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Items: 6


Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin.

Ashrafi G, Schlehe JS, LaVoie MJ, Schwarz TL.

J Cell Biol. 2014 Sep 1;206(5):655-70. doi: 10.1083/jcb.201401070. Epub 2014 Aug 25.


Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.

Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ.

Am J Hematol. 2014 Oct;89(10):974-7. doi: 10.1002/ajh.23796. Epub 2014 Jul 21.


The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress.

Schlehe JS, Journel MS, Taylor KP, Amodeo KD, LaVoie MJ.

Neurobiol Dis. 2013 Oct;58:57-67. doi: 10.1016/j.nbd.2013.05.007. Epub 2013 May 20.


Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.

Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF.

J Biol Chem. 2009 Aug 21;284(34):22938-51. doi: 10.1074/jbc.M109.035774. Epub 2009 Jun 22.


Aberrant folding of pathogenic Parkin mutants: aggregation versus degradation.

Schlehe JS, Lutz AK, Pilsl A, Lämmermann K, Grgur K, Henn IH, Tatzelt J, Winklhofer KF.

J Biol Chem. 2008 May 16;283(20):13771-9. doi: 10.1074/jbc.M707494200. Epub 2008 Mar 24.


Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling.

Henn IH, Bouman L, Schlehe JS, Schlierf A, Schramm JE, Wegener E, Nakaso K, Culmsee C, Berninger B, Krappmann D, Tatzelt J, Winklhofer KF.

J Neurosci. 2007 Feb 21;27(8):1868-78.

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