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Items: 1 to 50 of 134

1.

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.

Delaney JR, Patel CB, Bapat J, Jones CM, Ramos-Zapatero M, Ortell KK, Tanios R, Haghighiabyaneh M, Axelrod J, DeStefano JW, Tancioni I, Schlaepfer DD, Harismendy O, La Spada AR, Stupack DG.

PLoS Genet. 2020 Jan 10;16(1):e1008558. doi: 10.1371/journal.pgen.1008558. eCollection 2020 Jan.

2.

Soil and stand structure explain shrub mortality patterns following global change-type drought and extreme precipitation.

Renne RR, Schlaepfer DR, Palmquist KA, Bradford JB, Burke IC, Lauenroth WK.

Ecology. 2019 Dec;100(12):e02889. doi: 10.1002/ecy.2889. Epub 2019 Oct 9.

PMID:
31509244
3.

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.

Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Győrffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD.

Elife. 2019 Sep 3;8. pii: e47327. doi: 10.7554/eLife.47327.

4.

Rgnef promotes ovarian tumor progression and confers protection from oxidative stress.

Kleinschmidt EG, Miller NLG, Ozmadenci D, Tancioni I, Osterman CD, Barrie AM, Taylor KN, Ye A, Jiang S, Connolly DC, Stupack DG, Schlaepfer DD.

Oncogene. 2019 Sep;38(36):6323-6337. doi: 10.1038/s41388-019-0881-8. Epub 2019 Jul 15.

PMID:
31308489
5.

Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription.

Jeong K, Kim JH, Murphy JM, Park H, Kim SJ, Rodriguez YAR, Kong H, Choi C, Guan JL, Taylor JM, Lincoln TM, Gerthoffer WT, Kim JS, Ahn EE, Schlaepfer DD, Lim SS.

Circ Res. 2019 Jul 5;125(2):152-166. doi: 10.1161/CIRCRESAHA.118.314344. Epub 2019 May 17.

PMID:
31096851
6.

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK.

Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS.

Cancer Cell. 2019 Mar 18;35(3):457-472.e5. doi: 10.1016/j.ccell.2019.01.009. Epub 2019 Feb 14.

PMID:
30773340
7.

Adaptive Resistance to Chemotherapy, A Multi-FAK-torial Linkage.

Taylor KN, Schlaepfer DD.

Mol Cancer Ther. 2018 Apr;17(4):719-723. doi: 10.1158/1535-7163.MCT-17-1177.

8.

Future soil moisture and temperature extremes imply expanding suitability for rainfed agriculture in temperate drylands.

Bradford JB, Schlaepfer DR, Lauenroth WK, Yackulic CB, Duniway M, Hall S, Jia G, Jamiyansharav K, Munson SM, Wilson SD, Tietjen B.

Sci Rep. 2017 Oct 10;7(1):12923. doi: 10.1038/s41598-017-13165-x.

9.

Multi-model comparison highlights consistency in predicted effect of warming on a semi-arid shrub.

Renwick KM, Curtis C, Kleinhesselink AR, Schlaepfer D, Bradley BA, Aldridge CL, Poulter B, Adler PB.

Glob Chang Biol. 2018 Jan;24(1):424-438. doi: 10.1111/gcb.13900. Epub 2017 Oct 11.

PMID:
28895271
10.

Climate change may restrict dryland forest regeneration in the 21st century.

Petrie MD, Bradford JB, Hubbard RM, Lauenroth WK, Andrews CM, Schlaepfer DR.

Ecology. 2017 Jun;98(6):1548-1559. doi: 10.1002/ecy.1791.

PMID:
28266031
11.

Focal adhesion kinase signaling in unexpected places.

Kleinschmidt EG, Schlaepfer DD.

Curr Opin Cell Biol. 2017 Apr;45:24-30. doi: 10.1016/j.ceb.2017.01.003. Epub 2017 Feb 16. Review.

12.

Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.

Delaney JR, Patel CB, Willis KM, Haghighiabyaneh M, Axelrod J, Tancioni I, Lu D, Bapat J, Young S, Cadassou O, Bartakova A, Sheth P, Haft C, Hui S, Saenz C, Schlaepfer DD, Harismendy O, Stupack DG.

Nat Commun. 2017 Feb 15;8:14423. doi: 10.1038/ncomms14423.

13.

Climate change reduces extent of temperate drylands and intensifies drought in deep soils.

Schlaepfer DR, Bradford JB, Lauenroth WK, Munson SM, Tietjen B, Hall SA, Wilson SD, Duniway MC, Jia G, Pyke DA, Lkhagva A, Jamiyansharav K.

Nat Commun. 2017 Jan 31;8:14196. doi: 10.1038/ncomms14196.

14.

Climate change-induced vegetation shifts lead to more ecological droughts despite projected rainfall increases in many global temperate drylands.

Tietjen B, Schlaepfer DR, Bradford JB, Lauenroth WK, Hall SA, Duniway MC, Hochstrasser T, Jia G, Munson SM, Pyke DA, Wilson SD.

Glob Chang Biol. 2017 Jul;23(7):2743-2754. doi: 10.1111/gcb.13598. Epub 2017 Mar 6.

PMID:
27976449
15.

Mid-latitude shrub steppe plant communities: climate change consequences for soil water resources.

Palmquist KA, Schlaepfer DR, Bradford JB, Lauenroth WK.

Ecology. 2016 Sep;97(9):2342-2354. doi: 10.1002/ecy.1457.

PMID:
27859085
16.

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM.

Nat Med. 2016 May;22(5):497-505. doi: 10.1038/nm.4082. Epub 2016 Apr 18.

17.

Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression.

Yurdagul A Jr, Sulzmaier FJ, Chen XL, Pattillo CB, Schlaepfer DD, Orr AW.

J Cell Sci. 2016 Apr 15;129(8):1580-91. doi: 10.1242/jcs.182097. Epub 2016 Feb 18.

18.

A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer.

Delaney JR, Patel C, McCabe KE, Lu D, Davis MA, Tancioni I, von Schalscha T, Bartakova A, Haft C, Schlaepfer DD, Stupack DG.

Oncotarget. 2015 Oct 13;6(31):31104-18. doi: 10.18632/oncotarget.5093.

19.

FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β.

Gao C, Chen G, Kuan SF, Zhang DH, Schlaepfer DD, Hu J.

Elife. 2015 Sep 3;4. doi: 10.7554/eLife.10072.

20.

Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma.

Young SA, McCabe KE, Bartakova A, Delaney J, Pizzo DP, Newbury RO, Varner JA, Schlaepfer DD, Stupack DG.

PLoS One. 2015 May 14;10(5):e0120815. doi: 10.1371/journal.pone.0120815. eCollection 2015.

21.

Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.

Masià-Balagué M, Izquierdo I, Garrido G, Cordomí A, Pérez-Benito L, Miller NL, Schlaepfer DD, Gigoux V, Aragay AM.

J Biol Chem. 2015 Jun 12;290(24):15197-209. doi: 10.1074/jbc.M114.628164. Epub 2015 Apr 28.

22.

FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth.

Tancioni I, Miller NL, Uryu S, Lawson C, Jean C, Chen XL, Kleinschmidt EG, Schlaepfer DD.

Breast Cancer Res. 2015 Mar 28;17:47. doi: 10.1186/s13058-015-0551-x.

23.

Impacts of dichroic prism coatings on radiometry of the airborne imaging spectrometer APEX.

Hueni A, Schlaepfer D, Jehle M, Schaepman M.

Appl Opt. 2014 Aug 20;53(24):5344-52. doi: 10.1364/AO.53.005344.

PMID:
25321104
24.

FAK in cancer: mechanistic findings and clinical applications.

Sulzmaier FJ, Jean C, Schlaepfer DD.

Nat Rev Cancer. 2014 Sep;14(9):598-610. doi: 10.1038/nrc3792. Epub 2014 Aug 7. Review.

25.

FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth.

Tancioni I, Uryu S, Sulzmaier FJ, Shah NR, Lawson C, Miller NL, Jean C, Chen XL, Ward KK, Schlaepfer DD.

Mol Cancer Ther. 2014 Aug;13(8):2050-61. doi: 10.1158/1535-7163.MCT-13-1063. Epub 2014 Jun 4.

26.

Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer.

Shah NR, Tancioni I, Ward KK, Lawson C, Chen XL, Jean C, Sulzmaier FJ, Uryu S, Miller NL, Connolly DC, Schlaepfer DD.

Gynecol Oncol. 2014 Jul;134(1):104-11. doi: 10.1016/j.ygyno.2014.04.044. Epub 2014 Apr 27.

27.

RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.

Miller NL, Kleinschmidt EG, Schlaepfer DD.

Curr Mol Med. 2014 Feb;14(2):221-34. Review.

28.

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function.

Jean C, Chen XL, Nam JO, Tancioni I, Uryu S, Lawson C, Ward KK, Walsh CT, Miller NL, Ghassemian M, Turowski P, Dejana E, Weis S, Cheresh DA, Schlaepfer DD.

J Cell Biol. 2014 Jan 20;204(2):247-63. doi: 10.1083/jcb.201307067.

29.

Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.

Cheng SY, Sun G, Schlaepfer DD, Pallen CJ.

Mol Cell Biol. 2014 Feb;34(3):348-61. doi: 10.1128/MCB.00825-13. Epub 2013 Nov 18.

30.

pHocal adhesion kinase regulation is on a FERM foundation.

Lawson C, Schlaepfer DD.

J Cell Biol. 2013 Sep 16;202(6):833-6. doi: 10.1083/jcb.201308034.

31.

A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation.

Miller NL, Lawson C, Kleinschmidt EG, Tancioni I, Uryu S, Schlaepfer DD.

J Cell Sci. 2013 Nov 1;126(Pt 21):5074-85. doi: 10.1242/jcs.135509. Epub 2013 Sep 4.

32.

Src-inducible association of CrkL with procaspase-8 promotes cell migration.

Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D.

Cell Adh Migr. 2013 Jul-Aug;7(4):362-9. doi: 10.4161/cam.25284. Epub 2013 Jun 10.

33.

Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.

Ward KK, Tancioni I, Lawson C, Miller NL, Jean C, Chen XL, Uryu S, Kim J, Tarin D, Stupack DG, Plaxe SC, Schlaepfer DD.

Clin Exp Metastasis. 2013 Jun;30(5):579-94. doi: 10.1007/s10585-012-9562-5. Epub 2012 Dec 30.

34.

Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells.

Jung O, Choi S, Jang SB, Lee SA, Lim ST, Choi YJ, Kim HJ, Kim DH, Kwak TK, Kim H, Kang M, Lee MS, Park SY, Ryu J, Jeong D, Cheong HK, Kim HJ, Park KH, Lee BJ, Schlaepfer DD, Lee JW.

J Cell Sci. 2012 Dec 15;125(Pt 24):5960-73. doi: 10.1242/jcs.100586. Epub 2012 Oct 17.

35.

Integrin adhesions: who's on first? What's on second? Connections between FAK and talin.

Lawson C, Schlaepfer DD.

Cell Adh Migr. 2012 Jul-Aug;6(4):302-6. doi: 10.4161/cam.20488. Epub 2012 Jul 1.

36.

Cortactin as a target for FAK in the regulation of focal adhesion dynamics.

Tomar A, Lawson C, Ghassemian M, Schlaepfer DD.

PLoS One. 2012;7(8):e44041. doi: 10.1371/journal.pone.0044041. Epub 2012 Aug 29.

37.

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.

Lim ST, Miller NL, Chen XL, Tancioni I, Walsh CT, Lawson C, Uryu S, Weis SM, Cheresh DA, Schlaepfer DD.

J Cell Biol. 2012 Jun 25;197(7):907-19. doi: 10.1083/jcb.201109067.

38.

Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins.

Miller NL, Lawson C, Chen XL, Lim ST, Schlaepfer DD.

PLoS One. 2012;7(5):e37830. doi: 10.1371/journal.pone.0037830. Epub 2012 May 23.

39.

EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1.

Lau SK, Shields DJ, Murphy EA, Desgrosellier JS, Anand S, Huang M, Kato S, Lim ST, Weis SM, Stupack DG, Schlaepfer DD, Cheresh DA.

PLoS One. 2012;7(5):e36753. doi: 10.1371/journal.pone.0036753. Epub 2012 May 7.

40.

FAK promotes recruitment of talin to nascent adhesions to control cell motility.

Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD.

J Cell Biol. 2012 Jan 23;196(2):223-32. doi: 10.1083/jcb.201108078. Erratum in: J Cell Biol. 2012 Feb 6;196(3):387.

41.

VEGF-induced vascular permeability is mediated by FAK.

Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD.

Dev Cell. 2012 Jan 17;22(1):146-57. doi: 10.1016/j.devcel.2011.11.002.

42.

Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.

Li XY, Zhou X, Rowe RG, Hu Y, Schlaepfer DD, Ilić D, Dressler G, Park A, Guan JL, Weiss SJ.

J Cell Biol. 2011 Nov 28;195(5):729-38. doi: 10.1083/jcb.201105103. Epub 2011 Nov 21.

43.

EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation.

Huang M, Anand S, Murphy EA, Desgrosellier JS, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA.

Oncogene. 2012 May 31;31(22):2783-93. doi: 10.1038/onc.2011.450. Epub 2011 Oct 3.

44.

Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer.

Seong J, Ouyang M, Kim T, Sun J, Wen PC, Lu S, Zhuo Y, Llewellyn NM, Schlaepfer DD, Guan JL, Chien S, Wang Y.

Nat Commun. 2011 Jul 26;2:406. doi: 10.1038/ncomms1414.

45.

p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase.

Yu HG, Nam JO, Miller NL, Tanjoni I, Walsh C, Shi L, Kim L, Chen XL, Tomar A, Lim ST, Schlaepfer DD.

Cancer Res. 2011 Jan 15;71(2):360-70. doi: 10.1158/0008-5472.CAN-10-2894. Epub 2011 Jan 11.

46.

Are invaders different? A conceptual framework of comparative approaches for assessing determinants of invasiveness.

van Kleunen M, Dawson W, Schlaepfer D, Jeschke JM, Fischer M.

Ecol Lett. 2010 Aug 1;13(8):947-58. doi: 10.1111/j.1461-0248.2010.01503.x. Epub 2010 Jun 23.

PMID:
20576028
47.

Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD.

J Biol Chem. 2010 Jul 9;285(28):21526-36. doi: 10.1074/jbc.M110.129999. Epub 2010 May 4.

48.

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation.

Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD, Waterman CM.

J Cell Biol. 2010 Mar 22;188(6):877-90. doi: 10.1083/jcb.200906012.

49.

Why only tetraploid Solidago gigantea (Asteraceae) became invasive: a common garden comparison of ploidy levels.

Schlaepfer DR, Edwards PJ, Billeter R.

Oecologia. 2010 Jul;163(3):661-73. doi: 10.1007/s00442-010-1595-3. Epub 2010 Mar 18.

PMID:
20238128
50.

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

Walsh C, Tanjoni I, Uryu S, Tomar A, Nam JO, Luo H, Phillips A, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD.

Cancer Biol Ther. 2010 May 15;9(10):778-90.

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