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Items: 1 to 50 of 153


[Preoperative iron deficiency with/without anemia-an underestimated risk factor?]

Meybohm P, Neef V, Westphal S, Schnitzbauer A, Röder D, Schlegel N, Zacharowski K.

Chirurg. 2019 Sep 26. doi: 10.1007/s00104-019-01037-1. [Epub ahead of print] Review. German.


Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Liver Regeneration After Ischemia Reperfusion Injury in Mice.

Anger F, Camara M, Ellinger E, Germer CT, Schlegel N, Otto C, Klein I.

Stem Cells Dev. 2019 Oct 8. doi: 10.1089/scd.2019.0085. [Epub ahead of print]


Prognostic Relevance of Steroid Sulfation in Adrenocortical Carcinoma Revealed by Molecular Phenotyping Using High-Resolution Mass Spectrometry Imaging.

Sun N, Kunzke T, Sbiera S, Kircher S, Feuchtinger A, Aichler M, Herterich S, Ronchi CL, Weigand I, Schlegel N, Waldmann J, Candida Villares Fragoso M, Whitsett TG, Gill AJ, Fassnacht M, Walch A, Kroiss M.

Clin Chem. 2019 Oct;65(10):1276-1286. doi: 10.1373/clinchem.2019.306043. Epub 2019 Sep 6.


MYH9-related disorders display heterogeneous kidney involvement and outcome.

Tabibzadeh N, Fleury D, Labatut D, Bridoux F, Lionet A, Jourde-Chiche N, Vrtovsnik F, Schlegel N, Vanhille P.

Clin Kidney J. 2018 Dec 17;12(4):494-502. doi: 10.1093/ckj/sfy117. eCollection 2019 Aug.


Ureaplasma Species Modulate Cytokine and Chemokine Responses in Human Brain Microvascular Endothelial Cells.

Silwedel C, Speer CP, Haarmann A, Fehrholz M, Claus H, Schlegel N, Glaser K.

Int J Mol Sci. 2019 Jul 22;20(14). pii: E3583. doi: 10.3390/ijms20143583.


Correction to: Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion.

Ungewiß H, Rötzer V, Meir M, Fey C, Diefenbacher M, Schlegel N, Waschke J.

Cell Mol Life Sci. 2019 Sep;76(17):3477. doi: 10.1007/s00018-019-03210-5.


Novel ACTN1 variants in cases of thrombocytopenia.

Vincenot A, Saultier P, Kunishima S, Poggi M, Hurtaud-Roux MF, Roussel A; ACTN1 study co-investigators, Schlegel N, Alessi MC.

Hum Mutat. 2019 Jun 25. doi: 10.1002/humu.23840. [Epub ahead of print]


An underestimated pathogen: Staphylococcus epidermidis induces pro-inflammatory responses in human alveolar epithelial cells.

Dong Y, Glaser K, Schlegel N, Claus H, Speer CP.

Cytokine. 2019 Nov;123:154761. doi: 10.1016/j.cyto.2019.154761. Epub 2019 Jun 18.


Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease.

Meir M, Burkard N, Ungewiß H, Diefenbacher M, Flemming S, Kannapin F, Germer CT, Schweinlin M, Metzger M, Waschke J, Schlegel N.

J Clin Invest. 2019 Jun 17;129(7):2824-2840. doi: 10.1172/JCI120261. eCollection 2019 Jun 17.


Ureaplasma species modulate cell adhesion molecules and growth factors in human brain microvascular endothelial cells.

Silwedel C, Speer CP, Haarmann A, Fehrholz M, Claus H, Schlegel N, Glaser K.

Cytokine. 2019 Sep;121:154737. doi: 10.1016/j.cyto.2019.154737. Epub 2019 May 31.


ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in Parallel to Increased ERK Activation.

Radeva MY, Walter E, Stach RA, Yazdi AS, Schlegel N, Sarig O, Sprecher E, Waschke J.

Front Immunol. 2019 Apr 17;10:770. doi: 10.3389/fimmu.2019.00770. eCollection 2019.


Slowdown in Antarctic mass loss from solid Earth and sea-level feedbacks.

Larour E, Seroussi H, Adhikari S, Ivins E, Caron L, Morlighem M, Schlegel N.

Science. 2019 Jun 7;364(6444). pii: eaav7908. doi: 10.1126/science.aav7908. Epub 2019 Apr 25.


The time point of completion thyroidectomy has no prognostic impact in patients with differentiated thyroid cancer.

Lenschow C, Mäder U, Germer CT, Reiners C, Schlegel N, Verburg FA.

Clin Endocrinol (Oxf). 2019 Mar;90(3):479-486. doi: 10.1111/cen.13916. Epub 2018 Dec 28.


Obstructed defecation-an enteric neuropathy? An exploratory study of patient samples.

Kim M, Rosenbaum C, Schlegel N, Grumaz C, Sohn K, Isbert C, Walles H, Metzger M.

Int J Colorectal Dis. 2019 Jan;34(1):193-196. doi: 10.1007/s00384-018-3160-1. Epub 2018 Sep 3.


Selective Electrochemical Reduction of CO2 to CO on Zn-Based Foams Produced by Cu2+ and Template-Assisted Electrodeposition.

Moreno-García P, Schlegel N, Zanetti A, Cedeño López A, Gálvez-Vázquez MJ, Dutta A, Rahaman M, Broekmann P.

ACS Appl Mater Interfaces. 2018 Sep 19;10(37):31355-31365. doi: 10.1021/acsami.8b09894. Epub 2018 Sep 6.


Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.

Gross A, Pack LAP, Schacht GM, Kant S, Ungewiss H, Meir M, Schlegel N, Preisinger C, Boor P, Guldiken N, Krusche CA, Sellge G, Trautwein C, Waschke J, Heuser A, Leube RE, Strnad P.

Mucosal Immunol. 2018 Nov;11(6):1630-1639. doi: 10.1038/s41385-018-0062-z. Epub 2018 Aug 16.


Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion.

Ungewiß H, Rötzer V, Meir M, Fey C, Diefenbacher M, Schlegel N, Waschke J.

Cell Mol Life Sci. 2018 Nov;75(22):4251-4268. doi: 10.1007/s00018-018-2869-x. Epub 2018 Jul 6. Erratum in: Cell Mol Life Sci. 2019 Jul 10;:.


Analysis of ion beam teletherapy patient-specific quality assurance.

Liu X, Deng Y, Schlegel N, Huang Z, Moyers MF.

Med Dosim. 2019 Spring;44(1):43-50. doi: 10.1016/j.meddos.2018.01.002. Epub 2018 Mar 2.


Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase.

Ungewiß H, Vielmuth F, Suzuki ST, Maiser A, Harz H, Leonhardt H, Kugelmann D, Schlegel N, Waschke J.

Sci Rep. 2017 Jul 24;7(1):6329. doi: 10.1038/s41598-017-06713-y.


[Expectations of visceral surgeons from the results of clinical autopsies].

Schlegel N, Germer CT.

Pathologe. 2017 Sep;38(5):361-364. doi: 10.1007/s00292-017-0317-6. Review. German. No abstract available.


Sphingosine-1-Phosphate Receptor-1 Agonist Sew2871 Causes Severe Cardiac Side Effects and Does Not Improve Microvascular Barrier Breakdown in Sepsis.

Flemming S, Burkard N, Meir M, Schick MA, Germer CT, Schlegel N.

Shock. 2018 Jan;49(1):71-81. doi: 10.1097/SHK.0000000000000908.


[Phosphodiesterase 4 inhibition for treatment of endothelial barrier and microcirculation disorders in sepsis].

Wollborn J, Schlegel N, Schick MA.

Anaesthesist. 2017 May;66(5):347-352. doi: 10.1007/s00101-017-0305-5. Review. German.


Bleeding risk of surgery and its prevention in patients with inherited platelet disorders.

Orsini S, Noris P, Bury L, Heller PG, Santoro C, Kadir RA, Butta NC, Falcinelli E, Cid AR, Fabris F, Fouassier M, Miyazaki K, Lozano ML, Zúñiga P, Flaujac C, Podda GM, Bermejo N, Favier R, Henskens Y, De Maistre E, De Candia E, Mumford AD, Ozdemir GN, Eker I, Nurden P, Bayart S, Lambert MP, Bussel J, Zieger B, Tosetto A, Melazzini F, Glembotsky AC, Pecci A, Cattaneo M, Schlegel N, Gresele P; European Hematology Association - Scientific Working Group (EHA-SWG) on thrombocytopenias and platelet function disorders.

Haematologica. 2017 Jul;102(7):1192-1203. doi: 10.3324/haematol.2016.160754. Epub 2017 Apr 6.


[Updated definition of sepsis : Implications for diagnostics and therapy principles].

Schlegel N.

Chirurg. 2017 Jan;88(1):81-92. doi: 10.1007/s00104-016-0330-y. Review. German.


The glial cell-line derived neurotrophic factor: a novel regulator of intestinal barrier function in health and disease.

Meir M, Flemming S, Burkard N, Wagner J, Germer CT, Schlegel N.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1118-23. doi: 10.1152/ajpgi.00125.2016. Epub 2016 May 5. Review.


ANKRD26 normocytic thrombocytopenia: a family report.

Vincenot A, Hurtaud-Roux MF, René O, Binard S, Fenneteau O, Schlegel N.

Ann Biol Clin (Paris). 2016 Jun 1;74(3):317-22. doi: 10.1684/abc.2016.1142.


Gastric Bypass-Related Effects on Glucose Control, β Cell Function and Morphology in the Obese Zucker Rat.

Seyfried F, Miras AD, Rotzinger L, Nordbeck A, Corteville C, Li JV, Schlegel N, Hankir M, Fenske W, Otto C, Jurowich C.

Obes Surg. 2016 Jun;26(6):1228-36. doi: 10.1007/s11695-015-1882-5.


Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation.

Schick MA, Baar W, Bruno RR, Wollborn J, Held C, Schneider R, Flemming S, Schlegel N, Roewer N, Neuhaus W, Wunder C.

PLoS One. 2015 Sep 4;10(9):e0137247. doi: 10.1371/journal.pone.0137247. eCollection 2015.


Glial cell line-derived neurotrophic factor promotes barrier maturation and wound healing in intestinal epithelial cells in vitro.

Meir M, Flemming S, Burkard N, Bergauer L, Metzger M, Germer CT, Schlegel N.

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G613-24. doi: 10.1152/ajpgi.00357.2014. Epub 2015 Aug 20.


Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model.

Schick MA, Baar W, Flemming S, Schlegel N, Wollborn J, Held C, Schneider R, Brock RW, Roewer N, Wunder C.

Intensive Care Med Exp. 2014 Dec;2(1):34. doi: 10.1186/s40635-014-0034-x. Epub 2014 Dec 9.


Loss of Desmoglein 2 Contributes to the Pathogenesis of Crohn's Disease.

Spindler V, Meir M, Vigh B, Flemming S, Hütz K, Germer CT, Waschke J, Schlegel N.

Inflamm Bowel Dis. 2015 Oct;21(10):2349-59. doi: 10.1097/MIB.0000000000000486.


Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis.

Flemming S, Burkard N, Renschler M, Vielmuth F, Meir M, Schick MA, Wunder C, Germer CT, Spindler V, Waschke J, Schlegel N.

Cardiovasc Res. 2015 Jul 1;107(1):32-44. doi: 10.1093/cvr/cvv144. Epub 2015 May 14.


Sphincter-sparing intersphincteric rectal resection as an alternative to proctectomy in long-standing fistulizing and stenotic Crohn's proctitis?

Schlegel N, Kim M, Reibetanz J, Krajinovic K, Germer CT, Isbert C.

Int J Colorectal Dis. 2015 May;30(5):655-63. doi: 10.1007/s00384-015-2201-2. Epub 2015 Apr 8.


Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expression.

Wollborn J, Wunder C, Stix J, Neuhaus W, Bruno RR, Baar W, Flemming S, Roewer N, Schlegel N, Schick MA.

J Pharmacol Pharmacother. 2015 Jan-Mar;6(1):13-23. doi: 10.4103/0976-500X.149138.


[Late complications and functional disorders after rectal resection : Prevention, detection and therapy].

Reibetanz J, Kim M, Germer CT, Schlegel N.

Chirurg. 2015 Apr;86(4):326-31. doi: 10.1007/s00104-014-2851-6. Review. German.


Neurostimulated levator augmentation--a new approach in restoring continence.

Isbert C, Schlegel N, Reibetanz J, Krajinovic K, Schmidt K, Germer CT, Kim M.

Int J Colorectal Dis. 2015 Apr;30(4):505-12. doi: 10.1007/s00384-015-2134-9. Epub 2015 Feb 10.


Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia.

Schaefer N, Kluck CJ, Price KL, Meiselbach H, Vornberger N, Schwarzinger S, Hartmann S, Langlhofer G, Schulz S, Schlegel N, Brockmann K, Lynch B, Becker CM, Lummis SC, Villmann C.

J Neurosci. 2015 Jan 7;35(1):422-37. doi: 10.1523/JNEUROSCI.1509-14.2015.


E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.

Wiegering A, Korb D, Thalheimer A, Kämmerer U, Allmanritter J, Matthes N, Linnebacher M, Schlegel N, Klein I, Ergün S, Germer CT, Otto C.

Neoplasia. 2014 Nov 20;16(11):972-81. doi: 10.1016/j.neo.2014.09.008. eCollection 2014 Nov.


Multimodal therapy in treatment of rectal cancer is associated with improved survival and reduced local recurrence - a retrospective analysis over two decades.

Wiegering A, Isbert C, Dietz UA, Kunzmann V, Ackermann S, Kerscher A, Maeder U, Flentje M, Schlegel N, Reibetanz J, Germer CT, Klein I.

BMC Cancer. 2014 Nov 6;14:816. doi: 10.1186/1471-2407-14-816.


PI3K signalling is required for a TGFβ-induced epithelial-mesenchymal-like transition (EMT-like) in human melanoma cells.

Schlegel NC, von Planta A, Widmer DS, Dummer R, Christofori G.

Exp Dermatol. 2015 Jan;24(1):22-8. doi: 10.1111/exd.12580. Epub 2014 Nov 18.


Recurrence after perineal rectosigmoidectomy: when and why?

Kim M, Reibetanz J, Schlegel N, Krajinovic K, Köstler H, Germer CT, Isbert C.

Colorectal Dis. 2014 Nov;16(11):920-4. doi: 10.1111/codi.12756.


[Is a different view on the pathophysiology of sepsis the key for novel therapeutic options?].

Schlegel N, Flemming S, Meir M, Germer CT.

Chirurg. 2014 Aug;85(8):714-9. doi: 10.1007/s00104-014-2837-4. Review. German.


Mutation spectrum and genotype-phenotype correlations in a large French cohort of MYH9-Related Disorders.

Saposnik B, Binard S, Fenneteau O, Nurden A, Nurden P, Hurtaud-Roux MF, Schlegel N; French MYH9 networka.

Mol Genet Genomic Med. 2014 Jul;2(4):297-312. doi: 10.1002/mgg3.68. Epub 2014 Feb 7.


Cochlear implantation is safe and effective in patients with MYH9-related disease.

Pecci A, Verver EJ, Schlegel N, Canzi P, Boccio CM, Platokouki H, Krause E, Benazzo M, Topsakal V, Greinacher A.

Orphanet J Rare Dis. 2014 Jun 30;9:100. doi: 10.1186/1750-1172-9-100.


Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia.

Noris P, Schlegel N, Klersy C, Heller PG, Civaschi E, Pujol-Moix N, Fabris F, Favier R, Gresele P, Latger-Cannard V, Cuker A, Nurden P, Greinacher A, Cattaneo M, De Candia E, Pecci A, Hurtaud-Roux MF, Glembotsky AC, Muñiz-Diaz E, Randi ML, Trillot N, Bury L, Lecompte T, Marconi C, Savoia A, Balduini CL, Bayart S, Bauters A, Benabdallah-Guedira S, Boehlen F, Borg JY, Bottega R, Bussel J, De Rocco D, de Maistre E, Faleschini M, Falcinelli E, Ferrari S, Ferster A, Fierro T, Fleury D, Fontana P, James C, Lanza F, Le Cam Duchez V, Loffredo G, Magini P, Martin-Coignard D, Menard F, Mercier S, Mezzasoma A, Minuz P, Nichele I, Notarangelo LD, Pippucci T, Podda GM, Pouymayou C, Rigouzzo A, Royer B, Sie P, Siguret V, Trichet C, Tucci A, Saposnik B, Veneri D; European Hematology Association – Scientific Working Group on Thrombocytopenias and Platelet Function Disorders.

Haematologica. 2014 Aug;99(8):1387-94. doi: 10.3324/haematol.2014.105924. Epub 2014 Apr 24.


Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis.

Flemming S, Schlegel N, Wunder C, Meir M, Baar W, Wollborn J, Roewer N, Germer CT, Schick MA.

Shock. 2014 Jun;41(6):537-45. doi: 10.1097/SHK.0000000000000152.


cAMP with other signaling cues converges on Rac1 to stabilize the endothelial barrier- a signaling pathway compromised in inflammation.

Schlegel N, Waschke J.

Cell Tissue Res. 2014 Mar;355(3):587-96. doi: 10.1007/s00441-013-1755-y. Epub 2013 Dec 10. Review.


Influence of apneic oxygenation and minimal tidal volumes on ventilator-associated lung injury.

Johannes A, Kredel M, Zollhoefer B, Schlegel N, Von Kirschbaum C, Brederlau J, Kranke P, Roewer N, Muellenbach RM.

Minerva Anestesiol. 2014 May;80(5):526-36. Epub 2013 Nov 13.


The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.

Chen Y, Boukour S, Milloud R, Favier R, Saposnik B, Schlegel N, Nurden A, Raslova H, Vainchenker W, Balland M, Nurden P, Debili N.

J Thromb Haemost. 2013 Dec;11(12):2163-75. doi: 10.1111/jth.12436.


Lessons and challenges during a 5-year follow-up of 21 Composix Kugel implantations.

Wiegering A, Schlegel N, Isbert C, Jurowich C, Doht S, Germer CT, Dietz UA.

Hernia. 2013 Aug;17(4):435-43. doi: 10.1007/s10029-013-1096-5. Epub 2013 May 9.


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