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Items: 11


Vascular endothelial cells evade complement-mediated membrane injury via Weibel-Palade body mobilization.

Riedl Khursigara M, Schlam D, Noone DG, Bruno V, Ortiz Sandoval CG, Pluthero FG, Kahr WHA, Bowman ML, James P, Grinstein S, Licht C.

J Thromb Haemost. 2020 Feb 19. doi: 10.1111/jth.14767. [Epub ahead of print]


Screening for Rho GTPase Modulators in Actin-Dependent Processes Exemplified by Phagocytosis.

Schlam D, Grinstein S, Freeman SA.

Methods Mol Biol. 2018;1821:107-127. doi: 10.1007/978-1-4939-8612-5_8.


Every day I'm rufflin': Calcium sensing and actin dynamics in the growth factor-independent membrane ruffling of professional phagocytes.

Schlam D, Canton J.

Small GTPases. 2017 Apr 3;8(2):65-70. doi: 10.1080/21541248.2016.1197873. Epub 2016 Jun 7. Review.


Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.

Canton J, Schlam D, Breuer C, Gütschow M, Glogauer M, Grinstein S.

Nat Commun. 2016 Apr 6;7:11284. doi: 10.1038/ncomms11284.


Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis.

Schlam D, Canton J, Carreño M, Kopinski H, Freeman SA, Grinstein S, Fairn GD.

mBio. 2016 Apr 5;7(2):e02242. doi: 10.1128/mBio.02242-15.


Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation.

Wong HS, Jaumouillé V, Freeman SA, Doodnauth SA, Schlam D, Canton J, Mukovozov IM, Saric A, Grinstein S, Robinson LA.

Cell Rep. 2016 Mar 29;14(12):2859-71. doi: 10.1016/j.celrep.2016.02.071. Epub 2016 Mar 17.


Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.

Schlam D, Bagshaw RD, Freeman SA, Collins RF, Pawson T, Fairn GD, Grinstein S.

Nat Commun. 2015 Oct 14;6:8623. doi: 10.1038/ncomms9623.


Phosphoinositides in phagocytosis and macropinocytosis.

Levin R, Grinstein S, Schlam D.

Biochim Biophys Acta. 2015 Jun;1851(6):805-23. doi: 10.1016/j.bbalip.2014.09.005. Epub 2014 Sep 16. Review.


Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec4 to endomembranes.

Mukherjee D, Sen A, Boettner DR, Fairn GD, Schlam D, Bonilla Valentin FJ, Michael McCaffery J, Hazbun T, Staiger CJ, Grinstein S, Lemmon SK, Claudio Aguilar R.

J Cell Sci. 2013 Oct 15;126(Pt 20):4560-71. doi: 10.1242/jcs.117663. Epub 2013 Aug 13.


Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation.

Schlam D, Bohdanowicz M, Chatgilialoglu A, Steinberg BE, Ueyama T, Du G, Grinstein S, Fairn GD.

J Biol Chem. 2013 Aug 9;288(32):23090-104. doi: 10.1074/jbc.M113.457606. Epub 2013 Jun 27. Erratum in: J Biol Chem. 2014 Feb 21;289(8):4813. Chatilialoglu, Alexandros [corrected to Chatgilialoglu, Alexandros].


Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes.

Bohdanowicz M, Schlam D, Hermansson M, Rizzuti D, Fairn GD, Ueyama T, Somerharju P, Du G, Grinstein S.

Mol Biol Cell. 2013 Jun;24(11):1700-12, S1-7. doi: 10.1091/mbc.E12-11-0789. Epub 2013 Apr 10.

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