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Items: 32


Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines.

Hintze J, Ye Z, Narimatsu Y, Madsen TD, Joshi HJ, Goth CK, Linstedt A, Bachert C, Mandel U, Bennett EP, Vakhrushev SY, Schjoldager KT.

J Biol Chem. 2018 Dec 7;293(49):19064-19077. doi: 10.1074/jbc.RA118.004516. Epub 2018 Oct 16.


Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.

de Las Rivas M, Coelho H, Diniz A, Lira-Navarrete E, Compañón I, Jiménez-Barbero J, Schjoldager KT, Bennett EP, Vakhrushev SY, Clausen H, Corzana F, Marcelo F, Hurtado-Guerrero R.

Chemistry. 2018 Jun 12;24(33):8382-8392. doi: 10.1002/chem.201800701. Epub 2018 May 16.


TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation.

King SL, Goth CK, Eckhard U, Joshi HJ, Haue AD, Vakhrushev SY, Schjoldager KT, Overall CM, Wandall HH.

J Biol Chem. 2018 May 18;293(20):7629-7644. doi: 10.1074/jbc.RA118.001978. Epub 2018 Mar 28.


Glycosyltransferase genes that cause monogenic congenital disorders of glycosylation are distinct from glycosyltransferase genes associated with complex diseases.

Joshi HJ, Hansen L, Narimatsu Y, Freeze HH, Henrissat B, Bennett E, Wandall HH, Clausen H, Schjoldager KT.

Glycobiology. 2018 May 1;28(5):284-294. doi: 10.1093/glycob/cwy015.


Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2018 May 11;293(19):7408-7422. doi: 10.1074/jbc.M117.817981. Epub 2018 Mar 20.


Fine-Tuning Limited Proteolysis: A Major Role for Regulated Site-Specific O-Glycosylation.

Goth CK, Vakhrushev SY, Joshi HJ, Clausen H, Schjoldager KT.

Trends Biochem Sci. 2018 Apr;43(4):269-284. doi: 10.1016/j.tibs.2018.02.005. Epub 2018 Mar 2. Review.


SnapShot: O-Glycosylation Pathways across Kingdoms.

Joshi HJ, Narimatsu Y, Schjoldager KT, Tytgat HLP, Aebi M, Clausen H, Halim A.

Cell. 2018 Jan 25;172(3):632-632.e2. doi: 10.1016/j.cell.2018.01.016. Review.


A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome.

Narimatsu Y, Joshi HJ, Yang Z, Gomes C, Chen YH, Lorenzetti FC, Furukawa S, Schjoldager KT, Hansen L, Clausen H, Bennett EP, Wandall HH.

Glycobiology. 2018 May 1;28(5):295-305. doi: 10.1093/glycob/cwx101.


Characterizing the O-glycosylation landscape of human plasma, platelets, and endothelial cells.

King SL, Joshi HJ, Schjoldager KT, Halim A, Madsen TD, Dziegiel MH, Woetmann A, Vakhrushev SY, Wandall HH.

Blood Adv. 2017 Feb 23;1(7):429-442. doi: 10.1182/bloodadvances.2016002121. eCollection 2017 Feb 28.


GlycoDomainViewer: a bioinformatics tool for contextual exploration of glycoproteomes.

Joshi HJ, Jørgensen A, Schjoldager KT, Halim A, Dworkin LA, Steentoft C, Wandall HH, Clausen H, Vakhrushev SY.

Glycobiology. 2018 Mar 1;28(3):131-136. doi: 10.1093/glycob/cwx104.


Chromogranin A in the mammalian heart: expression without secretion.

Hansen LH, Darkner S, Svendsen JH, Henningsen K, Pehrson S, Chen X, Vakhrushev SY, Schjoldager KT, Goetze JP.

Biomark Med. 2017 Jul;11(7):541-545. doi: 10.2217/bmm-2017-0052. Epub 2017 Jul 7.


Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage.

Goth CK, Tuhkanen HE, Khan H, Lackman JJ, Wang S, Narimatsu Y, Hansen LH, Overall CM, Clausen H, Schjoldager KT, Petäjä-Repo UE.

J Biol Chem. 2017 Mar 17;292(11):4714-4726. doi: 10.1074/jbc.M116.730614. Epub 2017 Feb 6.


Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study, Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ.

Cell Metab. 2016 Aug 9;24(2):234-45. doi: 10.1016/j.cmet.2016.07.012.


Deconstruction of O-glycosylation--GalNAc-T isoforms direct distinct subsets of the O-glycoproteome.

Schjoldager KT, Joshi HJ, Kong Y, Goth CK, King SL, Wandall HH, Bennett EP, Vakhrushev SY, Clausen H.

EMBO Rep. 2015 Dec;16(12):1713-22. doi: 10.15252/embr.201540796. Epub 2015 Nov 13.


A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.

Goth CK, Halim A, Khetarpal SA, Rader DJ, Clausen H, Schjoldager KT.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14623-8. doi: 10.1073/pnas.1511175112. Epub 2015 Nov 9.


Development of isoform-specific sensors of polypeptide GalNAc-transferase activity.

Song L, Bachert C, Schjoldager KT, Clausen H, Linstedt AD.

J Biol Chem. 2014 Oct 31;289(44):30556-66. doi: 10.1074/jbc.M114.599563. Epub 2014 Sep 15.


Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis.

Kong Y, Joshi HJ, Schjoldager KT, Madsen TD, Gerken TA, Vester-Christensen MB, Wandall HH, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.

Glycobiology. 2015 Jan;25(1):55-65. doi: 10.1093/glycob/cwu089. Epub 2014 Aug 25.


Immature truncated O-glycophenotype of cancer directly induces oncogenic features.

Radhakrishnan P, Dabelsteen S, Madsen FB, Francavilla C, Kopp KL, Steentoft C, Vakhrushev SY, Olsen JV, Hansen L, Bennett EP, Woetmann A, Yin G, Chen L, Song H, Bak M, Hlady RA, Peters SL, Opavsky R, Thode C, Qvortrup K, Schjoldager KT, Clausen H, Hollingsworth MA, Wandall HH.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4066-75. doi: 10.1073/pnas.1406619111. Epub 2014 Aug 12.


The GalNAc-type O-Glycoproteome of CHO cells characterized by the SimpleCell strategy.

Yang Z, Halim A, Narimatsu Y, Jitendra Joshi H, Steentoft C, Schjoldager KT, Alder Schulz M, Sealover NR, Kayser KJ, Paul Bennett E, Levery SB, Vakhrushev SY, Clausen H.

Mol Cell Proteomics. 2014 Dec;13(12):3224-35. doi: 10.1074/mcp.M114.041541. Epub 2014 Aug 4.


Identification of distinct glycoforms of IgA1 in plasma from patients with immunoglobulin A (IgA) nephropathy and healthy individuals.

Lehoux S, Mi R, Aryal RP, Wang Y, Schjoldager KT, Clausen H, van Die I, Han Y, Chapman AB, Cummings RD, Ju T.

Mol Cell Proteomics. 2014 Nov;13(11):3097-113. doi: 10.1074/mcp.M114.039693. Epub 2014 Jul 28.


Precision genome editing: a small revolution for glycobiology.

Steentoft C, Bennett EP, Schjoldager KT, Vakhrushev SY, Wandall HH, Clausen H.

Glycobiology. 2014 Aug;24(8):663-80. doi: 10.1093/glycob/cwu046. Epub 2014 May 26. Review.


Low density lipoprotein receptor class A repeats are O-glycosylated in linker regions.

Pedersen NB, Wang S, Narimatsu Y, Yang Z, Halim A, Schjoldager KT, Madsen TD, Seidah NG, Bennett EP, Levery SB, Clausen H.

J Biol Chem. 2014 Jun 20;289(25):17312-24. doi: 10.1074/jbc.M113.545053. Epub 2014 May 5.


Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.

Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H.

EMBO J. 2013 May 15;32(10):1478-88. doi: 10.1038/emboj.2013.79. Epub 2013 Apr 12.


Site-specific protein O-glycosylation modulates proprotein processing - deciphering specific functions of the large polypeptide GalNAc-transferase gene family.

Schjoldager KT, Clausen H.

Biochim Biophys Acta. 2012 Dec;1820(12):2079-94. doi: 10.1016/j.bbagen.2012.09.014. Epub 2012 Sep 26. Review.


Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.

Schjoldager KT, Vakhrushev SY, Kong Y, Steentoft C, Nudelman AS, Pedersen NB, Wandall HH, Mandel U, Bennett EP, Levery SB, Clausen H.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9893-8. doi: 10.1073/pnas.1203563109. Epub 2012 May 7.


Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines.

Steentoft C, Vakhrushev SY, Vester-Christensen MB, Schjoldager KT, Kong Y, Bennett EP, Mandel U, Wandall H, Levery SB, Clausen H.

Nat Methods. 2011 Oct 9;8(11):977-82. doi: 10.1038/nmeth.1731.


A systematic study of site-specific GalNAc-type O-glycosylation modulating proprotein convertase processing.

Schjoldager KT, Vester-Christensen MB, Goth CK, Petersen TN, Brunak S, Bennett EP, Levery SB, Clausen H.

J Biol Chem. 2011 Nov 18;286(46):40122-32. doi: 10.1074/jbc.M111.287912. Epub 2011 Sep 20.


Lectin domains of polypeptide GalNAc transferases exhibit glycopeptide binding specificity.

Pedersen JW, Bennett EP, Schjoldager KT, Meldal M, Holmér AP, Blixt O, Cló E, Levery SB, Clausen H, Wandall HH.

J Biol Chem. 2011 Sep 16;286(37):32684-96. doi: 10.1074/jbc.M111.273722. Epub 2011 Jul 15.


O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids.

Schjoldager KT, Vester-Christensen MB, Bennett EP, Levery SB, Schwientek T, Yin W, Blixt O, Clausen H.

J Biol Chem. 2010 Nov 19;285(47):36293-303. doi: 10.1074/jbc.M110.156950. Epub 2010 Sep 13.


Characterization of an immunodominant cancer-specific O-glycopeptide epitope in murine podoplanin (OTS8).

Steentoft C, Schjoldager KT, Cló E, Mandel U, Levery SB, Pedersen JW, Jensen K, Blixt O, Clausen H.

Glycoconj J. 2010 Aug;27(6):571-82. doi: 10.1007/s10719-010-9301-6. Epub 2010 Aug 19.


Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11.

Bennett EP, Chen YW, Schwientek T, Mandel U, Schjoldager Kt, Cohen SM, Clausen H.

Glycoconj J. 2010 May;27(4):435-44. doi: 10.1007/s10719-010-9290-5. Epub 2010 Apr 27.


Cellular cross talk in the small intestinal mucosa: postnatal lymphocytic immigration elicits a specific epithelial transcriptional response.

Schjoldager KT, Maltesen HR, Balmer S, Lund LR, Claesson MH, Sjöström H, Troelsen JT, Olsen J.

Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1335-43. doi: 10.1152/ajpgi.00265.2007. Epub 2008 Apr 3.

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