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Items: 38

1.

mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5.

Hauser S, Poenisch M, Schelling Y, Höflinger P, Schuster S, Teegler A, Betten R, Gustafsson JÅ, Hübener-Schmid J, Schlake T, Chevessier-Tünnesen F, Horscroft N, Björkhem I, Schöls L.

Mol Ther Methods Clin Dev. 2019 Oct 31;15:359-370. doi: 10.1016/j.omtm.2019.10.011. eCollection 2019 Dec 13.

2.

mRNA: A Novel Avenue to Antibody Therapy?

Schlake T, Thran M, Fiedler K, Heidenreich R, Petsch B, Fotin-Mleczek M.

Mol Ther. 2019 Apr 10;27(4):773-784. doi: 10.1016/j.ymthe.2019.03.002. Epub 2019 Mar 6. Review.

PMID:
30885573
3.

mRNA as novel technology for passive immunotherapy.

Schlake T, Thess A, Thran M, Jordan I.

Cell Mol Life Sci. 2019 Jan;76(2):301-328. doi: 10.1007/s00018-018-2935-4. Epub 2018 Oct 17. Review.

4.

mRNA mediates passive vaccination against infectious agents, toxins, and tumors.

Thran M, Mukherjee J, Pönisch M, Fiedler K, Thess A, Mui BL, Hope MJ, Tam YK, Horscroft N, Heidenreich R, Fotin-Mleczek M, Shoemaker CB, Schlake T.

EMBO Mol Med. 2017 Oct;9(10):1434-1447. doi: 10.15252/emmm.201707678.

5.

RNActive® Technology: Generation and Testing of Stable and Immunogenic mRNA Vaccines.

Rauch S, Lutz J, Kowalczyk A, Schlake T, Heidenreich R.

Methods Mol Biol. 2017;1499:89-107.

PMID:
27987144
6.

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals.

Thess A, Grund S, Mui BL, Hope MJ, Baumhof P, Fotin-Mleczek M, Schlake T.

Mol Ther. 2015 Sep;23(9):1456-64. doi: 10.1038/mt.2015.103. Epub 2015 Jun 8.

7.

A novel, disruptive vaccination technology: self-adjuvanted RNActive(®) vaccines.

Kallen KJ, Heidenreich R, Schnee M, Petsch B, Schlake T, Thess A, Baumhof P, Scheel B, Koch SD, Fotin-Mleczek M.

Hum Vaccin Immunother. 2013 Oct;9(10):2263-76. doi: 10.4161/hv.25181. Epub 2013 Jun 4. Review.

8.

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection.

Petsch B, Schnee M, Vogel AB, Lange E, Hoffmann B, Voss D, Schlake T, Thess A, Kallen KJ, Stitz L, Kramps T.

Nat Biotechnol. 2012 Dec;30(12):1210-6. doi: 10.1038/nbt.2436. Epub 2012 Nov 25.

PMID:
23159882
9.

Developing mRNA-vaccine technologies.

Schlake T, Thess A, Fotin-Mleczek M, Kallen KJ.

RNA Biol. 2012 Nov;9(11):1319-30. doi: 10.4161/rna.22269. Epub 2012 Oct 12. Review.

10.

Protein expression from exogenous mRNA: uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway.

Lorenz C, Fotin-Mleczek M, Roth G, Becker C, Dam TC, Verdurmen WP, Brock R, Probst J, Schlake T.

RNA Biol. 2011 Jul-Aug;8(4):627-36. doi: 10.4161/rna.8.4.15394. Epub 2011 Jul 1.

PMID:
21654214
11.

Canonical WNT signalling controls hair follicle spacing.

Schlake T, Sick S.

Cell Adh Migr. 2007 Jul-Sep;1(3):149-51. Epub 2007 Jul 23. Review.

12.

Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs.

Hammerschmidt B, Schlake T.

Dev Biol. 2007 May 1;305(1):246-61. Epub 2007 Feb 16.

13.

Determination of hair structure and shape.

Schlake T.

Semin Cell Dev Biol. 2007 Apr;18(2):267-73. Epub 2007 Jan 23. Review.

PMID:
17324597
14.

WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism.

Sick S, Reinker S, Timmer J, Schlake T.

Science. 2006 Dec 1;314(5804):1447-50. Epub 2006 Nov 2.

15.
16.

Igf-I signalling controls the hair growth cycle and the differentiation of hair shafts.

Weger N, Schlake T.

J Invest Dermatol. 2005 Nov;125(5):873-82.

17.

Igfbp3 modulates cell proliferation in the hair follicle.

Weger N, Schlake T.

J Invest Dermatol. 2005 Oct;125(4):847-9. No abstract available.

18.
19.
20.

Major shifts in genomic activity accompany progression through different stages of the hair cycle.

Schlake T, Beibel M, Weger N, Boehm T.

Gene Expr Patterns. 2004 Mar;4(2):141-52.

PMID:
15161094
22.

The nude gene and the skin.

Schlake T.

Exp Dermatol. 2001 Oct;10(5):293-304. Review.

PMID:
11589726
23.

The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes.

Bode J, Schlake T, Iber M, Schübeler D, Seibler J, Snezhkov E, Nikolaev L.

Biol Chem. 2000 Sep-Oct;381(9-10):801-13. Review.

PMID:
11076013
24.

Formation of regulator/target gene relationships during evolution.

Schlake T, Schorpp M, Boehm T.

Gene. 2000 Oct 3;256(1-2):29-34.

PMID:
11054532
25.

Genetic dissection of thymus development.

Schorpp M, Wiest W, Egger C, Hammerschmidt M, Schlake T, Boehm T.

Curr Top Microbiol Immunol. 2000;251:119-24. No abstract available.

PMID:
11036766
26.

Genetically separable determinants of hair keratin gene expression.

Schorpp M, Schlake T, Kreamalmeyer D, Allen PM, Boehm T.

Dev Dyn. 2000 Jul;218(3):537-43.

27.

Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype.

Schlake T, Schorpp M, Maul-Pavicic A, Malashenko AM, Boehm T.

Dev Dyn. 2000 Apr;217(4):368-76.

28.

Predetermined chromosomal deletion encompassing the Nf-1 gene.

Schlake T, Schupp I, Kutsche K, Mincheva A, Lichter P, Boehm T.

Oncogene. 1999 Oct 28;18(44):6078-82.

29.
30.

Transposon-induced splicing defect in the rat nude gene.

Huth M, Schlake T, Boehm T.

Immunogenetics. 1997;45(4):282-3. No abstract available.

PMID:
9002451
31.

A yeast artificial chromosome contig spanning the mouse immunoglobulin kappa light chain locus.

Schupp IW, Schlake T, Kirschbaum T, Zachau HG, Boehm T.

Immunogenetics. 1997;45(3):180-7.

PMID:
8995184
32.

Scaffold/matrix-attached regions: topological switches with multiple regulatory functions.

Bode J, Stengert-Iber M, Kay V, Schlake T, Dietz-Pfeilstetter A.

Crit Rev Eukaryot Gene Expr. 1996;6(2-3):115-38. Review.

PMID:
8855385
33.

Scaffold/matrix-attached regions: structural properties creating transcriptionally active loci.

Bode J, Schlake T, Ríos-Ramírez M, Mielke C, Stengert M, Kay V, Klehr-Wirth D.

Int Rev Cytol. 1995;162A:389-454. Review.

PMID:
8575884
34.
35.

A plant scaffold attached region detected close to a T-DNA integration site is active in mammalian cells.

Dietz A, Kay V, Schlake T, Landsmann J, Bode J.

Nucleic Acids Res. 1994 Jul 25;22(14):2744-51.

36.

Gene expression within a chromatin domain: the role of core histone hyperacetylation.

Schlake T, Klehr-Wirth D, Yoshida M, Beppu T, Bode J.

Biochemistry. 1994 Apr 12;33(14):4197-206.

PMID:
8155635
37.
38.

Scaffold-attached regions (SAR elements) mediate transcriptional effects due to butyrate.

Klehr D, Schlake T, Maass K, Bode J.

Biochemistry. 1992 Mar 31;31(12):3222-9.

PMID:
1554707

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