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Items: 1 to 50 of 84

1.

The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses.

Duan J, Navarro-Dorado J, Clark JH, Kinnear NP, Meinke P, Schirmer EC, Evans AM.

Nat Commun. 2019 May 24;10(1):2299. doi: 10.1038/s41467-019-10055-w.

2.

Spatial Genome Organization: From Development to Disease.

Sivakumar A, de Las Heras JI, Schirmer EC.

Front Cell Dev Biol. 2019 Mar 21;7:18. doi: 10.3389/fcell.2019.00018. eCollection 2019. Review.

3.

Host Vesicle Fusion Protein VAPB Contributes to the Nuclear Egress Stage of Herpes Simplex Virus Type-1 (HSV-1) Replication.

Saiz-Ros N, Czapiewski R, Epifano I, Stevenson A, Swanson SK, Dixon CR, Zamora DB, McElwee M, Vijayakrishnan S, Richardson CA, Dong L, Kelly DA, Pytowski L, Goldberg MW, Florens L, Graham SV, Schirmer EC.

Cells. 2019 Feb 3;8(2). pii: E120. doi: 10.3390/cells8020120.

4.

Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform.

Bikkul MU, Faragher RGA, Worthington G, Meinke P, Kerr ARW, Sammy A, Riyahi K, Horton D, Schirmer EC, Hubank M, Kill IR, Anderson RM, Slijepcevic P, Makarov E, Bridger JM.

Genes Chromosomes Cancer. 2019 Jun;58(6):341-356. doi: 10.1002/gcc.22711. Epub 2019 Jan 7.

PMID:
30474255
5.

Optimization of DamID for use in primary cultures of mouse hepatocytes.

Gatticchi L, de Las Heras JI, Roberti R, Schirmer EC.

Methods. 2019 Mar 15;157:88-99. doi: 10.1016/j.ymeth.2018.11.005. Epub 2018 Nov 13.

6.

Analysis of RNA-Seq datasets reveals enrichment of tissue-specific splice variants for nuclear envelope proteins.

Capitanchik C, Dixon CR, Swanson SK, Florens L, Kerr ARW, Schirmer EC.

Nucleus. 2018;9(1):410-430. doi: 10.1080/19491034.2018.1469351.

PMID:
29912636
7.

Breaking the scale: how disrupting the karyoplasmic ratio gives cancer cells an advantage for metastatic invasion.

Rizzotto A, Schirmer EC.

Biochem Soc Trans. 2017 Dec 15;45(6):1333-1344. doi: 10.1042/BST20170153. Epub 2017 Nov 17. Review.

PMID:
29150524
8.

Mitotic post-translational modifications of histones promote chromatin compaction in vitro.

Zhiteneva A, Bonfiglio JJ, Makarov A, Colby T, Vagnarelli P, Schirmer EC, Matic I, Earnshaw WC.

Open Biol. 2017 Sep;7(9). pii: 170076. doi: 10.1098/rsob.170076.

9.

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments.

Robson MI, de Las Heras JI, Czapiewski R, Sivakumar A, Kerr ARW, Schirmer EC.

Genome Res. 2017 Jul;27(7):1126-1138. doi: 10.1101/gr.212308.116. Epub 2017 Apr 19.

10.
11.

Immunohistochemistry on a panel of Emery-Dreifuss muscular dystrophy samples reveals nuclear envelope proteins as inconsistent markers for pathology.

Le Thanh P, Meinke P, Korfali N, Srsen V, Robson MI, Wehnert M, Schoser B, Sewry CA, Schirmer EC.

Neuromuscul Disord. 2017 Apr;27(4):338-351. doi: 10.1016/j.nmd.2016.12.003. Epub 2016 Dec 21.

12.

Repo-Man/PP1 regulates heterochromatin formation in interphase.

de Castro IJ, Budzak J, Di Giacinto ML, Ligammari L, Gokhan E, Spanos C, Moralli D, Richardson C, de Las Heras JI, Salatino S, Schirmer EC, Ullman KS, Bickmore WA, Green C, Rappsilber J, Lamble S, Goldberg MW, Vinciotti V, Vagnarelli P.

Nat Commun. 2017 Jan 16;8:14048. doi: 10.1038/ncomms14048.

13.

Tissue-specific NETs alter genome organization and regulation even in a heterologous system.

de Las Heras JI, Zuleger N, Batrakou DG, Czapiewski R, Kerr AR, Schirmer EC.

Nucleus. 2017 Jan 2;8(1):81-97. doi: 10.1080/19491034.2016.1261230. Epub 2017 Jan 3.

14.

Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution.

Mudumbi KC, Schirmer EC, Yang W.

Nat Commun. 2016 Aug 25;7:12562. doi: 10.1038/ncomms12562.

15.

The increasing relevance of nuclear envelope myopathies.

Meinke P, Schirmer EC.

Curr Opin Neurol. 2016 Oct;29(5):651-61. doi: 10.1097/WCO.0000000000000359. Review.

PMID:
27389815
16.

Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis.

Robson MI, de Las Heras JI, Czapiewski R, Lê Thành P, Booth DG, Kelly DA, Webb S, Kerr ARW, Schirmer EC.

Mol Cell. 2016 Jun 16;62(6):834-847. doi: 10.1016/j.molcel.2016.04.035. Epub 2016 Jun 2.

17.

Anchoring a Leviathan: How the Nuclear Membrane Tethers the Genome.

Czapiewski R, Robson MI, Schirmer EC.

Front Genet. 2016 May 6;7:82. doi: 10.3389/fgene.2016.00082. eCollection 2016. Review.

18.

The Application of DamID to Identify Peripheral Gene Sequences in Differentiated and Primary Cells.

Robson MI, Schirmer EC.

Methods Mol Biol. 2016;1411:359-86. doi: 10.1007/978-1-4939-3530-7_23.

PMID:
27147054
19.

Isolation, Proteomic Analysis, and Microscopy Confirmation of the Liver Nuclear Envelope Proteome.

Korfali N, Florens L, Schirmer EC.

Methods Mol Biol. 2016;1411:3-44. doi: 10.1007/978-1-4939-3530-7_1.

PMID:
27147032
20.

Purification of Lamins and Soluble Fragments of NETs.

Makarov AA, Rizzotto A, Meinke P, Schirmer EC.

Methods Enzymol. 2016;569:79-100. doi: 10.1016/bs.mie.2015.09.006. Epub 2015 Sep 28.

PMID:
26778554
21.

Nuclear membrane diversity: underlying tissue-specific pathologies in disease?

Worman HJ, Schirmer EC.

Curr Opin Cell Biol. 2015 Jun;34:101-12. doi: 10.1016/j.ceb.2015.06.003. Epub 2015 Jun 24. Review.

22.

LINC'ing form and function at the nuclear envelope.

Meinke P, Schirmer EC.

FEBS Lett. 2015 Sep 14;589(19 Pt A):2514-21. doi: 10.1016/j.febslet.2015.06.011. Epub 2015 Jun 19. Review.

23.

TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation.

Batrakou DG, de Las Heras JI, Czapiewski R, Mouras R, Schirmer EC.

PLoS One. 2015 May 29;10(5):e0127712. doi: 10.1371/journal.pone.0127712. eCollection 2015.

24.

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.

Agirre X, Castellano G, Pascual M, Heath S, Kulis M, Segura V, Bergmann A, Esteve A, Merkel A, Raineri E, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Russiñol N, Queirós AC, Beekman R, Rodríguez-Madoz JR, San José-Enériz E, Fang F, Gutiérrez NC, García-Verdugo JM, Robson MI, Schirmer EC, Guruceaga E, Martens JH, Gut M, Calasanz MJ, Flicek P, Siebert R, Campo E, Miguel JF, Melnick A, Stunnenberg HG, Gut IG, Prosper F, Martín-Subero JI.

Genome Res. 2015 Apr;25(4):478-87. doi: 10.1101/gr.180240.114. Epub 2015 Feb 2.

25.

Abnormal proliferation and spontaneous differentiation of myoblasts from a symptomatic female carrier of X-linked Emery-Dreifuss muscular dystrophy.

Meinke P, Schneiderat P, Srsen V, Korfali N, Lê Thành P, Cowan GJ, Cavanagh DR, Wehnert M, Schirmer EC, Walter MC.

Neuromuscul Disord. 2015 Feb;25(2):127-36. doi: 10.1016/j.nmd.2014.09.012. Epub 2014 Oct 6.

26.

NET23/STING promotes chromatin compaction from the nuclear envelope.

Malik P, Zuleger N, de las Heras JI, Saiz-Ros N, Makarov AA, Lazou V, Meinke P, Waterfall M, Kelly DA, Schirmer EC.

PLoS One. 2014 Nov 11;9(11):e111851. doi: 10.1371/journal.pone.0111851. eCollection 2014.

27.

Nuclear envelope: connecting structural genome organization to regulation of gene expression.

Stancheva I, Schirmer EC.

Adv Exp Med Biol. 2014;773:209-44. doi: 10.1007/978-1-4899-8032-8_10. Review.

PMID:
24563350
28.

NETs and cell cycle regulation.

Robson MI, Le Thanh P, Schirmer EC.

Adv Exp Med Biol. 2014;773:165-85. doi: 10.1007/978-1-4899-8032-8_8. Review.

PMID:
24563348
29.

The nuclear envelope and cancer: a diagnostic perspective and historical overview.

de Las Heras JI, Schirmer EC.

Adv Exp Med Biol. 2014;773:5-26. doi: 10.1007/978-1-4899-8032-8_1. Review.

PMID:
24563341
30.

Tissue specificity in the nuclear envelope supports its functional complexity.

de Las Heras JI, Meinke P, Batrakou DG, Srsen V, Zuleger N, Kerr AR, Schirmer EC.

Nucleus. 2013 Nov-Dec;4(6):460-77. doi: 10.4161/nucl.26872. Epub 2013 Nov 8. Review.

31.

Considering discrete protein pools when measuring the dynamics of nuclear membrane proteins.

Zuleger N, Kelly DA, Schirmer EC.

Methods Mol Biol. 2013;1042:275-98. doi: 10.1007/978-1-62703-526-2_20.

PMID:
23980015
32.

Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.

Zuleger N, Boyle S, Kelly DA, de las Heras JI, Lazou V, Korfali N, Batrakou DG, Randles KN, Morris GE, Harrison DJ, Bickmore WA, Schirmer EC.

Genome Biol. 2013 Feb 15;14(2):R14. doi: 10.1186/gb-2013-14-2-r14.

33.

The nuclear envelope proteome differs notably between tissues.

Korfali N, Wilkie GS, Swanson SK, Srsen V, de Las Heras J, Batrakou DG, Malik P, Zuleger N, Kerr AR, Florens L, Schirmer EC.

Nucleus. 2012 Nov-Dec;3(6):552-64. doi: 10.4161/nucl.22257. Epub 2012 Sep 18.

34.

Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways.

Malik P, Tabarraei A, Kehlenbach RH, Korfali N, Iwasawa R, Graham SV, Schirmer EC.

J Biol Chem. 2012 Apr 6;287(15):12277-92. doi: 10.1074/jbc.M111.331777. Epub 2012 Feb 14.

35.

Many mechanisms, one entrance: membrane protein translocation into the nucleus.

Zuleger N, Kerr AR, Schirmer EC.

Cell Mol Life Sci. 2012 Jul;69(13):2205-16. doi: 10.1007/s00018-012-0929-1. Epub 2012 Feb 12. Review.

36.

Cancer biology and the nuclear envelope: a convoluted relationship.

de Las Heras JI, Batrakou DG, Schirmer EC.

Semin Cancer Biol. 2013 Apr;23(2):125-37. doi: 10.1016/j.semcancer.2012.01.008. Epub 2012 Jan 28. Review.

37.

Nuclear envelope influences on cell-cycle progression.

Srsen V, Korfali N, Schirmer EC.

Biochem Soc Trans. 2011 Dec;39(6):1742-6. doi: 10.1042/BST20110656. Review.

38.

FG repeats facilitate integral protein trafficking to the inner nuclear membrane.

Kerr AR, Schirmer EC.

Commun Integr Biol. 2011 Sep;4(5):557-9. doi: 10.4161/cib.4.5.16052. Epub 2011 Sep 1.

39.

The nuclear envelope as a chromatin organizer.

Zuleger N, Robson MI, Schirmer EC.

Nucleus. 2011 Sep-Oct;2(5):339-49. doi: 10.4161/nucl.2.5.17846. Epub 2011 Sep 1. Review.

40.

A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/Tmem53 as involved in stress-dependent cell cycle withdrawal.

Korfali N, Srsen V, Waterfall M, Batrakou DG, Pekovic V, Hutchison CJ, Schirmer EC.

PLoS One. 2011 Apr 14;6(4):e18762. doi: 10.1371/journal.pone.0018762.

41.

System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics.

Zuleger N, Kelly DA, Richardson AC, Kerr AR, Goldberg MW, Goryachev AB, Schirmer EC.

J Cell Biol. 2011 Apr 4;193(1):109-23. doi: 10.1083/jcb.201009068. Epub 2011 Mar 28.

42.

Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations.

Wilkie GS, Korfali N, Swanson SK, Malik P, Srsen V, Batrakou DG, de las Heras J, Zuleger N, Kerr AR, Florens L, Schirmer EC.

Mol Cell Proteomics. 2011 Jan;10(1):M110.003129. doi: 10.1074/mcp.M110.003129. Epub 2010 Sep 27.

43.

The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture.

Korfali N, Wilkie GS, Swanson SK, Srsen V, Batrakou DG, Fairley EA, Malik P, Zuleger N, Goncharevich A, de Las Heras J, Kelly DA, Kerr AR, Florens L, Schirmer EC.

Mol Cell Proteomics. 2010 Dec;9(12):2571-85. doi: 10.1074/mcp.M110.002915. Epub 2010 Aug 6.

44.

Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope.

Malik P, Korfali N, Srsen V, Lazou V, Batrakou DG, Zuleger N, Kavanagh DM, Wilkie GS, Goldberg MW, Schirmer EC.

Cell Mol Life Sci. 2010 Apr;67(8):1353-69. doi: 10.1007/s00018-010-0257-2. Epub 2010 Jan 21.

45.

Nuclear envelope influences on genome organization.

Malik P, Zuleger N, Schirmer EC.

Biochem Soc Trans. 2010 Feb;38(Pt 1):268-72. doi: 10.1042/BST0380268.

46.

Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation.

Ostlund C, Guan T, Figlewicz DA, Hays AP, Worman HJ, Gerace L, Schirmer EC.

Biochem Biophys Res Commun. 2009 Nov 13;389(2):279-83. doi: 10.1016/j.bbrc.2009.08.133. Epub 2009 Aug 28.

47.

Use of sequential chemical extractions to purify nuclear membrane proteins for proteomics identification.

Korfali N, Fairley EA, Swanson SK, Florens L, Schirmer EC.

Methods Mol Biol. 2009;528:201-25. doi: 10.1007/978-1-60327-310-7_15.

48.

Inner nuclear membrane protein transport is mediated by multiple mechanisms.

Zuleger N, Korfali N, Schirmer EC.

Biochem Soc Trans. 2008 Dec;36(Pt 6):1373-7. doi: 10.1042/BST0361373. Review.

49.

Purification of nuclei and preparation of nuclear envelopes from skeletal muscle.

Wilkie GS, Schirmer EC.

Methods Mol Biol. 2008;463:23-41. doi: 10.1007/978-1-59745-406-3_2.

50.

Comparative proteomic analyses of the nuclear envelope and pore complex suggests a wide range of heretofore unexpected functions.

Batrakou DG, Kerr AR, Schirmer EC.

J Proteomics. 2009 Feb 15;72(1):56-70. doi: 10.1016/j.jprot.2008.09.004. Epub 2008 Sep 27. Review.

PMID:
18852071

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