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Items: 38

1.

Enzymatic Cascade To Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign.

Tailhades J, Zhao Y, Schoppet M, Greule A, Goode RJA, Schittenhelm RB, De Voss JJ, Cryle MJ.

Org Lett. 2019 Oct 11. doi: 10.1021/acs.orglett.9b03245. [Epub ahead of print]

PMID:
31603691
2.

Ligand-dependent spatiotemporal signaling profiles of the mu-opioid receptor are controlled by distinct protein-interaction networks.

Civciristov S, Huang C, Liu B, Marquez EA, Gondin AB, Schittenhelm RB, Ellisdon AM, Canals M, Halls ML.

J Biol Chem. 2019 Sep 12. pii: jbc.RA119.008685. doi: 10.1074/jbc.RA119.008685. [Epub ahead of print]

3.

Atmospheric carbon monoxide oxidation is a widespread mechanism supporting microbial survival.

Cordero PRF, Bayly K, Man Leung P, Huang C, Islam ZF, Schittenhelm RB, King GM, Greening C.

ISME J. 2019 Nov;13(11):2868-2881. doi: 10.1038/s41396-019-0479-8. Epub 2019 Jul 29.

PMID:
31358912
4.

Molecular Basis of Unexpected Specificity of ABC Transporter-Associated Substrate-Binding Protein DppA from Helicobacter pylori.

Rahman MM, Machuca MA, Khan MF, Barlow CK, Schittenhelm RB, Roujeinikova A.

J Bacteriol. 2019 Sep 20;201(20). pii: e00400-19. doi: 10.1128/JB.00400-19. Print 2019 Oct 15.

PMID:
31358613
5.

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics.

Greule A, Izoré T, Iftime D, Tailhades J, Schoppet M, Zhao Y, Peschke M, Ahmed I, Kulik A, Adamek M, Goode RJA, Schittenhelm RB, Kaczmarski JA, Jackson CJ, Ziemert N, Krenske EH, De Voss JJ, Stegmann E, Cryle MJ.

Nat Commun. 2019 Jun 13;10(1):2613. doi: 10.1038/s41467-019-10384-w.

6.

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues.

Raajendiran A, Ooi G, Bayliss J, O'Brien PE, Schittenhelm RB, Clark AK, Taylor RA, Rodeheffer MS, Burton PR, Watt MJ.

Cell Rep. 2019 Apr 30;27(5):1528-1540.e7. doi: 10.1016/j.celrep.2019.04.010.

7.

RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2.

Zhang Q, McKenzie NJ, Warneford-Thomson R, Gail EH, Flanigan SF, Owen BM, Lauman R, Levina V, Garcia BA, Schittenhelm RB, Bonasio R, Davidovich C.

Nat Struct Mol Biol. 2019 Mar;26(3):237-247. doi: 10.1038/s41594-019-0197-y. Epub 2019 Mar 4.

8.

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer.

Watt MJ, Clark AK, Selth LA, Haynes VR, Lister N, Rebello R, Porter LH, Niranjan B, Whitby ST, Lo J, Huang C, Schittenhelm RB, Anderson KE, Furic L, Wijayaratne PR, Matzaris M, Montgomery MK, Papargiris M, Norden S, Febbraio M, Risbridger GP, Frydenberg M, Nomura DK, Taylor RA.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau5758. doi: 10.1126/scitranslmed.aau5758.

PMID:
30728288
9.

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation.

Ma X, Zhang L, Song J, Nguyen E, Lee RS, Rodgers SJ, Li F, Huang C, Schittenhelm RB, Chan H, Chheang C, Wu J, Brown KK, Mitchell CA, Simpson KJ, Daly RJ.

Nat Commun. 2019 Jan 17;10(1):296. doi: 10.1038/s41467-018-08154-1.

10.

A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling.

Koch B, Barugahare AA, Lo TL, Huang C, Schittenhelm RB, Powell DR, Beilharz TH, Traven A.

Cell Rep. 2018 Nov 20;25(8):2244-2258.e7. doi: 10.1016/j.celrep.2018.10.080.

11.

Biodosimetric transcriptional and proteomic changes are conserved in irradiated human tissue.

Keam SP, Gulati T, Gamell C, Caramia F, Arnau GM, Huang C, Schittenhelm RB, Kleifeld O, Neeson PJ, Williams SG, Haupt Y.

Radiat Environ Biophys. 2018 Aug;57(3):241-249. doi: 10.1007/s00411-018-0746-5. Epub 2018 May 30.

PMID:
29850926
12.

Identification of Novel Acinetobacter baumannii Type VI Secretion System Antibacterial Effector and Immunity Pairs.

Fitzsimons TC, Lewis JM, Wright A, Kleifeld O, Schittenhelm RB, Powell D, Harper M, Boyce JD.

Infect Immun. 2018 Jul 23;86(8). pii: e00297-18. doi: 10.1128/IAI.00297-18. Print 2018 Aug.

13.

Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data-independent acquisition (DIA) mass spectrometry.

Keam SP, Gulati T, Gamell C, Caramia F, Huang C, Schittenhelm RB, Kleifeld O, Neeson PJ, Haupt Y, Williams SG.

Prostate. 2018 Jun;78(8):563-575. doi: 10.1002/pros.23500. Epub 2018 Mar 9.

PMID:
29520850
14.

Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization.

Huang C, Lewis C, Borg NA, Canals M, Diep H, Drummond GR, Goode RJ, Schittenhelm RB, Vinh A, Zhu M, Kemp-Harper B, Kleifeld O, Stone MJ.

J Proteome Res. 2018 Apr 6;17(4):1485-1499. doi: 10.1021/acs.jproteome.7b00828. Epub 2018 Mar 13.

PMID:
29508616
15.

Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells.

Gulati T, Huang C, Caramia F, Raghu D, Paul PJ, Goode RJA, Keam SP, Williams SG, Haupt S, Kleifeld O, Schittenhelm RB, Gamell C, Haupt Y.

Mol Cell Proteomics. 2018 Jun;17(6):1170-1183. doi: 10.1074/mcp.RA117.000504. Epub 2018 Feb 20.

16.

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning.

Reichenbach A, Stark R, Mequinion M, Denis RRG, Goularte JF, Clarke RE, Lockie SH, Lemus MB, Kowalski GM, Bruce CR, Huang C, Schittenhelm RB, Mynatt RL, Oldfield BJ, Watt MJ, Luquet S, Andrews ZB.

Cell Rep. 2018 Feb 13;22(7):1745-1759. doi: 10.1016/j.celrep.2018.01.067.

17.

Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region.

Gulliver EL, Wright A, Lucas DD, Mégroz M, Kleifeld O, Schittenhelm RB, Powell DR, Seemann T, Bulitta JB, Harper M, Boyce JD.

RNA. 2018 May;24(5):704-720. doi: 10.1261/rna.063248.117. Epub 2018 Feb 12.

18.

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity.

Chan FL, Vinod B, Novy K, Schittenhelm RB, Huang C, Udugama M, Nunez-Iglesias J, Lin JI, Hii L, Chan J, Pickett HA, Daly RJ, Wong LH.

Nucleic Acids Res. 2017 Dec 1;45(21):12340-12353. doi: 10.1093/nar/gkx904.

19.

Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis.

Kittilä T, Kittel C, Tailhades J, Butz D, Schoppet M, Büttner A, Goode RJA, Schittenhelm RB, van Pee KH, Süssmuth RD, Wohlleben W, Cryle MJ, Stegmann E.

Chem Sci. 2017 Sep 1;8(9):5992-6004. doi: 10.1039/c7sc00460e. Epub 2017 Jul 13.

20.

Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming.

Liu X, Nefzger CM, Rossello FJ, Chen J, Knaupp AS, Firas J, Ford E, Pflueger J, Paynter JM, Chy HS, O'Brien CM, Huang C, Mishra K, Hodgson-Garms M, Jansz N, Williams SM, Blewitt ME, Nilsson SK, Schittenhelm RB, Laslett AL, Lister R, Polo JM.

Nat Methods. 2017 Nov;14(11):1055-1062. doi: 10.1038/nmeth.4436. Epub 2017 Sep 25.

PMID:
28945704
21.

Structural basis for substrate selection by the translocation and assembly module of the β-barrel assembly machinery.

Bamert RS, Lundquist K, Hwang H, Webb CT, Shiota T, Stubenrauch CJ, Belousoff MJ, Goode RJA, Schittenhelm RB, Zimmerman R, Jung M, Gumbart JC, Lithgow T.

Mol Microbiol. 2017 Oct;106(1):142-156. doi: 10.1111/mmi.13757. Epub 2017 Aug 9.

22.

Chlorinated Glycopeptide Antibiotic Peptide Precursors Improve Cytochrome P450-Catalyzed Cyclization Cascade Efficiency.

Peschke M, Brieke C, Goode RJ, Schittenhelm RB, Cryle MJ.

Biochemistry. 2017 Mar 7;56(9):1239-1247. doi: 10.1021/acs.biochem.6b01102. Epub 2017 Feb 24.

PMID:
28218515
23.

A prominent role of PDIA6 in processing of misfolded proinsulin.

Gorasia DG, Dudek NL, Safavi-Hemami H, Perez RA, Schittenhelm RB, Saunders PM, Wee S, Mangum JE, Hubbard MJ, Purcell AW.

Biochim Biophys Acta. 2016 Jun;1864(6):715-723. doi: 10.1016/j.bbapap.2016.03.002. Epub 2016 Mar 3.

PMID:
26947243
24.

Human Leukocyte Antigen (HLA) B27 Allotype-Specific Binding and Candidate Arthritogenic Peptides Revealed through Heuristic Clustering of Data-independent Acquisition Mass Spectrometry (DIA-MS) Data.

Schittenhelm RB, Sivaneswaran S, Lim Kam Sian TC, Croft NP, Purcell AW.

Mol Cell Proteomics. 2016 Jun;15(6):1867-76. doi: 10.1074/mcp.M115.056358. Epub 2016 Feb 29.

25.

Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma.

Woods K, Knights AJ, Anaka M, Schittenhelm RB, Purcell AW, Behren A, Cebon J.

J Immunother Cancer. 2016 Feb 16;4:10. doi: 10.1186/s40425-016-0111-7. eCollection 2016.

26.

A Systems Approach to Understand Antigen Presentation and the Immune Response.

Dudek NL, Croft NP, Schittenhelm RB, Ramarathinam SH, Purcell AW.

Methods Mol Biol. 2016;1394:189-209. doi: 10.1007/978-1-4939-3341-9_14.

PMID:
26700050
27.

An open-source computational and data resource to analyze digital maps of immunopeptidomes.

Caron E, Espona L, Kowalewski DJ, Schuster H, Ternette N, Alpízar A, Schittenhelm RB, Ramarathinam SH, Lindestam Arlehamn CS, Chiek Koh C, Gillet LC, Rabsteyn A, Navarro P, Kim S, Lam H, Sturm T, Marcilla M, Sette A, Campbell DS, Deutsch EW, Moritz RL, Purcell AW, Rammensee HG, Stevanovic S, Aebersold R.

Elife. 2015 Jul 8;4. doi: 10.7554/eLife.07661.

28.

Assembly of the secretion pores GspD, Wza and CsgG into bacterial outer membranes does not require the Omp85 proteins BamA or TamA.

Dunstan RA, Hay ID, Wilksch JJ, Schittenhelm RB, Purcell AW, Clark J, Costin A, Ramm G, Strugnell RA, Lithgow T.

Mol Microbiol. 2015 Aug;97(4):616-29. doi: 10.1111/mmi.13055. Epub 2015 Jun 6.

29.

A comprehensive analysis of peptides presented by HLA-A1.

Giam K, Ayala-Perez R, Illing PT, Schittenhelm RB, Croft NP, Purcell AW, Dudek NL.

Tissue Antigens. 2015 Jun;85(6):492-6. doi: 10.1111/tan.12565. Epub 2015 Apr 16.

PMID:
25880248
30.

Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex.

Okada H, Schittenhelm RB, Straessle A, Hafen E.

PLoS One. 2015 Mar 20;10(3):e0113902. doi: 10.1371/journal.pone.0113902. eCollection 2015.

31.

Simultaneous Quantification of Viral Antigen Expression Kinetics Using Data-Independent (DIA) Mass Spectrometry.

Croft NP, de Verteuil DA, Smith SA, Wong YC, Schittenhelm RB, Tscharke DC, Purcell AW.

Mol Cell Proteomics. 2015 May;14(5):1361-72. doi: 10.1074/mcp.M114.047373. Epub 2015 Mar 9.

32.

Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes.

Schittenhelm RB, Sian TC, Wilmann PG, Dudek NL, Purcell AW.

Arthritis Rheumatol. 2015 Mar;67(3):702-13. doi: 10.1002/art.38963.

33.

A comprehensive analysis of constitutive naturally processed and presented HLA-C*04:01 (Cw4)-specific peptides.

Schittenhelm RB, Dudek NL, Croft NP, Ramarathinam SH, Purcell AW.

Tissue Antigens. 2014 Mar;83(3):174-9. doi: 10.1111/tan.12282. Epub 2014 Jan 7.

PMID:
24397554
34.

Biochemical membrane lipidomics during Drosophila development.

Guan XL, Cestra G, Shui G, Kuhrs A, Schittenhelm RB, Hafen E, van der Goot FG, Robinett CC, Gatti M, Gonzalez-Gaitan M, Wenk MR.

Dev Cell. 2013 Jan 14;24(1):98-111. doi: 10.1016/j.devcel.2012.11.012. Epub 2012 Dec 20.

35.

Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome.

Glatter T, Schittenhelm RB, Rinner O, Roguska K, Wepf A, Jünger MA, Köhler K, Jevtov I, Choi H, Schmidt A, Nesvizhskii AI, Stocker H, Hafen E, Aebersold R, Gstaiger M.

Mol Syst Biol. 2011 Nov 8;7:547. doi: 10.1038/msb.2011.79.

36.

Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1.

Schittenhelm RB, Althoff F, Heidmann S, Lehner CF.

J Cell Sci. 2010 Nov 1;123(Pt 21):3768-79. doi: 10.1242/jcs.067934. Epub 2010 Oct 12.

37.

Intrakinetochore localization and essential functional domains of Drosophila Spc105.

Schittenhelm RB, Chaleckis R, Lehner CF.

EMBO J. 2009 Aug 19;28(16):2374-86. doi: 10.1038/emboj.2009.188. Epub 2009 Jul 9.

38.

Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes.

Schittenhelm RB, Heeger S, Althoff F, Walter A, Heidmann S, Mechtler K, Lehner CF.

Chromosoma. 2007 Aug;116(4):385-402. Epub 2007 Mar 1.

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