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Real-world evidence research based on big data: Motivation-challenges-success factors.

Maissenhaelter BE, Woolmore AL, Schlag PM.

Onkologe (Berl). 2018;24(Suppl 2):91-98. doi: 10.1007/s00761-018-0358-3. Epub 2018 Jun 7. Review.


Loss-of-function uORF mutations in human malignancies.

Schulz J, Mah N, Neuenschwander M, Kischka T, Ratei R, Schlag PM, Castaños-Vélez E, Fichtner I, Tunn PU, Denkert C, Klaas O, Berdel WE, von Kries JP, Makalowski W, Andrade-Navarro MA, Leutz A, Wethmar K.

Sci Rep. 2018 Feb 5;8(1):2395. doi: 10.1038/s41598-018-19201-8.


Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.

Juneja M, Kobelt D, Walther W, Voss C, Smith J, Specker E, Neuenschwander M, Gohlke BO, Dahlmann M, Radetzki S, Preissner R, von Kries JP, Schlag PM, Stein U.

PLoS Biol. 2017 Jun 1;15(6):e2000784. doi: 10.1371/journal.pbio.2000784. eCollection 2017 Jun.


C/EBPβ regulates homeostatic and oncogenic gastric cell proliferation.

Regalo G, Förster S, Resende C, Bauer B, Fleige B, Kemmner W, Schlag PM, Meyer TF, Machado JC, Leutz A.

J Mol Med (Berl). 2016 Dec;94(12):1385-1395. Epub 2016 Aug 13.


SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival.

Schmid F, Wang Q, Huska MR, Andrade-Navarro MA, Lemm M, Fichtner I, Dahlmann M, Kobelt D, Walther W, Smith J, Schlag PM, Stein U.

Oncogene. 2016 Nov 17;35(46):5942-5952. doi: 10.1038/onc.2015.451. Epub 2015 Dec 21.


High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients.

Ilm K, Kemmner W, Osterland M, Burock S, Koch G, Herrmann P, Schlag PM, Stein U.

Mol Cancer. 2015 Feb 14;14:38. doi: 10.1186/s12943-015-0316-2.


RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis.

Dahlmann M, Okhrimenko A, Marcinkowski P, Osterland M, Herrmann P, Smith J, Heizmann CW, Schlag PM, Stein U.

Oncotarget. 2014 May 30;5(10):3220-33.


The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1β.

van der Ploeg AH, Kumpf O, Seelow E, Almanza LC, Schlag PM, Schumann RR, Hamann L.

Gastric Cancer. 2015 Jan;18(1):77-83. doi: 10.1007/s10120-014-0349-z. Epub 2014 Feb 21.


Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector.

Kobelt D, Aumann J, Schmidt M, Wittig B, Fichtner I, Behrens D, Lemm M, Freundt G, Schlag PM, Walther W.

Mol Oncol. 2014 May;8(3):609-19. doi: 10.1016/j.molonc.2013.12.019. Epub 2014 Jan 18.


Local recurrence rates after radiofrequency ablation or resection of colorectal liver metastases. Analysis of the European Organisation for Research and Treatment of Cancer #40004 and #40983.

Tanis E, Nordlinger B, Mauer M, Sorbye H, van Coevorden F, Gruenberger T, Schlag PM, Punt CJ, Ledermann J, Ruers TJ.

Eur J Cancer. 2014 Mar;50(5):912-9. doi: 10.1016/j.ejca.2013.12.008. Epub 2014 Jan 7.


Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial.

Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, Bechstein WO, Primrose JN, Walpole ET, Finch-Jones M, Jaeck D, Mirza D, Parks RW, Mauer M, Tanis E, Van Cutsem E, Scheithauer W, Gruenberger T; EORTC Gastro-Intestinal Tract Cancer Group; Cancer Research UK; Arbeitsgruppe Lebermetastasen und–tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie (ALM-CAO); Australasian Gastro-Intestinal Trials Group (AGITG); Fédération Francophone de Cancérologie Digestive (FFCD).

Lancet Oncol. 2013 Nov;14(12):1208-15. doi: 10.1016/S1470-2045(13)70447-9. Epub 2013 Oct 11.


Current status of gene therapy for cancer.

Walther W, Schlag PM.

Curr Opin Oncol. 2013 Nov;25(6):659-64. Review.


Promoter identification and transcriptional regulation of the metastasis gene MACC1 in colorectal cancer.

Juneja M, Ilm K, Schlag PM, Stein U.

Mol Oncol. 2013 Oct;7(5):929-43. doi: 10.1016/j.molonc.2013.05.003. Epub 2013 Jun 6.


HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model: Gene gun is superior to jet injector in inducing CTL responses and protective immunity.

Nguyen-Hoai T, Kobelt D, Hohn O, Vu MD, Schlag PM, Dörken B, Norley S, Lipp M, Walther W, Pezzutto A, Westermann J.

Oncoimmunology. 2012 Dec 1;1(9):1537-1545.


Circulating MACC1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis.

Stein U, Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke KD, Schlag PM.

PLoS One. 2012;7(11):e49249. doi: 10.1371/journal.pone.0049249. Epub 2012 Nov 14.


Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer.

Nitsche U, Rosenberg R, Balmert A, Schuster T, Slotta-Huspenina J, Herrmann P, Bader FG, Friess H, Schlag PM, Stein U, Janssen KP.

Ann Surg. 2012 Nov;256(5):763-71; discussion 771. doi: 10.1097/SLA.0b013e318272de87.


Intratumoral dispersion, retention, systemic biodistribution, and clearance of a small-size tumor necrosis factor-α-expressing MIDGE vector after nonviral in vivo jet-injection gene transfer.

Galling N, Kobelt D, Aumann J, Schmidt M, Wittig B, Schlag PM, Walther W.

Hum Gene Ther Methods. 2012 Aug;23(4):264-70. doi: 10.1089/hgtb.2012.064. Epub 2012 Aug 27.


Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation.

Dahlmann M, Sack U, Herrmann P, Lemm M, Fichtner I, Schlag PM, Stein U.

Oncotarget. 2012 Aug;3(8):783-97.


SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer.

Schmid F, Burock S, Klockmeier K, Schlag PM, Stein U.

Mol Cancer. 2012 Jul 29;11:49. doi: 10.1186/1476-4598-11-49.


In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice.

Pichorner A, Sack U, Kobelt D, Kelch I, Arlt F, Smith J, Walther W, Schlag PM, Stein U.

Clin Exp Metastasis. 2012 Aug;29(6):573-83. doi: 10.1007/s10585-012-9472-6. Epub 2012 Apr 7.


Performance of high quality minicircle DNA for in vitro and in vivo gene transfer.

Kobelt D, Schleef M, Schmeer M, Aumann J, Schlag PM, Walther W.

Mol Biotechnol. 2013 Jan;53(1):80-9. doi: 10.1007/s12033-012-9535-6.


Impact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells.

Stein U, Fleuter C, Siegel F, Smith J, Kopacek A, Scudiero DA, Hite KM, Schlag PM, Shoemaker RH, Walther W.

Br J Cancer. 2012 Apr 10;106(8):1395-405. doi: 10.1038/bjc.2012.81. Epub 2012 Mar 29.


Predictive factors for the benefit of perioperative FOLFOX for resectable liver metastasis in colorectal cancer patients (EORTC Intergroup Trial 40983).

Sorbye H, Mauer M, Gruenberger T, Glimelius B, Poston GJ, Schlag PM, Rougier P, Bechstein WO, Primrose JN, Walpole ET, Finch-Jones M, Jaeck D, Mirza D, Parks RW, Collette L, Van Cutsem E, Scheithauer W, Lutz MP, Nordlinger B; EORTC Gastro-Intestinal Tract Cancer Group; Cancer Research UK (CRUK); Arbeitsgruppe Lebermetastasen und-tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie (ALM-CAO); Australasian Gastro-Intestinal Trials Group (AGITG); Fédération Francophone de Cancérologie Digestive (FFCD).

Ann Surg. 2012 Mar;255(3):534-9. doi: 10.1097/SLA.0b013e3182456aa2.


Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells.

Kemmner W, Kessel P, Sanchez-Ruderisch H, Möller H, Hinderlich S, Schlag PM, Detjen K.

FASEB J. 2012 Feb;26(2):938-46. doi: 10.1096/fj.11-186700. Epub 2011 Nov 2.


Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors.

Walther W, Petkov S, Kuvardina ON, Aumann J, Kobelt D, Fichtner I, Lemm M, Piontek J, Blasig IE, Stein U, Schlag PM.

Gene Ther. 2012 May;19(5):494-503. doi: 10.1038/gt.2011.136. Epub 2011 Oct 6.


S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells.

Sack U, Walther W, Scudiero D, Selby M, Aumann J, Lemos C, Fichtner I, Schlag PM, Shoemaker RH, Stein U.

Mol Biol Cell. 2011 Sep;22(18):3344-54. doi: 10.1091/mbc.E10-09-0739. Epub 2011 Jul 27.


Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.

Sack U, Walther W, Scudiero D, Selby M, Kobelt D, Lemm M, Fichtner I, Schlag PM, Shoemaker RH, Stein U.

J Natl Cancer Inst. 2011 Jul 6;103(13):1018-36. doi: 10.1093/jnci/djr190. Epub 2011 Jun 17.


The impact of short-term psycho-oncological interventions on the psychological outcome of cancer patients of a surgical-oncology department - a randomised controlled study.

Goerling U, Foerg A, Sander S, Schramm N, Schlag PM.

Eur J Cancer. 2011 Sep;47(13):2009-14. doi: 10.1016/j.ejca.2011.04.031. Epub 2011 May 24.


[German S3-guideline "Diagnosis and treatment of esophagogastric cancer"].

Moehler M, Al-Batran SE, Andus T, Anthuber M, Arends J, Arnold D, Aust D, Baier P, Baretton G, Bernhardt J, Boeing H, Böhle E, Bokemeyer C, Bornschein J, Budach W, Burmester E, Caca K, Diemer WA, Dietrich CF, Ebert M, Eickhoff A, Ell C, Fahlke J, Feussner H, Fietkau R, Fischbach W, Fleig W, Flentje M, Gabbert HE, Galle PR, Geissler M, Gockel I, Graeven U, Grenacher L, Gross S, Hartmann JT, Heike M, Heinemann V, Herbst B, Herrmann T, Höcht S, Hofheinz RD, Höfler H, Höhler T, Hölscher AH, Horneber M, Hübner J, Izbicki JR, Jakobs R, Jenssen C, Kanzler S, Keller M, Kiesslich R, Klautke G, Körber J, Krause BJ, Kuhn C, Kullmann F, Lang H, Link H, Lordick F, Ludwig K, Lutz M, Mahlberg R, Malfertheiner P, Merkel S, Messmann H, Meyer HJ, Mönig S, Piso P, Pistorius S, Porschen R, Rabenstein T, Reichardt P, Ridwelski K, Röcken C, Roetzer I, Rohr P, Schepp W, Schlag PM, Schmid RM, Schmidberger H, Schmiegel WH, Schmoll HJ, Schuch G, Schuhmacher C, Schütte K, Schwenk W, Selgrad M, Sendler A, Seraphin J, Seufferlein T, Stahl M, Stein H, Stoll C, Stuschke M, Tannapfel A, Tholen R, Thuss-Patience P, Treml K, Vanhoefer U, Vieth M, Vogelsang H, Wagner D, Wedding U, Weimann A, Wilke H, Wittekind C; AWMF; AWMF.

Z Gastroenterol. 2011 Apr;49(4):461-531. doi: 10.1055/s-0031-1273201. Epub 2011 Apr 7. German. No abstract available.


Intervening in β-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis.

Stein U, Arlt F, Smith J, Sack U, Herrmann P, Walther W, Lemm M, Fichtner I, Shoemaker RH, Schlag PM.

Neoplasia. 2011 Feb;13(2):131-44.


A multichannel time-domain scanning fluorescence mammograph: performance assessment and first in vivo results.

Grosenick D, Hagen A, Steinkellner O, Poellinger A, Burock S, Schlag PM, Rinneberg H, Macdonald R.

Rev Sci Instrum. 2011 Feb;82(2):024302. doi: 10.1063/1.3543820.


Diagnostic and prognostic value of metastasis inducer S100A4 transcripts in plasma of colon, rectal, and gastric cancer patients.

Stein U, Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke KD, Schlag PM.

J Mol Diagn. 2011 Mar;13(2):189-98. doi: 10.1016/j.jmoldx.2010.10.002.


Identification of early molecular markers for breast cancer.

Kretschmer C, Sterner-Kock A, Siedentopf F, Schoenegg W, Schlag PM, Kemmner W.

Mol Cancer. 2011 Feb 11;10(1):15. doi: 10.1186/1476-4598-10-15.


Breast cancer: early- and late-fluorescence near-infrared imaging with indocyanine green--a preliminary study.

Poellinger A, Burock S, Grosenick D, Hagen A, Lüdemann L, Diekmann F, Engelken F, Macdonald R, Rinneberg H, Schlag PM.

Radiology. 2011 Feb;258(2):409-16. doi: 10.1148/radiol.10100258. Epub 2010 Dec 21.


Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.

Jürchott K, Kuban RJ, Krech T, Blüthgen N, Stein U, Walther W, Friese C, Kiełbasa SM, Ungethüm U, Lund P, Knösel T, Kemmner W, Morkel M, Fritzmann J, Schlag PM, Birchmeier W, Krueger T, Sperling S, Sers C, Royer HD, Herzel H, Schäfer R.

PLoS Genet. 2010 Dec 2;6(12):e1001231. doi: 10.1371/journal.pgen.1001231.


Therapeutic potential of CAMPATH-1H in skeletal tumours.

Fritsche-Guenther R, Gruetzkau A, Noske A, Melcher I, Schaser KD, Schlag PM, Kasper HU, Krenn V, Sers C.

Histopathology. 2010 Dec;57(6):851-61. doi: 10.1111/j.1365-2559.2010.03722.x.


De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway.

Fritsche-Guenther R, Noske A, Ungethüm U, Kuban RJ, Schlag PM, Tunn PU, Karle J, Krenn V, Dietel M, Sers C.

Histopathology. 2010 Dec;57(6):836-50. doi: 10.1111/j.1365-2559.2010.03713.x.


Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organisation for Research and Treatment of Cancer randomized trial 40954.

Schuhmacher C, Gretschel S, Lordick F, Reichardt P, Hohenberger W, Eisenberger CF, Haag C, Mauer ME, Hasan B, Welch J, Ott K, Hoelscher A, Schneider PM, Bechstein W, Wilke H, Lutz MP, Nordlinger B, Van Cutsem E, Siewert JR, Schlag PM.

J Clin Oncol. 2010 Dec 10;28(35):5210-8. doi: 10.1200/JCO.2009.26.6114. Epub 2010 Nov 8.


Practice and effectiveness of outpatient psycho-oncological counseling for cancer patients.

Goerling U, Tagmat D, Muffler E, Schramm N, Wernecke KD, Schlag PM.

J Cancer. 2010 Aug 23;1:112-9.


Current status of sentinel lymph node biopsy in adenocarcinoma of the distal esophagus, gastric cardia, and proximal stomach.

Gretschel S, Schlag PM.

Recent Results Cancer Res. 2010;182:107-14. doi: 10.1007/978-3-540-70579-6_9. Review.


Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.

Kumpf O, Giamarellos-Bourboulis EJ, Koch A, Hamann L, Mouktaroudi M, Oh DY, Latz E, Lorenz E, Schwartz DA, Ferwerda B, Routsi C, Skalioti C, Kullberg BJ, van der Meer JW, Schlag PM, Netea MG, Zacharowski K, Schumann RR.

Crit Care. 2010;14(3):R103. doi: 10.1186/cc9047. Epub 2010 Jun 3.


Activation of the CMV-IE promoter by hyperthermia in vitro and in vivo: biphasic heat induction of cytosine deaminase suicide gene expression.

Kobelt D, Aumann J, Fichtner I, Stein U, Schlag PM, Walther W.

Mol Biotechnol. 2010 Oct;46(2):197-205. doi: 10.1007/s12033-010-9292-3.


3D ultrasound-CT registration of the liver using combined landmark-intensity information.

Lange T, Papenberg N, Heldmann S, Modersitzki J, Fischer B, Lamecker H, Schlag PM.

Int J Comput Assist Radiol Surg. 2009 Jan;4(1):79-88. doi: 10.1007/s11548-008-0270-1. Epub 2008 Oct 19.


Late-fluorescence mammography assesses tumor capillary permeability and differentiates malignant from benign lesions.

Hagen A, Grosenick D, Macdonald R, Rinneberg H, Burock S, Warnick P, Poellinger A, Schlag PM.

Opt Express. 2009 Sep 14;17(19):17016-33. doi: 10.1364/OE.17.017016.


Ductoscopy of intraductal neoplasia of the breast.

Hünerbein M, Raubach M, Dai K, Schlag PM.

Recent Results Cancer Res. 2009;173:129-36. doi: 10.1007/978-3-540-31611-4_7. Review. No abstract available.


Treatment of oesophageal anastomotic leaks by temporary stenting with self-expanding plastic stents.

Dai YY, Gretschel S, Dudeck O, Rau B, Schlag PM, Hünerbein M.

Br J Surg. 2009 Aug;96(8):887-91. doi: 10.1002/bjs.6648.


Nonviral jet-injection technology for intratumoral in vivo gene transfer of naked DNA.

Walther W, Fichtner I, Schlag PM, Stein US.

Methods Mol Biol. 2009;542:195-208. doi: 10.1007/978-1-59745-561-9_11.


Sentinel node biopsy for the individualization of surgical strategy for cure of early-stage colon cancer.

Cahill RA, Bembenek A, Sirop S, Waterhouse DF, Schneider W, Leroy J, Wiese D, Beutler T, Bilchik A, Saha S, Schlag PM.

Ann Surg Oncol. 2009 Aug;16(8):2170-80. doi: 10.1245/s10434-009-0510-9. Epub 2009 May 27.


A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.

Fritzmann J, Morkel M, Besser D, Budczies J, Kosel F, Brembeck FH, Stein U, Fichtner I, Schlag PM, Birchmeier W.

Gastroenterology. 2009 Jul;137(1):165-75. doi: 10.1053/j.gastro.2009.03.041. Epub 2009 Mar 26.


HIF-1alpha determines the metastatic potential of gastric cancer cells.

Rohwer N, Lobitz S, Daskalow K, Jöns T, Vieth M, Schlag PM, Kemmner W, Wiedenmann B, Cramer T, Höcker M.

Br J Cancer. 2009 Mar 10;100(5):772-81. doi: 10.1038/sj.bjc.6604919. Epub 2009 Feb 17.

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