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Changes in protein function underlie the disease spectrum in patients with CHIP mutations.

Madrigal SC, McNeil Z, Sanchez-Hodge R, Shi CH, Patterson C, Scaglione KM, Schisler JC.

J Biol Chem. 2019 Dec 13;294(50):19236-19245. doi: 10.1074/jbc.RA119.011173. Epub 2019 Oct 16.


Non-radiometric Cell-free Assay to Measure the Effect of Molecular Chaperones on AMP-activated Kinase Activity.

Wilson EB, Rubel CE, Schisler JC.

Bio Protoc. 2019 Apr 20;9(8). pii: e3218. doi: 10.21769/BioProtoc.3218.


Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.

Shi CH, Rubel C, Soss SE, Sanchez-Hodge R, Zhang S, Madrigal SC, Ravi S, McDonough H, Page RC, Chazin WJ, Patterson C, Mao CY, Willis MS, Luo HY, Li YS, Stevens DA, Tang MB, Du P, Wang YH, Hu ZW, Xu YM, Schisler JC.

PLoS Genet. 2018 Sep 17;14(9):e1007664. doi: 10.1371/journal.pgen.1007664. eCollection 2018 Sep.


Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP.

Ravi S, Parry TL, Willis MS, Lockyer P, Patterson C, Bain JR, Stevens RD, Ilkayeva OR, Newgard CB, Schisler JC.

J Cardiovasc Dev Dis. 2018 Aug 15;5(3). pii: E43. doi: 10.3390/jcdd5030043.


Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo.

Mota R, Parry TL, Yates CC, Qiang Z, Eaton SC, Mwiza JM, Tulasi D, Schisler JC, Patterson C, Zaglia T, Sandri M, Willis MS.

Am J Pathol. 2018 Jul;188(7):1676-1692. doi: 10.1016/j.ajpath.2018.04.007. Epub 2018 May 23.


Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations.

Halladay JR, Lenhart KC, Robasky K, Jones W, Homan WF, Cummings DM, Cené CW, Hinderliter AL, Miller CL, Donahue KE, Garcia BA, Keyserling TC, Ammerman AS, Patterson C, DeWalt DA, Johnston LF, Willis MS, Schisler JC.

J Pers Med. 2018 Apr 30;8(2). pii: E16. doi: 10.3390/jpm8020016.


Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP.

Tang MB, Li YS, Li SH, Cheng Y, Zhang S, Luo HY, Mao CY, Hu ZW, Schisler JC, Shi CH, Xu YM.

Sci Rep. 2018 Apr 23;8(1):6379. doi: 10.1038/s41598-018-24414-y.


TAS2R38 Predisposition to Bitter Taste Associated with Differential Changes in Vegetable Intake in Response to a Community-Based Dietary Intervention.

Calancie L, Keyserling TC, Taillie LS, Robasky K, Patterson C, Ammerman AS, Schisler JC.

G3 (Bethesda). 2018 May 31;8(6):2107-2119. doi: 10.1534/g3.118.300547.


Modeling the Transition From Decompensated to Pathological Hypertrophy.

Pascual F, Schisler JC, Grevengoed TJ, Willis MS, Coleman RA.

J Am Heart Assoc. 2018 Apr 5;7(8). pii: e008293. doi: 10.1161/JAHA.117.008293.


CHIP Regulates Aquaporin-2 Quality Control and Body Water Homeostasis.

Wu Q, Moeller HB, Stevens DA, Sanchez-Hodge R, Childers G, Kortenoeven MLA, Cheng L, Rosenbaek LL, Rubel C, Patterson C, Pisitkun T, Schisler JC, Fenton RA.

J Am Soc Nephrol. 2018 Mar;29(3):936-948. doi: 10.1681/ASN.2017050526. Epub 2017 Dec 14.


Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease.

Ravi S, Schuck RN, Hilliard E, Lee CR, Dai X, Lenhart K, Willis MS, Jensen BC, Stouffer GA, Patterson C, Schisler JC.

Am J Pathol. 2017 Dec;187(12):2895-2911. doi: 10.1016/j.ajpath.2017.08.006. Epub 2017 Nov 16.


Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.

Bai X, Mangum KD, Dee RA, Stouffer GA, Lee CR, Oni-Orisan A, Patterson C, Schisler JC, Viera AJ, Taylor JM, Mack CP.

J Clin Invest. 2017 Feb 1;127(2):670-680. doi: 10.1172/JCI88899. Epub 2017 Jan 23.


Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities.

Smith CE, Fullerton SM, Dookeran KA, Hampel H, Tin A, Maruthur NM, Schisler JC, Henderson JA, Tucker KL, Ordovás JM.

Health Aff (Millwood). 2016 Aug 1;35(8):1367-73. doi: 10.1377/hlthaff.2015.1476. Review.


Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo.

Ilaiwy A, Liu M, Parry TL, Bain JR, Newgard CB, Schisler JC, Muehlbauer MJ, Despa F, Willis MS.

Metabolomics. 2016 May;12(5). pii: 95. doi: 10.1007/s11306-016-1022-9. Epub 2016 Apr 23.


Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.

Parry TL, Desai G, Schisler JC, Li L, Quintana MT, Stanley N, Lockyer P, Patterson C, Willis MS.

Cardiovasc Pathol. 2016 Mar-Apr;25(2):127-140. doi: 10.1016/j.carpath.2015.09.008. Epub 2015 Oct 29.


Global gene expression profiling of a mouse model of ovarian clear cell carcinoma caused by ARID1A and PIK3CA mutations implicates a role for inflammatory cytokine signaling.

Chandler RL, Raab JR, Vernon M, Magnuson T, Schisler JC.

Genom Data. 2015 Jul 14;5:329-32. doi: 10.1016/j.gdata.2015.06.027. eCollection 2015 Sep.


MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.

He J, Quintana MT, Sullivan J, L Parry T, J Grevengoed T, Schisler JC, Hill JA, Yates CC, Mapanga RF, Essop MF, Stansfield WE, Bain JR, Newgard CB, Muehlbauer MJ, Han Y, Clarke BA, Willis MS.

Cardiovasc Diabetol. 2015 Aug 5;14:97. doi: 10.1186/s12933-015-0252-x.


mTORtuous effect on the elastic heart.

Schisler JC, Coleman RA.

Oncotarget. 2015 Jul 10;6(19):16810-1. No abstract available.


The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.

Rodríguez JE, Liao JY, He J, Schisler JC, Newgard CB, Drujan D, Glass DJ, Frederick CB, Yoder BC, Lalush DS, Patterson C, Willis MS.

Mol Cell Endocrinol. 2015 Sep 15;413:36-48. doi: 10.1016/j.mce.2015.06.008. Epub 2015 Jun 25.


PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C.

J Clin Invest. 2015 Jul 1;125(7):2759-71. doi: 10.1172/JCI80369. Epub 2015 Jun 15.


Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions.

Schisler JC, Ronnebaum SM, Madden M, Channell M, Campen M, Willis MS.

Inhal Toxicol. 2015;27(5):272-80. doi: 10.3109/08958378.2015.1030481. Epub 2015 May 5.


Using community-based participatory research principles to develop more understandable recruitment and informed consent documents in genomic research.

Skinner HG, Calancie L, Vu MB, Garcia B, DeMarco M, Patterson C, Ammerman A, Schisler JC.

PLoS One. 2015 May 4;10(5):e0125466. doi: 10.1371/journal.pone.0125466. eCollection 2015.


Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin.

Schisler JC, Grevengoed TJ, Pascual F, Cooper DE, Ellis JM, Paul DS, Willis MS, Patterson C, Jia W, Coleman RA.

J Am Heart Assoc. 2015 Feb 24;4(2). pii: e001136. doi: 10.1161/JAHA.114.001136.


Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.

Chandler RL, Damrauer JS, Raab JR, Schisler JC, Wilkerson MD, Didion JP, Starmer J, Serber D, Yee D, Xiong J, Darr DB, Pardo-Manuel de Villena F, Kim WY, Magnuson T.

Nat Commun. 2015 Jan 27;6:6118. doi: 10.1038/ncomms7118.


Minireview: hey U(PS): metabolic and proteolytic homeostasis linked via AMPK and the ubiquitin proteasome system.

Ronnebaum SM, Patterson C, Schisler JC.

Mol Endocrinol. 2014 Oct;28(10):1602-15. doi: 10.1210/me.2014-1180. Epub 2014 Aug 6. Review.


Emerging evidence of coding mutations in the ubiquitin-proteasome system associated with cerebellar ataxias.

Ronnebaum SM, Patterson C, Schisler JC.

Hum Genome Var. 2014 Oct 23;1:14018. doi: 10.1038/hgv.2014.18. eCollection 2014. Review.


Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP.

Shi CH, Schisler JC, Rubel CE, Tan S, Song B, McDonough H, Xu L, Portbury AL, Mao CY, True C, Wang RH, Wang QZ, Sun SL, Seminara SB, Patterson C, Xu YM.

Hum Mol Genet. 2014 Feb 15;23(4):1013-24. doi: 10.1093/hmg/ddt497. Epub 2013 Oct 9.


Cardio-metabolic effectsof HIV protease inhibitors (lopinavir/ritonavir).

Reyskens KM, Fisher TL, Schisler JC, O'Connor WG, Rogers AB, Willis MS, Planesse C, Boyer F, Rondeau P, Bourdon E, Essop MF.

PLoS One. 2013 Sep 30;8(9):e73347. doi: 10.1371/journal.pone.0073347. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/a1e2a42f-7f10-4654-a042-57d19de50208.


Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.

Hayes HL, Moss LG, Schisler JC, Haldeman JM, Zhang Z, Rosenberg PB, Newgard CB, Hohmeier HE.

Mol Cell Biol. 2013 Oct;33(20):4017-29. doi: 10.1128/MCB.00469-13. Epub 2013 Aug 12.


CHIP protects against cardiac pressure overload through regulation of AMPK.

Schisler JC, Rubel CE, Zhang C, Lockyer P, Cyr DM, Patterson C.

J Clin Invest. 2013 Aug;123(8):3588-99. doi: 10.1172/JCI69080. Epub 2013 Jul 25.


Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates.

Rubel CE, Schisler JC, Hamlett ED, DeKroon RM, Gautel M, Alzate O, Patterson C.

Cell Biochem Biophys. 2013 Sep;67(1):127-38. doi: 10.1007/s12013-013-9624-6.


Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.

Willis MS, Wadosky KM, Rodríguez JE, Schisler JC, Lockyer P, Hilliard EG, Glass DJ, Patterson C.

Cell Biochem Funct. 2014 Jan;32(1):39-50. doi: 10.1002/cbf.2969. Epub 2013 Mar 20.


BMPER regulates cardiomyocyte size and vessel density in vivo.

Willis MS, Dyer LA, Ren R, Lockyer P, Moreno-Miralles I, Schisler JC, Patterson C.

Cardiovasc Pathol. 2013 May-Jun;22(3):228-40. doi: 10.1016/j.carpath.2012.10.005. Epub 2012 Nov 28.


ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.

Chandler RL, Brennan J, Schisler JC, Serber D, Patterson C, Magnuson T.

Mol Cell Biol. 2013 Jan;33(2):265-80. doi: 10.1128/MCB.01008-12. Epub 2012 Nov 5.


Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis.

Pi X, Lockyer P, Dyer LA, Schisler JC, Russell B, Carey S, Sweet DT, Chen Z, Tzima E, Willis MS, Homeister JW, Moser M, Patterson C.

Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2214-22. doi: 10.1161/ATVBAHA.112.252015. Epub 2012 Jul 5.


A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.

Stephens SB, Schisler JC, Hohmeier HE, An J, Sun AY, Pitt GS, Newgard CB.

Cell Metab. 2012 Jul 3;16(1):33-43. doi: 10.1016/j.cmet.2012.05.011.


Tear me down: role of calpain in the development of cardiac ventricular hypertrophy.

Patterson C, Portbury AL, Schisler JC, Willis MS.

Circ Res. 2011 Aug 5;109(4):453-62. doi: 10.1161/CIRCRESAHA.110.239749. Review.


Regulation of AMPK by the ubiquitin proteasome system.

Zungu M, Schisler JC, Essop MF, McCudden C, Patterson C, Willis MS.

Am J Pathol. 2011 Jan;178(1):4-11. doi: 10.1016/j.ajpath.2010.11.030. Epub 2010 Dec 23. Review.


Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry.

Schisler JC, Charles PC, Parker JS, Hilliard EG, Mapara S, Meredith D, Lineberger RE, Wu SS, Alder BD, Stouffer GA, Patterson C.

PLoS One. 2009 Dec 9;4(12):e8183. doi: 10.1371/journal.pone.0008183.


Minireview: Won't get fooled again: the nonmetabolic roles of peroxisome proliferator-activated receptors (PPARs) in the heart.

Lockyer P, Schisler JC, Patterson C, Willis MS.

Mol Endocrinol. 2010 Jun;24(6):1111-9. doi: 10.1210/me.2009-0374. Epub 2009 Dec 16. Review.


Seek and destroy: the ubiquitin----proteasome system in cardiac disease.

Rodríguez JE, Schisler JC, Patterson C, Willis MS.

Curr Hypertens Rep. 2009 Dec;11(6):396-405. Review.


Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo.

Willis MS, Schisler JC, Li L, Rodríguez JE, Hilliard EG, Charles PC, Patterson C.

Circ Res. 2009 Jul 2;105(1):80-8. doi: 10.1161/CIRCRESAHA.109.194928. Epub 2009 Jun 4.


New insights into bone morphogenetic protein signaling: focus on angiogenesis.

Moreno-Miralles I, Schisler JC, Patterson C.

Curr Opin Hematol. 2009 May;16(3):195-201. doi: 10.1097/MOH.0b013e32832a07d6. Review.


Build it up-Tear it down: protein quality control in the cardiac sarcomere.

Willis MS, Schisler JC, Portbury AL, Patterson C.

Cardiovasc Res. 2009 Feb 15;81(3):439-48. doi: 10.1093/cvr/cvn289. Epub 2008 Oct 29. Review.


Brothers and sisters: molecular insights into arterial-venous heterogeneity.

Aitsebaomo J, Portbury AL, Schisler JC, Patterson C.

Circ Res. 2008 Oct 24;103(9):929-39. doi: 10.1161/CIRCRESAHA.108.184937. Review.


Tobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males.

Charles PC, Alder BD, Hilliard EG, Schisler JC, Lineberger RE, Parker JS, Mapara S, Wu SS, Portbury A, Patterson C, Stouffer GA.

BMC Med Genomics. 2008 Aug 18;1:38. doi: 10.1186/1755-8794-1-38.


Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.

Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB.

Mol Cell Biol. 2008 May;28(10):3465-76. doi: 10.1128/MCB.01791-07. Epub 2008 Mar 17.


Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.

Fueger PT, Schisler JC, Lu D, Babu DA, Mirmira RG, Newgard CB, Hohmeier HE.

Mol Endocrinol. 2008 May;22(5):1251-9. doi: 10.1210/me.2007-0500. Epub 2008 Feb 7.


You spin me round: MaFBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record).

Schisler JC, Willis MS, Patterson C.

Cell Cycle. 2008 Feb 15;7(4):440-3. Epub 2007 Dec 12. Review.


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