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Items: 1 to 50 of 160

1.

A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40.

Spyrantis A, Krieger J, Stifter K, Boehm BO, Schirmbeck R.

Cell Mol Immunol. 2019 Oct 24. doi: 10.1038/s41423-019-0309-y. [Epub ahead of print] No abstract available.

PMID:
31649307
2.

An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation.

Svinarenko M, Katz SF, Tharehalli U, Mulaw MA, Maier HJ, Sunami Y, Fischer SK, Chen Y, Heurich S, Erkert L, Tannapfel A, Wirth T, Schirmbeck R, Seufferlein T, Lechel A.

Cancers (Basel). 2019 Sep 21;11(10). pii: E1410. doi: 10.3390/cancers11101410.

3.

Endogenously Expressed Antigens Bind Mammalian RNA via Cationic Domains that Enhance Priming of Effector CD8 T Cells by DNA Vaccination.

Krieger J, Riedl P, Stifter K, Roman-Sosa G, Seufferlein T, Wagner M, Schirmbeck R.

Mol Ther. 2019 Mar 6;27(3):661-672. doi: 10.1016/j.ymthe.2019.01.011. Epub 2019 Jan 22.

4.

Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination.

Stifter K, Schuster C, Krieger J, Spyrantis A, Boehm BO, Schirmbeck R.

Mol Ther Methods Clin Dev. 2018 Dec 13;12:123-133. doi: 10.1016/j.omtm.2018.12.002. eCollection 2019 Mar 15.

5.

Impaired immune surveillance accelerates accumulation of senescent cells and aging.

Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V.

Nat Commun. 2018 Dec 21;9(1):5435. doi: 10.1038/s41467-018-07825-3.

6.

YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion.

Tharehalli U, Svinarenko M, Kraus JM, Kühlwein SD, Szekely R, Kiesle U, Scheffold A, Barth TFE, Kleger A, Schirmbeck R, Kestler HA, Seufferlein T, Oswald F, Katz SF, Lechel A.

Int J Mol Sci. 2018 Nov 29;19(12). pii: E3801. doi: 10.3390/ijms19123801.

7.

Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate-derived mercapturic acids.

Cwiklowska K, Westhoff MA, Freisinger S, Dwucet A, Halatsch ME, Knippschild U, Debatin KM, Schirmbeck R, Winiarski L, Oleksyszyn J, Wirtz CR, Burster T.

Oncol Lett. 2018 Nov;16(5):6181-6187. doi: 10.3892/ol.2018.9347. Epub 2018 Aug 21.

8.
9.

Aged murine hematopoietic stem cells drive aging-associated immune remodeling.

Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R.

Blood. 2018 Aug 9;132(6):565-576. doi: 10.1182/blood-2018-02-831065. Epub 2018 Jun 11.

10.

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR.

Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0.

11.

Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.

Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.

Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.

PMID:
28414328
12.

High-Resolution PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers.

Hettich M, Braun F, Bartholomä MD, Schirmbeck R, Niedermann G.

Theranostics. 2016 Jun 18;6(10):1629-40. doi: 10.7150/thno.15253. eCollection 2016.

13.

Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.

Stifter K, Schuster C, Schlosser M, Boehm BO, Schirmbeck R.

Sci Rep. 2016 Jul 11;6:29419. doi: 10.1038/srep29419.

14.

Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen.

Real CI, Lu M, Liu J, Huang X, Trippler M, Hossbach M, Deckert J, Jahn-Hofmann K, Ickenstein LM, John MJ, Gibbert K, Dittmer U, Vornlocher HP, Schirmbeck R, Gerken G, Schlaak JF, Broering R.

Sci Rep. 2016 Apr 28;6:24865. doi: 10.1038/srep24865.

15.

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

Sunami Y, Ringelhan M, Kokai E, Lu M, O'Connor T, Lorentzen A, Weber A, Rodewald AK, Müllhaupt B, Terracciano L, Gul S, Wissel S, Leithäuser F, Krappmann D, Riedl P, Hartmann D, Schirmbeck R, Strnad P, Hüser N, Kleeff J, Friess H, Schmid RM, Geisler F, Wirth T, Heikenwalder M.

Hepatology. 2016 May;63(5):1592-607. doi: 10.1002/hep.28435. Epub 2016 Mar 4.

16.

HSC Aging and Senescent Immune Remodeling.

Denkinger MD, Leins H, Schirmbeck R, Florian MC, Geiger H.

Trends Immunol. 2015 Dec;36(12):815-824. doi: 10.1016/j.it.2015.10.008. Epub 2015 Nov 21. Review.

17.

Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes.

Ochel A, Cebula M, Riehn M, Hillebrand U, Lipps C, Schirmbeck R, Hauser H, Wirth D.

Cell Mol Immunol. 2016 Nov;13(6):805-815. doi: 10.1038/cmi.2015.80. Epub 2015 Oct 12.

18.

Minicircle: Next Generation DNA Vectors for Vaccination.

Schleef M, Schirmbeck R, Reiser M, Michel ML, Schmeer M.

Methods Mol Biol. 2015;1317:327-39. doi: 10.1007/978-1-4939-2727-2_18.

PMID:
26072415
19.

Hematopoietic stem cell aging.

Geiger H, Denkinger M, Schirmbeck R.

Curr Opin Immunol. 2014 Aug;29:86-92. doi: 10.1016/j.coi.2014.05.002. Epub 2014 Jun 3. Review.

PMID:
24905894
20.

Differential presentation of endogenous and exogenous hepatitis B surface antigens influences priming of CD8(+) T cells in an epitope-specific manner.

Riedl P, Reiser M, Stifter K, Krieger J, Schirmbeck R.

Eur J Immunol. 2014 Jul;44(7):1981-91. doi: 10.1002/eji.201343933. Epub 2014 May 11.

21.

Long-term IKK2/NF-κB signaling in pancreatic β-cells induces immune-mediated diabetes.

Salem HH, Trojanowski B, Fiedler K, Maier HJ, Schirmbeck R, Wagner M, Boehm BO, Wirth T, Baumann B.

Diabetes. 2014 Mar;63(3):960-75. doi: 10.2337/db13-1037. Epub 2013 Dec 2.

22.

A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.

Schuster C, Brosi H, Stifter K, Boehm BO, Schirmbeck R.

PLoS One. 2013 Aug 19;8(8):e71746. doi: 10.1371/journal.pone.0071746. eCollection 2013.

23.

An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells.

Cebula M, Ochel A, Hillebrand U, Pils MC, Schirmbeck R, Hauser H, Wirth D.

PLoS One. 2013 Jul 15;8(7):e68720. doi: 10.1371/journal.pone.0068720. Print 2013.

24.

Human cytomegalovirus-induced NKG2C(hi) CD57(hi) natural killer cells are effectors dependent on humoral antiviral immunity.

Wu Z, Sinzger C, Frascaroli G, Reichel J, Bayer C, Wang L, Schirmbeck R, Mertens T.

J Virol. 2013 Jul;87(13):7717-25. doi: 10.1128/JVI.01096-13. Epub 2013 May 1.

25.

Application of a novel highly sensitive activity-based probe for detection of cathepsin G.

Zou F, Schmon M, Sienczyk M, Grzywa R, Palesch D, Boehm BO, Sun ZL, Watts C, Schirmbeck R, Burster T.

Anal Biochem. 2012 Feb 15;421(2):667-72. doi: 10.1016/j.ab.2011.11.016. Epub 2011 Nov 23.

PMID:
22178917
26.

High-capacity adenoviral vectors circumvent the limitations of ΔE1 and ΔE1/ΔE3 adenovirus vectors to induce multispecific transgene product-directed CD8 T-cell responses.

Kron MW, Engler T, Schmidt E, Schirmbeck R, Kochanek S, Kreppel F.

J Gene Med. 2011 Dec;13(12):648-57. doi: 10.1002/jgm.1629.

PMID:
22095925
27.

The immunodominant CD8 T cell response to the human cytomegalovirus tegument phosphoprotein pp65(495-503) epitope critically depends on CD4 T cell help in vaccinated HLA-A*0201 transgenic mice.

Reiser M, Wieland A, Plachter B, Mertens T, Greiner J, Schirmbeck R.

J Immunol. 2011 Sep 1;187(5):2172-80. doi: 10.4049/jimmunol.1002512. Epub 2011 Aug 1.

28.

miRNA-mediated silencing in hepatocytes can increase adaptive immune responses to adenovirus vector-delivered transgenic antigens.

Kron MW, Espenlaub S, Engler T, Schirmbeck R, Kochanek S, Kreppel F.

Mol Ther. 2011 Aug;19(8):1547-57. doi: 10.1038/mt.2011.83. Epub 2011 May 10.

29.

Inflammation, regeneration, and transformation in the pancreas: results of the Collaborative Research Center 518 (SFB 518) at the University of Ulm.

Giehl K, Bachem M, Beil M, Böhm BO, Ellenrieder V, Fulda S, Gress TM, Holzmann K, Kestler HA, Kornmann M, Menke A, Möller P, Oswald F, Schmid RM, Schmidt V, Schirmbeck R, Seufferlein T, von Wichert G, Wagner M, Walther P, Wirth T, Adler G.

Pancreas. 2011 May;40(4):489-502. doi: 10.1097/MPA.0b013e318214f33a. Review.

PMID:
21483252
30.

Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells.

Sandhu U, Cebula M, Behme S, Riemer P, Wodarczyk C, Metzger D, Reimann J, Schirmbeck R, Hauser H, Wirth D.

Nucleic Acids Res. 2011 Jan;39(1):e1. doi: 10.1093/nar/gkq868. Epub 2010 Oct 8.

31.

Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.

Rajasalu T, Brosi H, Schuster C, Spyrantis A, Boehm BO, Chen L, Reimann J, Schirmbeck R.

Diabetes. 2010 Aug;59(8):1966-73. doi: 10.2337/db09-1135. Epub 2010 May 18.

32.

Processing in the endoplasmic reticulum generates an epitope on the insulin A chain that stimulates diabetogenic CD8 T cell responses.

Brosi H, Reiser M, Rajasalu T, Spyrantis A, Oswald F, Boehm BO, Schirmbeck R.

J Immunol. 2009 Dec 1;183(11):7187-95. doi: 10.4049/jimmunol.0901573. Epub 2009 Nov 4.

33.

Silencing an immunodominant epitope of hepatitis B surface antigen reveals an alternative repertoire of CD8 T cell epitopes of this viral antigen.

Wieland A, Riedl P, Reimann J, Schirmbeck R.

Vaccine. 2009 Dec 10;28(1):114-9. doi: 10.1016/j.vaccine.2009.09.096. Epub 2009 Oct 8.

PMID:
19818719
34.

Intracellular delivery of major histocompatibility complex class I-binding epitopes: dendritic cells loaded and matured with cationic peptide/poly(I:C) complexes efficiently activate T cells.

Haenssle HA, Riedl P, Buhl T, Schardt A, Rosenberger A, Schön MP, Schirmbeck R.

Exp Dermatol. 2010 Jan;19(1):19-28. doi: 10.1111/j.1600-0625.2009.00954.x. Epub 2009 Sep 16.

PMID:
19758325
35.

Elimination of immunodominant epitopes from multispecific DNA-based vaccines allows induction of CD8 T cells that have a striking antiviral potential.

Riedl P, Wieland A, Lamberth K, Buus S, Lemonnier F, Reifenberg K, Reimann J, Schirmbeck R.

J Immunol. 2009 Jul 1;183(1):370-80. doi: 10.4049/jimmunol.0900505.

36.

IL-22-dependent attenuation of T cell-dependent (ConA) hepatitis in herpes virus entry mediator deficiency.

Wahl C, Wegenka UM, Leithäuser F, Schirmbeck R, Reimann J.

J Immunol. 2009 Apr 15;182(8):4521-8. doi: 10.4049/jimmunol.0802810.

37.

IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses.

Wahl C, Müller W, Leithäuser F, Adler G, Oswald F, Reimann J, Schirmbeck R, Seier A, Weiss JM, Prochnow B, Wegenka UM.

J Immunol. 2009 Jan 15;182(2):802-10.

38.

Local accumulation and activation of regulatory Foxp3+ CD4 T(R) cells accompanies the appearance of activated CD8 T cells in the liver.

Bochtler P, Riedl P, Gomez I, Schirmbeck R, Reimann J.

Hepatology. 2008 Dec;48(6):1954-63. doi: 10.1002/hep.22559.

PMID:
19003876
39.

Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells.

Bochtler P, Kröger A, Schirmbeck R, Reimann J.

J Immunol. 2008 Aug 1;181(3):1633-43.

40.

B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses.

Wahl C, Bochtler P, Chen L, Schirmbeck R, Reimann J.

Gastroenterology. 2008 Sep;135(3):980-8. doi: 10.1053/j.gastro.2008.05.076. Epub 2008 Jun 4.

PMID:
18621049
41.

The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigens.

Schirmbeck R, Reimann J, Kochanek S, Kreppel F.

Mol Ther. 2008 Sep;16(9):1609-16. doi: 10.1038/mt.2008.141. Epub 2008 Jul 8.

42.

Recombinant complexes of antigen with stress proteins are potent CD8 T-cell-stimulating immunogens.

Wieland A, Denzel M, Schmidt E, Kochanek S, Kreppel F, Reimann J, Schirmbeck R.

J Mol Med (Berl). 2008 Sep;86(9):1067-79. doi: 10.1007/s00109-008-0371-x. Epub 2008 Jun 13.

PMID:
18551265
43.

Transgenic mice replicating hepatitis B virus but lacking expression of the major HBsAg.

Halverscheid L, Mannes NK, Weth R, Kleinschmidt M, Schultz U, Reifenberg K, Schirmbeck R, Nassal M, Blum HE, Reimann J, Geissler M.

J Med Virol. 2008 Apr;80(4):583-90. doi: 10.1002/jmv.21115.

PMID:
18297704
44.

Fully detargeted polyethylene glycol-coated adenovirus vectors are potent genetic vaccines and escape from pre-existing anti-adenovirus antibodies.

Wortmann A, Vöhringer S, Engler T, Corjon S, Schirmbeck R, Reimann J, Kochanek S, Kreppel F.

Mol Ther. 2008 Jan;16(1):154-62. Epub 2007 Sep 11.

45.

The diabetogenic, insulin-specific CD8 T cell response primed in the experimental autoimmune diabetes model in RIP-B7.1 mice.

Karges W, Rajasalu T, Spyrantis A, Wieland A, Boehm B, Schirmbeck R.

Eur J Immunol. 2007 Aug;37(8):2097-103.

46.

Type I IFN-producing CD4 Valpha14i NKT cells facilitate priming of IL-10-producing CD8 T cells by hepatocytes.

Wahl C, Bochtler P, Schirmbeck R, Reimann J.

J Immunol. 2007 Feb 15;178(4):2083-93.

47.

Contributions of host and symbiont pigments to the coloration of reef corals.

Oswald F, Schmitt F, Leutenegger A, Ivanchenko S, D'Angelo C, Salih A, Maslakova S, Bulina M, Schirmbeck R, Nienhaus GU, Matz MV, Wiedenmann J.

FEBS J. 2007 Feb;274(4):1102-9. Epub 2007 Jan 22.

48.

Functional adaptive CD4 Foxp3 T cells develop in MHC class II-deficient mice.

Bochtler P, Wahl C, Schirmbeck R, Reimann J.

J Immunol. 2006 Dec 15;177(12):8307-14.

49.
50.

A stress protein-facilitated antigen expression system for plasmid DNA vaccines.

Riedl P, Fissolo N, Reimann J, Schirmbeck R.

Methods Mol Med. 2006;127:41-53. Review.

PMID:
16988445

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