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Items: 29


Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.

Schroeder MP, Bastian L, Eckert C, Gökbuget N, James AR, Tanchez JO, Schlee C, Isaakidis K, Häupl B, Baum K, Migueles Lozano OA, Kouidri K, Pan KT, Urlaub H, Schwartz S, Burmeister T, von Stackelberg A, Hoelzer D, Pfeiffer H, Rieger MA, Göllner S, Oellerich T, Horstman M, Schrappe M, Wolf J, Kirschner-Schwabe R, Brüggemann M, Müller-Tidow C, Serve H, Neumann M, Baldus CD.

Sci Rep. 2019 Mar 12;9(1):4188. doi: 10.1038/s41598-019-40786-1.


PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia.

Bastian L, Schroeder MP, Eckert C, Schlee C, Tanchez JO, Kämpf S, Wagner DL, Schulze V, Isaakidis K, Lázaro-Navarro J, Hänzelmann S, James AR, Ekici A, Burmeister T, Schwartz S, Schrappe M, Horstmann M, Vosberg S, Krebs S, Blum H, Hecht J, Greif PA, Rieger MA, Brüggemann M, Gökbuget N, Neumann M, Baldus CD.

Leukemia. 2019 Mar 6. doi: 10.1038/s41375-019-0430-z. [Epub ahead of print]


Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.

James AR, Schroeder MP, Neumann M, Bastian L, Eckert C, Gökbuget N, Tanchez JO, Schlee C, Isaakidis K, Schwartz S, Burmeister T, von Stackelberg A, Rieger MA, Göllner S, Horstman M, Schrappe M, Kirschner-Schwabe R, Brüggemann M, Müller-Tidow C, Serve H, Akalin A, Baldus CD.

J Hematol Oncol. 2019 Jan 14;12(1):8. doi: 10.1186/s13045-018-0692-3.


Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape.

Silva P, Neumann M, Schroeder MP, Vosberg S, Schlee C, Isaakidis K, Ortiz-Tanchez J, Fransecky LR, Hartung T, Türkmen S, Graf A, Krebs S, Blum H, Müller-Tidow C, Thiede C, Ehninger G, Serve H, Hecht J, Berdel WE, Greif PA, Röllig C, Baldus CD.

Leukemia. 2017 Jul;31(7):1640-1644. doi: 10.1038/leu.2017.109. Epub 2017 Apr 3. No abstract available.


Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients.

von der Heide EK, Neumann M, Vosberg S, James AR, Schroeder MP, Ortiz-Tanchez J, Isaakidis K, Schlee C, Luther M, Jöhrens K, Anagnostopoulos I, Mochmann LH, Nowak D, Hofmann WK, Greif PA, Baldus CD.

Leukemia. 2017 May;31(5):1069-1078. doi: 10.1038/leu.2016.324. Epub 2016 Nov 11.


Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL.

Fransecky L, Neumann M, Heesch S, Schlee C, Ortiz-Tanchez J, Heller S, Mossner M, Schwartz S, Mochmann LH, Isaakidis K, Bastian L, Kees UR, Herold T, Spiekermann K, Gökbuget N, Baldus CD.

J Hematol Oncol. 2016 Sep 22;9(1):95.


Inhibition of IGF1-R overcomes IGFBP7-induced chemotherapy resistance in T-ALL.

Bartram I, Erben U, Ortiz-Tanchez J, Blunert K, Schlee C, Neumann M, Heesch S, Baldus CD.

BMC Cancer. 2015 Oct 8;15:663. doi: 10.1186/s12885-015-1677-z.


Mutational spectrum of adult T-ALL.

Neumann M, Vosberg S, Schlee C, Heesch S, Schwartz S, Gökbuget N, Hoelzer D, Graf A, Krebs S, Bartram I, Blum H, Brüggemann M, Hecht J, Bohlander SK, Greif PA, Baldus CD.

Oncotarget. 2015 Feb 20;6(5):2754-66.


Chemical analysis and risk assessment of prohibited colouring agents in face paint with special regard to CI 15585 (D&C Red No. 9, Pigment Red 53:1).

Keck-Wilhelm A, Kratz E, Mildau G, Ilse M, Schlee C, Lachenmeier DW.

Int J Cosmet Sci. 2015 Apr;37(2):187-95. doi: 10.1111/ics.12181. Epub 2014 Dec 29.


Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients.

Bartram I, Gökbuget N, Schlee C, Heesch S, Fransecky L, Schwartz S, Stuhlmann R, Schäfer-Eckhart K, Starck M, Reichle A, Hoelzer D, Baldus CD, Neumann M.

J Hematol Oncol. 2014 Jul 15;7:51. doi: 10.1186/s13045-014-0051-y.


FAT1 expression and mutations in adult acute lymphoblastic leukemia.

Neumann M, Seehawer M, Schlee C, Vosberg S, Heesch S, von der Heide EK, Graf A, Krebs S, Blum H, Gökbuget N, Schwartz S, Hoelzer D, Greif PA, Baldus CD.

Blood Cancer J. 2014 Jun 27;4:e224. doi: 10.1038/bcj.2014.44. No abstract available.


Prevention of hemolytic uremic syndrome with daily bowel lavage in patients with Shiga toxin-producing enterohemorrhagic Escherichia coli O104:H4 infection.

Lüth S, Fründt TW, Rösch T, Schlee C, Lohse AW.

JAMA Intern Med. 2014 Jun;174(6):1003-5. doi: 10.1001/jamainternmed.2014.1175. No abstract available.


Composition of distilled Perique tobacco liqueur: a connoisseur's spirit or a health risk due to nicotine?

Lachenmeier DW, Breaux TA, Kuballa T, Schlee C, Monakhova YB.

Food Chem. 2014 Sep 15;159:230-5. doi: 10.1016/j.foodchem.2014.02.152. Epub 2014 Mar 10.


Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.

Neumann M, Heesch S, Schlee C, Schwartz S, Gökbuget N, Hoelzer D, Konstandin NP, Ksienzyk B, Vosberg S, Graf A, Krebs S, Blum H, Raff T, Brüggemann M, Hofmann WK, Hecht J, Bohlander SK, Greif PA, Baldus CD.

Blood. 2013 Jun 6;121(23):4749-52. doi: 10.1182/blood-2012-11-465138. Epub 2013 Apr 19.


MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia.

Coskun E, Neumann M, Schlee C, Liebertz F, Heesch S, Goekbuget N, Hoelzer D, Baldus CD.

Leuk Res. 2013 Jun;37(6):647-56. doi: 10.1016/j.leukres.2013.02.019. Epub 2013 Mar 20.


Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization.

Heesch S, Neumann M, Schwartz S, Bartram I, Schlee C, Burmeister T, Hänel M, Ganser A, Heuser M, Wendtner CM, Berdel WE, Gökbuget N, Hoelzer D, Hofmann WK, Thiel E, Baldus CD.

Ann Hematol. 2013 Jun;92(6):747-58. doi: 10.1007/s00277-013-1694-4. Epub 2013 Feb 15.


FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors.

Neumann M, Coskun E, Fransecky L, Mochmann LH, Bartram I, Sartangi NF, Heesch S, Gökbuget N, Schwartz S, Brandts C, Schlee C, Haas R, Dührsen U, Griesshammer M, Döhner H, Ehninger G, Burmeister T, Blau O, Thiel E, Hoelzer D, Hofmann WK, Baldus CD.

PLoS One. 2013;8(1):e53190. doi: 10.1371/journal.pone.0053190. Epub 2013 Jan 24.


ERG transcriptional networks in primary acute leukemia cells implicate a role for ERG in deregulated kinase signaling.

Bock J, Mochmann LH, Schlee C, Farhadi-Sartangi N, Göllner S, Müller-Tidow C, Baldus CD.

PLoS One. 2013;8(1):e52872. doi: 10.1371/journal.pone.0052872. Epub 2013 Jan 3.


Determination of 2-methylimidazole, 4-methylimidazole and 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole in caramel colours and cola using LC/MS/MS.

Schlee C, Markova M, Schrank J, Laplagne F, Schneider R, Lachenmeier DW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 15;927:223-6. doi: 10.1016/j.jchromb.2012.10.021. Epub 2012 Oct 23.


Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations.

Neumann M, Heesch S, Gökbuget N, Schwartz S, Schlee C, Benlasfer O, Farhadi-Sartangi N, Thibaut J, Burmeister T, Hoelzer D, Hofmann WK, Thiel E, Baldus CD.

Blood Cancer J. 2012 Jan;2(1):e55. doi: 10.1038/bcj.2011.49. Epub 2012 Jan 27.


Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia.

Kaiser M, Kühnl A, Reins J, Fischer S, Ortiz-Tanchez J, Schlee C, Mochmann LH, Heesch S, Benlasfer O, Hofmann WK, Thiel E, Baldus CD.

Blood Cancer J. 2011 Jul;1(7):e28. doi: 10.1038/bcj.2011.28. Epub 2011 Jul 15.


Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia.

Kühnl A, Gökbuget N, Kaiser M, Schlee C, Stroux A, Burmeister T, Mochmann LH, Hoelzer D, Hofmann WK, Thiel E, Baldus CD.

Blood. 2011 Dec 8;118(24):6362-7. doi: 10.1182/blood-2011-04-350850. Epub 2011 Oct 18.


Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG.

Mochmann LH, Bock J, Ortiz-Tánchez J, Schlee C, Bohne A, Neumann K, Hofmann WK, Thiel E, Baldus CD.

Oncogene. 2011 Apr 28;30(17):2044-56. doi: 10.1038/onc.2010.582. Epub 2011 Jan 17.


Expression of IGFBP7 in acute leukemia is regulated by DNA methylation.

Heesch S, Bartram I, Neumann M, Reins J, Mossner M, Schlee C, Stroux A, Haferlach T, Goekbuget N, Hoelzer D, Hofmann WK, Thiel E, Baldus CD.

Cancer Sci. 2011 Jan;102(1):253-9. doi: 10.1111/j.1349-7006.2010.01760.x. Epub 2010 Oct 29.


The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia.

Coskun E, von der Heide EK, Schlee C, Kühnl A, Gökbuget N, Hoelzer D, Hofmann WK, Thiel E, Baldus CD.

Leuk Res. 2011 Feb;35(2):208-13. doi: 10.1016/j.leukres.2010.05.007. Epub 2010 Jun 8.


BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia.

Heesch S, Schlee C, Neumann M, Stroux A, Kühnl A, Schwartz S, Haferlach T, Goekbuget N, Hoelzer D, Thiel E, Hofmann WK, Baldus CD.

Leukemia. 2010 Aug;24(8):1429-36. doi: 10.1038/leu.2010.130. Epub 2010 Jun 10.


Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia.

Heesch S, Goekbuget N, Stroux A, Tanchez JO, Schlee C, Burmeister T, Schwartz S, Blau O, Keilholz U, Busse A, Hoelzer D, Thiel E, Hofmann WK, Baldus CD.

Haematologica. 2010 Jun;95(6):942-9. doi: 10.3324/haematol.2009.016386. Epub 2010 Apr 30.


Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia.

Baldus CD, Thibaut J, Goekbuget N, Stroux A, Schlee C, Mossner M, Burmeister T, Schwartz S, Bloomfield CD, Hoelzer D, Thiel E, Hofmann WK.

Haematologica. 2009 Oct;94(10):1383-90. doi: 10.3324/haematol.2008.005272.


Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia.

Bohne A, Schlee C, Mossner M, Thibaut J, Heesch S, Thiel E, Hofmann WK, Baldus CD.

Leuk Res. 2009 Jun;33(6):817-22. doi: 10.1016/j.leukres.2008.11.012. Epub 2008 Dec 23.


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