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A Rare Mutation in SPLUNC1 Affects Bacterial Adherence and Invasion in Meningococcal Disease.

Mashbat B, Bellos E, Hodeib S, Bidmos F, Thwaites RS, Lu Y, Wright VJ, Herberg JA, Klobassa DS, Zenz W, Hansel TT, Nadel S, Langford PR, Schlapbach LJ, Li MS, Redinbo MR, Di YP, Levin M, Sancho-Shimizu V; European Union Childhood Life-Threatening Infectious Disease Study (EUCLIDS) Consortium.

Clin Infect Dis. 2019 Jul 1. pii: ciz600. doi: 10.1093/cid/ciz600. [Epub ahead of print]


Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis.

Achten NB, Klingenberg C, Benitz WE, Stocker M, Schlapbach LJ, Giannoni E, Bokelaar R, Driessen GJA, Brodin P, Uthaya S, van Rossum AMC, Plötz FB.

JAMA Pediatr. 2019 Sep 3. doi: 10.1001/jamapediatrics.2019.2825. [Epub ahead of print]


Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial.

Schlapbach LJ, Horton SB, Long DA, Beca J, Erickson S, Festa M, d'Udekem Y, Alphonso N, Winlaw D, Johnson K, Delzoppo C, van Loon K, Gannon B, Fooken J, Blumenthal A, Young P, Jones M, Butt W, Schibler A; NITRIC Study Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG), the Paediatric Critical Care Research group (PCCRG) and the ANZICS Paediatric Study Group (PSG).

BMJ Open. 2019 Aug 15;9(8):e026664. doi: 10.1136/bmjopen-2018-026664.


Paediatric sepsis.

Schlapbach LJ.

Curr Opin Infect Dis. 2019 Oct;32(5):497-504. doi: 10.1097/QCO.0000000000000583.


The WHO resolution on sepsis: what action is needed in Australia?

Schlapbach LJ, Thompson K, Finfer SR.

Med J Aust. 2019 Jul 22. doi: 10.5694/mja2.50279. [Epub ahead of print] No abstract available.


Epidemiology of childhood death in Australian and New Zealand intensive care units.

Moynihan KM, Alexander PMA, Schlapbach LJ, Millar J, Jacobe S, Ravindranathan H, Croston EJ, Staffa SJ, Burns JP, Gelbart B; Australian and New Zealand Intensive Care Society Pediatric Study Group (ANZICS PSG) and the ANZICS Centre for Outcome and Resource Evaluation (ANZICS CORE).

Intensive Care Med. 2019 Sep;45(9):1262-1271. doi: 10.1007/s00134-019-05675-1. Epub 2019 Jul 3.


Translational gap in pediatric septic shock management: an ESPNIC perspective.

Morin L, Kneyber M, Jansen NJG, Peters MJ, Javouhey E, Nadel S, Maclaren G, Schlapbach LJ, Tissieres P; ESPNIC Refractory Septic Shock Definition taskforce and the Infection, Systemic Inflammation and Sepsis ESPNIC section.

Ann Intensive Care. 2019 Jun 28;9(1):73. doi: 10.1186/s13613-019-0545-4.


Insertion, management, and complications associated with arterial catheters in paediatric intensive care: A clinical audit.

Schults JA, Long D, Pearson K, Takashima M, Baveas T, Schlapbach LJ, Macfarlane F, Ullman AJ.

Aust Crit Care. 2019 Jun 11. pii: S1036-7314(18)30349-7. doi: 10.1016/j.aucc.2019.05.003. [Epub ahead of print]


Attitudes of Australian health professionals towards rapid genomic testing in neonatal and paediatric intensive care.

Stark Z, Nisselle A, McClaren B, Lynch F, Best S, Long JC, Martyn M, Patel C, Schlapbach LJ, Barnett C, Theda C, Pinner J, Dinger ME, Lunke S, Gaff CL.

Eur J Hum Genet. 2019 Oct;27(10):1493-1501. doi: 10.1038/s41431-019-0429-y. Epub 2019 May 31.


Infections on Extracorporeal Life Support in Adults and Children-A Survey of International Practice on Prevention, Diagnosis, and Treatment.

Farrell D, MacLaren G, Schlapbach LJ.

Pediatr Crit Care Med. 2019 Jul;20(7):667-671. doi: 10.1097/PCC.0000000000001941.


The Role of Parental Concerns in the Recognition of Sepsis in Children: A Literature Review.

Harley A, Latour JM, Schlapbach LJ.

Front Pediatr. 2019 May 3;7:161. doi: 10.3389/fped.2019.00161. eCollection 2019.


Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

Borghini L, Png E, Binder A, Wright VJ, Pinnock E, de Groot R, Hazelzet J, Emonts M, Van der Flier M, Schlapbach LJ, Anderson S, Secka F, Salas A, Fink C, Carrol ED, Pollard AJ, Coin LJ, Kuijpers TW, Martinon-Torres F, Zenz W, Levin M, Hibberd ML, Davila S; EUCLIDS consortium.

Sci Rep. 2019 May 6;9(1):6966. doi: 10.1038/s41598-019-43292-6.


Transforming Data Into a Crystal Ball-Predicting Outcomes After Extracorporeal Membrane Oxygenation.

MacLaren G, Cho HJ, Schlapbach LJ.

Pediatr Crit Care Med. 2019 May;20(5):490-491. doi: 10.1097/PCC.0000000000001910. No abstract available.


Reducing Collateral Damage From Mandates for Time to Antibiotics in Pediatric Sepsis-Primum Non Nocere.

Schlapbach LJ, Weiss SL, Wolf J.

JAMA Pediatr. 2019 May 1;173(5):409-410. doi: 10.1001/jamapediatrics.2019.0174. No abstract available.


Global paediatric critical care research: mind the gaps.

Schlapbach LJ, Gelbart B, Festa M; Australian & New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG), Kanthimathinathan HK, Peters MJ.

Intensive Care Med. 2019 May;45(5):753-754. doi: 10.1007/s00134-019-05571-8. Epub 2019 Mar 6. No abstract available.


Applying Sepsis-3 Criteria for Septic Shock to Children-Not As Shocking As at First Sight?

Schlapbach LJ, Argent A.

Pediatr Crit Care Med. 2019 Mar;20(3):299-300. doi: 10.1097/PCC.0000000000001884. No abstract available.


Transnasal Humidified Rapid Insufflation Ventilatory Exchange in children requiring emergent intubation (Kids THRIVE): a protocol for a randomised controlled trial.

George S, Humphreys S, Williams T, Gelbart B, Chavan A, Rasmussen K, Ganeshalingham A, Erickson S, Ganu SS, Singhal N, Foster K, Gannon B, Gibbons K, Schlapbach LJ, Festa M, Dalziel S, Schibler A; Paediatric Critical Care Research Group (PCCRG), Paediatric Research in Emergency Departments International Collaborative (PREDICT) and the Australia and New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG).

BMJ Open. 2019 Feb 20;9(2):e025997. doi: 10.1136/bmjopen-2018-025997.


Sepsis: Changing Definitions, Unchanging Treatment.

Obonyo NG, Schlapbach LJ, Fraser JF.

Front Pediatr. 2019 Jan 23;6:425. doi: 10.3389/fped.2018.00425. eCollection 2018.


Paediatric intensive care admissions during the 2015-2016 Queensland human parechovirus outbreak.

McKenna R, Joseph L, Sargent P, May M, Tozer S, Bialasiewicz S, Heney C, Schlapbach LJ, Clark JE.

J Paediatr Child Health. 2019 Aug;55(8):968-974. doi: 10.1111/jpc.14336. Epub 2019 Jan 24.


Burden of Streptococcus pneumoniae sepsis in children after introduction of pneumococcal conjugate vaccines - a prospective population-based cohort study.

Asner SA, Agyeman PKA, Gradoux E, Posfay-Barbe KM, Heininger U, Giannoni E, Crisinel PA, Stocker M, Bernhard-Stirnemann S, Niederer-Loher A, Kahlert CR, Hasters P, Relly C, Baer W, Aebi C, Schlapbach LJ, Berger C; Swiss Paediatric Sepsis Study group.

Clin Infect Dis. 2019 Jan 2. doi: 10.1093/cid/ciy1139. [Epub ahead of print]


Viral Respiratory Infections Diagnosed After PICU Admission.

Moynihan KM, Barlow A, Heney C, Clark JE, Schlebusch S, Schlapbach LJ.

Pediatr Crit Care Med. 2019 Jan;20(1):e46-e50. doi: 10.1097/PCC.0000000000001757.


Prolonged Postoperative Vasoplegia in Pediatric Patients on Chronic Angiotensin II Blocker Treatment.

Pandya NR, Alphonso N, Tu Q, Venugopal P, Schlapbach LJ.

Front Cardiovasc Med. 2018 Sep 4;5:121. doi: 10.3389/fcvm.2018.00121. eCollection 2018.


Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study.

Martinón-Torres F, Salas A, Rivero-Calle I, Cebey-López M, Pardo-Seco J, Herberg JA, Boeddha NP, Klobassa DS, Secka F, Paulus S, de Groot R, Schlapbach LJ, Driessen GJ, Anderson ST, Emonts M, Zenz W, Carrol ED, Van der Flier M, Levin M; EUCLIDS Consortium.

Lancet Child Adolesc Health. 2018 Jun;2(6):404-414. doi: 10.1016/S2352-4642(18)30113-5. Epub 2018 Apr 28.


Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study.

Agyeman PKA, Schlapbach LJ, Giannoni E, Stocker M, Posfay-Barbe KM, Heininger U, Schindler M, Korten I, Konetzny G, Niederer-Loher A, Kahlert CR, Donas A, Leone A, Hasters P, Relly C, Baer W, Kuehni CE, Aebi C, Berger C; Swiss Pediatric Sepsis Study.

Lancet Child Adolesc Health. 2017 Oct;1(2):124-133. doi: 10.1016/S2352-4642(17)30010-X. Epub 2017 Jul 21.


Time-to-Positivity of Blood Cultures in Children With Sepsis.

Dierig A, Berger C, Agyeman PKA, Bernhard-Stirnemann S, Giannoni E, Stocker M, Posfay-Barbe KM, Niederer-Loher A, Kahlert CR, Donas A, Hasters P, Relly C, Riedel T, Aebi C, Schlapbach LJ, Heininger U; Swiss Pediatric Sepsis Study.

Front Pediatr. 2018 Aug 8;6:222. doi: 10.3389/fped.2018.00222. eCollection 2018.


Neonatal Sepsis of Early Onset, and Hospital-Acquired and Community-Acquired Late Onset: A Prospective Population-Based Cohort Study.

Giannoni E, Agyeman PKA, Stocker M, Posfay-Barbe KM, Heininger U, Spycher BD, Bernhard-Stirnemann S, Niederer-Loher A, Kahlert CR, Donas A, Leone A, Hasters P, Relly C, Riedel T, Kuehni C, Aebi C, Berger C, Schlapbach LJ; Swiss Pediatric Sepsis Study.

J Pediatr. 2018 Oct;201:106-114.e4. doi: 10.1016/j.jpeds.2018.05.048. Epub 2018 Jul 24.


Postoperative catecholamine resistance following fetal methamphetamine exposure.

Perumal G, Marathe SP, Schlapbach LJ, Morwood J, Venugopal P, Alphonso N.

Asian Cardiovasc Thorac Ann. 2019 Jan;27(1):30-32. doi: 10.1177/0218492318784740. Epub 2018 Jun 22.


Severe Mycoplasma Pneumoniae Infection in Children Admitted to Pediatric Intensive Care.

Moynihan KM, Barlow A, Nourse C, Heney C, Schlebusch S, Schlapbach LJ.

Pediatr Infect Dis J. 2018 Dec;37(12):e336-e338. doi: 10.1097/INF.0000000000002029.


SIRS in the Time of Sepsis-3: What About the Children?

Schlapbach LJ, Berger C, Aebi C, Agyeman PKA; Swiss Pediatric Sepsis Study.

Chest. 2018 Jun;153(6):1512. doi: 10.1016/j.chest.2018.02.037. No abstract available.


Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS).

Boeddha NP, Schlapbach LJ, Driessen GJ, Herberg JA, Rivero-Calle I, Cebey-López M, Klobassa DS, Philipsen R, de Groot R, Inwald DP, Nadel S, Paulus S, Pinnock E, Secka F, Anderson ST, Agbeko RS, Berger C, Fink CG, Carrol ED, Zenz W, Levin M, van der Flier M, Martinón-Torres F, Hazelzet JA, Emonts M; EUCLIDS consortium.

Crit Care. 2018 May 31;22(1):143. doi: 10.1186/s13054-018-2052-7.


Evaluation of a paediatric clinical ethics service.

Jansen MA, Schlapbach LJ, Irving H.

J Paediatr Child Health. 2018 Nov;54(11):1199-1205. doi: 10.1111/jpc.13933. Epub 2018 May 10.


Paediatric sequential organ failure assessment score (pSOFA): a plea for the world-wide collaboration for consensus.

Kawasaki T, Shime N, Straney L, Bellomo R, MacLaren G, Pilcher D, Schlapbach LJ.

Intensive Care Med. 2018 Jun;44(6):995-997. doi: 10.1007/s00134-018-5188-7. Epub 2018 Apr 27. No abstract available.


Which organ dysfunction scores to use in children with infection?

Leclerc F, Duhamel A, Leteurtre S, Straney L, Bellomo R, MacLaren G, Pilcher D, Schlapbach LJ.

Intensive Care Med. 2018 May;44(5):697-698. doi: 10.1007/s00134-018-5123-y. Epub 2018 Mar 22. No abstract available.


A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis.

Franklin D, Babl FE, Schlapbach LJ, Oakley E, Craig S, Neutze J, Furyk J, Fraser JF, Jones M, Whitty JA, Dalziel SR, Schibler A.

N Engl J Med. 2018 Mar 22;378(12):1121-1131. doi: 10.1056/NEJMoa1714855.


The global burden of paediatric and neonatal sepsis: a systematic review.

Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N.

Lancet Respir Med. 2018 Mar;6(3):223-230. doi: 10.1016/S2213-2600(18)30063-8. Review.


Defining Pediatric Sepsis.

Schlapbach LJ, Kissoon N.

JAMA Pediatr. 2018 Apr 1;172(4):312-314. doi: 10.1001/jamapediatrics.2017.5208. No abstract available.


Extracorporeal Membrane Oxygenation for Pertussis: Predictors of Outcome Including Pulmonary Hypertension and Leukodepletion.

Domico M, Ridout D, MacLaren G, Barbaro R, Annich G, Schlapbach LJ, Brown KL.

Pediatr Crit Care Med. 2018 Mar;19(3):254-261. doi: 10.1097/PCC.0000000000001454.


Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit.

Schlapbach LJ, Straney L, Bellomo R, MacLaren G, Pilcher D.

Intensive Care Med. 2018 Feb;44(2):179-188. doi: 10.1007/s00134-017-5021-8. Epub 2017 Dec 19.


Lemierre's syndrome, necrotizing pneumonia and staphylococcal septic shock treated with extracorporeal life support.

Mattke AC, Prabhu S, Clark J, Labrom R, Burns H, Schlapbach LJ.

SAGE Open Med Case Rep. 2017 Aug 1;5:2050313X17722726. doi: 10.1177/2050313X17722726. eCollection 2017.


Time for Sepsis-3 in Children?

Schlapbach LJ.

Pediatr Crit Care Med. 2017 Aug;18(8):805-806. doi: 10.1097/PCC.0000000000001203. No abstract available.


Severe viral respiratory infections in children with IFIH1 loss-of-function mutations.

Asgari S, Schlapbach LJ, Anchisi S, Hammer C, Bartha I, Junier T, Mottet-Osman G, Posfay-Barbe KM, Longchamp D, Stocker M, Cordey S, Kaiser L, Riedel T, Kenna T, Long D, Schibler A, Telenti A, Tapparel C, McLaren PJ, Garcin D, Fellay J.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8342-8347. doi: 10.1073/pnas.1704259114. Epub 2017 Jul 17.


Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns).

Stocker M, van Herk W, El Helou S, Dutta S, Fontana MS, Schuerman FABA, van den Tooren-de Groot RK, Wieringa JW, Janota J, van der Meer-Kappelle LH, Moonen R, Sie SD, de Vries E, Donker AE, Zimmerman U, Schlapbach LJ, de Mol AC, Hoffman-Haringsma A, Roy M, Tomaske M, Kornelisse RF, van Gijsel J, Visser EG, Willemsen SP, van Rossum AMC; NeoPInS Study Group.

Lancet. 2017 Aug 26;390(10097):871-881. doi: 10.1016/S0140-6736(17)31444-7. Epub 2017 Jul 12.


The excess burden of severe sepsis in Indigenous Australian children: can anything be done?

Schlapbach LJ, Ostrowski JA, MacLaren G.

Med J Aust. 2017 Jul 3;207(1):45-46. No abstract available.


Venous vs Arterial Lactate and 30-Day Mortality in Pediatric Sepsis.

Schlapbach LJ, MacLaren G, Straney L.

JAMA Pediatr. 2017 Aug 1;171(8):813. doi: 10.1001/jamapediatrics.2017.1598. No abstract available.


Burden of disease and change in practice in critically ill infants with bronchiolitis.

Schlapbach LJ, Straney L, Gelbart B, Alexander J, Franklin D, Beca J, Whitty JA, Ganu S, Wilkins B, Slater A, Croston E, Erickson S, Schibler A; Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and the Australian & New Zealand Intensive Care Society (ANZICS) Paediatric Study Group.

Eur Respir J. 2017 Jun 1;49(6). pii: 1601648. doi: 10.1183/13993003.01648-2016. Print 2017 Jun.


Paediatric sepsis: old wine in new bottles?

Schlapbach LJ, Javouhey E, Jansen NJG.

Intensive Care Med. 2017 Nov;43(11):1686-1689. doi: 10.1007/s00134-017-4800-6. Epub 2017 Apr 22. No abstract available.


Low L-Ficolin associated with disease severity during sepsis in adult ICU patients.

Kessler U, Schlapbach LJ, Klimek P, Jakob SM.

Liver Int. 2017 Sep;37(9):1409. doi: 10.1111/liv.13448. Epub 2017 May 4. No abstract available.


Prediction of pediatric sepsis mortality within 1 h of intensive care admission.

Schlapbach LJ, MacLaren G, Festa M, Alexander J, Erickson S, Beca J, Slater A, Schibler A, Pilcher D, Millar J, Straney L; Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and Australian & New Zealand Intensive Care Society (ANZICS) Paediatric Study Group.

Intensive Care Med. 2017 Aug;43(8):1085-1096. doi: 10.1007/s00134-017-4701-8. Epub 2017 Feb 20.


Plasma Levels of Macrophage Migration Inhibitory Factor and d-Dopachrome Tautomerase Show a Highly Specific Profile in Early Life.

Roger T, Schlapbach LJ, Schneider A, Weier M, Wellmann S, Marquis P, Vermijlen D, Sweep FC, Leng L, Bucala R, Calandra T, Giannoni E.

Front Immunol. 2017 Jan 25;8:26. doi: 10.3389/fimmu.2017.00026. eCollection 2017.


The burden of invasive infections in critically ill Indigenous children in Australia.

Ostrowski JA, MacLaren G, Alexander J, Stewart P, Gune S, Francis JR, Ganu S, Festa M, Erickson SJ, Straney L, Schlapbach LJ.

Med J Aust. 2017 Feb 6;206(2):78-84.


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