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Items: 1 to 50 of 100

1.

Tropomyosin receptor kinase inhibitors: an updated patent review for 2016-2019.

Bailey JJ, Jaworski C, Tung D, Wängler C, Wängler B, Schirrmacher R.

Expert Opin Ther Pat. 2020 Mar 10:1-15. doi: 10.1080/13543776.2020.1737011. [Epub ahead of print]

PMID:
32129124
2.

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography.

Connolly D, Bailey JJ, Ilhan H, Bartenstein P, Wängler C, Wängler B, Wuest M, Wuest F, Schirrmacher R.

J Vis Exp. 2020 Jan 11;(155). doi: 10.3791/60623.

PMID:
31984969
3.

Efficient radiosynthesis and preclinical evaluation of [18 F]FOMPyD as a positron emission tomography tracer candidate for TrkB/C receptor imaging.

Singleton TA, Bdair H, Bailey JJ, Choi S, Aliaga A, Rosa-Neto P, Schirrmacher R, Bernard-Gauthier V, Kostikov A.

J Labelled Comp Radiopharm. 2020 Mar;63(3):144-150. doi: 10.1002/jlcr.3827. Epub 2020 Jan 29.

PMID:
31919878
4.

Biodistribution and first clinical results of 18F-SiFAlin-TATE PET: a novel 18F-labeled somatostatin analog for imaging of neuroendocrine tumors.

Ilhan H, Lindner S, Todica A, Cyran CC, Tiling R, Auernhammer CJ, Spitzweg C, Boeck S, Unterrainer M, Gildehaus FJ, Böning G, Jurkschat K, Wängler C, Wängler B, Schirrmacher R, Bartenstein P.

Eur J Nucl Med Mol Imaging. 2020 Apr;47(4):870-880. doi: 10.1007/s00259-019-04501-6. Epub 2019 Sep 6.

PMID:
31492994
5.

First-in-human 18F-SiFAlin-TATE PET/CT for NET imaging and theranostics.

Ilhan H, Todica A, Lindner S, Boening G, Gosewisch A, Wängler C, Wängler B, Schirrmacher R, Bartenstein P.

Eur J Nucl Med Mol Imaging. 2019 Oct;46(11):2400-2401. doi: 10.1007/s00259-019-04448-8. Epub 2019 Jul 27. No abstract available.

PMID:
31352578
6.

First-in-Human Brain Imaging of [18F]TRACK, a PET tracer for Tropomyosin Receptor Kinases.

Bailey JJ, Kaiser L, Lindner S, Wüst M, Thiel A, Soucy JP, Rosa-Neto P, Scott PJH, Unterrainer M, Kaplan DR, Wängler C, Wängler B, Bartenstein P, Bernard-Gauthier V, Schirrmacher R.

ACS Chem Neurosci. 2019 Jun 19;10(6):2697-2702. doi: 10.1021/acschemneuro.9b00144. Epub 2019 Apr 29.

PMID:
31017386
7.

Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging.

Schirrmacher R, Bailey JJ, Mossine AV, Scott PJH, Kaiser L, Bartenstein P, Lindner S, Kaplan DR, Kostikov A, Fricker G, Mahringer A, Rosa-Neto P, Schirrmacher E, Wängler C, Wängler B, Thiel A, Soucy JP, Bernard-Gauthier V.

Pharmaceuticals (Basel). 2019 Jan 3;12(1). pii: E7. doi: 10.3390/ph12010007. Review.

8.

iEDDA Conjugation Reaction in Radiometal Labeling of Peptides with 68Ga and 64Cu: Unexpected Findings.

Litau S, Seibold U, Wängler B, Schirrmacher R, Wängler C.

ACS Omega. 2018 Oct 31;3(10):14039-14053. doi: 10.1021/acsomega.8b01926. Epub 2018 Oct 25.

9.

Design, Synthesis, In Vitro, and Initial In Vivo Evaluation of Heterobivalent Peptidic Ligands Targeting Both NPY(Y₁)- and GRP-Receptors-An Improvement for Breast Cancer Imaging?

Vall-Sagarra A, Litau S, Decristoforo C, Wängler B, Schirrmacher R, Fricker G, Wängler C.

Pharmaceuticals (Basel). 2018 Jul 4;11(3). pii: E65. doi: 10.3390/ph11030065.

10.

Design, synthesis and in vitro evaluation of heterobivalent peptidic radioligands targeting both GRP- and VPAC1-Receptors concomitantly overexpressed on various malignancies - Is the concept feasible?

Lindner S, Fiedler L, Wängler B, Bartenstein P, Schirrmacher R, Wängler C.

Eur J Med Chem. 2018 Jul 15;155:84-95. doi: 10.1016/j.ejmech.2018.05.047. Epub 2018 May 29.

PMID:
29864700
11.

Gastrin-Releasing Peptide Receptor- and Prostate-Specific Membrane Antigen-Specific Ultrasmall Gold Nanoparticles for Characterization and Diagnosis of Prostate Carcinoma via Fluorescence Imaging.

Pretze M, Hien A, Rädle M, Schirrmacher R, Wängler C, Wängler B.

Bioconjug Chem. 2018 May 16;29(5):1525-1533. doi: 10.1021/acs.bioconjchem.8b00067. Epub 2018 Mar 27.

PMID:
29542916
12.

Recent Advances in 18F Radiochemistry: A Focus on B-18F, Si-18F, Al-18F, and C-18F Radiofluorination via Spirocyclic Iodonium Ylides.

Bernard-Gauthier V, Lepage ML, Waengler B, Bailey JJ, Liang SH, Perrin DM, Vasdev N, Schirrmacher R.

J Nucl Med. 2018 Apr;59(4):568-572. doi: 10.2967/jnumed.117.197095. Epub 2017 Dec 28. Review.

13.

Identification of [18F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging.

Bernard-Gauthier V, Mossine AV, Mahringer A, Aliaga A, Bailey JJ, Shao X, Stauff J, Arteaga J, Sherman P, Grand'Maison M, Rochon PL, Wängler B, Wängler C, Bartenstein P, Kostikov A, Kaplan DR, Fricker G, Rosa-Neto P, Scott PJH, Schirrmacher R.

J Med Chem. 2018 Feb 22;61(4):1737-1743. doi: 10.1021/acs.jmedchem.7b01607. Epub 2018 Jan 5.

PMID:
29257860
14.

18F-Radiolabeling and In Vivo Analysis of SiFA-Derivatized Polymeric Core-Shell Nanoparticles.

Berke S, Kampmann AL, Wuest M, Bailey JJ, Glowacki B, Wuest F, Jurkschat K, Weberskirch R, Schirrmacher R.

Bioconjug Chem. 2018 Jan 17;29(1):89-95. doi: 10.1021/acs.bioconjchem.7b00630. Epub 2017 Dec 14.

PMID:
29202229
15.

Synthesis, in vitro and in vivo evaluation of 18F-fluoronorimatinib as radiotracer for Imatinib-sensitive gastrointestinal stromal tumors.

Prause M, Niedermoser S, Wängler C, Decristoforo C, Seibold U, Riester S, Taguchi T, Schirrmacher R, Fricker G, Wängler B.

Nucl Med Biol. 2018 Feb;57:1-11. doi: 10.1016/j.nucmedbio.2017.11.004. Epub 2017 Nov 17.

PMID:
29175467
16.

Automated synthesis of PET radiotracers by copper-mediated 18 F-fluorination of organoborons: Importance of the order of addition and competing protodeborylation.

Mossine AV, Brooks AF, Bernard-Gauthier V, Bailey JJ, Ichiishi N, Schirrmacher R, Sanford MS, Scott PJH.

J Labelled Comp Radiopharm. 2018 Mar;61(3):228-236. doi: 10.1002/jlcr.3583. Epub 2018 Feb 2.

17.

Small Prosthetic Groups in 18F-Radiochemistry: Useful Auxiliaries for the Design of 18F-PET Tracers.

Schirrmacher R, Wängler B, Bailey J, Bernard-Gauthier V, Schirrmacher E, Wängler C.

Semin Nucl Med. 2017 Sep;47(5):474-492. doi: 10.1053/j.semnuclmed.2017.07.001. Epub 2017 Jul 17. Review.

PMID:
28826522
18.

A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human.

Bernard-Gauthier V, Bailey JJ, Mossine AV, Lindner S, Vomacka L, Aliaga A, Shao X, Quesada CA, Sherman P, Mahringer A, Kostikov A, Grand'Maison M, Rosa-Neto P, Soucy JP, Thiel A, Kaplan DR, Fricker G, Wängler B, Bartenstein P, Schirrmacher R, Scott PJH.

J Med Chem. 2017 Aug 24;60(16):6897-6910. doi: 10.1021/acs.jmedchem.7b00396. Epub 2017 Jul 21.

PMID:
28696690
19.

Design and synthesis of a fluorinated quinazoline-based type-II Trk inhibitor as a scaffold for PET radiotracer development.

Bernard-Gauthier V, Mahringer A, Vesnaver M, Fricker G, Schirrmacher R.

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2771-2775. doi: 10.1016/j.bmcl.2017.04.064. Epub 2017 Apr 21.

PMID:
28476569
20.

A Nutritional Perspective of Ketogenic Diet in Cancer: A Narrative Review.

Oliveira CLP, Mattingly S, Schirrmacher R, Sawyer MB, Fine EJ, Prado CM.

J Acad Nutr Diet. 2018 Apr;118(4):668-688. doi: 10.1016/j.jand.2017.02.003. Epub 2017 Mar 30. Review.

PMID:
28366810
21.

Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.

Bailey JJ, Schirrmacher R, Farrell K, Bernard-Gauthier V.

Expert Opin Ther Pat. 2017 Jul;27(7):831-849. doi: 10.1080/13543776.2017.1297797. Epub 2017 Mar 8. Review.

PMID:
28270021
22.

Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.

Bailey JJ, Schirrmacher R, Farrell K, Bernard-Gauthier V.

Expert Opin Ther Pat. 2017 Jun;27(6):733-751. doi: 10.1080/13543776.2017.1297796. Epub 2017 Mar 8. Review.

PMID:
28270010
23.

Radiosynthesis and Preclinical Evaluation of 18F-Fluoroglycosylated Octreotate for Somatostatin Receptor Imaging.

Maschauer S, Heilmann M, Wängler C, Schirrmacher R, Prante O.

Bioconjug Chem. 2016 Nov 16;27(11):2707-2714. Epub 2016 Oct 18.

PMID:
27715017
24.

Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1.

Schirrmacher R, Dea M, Heiss WD, Kostikov A, Funck T, Quessy S, Bedell B, Dancause N, Thiel A.

Cerebrovasc Dis. 2016;41(3-4):139-47. doi: 10.1159/000442997. Epub 2016 Jan 12.

PMID:
26752046
25.

Recent Advances in the Development and Application of Radiolabeled Kinase Inhibitors for PET Imaging.

Bernard-Gauthier V, Bailey JJ, Berke S, Schirrmacher R.

Molecules. 2015 Dec 9;20(12):22000-27. doi: 10.3390/molecules201219816. Review.

26.

From Unorthodox to Established: The Current Status of (18)F-Trifluoroborate- and (18)F-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging.

Bernard-Gauthier V, Bailey JJ, Liu Z, Wängler B, Wängler C, Jurkschat K, Perrin DM, Schirrmacher R.

Bioconjug Chem. 2016 Feb 17;27(2):267-79. doi: 10.1021/acs.bioconjchem.5b00560. Epub 2015 Nov 25. Review.

PMID:
26566577
27.

Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition.

Bernard-Gauthier V, Schirrmacher R.

Expert Opin Ther Pat. 2016;26(2):291-5. doi: 10.1517/13543776.2016.1118062. Epub 2015 Nov 26.

PMID:
26561352
28.

Next Generation of SiFAlin-Based TATE Derivatives for PET Imaging of SSTR-Positive Tumors: Influence of Molecular Design on In Vitro SSTR Binding and In Vivo Pharmacokinetics.

Litau S, Niedermoser S, Vogler N, Roscher M, Schirrmacher R, Fricker G, Wängler B, Wängler C.

Bioconjug Chem. 2015 Dec 16;26(12):2350-9. doi: 10.1021/acs.bioconjchem.5b00510. Epub 2015 Oct 14.

PMID:
26420336
29.

Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors.

Tomaszowski KH, Schirrmacher R, Kaina B.

Mol Pharm. 2015 Nov 2;12(11):3924-34. doi: 10.1021/acs.molpharmaceut.5b00341. Epub 2015 Oct 1.

PMID:
26379107
30.

Improving the stability of peptidic radiotracers by the introduction of artificial scaffolds: which structure element is most useful?

Bacher L, Fischer G, Litau S, Schirrmacher R, Wängler B, Baller M, Wängler C.

J Labelled Comp Radiopharm. 2015 Aug;58(10):395-402. doi: 10.1002/jlcr.3315. Epub 2015 Jul 27.

PMID:
26219022
31.

Next Step toward Optimization of GRP Receptor Avidities: Determination of the Minimal Distance between BBN(7-14) Units in Peptide Homodimers.

Fischer G, Lindner S, Litau S, Schirrmacher R, Wängler B, Wängler C.

Bioconjug Chem. 2015 Aug 19;26(8):1479-83. doi: 10.1021/acs.bioconjchem.5b00362. Epub 2015 Jul 24.

PMID:
26200324
32.

Synthesis of 3-chloro-6-((4-(di-tert-butyl[(18)F]fluorosilyl)-benzyl)oxy)-1,2,4,5-tetrazine ([(18)F]SiFA-OTz) for rapid tetrazine-based (18)F-radiolabeling.

Zhu J, Li S, Wängler C, Wängler B, Lennox RB, Schirrmacher R.

Chem Commun (Camb). 2015 Aug 11;51(62):12415-8. doi: 10.1039/c5cc03623b.

PMID:
26145162
33.

In Vivo Evaluation of ¹⁸F-SiFAlin-Modified TATE: A Potential Challenge for ⁶⁸Ga-DOTATATE, the Clinical Gold Standard for Somatostatin Receptor Imaging with PET.

Niedermoser S, Chin J, Wängler C, Kostikov A, Bernard-Gauthier V, Vogler N, Soucy JP, McEwan AJ, Schirrmacher R, Wängler B.

J Nucl Med. 2015 Jul;56(7):1100-5. doi: 10.2967/jnumed.114.149583. Epub 2015 May 14.

34.

Syntheses and evaluation of carbon-11- and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-aza-2-oxindole scaffold as Trk PET imaging agents.

Bernard-Gauthier V, Aliaga A, Aliaga A, Boudjemeline M, Hopewell R, Kostikov A, Rosa-Neto P, Thiel A, Schirrmacher R.

ACS Chem Neurosci. 2015 Feb 18;6(2):260-76. doi: 10.1021/cn500193f. Epub 2014 Nov 10.

PMID:
25350780
35.

5-(4-((4-[(18)F]Fluorobenzyl)oxy)-3-methoxybenzyl)pyrimidine-2,4-diamine: a selective dual inhibitor for potential PET imaging of Trk/CSF-1R.

Bernard-Gauthier V, Schirrmacher R.

Bioorg Med Chem Lett. 2014 Oct 15;24(20):4784-90. doi: 10.1016/j.bmcl.2014.09.014. Epub 2014 Sep 16.

PMID:
25257201
36.

¹⁸F-labeled silicon-based fluoride acceptors: potential opportunities for novel positron emitting radiopharmaceuticals.

Bernard-Gauthier V, Wängler C, Schirrmacher E, Kostikov A, Jurkschat K, Wängler B, Schirrmacher R.

Biomed Res Int. 2014;2014:454503. doi: 10.1155/2014/454503. Epub 2014 Jul 24. Review.

37.

Bimodal imaging probes for combined PET and OI: recent developments and future directions for hybrid agent development.

Seibold U, Wängler B, Schirrmacher R, Wängler C.

Biomed Res Int. 2014;2014:153741. doi: 10.1155/2014/153741. Epub 2014 Apr 16. Review.

38.

Rapid (18)F-labeling and loading of PEGylated gold nanoparticles for in vivo applications.

Zhu J, Chin J, Wängler C, Wängler B, Lennox RB, Schirrmacher R.

Bioconjug Chem. 2014 Jun 18;25(6):1143-50. doi: 10.1021/bc5001593. Epub 2014 May 23.

PMID:
24807200
39.

Shuttle-cargo fusion molecules of transport peptides and the hD2/3 receptor antagonist fallypride: a feasible approach to preserve ligand-receptor binding?

Wängler C, Chowdhury S, Höfner G, Djurova P, Purisima EO, Bartenstein P, Wängler B, Fricker G, Wanner KT, Schirrmacher R.

J Med Chem. 2014 May 22;57(10):4368-81. doi: 10.1021/jm5004123. Epub 2014 May 8.

PMID:
24779610
40.

Synthesis and in vitro and in vivo evaluation of SiFA-tagged bombesin and RGD peptides as tumor imaging probes for positron emission tomography.

Lindner S, Michler C, Leidner S, Rensch C, Wängler C, Schirrmacher R, Bartenstein P, Wängler B.

Bioconjug Chem. 2014 Apr 16;25(4):738-49. doi: 10.1021/bc400588e. Epub 2014 Apr 4.

PMID:
24666287
41.

Automated radiosynthesis of N-succinimidyl 3-(di-tert-butyl[(18)F]fluorosilyl)benzoate ([(18)F]SiFB) for peptides and proteins radiolabeling for positron emission tomography.

Koudih R, Kostikov A, Kovacevic M, Jolly D, Bernard-Gauthier V, Chin J, Jurkschat K, Wängler C, Wängler B, Schirrmacher R.

Appl Radiat Isot. 2014 Jul;89:146-50. doi: 10.1016/j.apradiso.2014.02.017. Epub 2014 Feb 22.

PMID:
24631747
42.

PESIN multimerization improves receptor avidities and in vivo tumor targeting properties to GRPR-overexpressing tumors.

Lindner S, Michler C, Wängler B, Bartenstein P, Fischer G, Schirrmacher R, Wängler C.

Bioconjug Chem. 2014 Mar 19;25(3):489-500. doi: 10.1021/bc4004662. Epub 2014 Feb 25.

PMID:
24533789
43.
44.

Chemical modification of single walled carbon nanotubes with tetrazine-tethered gold nanoparticles via a Diels-Alder reaction.

Zhu J, Hiltz J, Lennox RB, Schirrmacher R.

Chem Commun (Camb). 2013 Nov 11;49(87):10275-7. doi: 10.1039/c3cc46325g.

PMID:
24061535
45.

Design of brain imaging agents for positron emission tomography: do large bioconjugates provide an opportunity for in vivo brain imaging?

Schirrmacher R, Bernard-Gauthier V, Reader A, Soucy JP, Schirrmacher E, Wängler B, Wängler C.

Future Med Chem. 2013 Sep;5(14):1621-34. doi: 10.4155/fmc.13.128.

PMID:
24047268
46.

Direct one-step labeling of cysteine residues on peptides with [(11)C]methyl triflate for the synthesis of PET radiopharmaceuticals.

Chin J, Vesnaver M, Bernard-Gauthier V, Saucke-Lacelle E, Wängler B, Wängler C, Schirrmacher R.

Amino Acids. 2013 Nov;45(5):1097-108. doi: 10.1007/s00726-013-1562-5. Epub 2013 Aug 7.

PMID:
23921782
47.

(89)Zr, a radiometal nuclide with high potential for molecular imaging with PET: chemistry, applications and remaining challenges.

Fischer G, Seibold U, Schirrmacher R, Wängler B, Wängler C.

Molecules. 2013 Jun 3;18(6):6469-90. doi: 10.3390/molecules18066469. Review.

48.

Physician health programmes and malpractice claims: reducing risk through monitoring.

Brooks E, Gendel MH, Gundersen DC, Early SR, Schirrmacher R, Lembitz A, Shore JH.

Occup Med (Lond). 2013 Jun;63(4):274-80. doi: 10.1093/occmed/kqt036. Epub 2013 Apr 19.

PMID:
23606266
49.

Radiolabeled heterobivalent peptidic ligands: an approach with high future potential for in vivo imaging and therapy of malignant diseases.

Fischer G, Schirrmacher R, Wängler B, Wängler C.

ChemMedChem. 2013 Jun;8(6):883-90. doi: 10.1002/cmdc.201300081. Epub 2013 Apr 5. Review.

PMID:
23564566
50.

[68Ga]-albumin-PET in the monitoring of left ventricular function in murine models of ischemic and dilated cardiomyopathy: comparison with cardiac MRI.

Todica A, Brunner S, Böning G, Lehner S, Nekolla SG, Wildgruber M, Übleis C, Wängler C, Sauter M, Klingel K, Cumming P, Bartenstein P, Schirrmacher R, Franz WM, Hacker M.

Mol Imaging Biol. 2013 Aug;15(4):441-9. doi: 10.1007/s11307-013-0618-y.

PMID:
23408338

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