klanke B, Schödel J, Forstreuter F, Shukla D, Kurtz A, Amann K, Wiesener MS, Rosen S, Eckardt KU, Maxwell PH, Willam C.

J Am Soc Nephrol. 2011 Nov;22(11):2004-15. doi: 10.1681/ASN.2010121249. Epub 2011 Sep 15.

24.

The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.

Buchholz B, Klanke B, Schley G, Bollag G, Tsai J, Kroening S, Yoshihara D, Wallace DP, Kraenzlin B, Gretz N, Hirth P, Eckardt KU, Bernhardt WM.

Nephrol Dial Transplant. 2011 Nov;26(11):3458-65. doi: 10.1093/ndt/gfr432. Epub 2011 Jul 29.

25.

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.

Wang Z, Schley G, Türkoglu G, Burzlaff N, Amann KU, Willam C, Eckardt KU, Bernhardt WM.

Nephrol Dial Transplant. 2012 Mar;27(3):929-36. doi: 10.1093/ndt/gfr379. Epub 2011 Jul 8.

PMID:
21742784
26.

Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion.

Buchholz B, Teschemacher B, Schley G, Schillers H, Eckardt KU.

J Mol Med (Berl). 2011 Mar;89(3):251-61. doi: 10.1007/s00109-010-0715-1. Epub 2011 Jan 5.

PMID:
21206992
27.

Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells.

Schödel J, Bohr D, Klanke B, Schley G, Schlötzer-Schrehardt U, Warnecke C, Kurtz A, Amann K, Eckardt KU, Willam C.

Kidney Int. 2010 Nov;78(9):857-67. doi: 10.1038/ki.2010.284. Epub 2010 Aug 18.

28.

Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.

Volke M, Gale DP, Maegdefrau U, Schley G, Klanke B, Bosserhoff AK, Maxwell PH, Eckardt KU, Warnecke C.

PLoS One. 2009 Nov 18;4(11):e7875. doi: 10.1371/journal.pone.0007875.

29.

[Elevated serum creatinine without discernible kidney disease].

Schley G, Höfliger N, Vogt M.

Dtsch Med Wochenschr. 2009 Mar;134(13):629-31. doi: 10.1055/s-0029-1208096. Epub 2009 Mar 17. German.

PMID:
19294604
30.

Sweet and sour-a patient with life-threatening metabolic acidosis and acute renal failure.

Schorn R, Kalicki R, Remschmidt C, Schley G, Höfliger N, Aregger F.

NDT Plus. 2008 Dec;1(6):433-436. doi: 10.1093/ndtplus/sfn108. Epub 2008 Aug 4. No abstract available.

31.

1,25-dihydroxyvitamin D3-induced apoptosis of retinoblastoma cells is associated with reciprocal changes of Bcl-2 and bax.

Wagner N, Wagner KD, Schley G, Badiali L, Theres H, Scholz H.

Exp Eye Res. 2003 Jul;77(1):1-9.

PMID:
12823982
32.

Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1).

Wagner KD, Wagner N, Wellmann S, Schley G, Bondke A, Theres H, Scholz H.

FASEB J. 2003 Jul;17(10):1364-6. Epub 2003 May 8.

PMID:
12738801
33.

The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b).

Wagner KD, Wagner N, Schley G, Theres H, Scholz H.

Gene. 2003 Feb 27;305(2):217-23.

PMID:
12609742
34.

The Wilms' tumor suppressor Wt1 is associated with the differentiation of retinoblastoma cells.

Wagner N, Wagner KD, Schley G, Coupland SE, Heimann H, Grantyn R, Scholz H.

Cell Growth Differ. 2002 Jul;13(7):297-305.

35.

The Wilms' tumor gene Wt1 is required for normal development of the retina.

Wagner KD, Wagner N, Vidal VP, Schley G, Wilhelm D, Schedl A, Englert C, Scholz H.

EMBO J. 2002 Mar 15;21(6):1398-405.

36.

[Angioendotheliomatosis proliferans systematizata].

Schley G, Kauffold D, Guse E, Slucka S, Jeschke M.

Hautarzt. 2001 Nov;52(11):1030-4. German.

PMID:
11757458
37.

[The treatment of bacterial infections with the newer antibiotics].

Schley G, Wenzel H.

Med Klin. 1981 Mar 27;76(7):200-7. German. No abstract available.

PMID:
6971983
38.

[Follow-up in treated malignant hypertension].

Schley G, Kapp A, Günnewig H, Bock KD.

Med Welt. 1979 Dec 14;30(50):1875-84. German. No abstract available.

PMID:
548692
39.

[Management of acute arrhythmias using atenolol in the myocardial-infarct patient].

Beckmann R, Schley G, Günnewig H.

Med Welt. 1978 Oct 27;29(43):1697-9. German. No abstract available.

PMID:
713788
40.

[The treatment of acute cardiac dysrhythmias with atenolol (Tenormin) particularly after myocardial infarction (author's transl)].

Schley G, Beckmann R, Hengstebeck W.

Z Kardiol. 1978 Apr;67(4):280-8. German. No abstract available.

PMID:
77592
41.
42.

[The reversing of fundus oculi changes in treated malignant hypertension].

Bock KD, Anlauf M, Schley G, Hengstebeck W, Zimmermann A, Vogel M.

Verh Dtsch Ges Kreislaufforsch. 1977;43:229-30. German. No abstract available.

PMID:
613583
43.

[Acute intermitting porphyria].

Schley G, Hengstebeck W.

Dtsch Med Wochenschr. 1976 Dec 24;101(52):1921-6. German. No abstract available.

PMID:
1033826
44.

[Oral contraceptives in prophylaxis of acute exacerbations of intermittent porphyria (author's transl)].

Schley G, Anlauf M, Bock KD.

Dtsch Med Wochenschr. 1976 Dec 24;101(52):1901-7. German.

PMID:
1001215
45.

[Acute intermittent porphyria: report on 17 patients with 49 attacks (author's transl)].

Schley G, Anlauf M, Bock KD.

Med Klin. 1976 Oct 29;71(44):1891-7. German.

PMID:
995030
46.

[Plasma catecholamines in patients with thyroid gland function disorders].

Werner U, Hackenberg K, Schley G, Reinwein D.

Med Welt. 1976 Jun 11;27(24):1187-8. German. No abstract available.

PMID:
940464
47.
48.

[Experimental studies on the use of beta-sympatholytics in infarct-induced ventricular fibrillation].

Schley G, Meesmann W, Wild U.

Med Welt. 1975 Jul 11;26(27-28):1313-5. German. No abstract available.

PMID:
1177696
49.

[Problem of differential therapy of arrythmias in acute myocardial infarct].

Meesmann W, Stephan K, Schley G, Gülker H.

Dtsch Med Wochenschr. 1975 Apr 25;100(17):954-60. German. No abstract available.

PMID:
1122865
50.

[Pathophysiology of ventricular fibrillation].

Schley G.

Dtsch Med Wochenschr. 1975 Apr 4;100(14):771-8. German. No abstract available.

PMID:
1126286

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