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Items: 1 to 50 of 126

1.

Effects of short-term exposure to fine and ultrafine particles from indoor sources on arterial stiffness - A randomized sham-controlled exposure study.

Soppa VJ, Shinnawi S, Hennig F, Sasse B, Hellack B, Kaminski H, Quass U, Schins RPF, Kuhlbusch TAJ, Hoffmann B.

Int J Hyg Environ Health. 2019 Sep;222(8):1115-1132. doi: 10.1016/j.ijheh.2019.08.002. Epub 2019 Aug 20.

PMID:
31444115
2.

The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?

Pavan C, Delle Piane M, Gullo M, Filippi F, Fubini B, Hoet P, Horwell CJ, Huaux F, Lison D, Lo Giudice C, Martra G, Montfort E, Schins R, Sulpizi M, Wegner K, Wyart-Remy M, Ziemann C, Turci F.

Part Fibre Toxicol. 2019 Aug 16;16(1):32. doi: 10.1186/s12989-019-0315-3.

3.

Investigation of spatial and temporal variation of particulate matter in vitro genotoxicity and cytotoxicity in relation to the elemental composition.

Çakmak G, Ertürk Arı P, Emerce E, Arı A, Odabaşı M, Schins R, Burgaz S, Gaga EO.

Mutat Res. 2019 Jun;842:22-34. doi: 10.1016/j.mrgentox.2019.01.009. Epub 2019 Jan 18.

PMID:
31255223
4.

Differences in the toxicity of cerium dioxide nanomaterials after inhalation can be explained by lung deposition, animal species and nanoforms.

Dekkers S, Ma-Hock L, Lynch I, Russ M, Miller MR, Schins RPF, Keller J, Römer I, Küttler K, Strauss V, De Jong WH, Landsiedel R, Cassee FR.

Inhal Toxicol. 2018 Jun - Jul;30(7-8):273-286. doi: 10.1080/08958378.2018.1516834. Epub 2018 Oct 4.

PMID:
30286672
5.

Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells.

Perkins TN, Peeters PM, Albrecht C, Schins RPF, Dentener MA, Mossman BT, Wouters EFM, Reynaert NL.

Toxicol Appl Pharmacol. 2018 Jun 1;348:43-53. doi: 10.1016/j.taap.2018.04.011. Epub 2018 Apr 17.

PMID:
29673857
6.

Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge.

Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF, Vogel U, Kreyling WG, Alstrup Jensen K, Kuhlbusch TAJ, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Teixeira JP, Tran CL, Cassee FR.

Environ Health Perspect. 2017 Oct 10;125(10):106002. doi: 10.1289/EHP424. Review.

7.

Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.

Hullmann M, Albrecht C, van Berlo D, Gerlofs-Nijland ME, Wahle T, Boots AW, Krutmann J, Cassee FR, Bayer TA, Schins RPF.

Part Fibre Toxicol. 2017 Aug 30;14(1):35. doi: 10.1186/s12989-017-0213-5.

8.

The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation.

Dekkers S, Miller MR, Schins RPF, Römer I, Russ M, Vandebriel RJ, Lynch I, Belinga-Desaunay MF, Valsami-Jones E, Connell SP, Smith IP, Duffin R, Boere JAF, Heusinkveld HJ, Albrecht C, de Jong WH, Cassee FR.

Nanotoxicology. 2017 Aug;11(6):794-808. doi: 10.1080/17435390.2017.1357214. Epub 2017 Aug 9.

PMID:
28741972
9.

Arterial blood pressure responses to short-term exposure to fine and ultrafine particles from indoor sources - A randomized sham-controlled exposure study of healthy volunteers.

Soppa VJ, Schins RPF, Hennig F, Nieuwenhuijsen MJ, Hellack B, Quass U, Kaminski H, Sasse B, Shinnawi S, Kuhlbusch TAJ, Hoffmann B.

Environ Res. 2017 Oct;158:225-232. doi: 10.1016/j.envres.2017.06.006. Epub 2017 Jul 3.

PMID:
28662448
10.

Silver nanoparticles induce hormesis in A549 human epithelial cells.

Sthijns MM, Thongkam W, Albrecht C, Hellack B, Bast A, Haenen GR, Schins RP.

Toxicol In Vitro. 2017 Apr;40:223-233. doi: 10.1016/j.tiv.2017.01.010. Epub 2017 Jan 18.

11.

Oxidant generation, DNA damage and cytotoxicity by a panel of engineered nanomaterials in three different human epithelial cell lines.

Thongkam W, Gerloff K, van Berlo D, Albrecht C, Schins RP.

Mutagenesis. 2017 Jan;32(1):105-115. doi: 10.1093/mutage/gew056. Epub 2016 Nov 10.

PMID:
27834732
12.

Neurodegenerative and neurological disorders by small inhaled particles.

Heusinkveld HJ, Wahle T, Campbell A, Westerink RHS, Tran L, Johnston H, Stone V, Cassee FR, Schins RPF.

Neurotoxicology. 2016 Sep;56:94-106. doi: 10.1016/j.neuro.2016.07.007. Epub 2016 Jul 19. Review.

PMID:
27448464
13.

A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health--ENPRA Project--The Highlights, Limitations, and Current and Future Challenges.

Kermanizadeh A, Gosens I, MacCalman L, Johnston H, Danielsen PH, Jacobsen NR, Lenz AG, Fernandes T, Schins RP, Cassee FR, Wallin H, Kreyling W, Stoeger T, Loft S, Møller P, Tran L, Stone V.

J Toxicol Environ Health B Crit Rev. 2016;19(1):1-28. doi: 10.1080/10937404.2015.1126210. Review.

PMID:
27030582
14.

Oxidative potential of particulate matter at a German motorway.

Hellack B, Quass U, Nickel C, Wick G, Schins RP, Kuhlbusch TA.

Environ Sci Process Impacts. 2015 Apr;17(4):868-76. doi: 10.1039/c4em00605d.

PMID:
25787944
15.

Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children.

Klümper C, Krämer U, Lehmann I, von Berg A, Berdel D, Herberth G, Beckmann C, Link E, Heinrich J, Hoffmann B, Schins RP; GINIplus and LISAplus study groups.

Environ Res. 2015 Apr;138:381-90. doi: 10.1016/j.envres.2015.02.034. Epub 2015 Mar 10.

PMID:
25769127
16.

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs.

Peeters PM, Eurlings IM, Perkins TN, Wouters EF, Schins RP, Borm PJ, Drommer W, Reynaert NL, Albrecht C.

Part Fibre Toxicol. 2014 Nov 19;11:58. doi: 10.1186/s12989-014-0058-0.

17.

Respiratory effects of fine and ultrafine particles from indoor sources--a randomized sham-controlled exposure study of healthy volunteers.

Soppa VJ, Schins RP, Hennig F, Hellack B, Quass U, Kaminski H, Kuhlbusch TA, Hoffmann B, Weinmayr G.

Int J Environ Res Public Health. 2014 Jul 4;11(7):6871-89. doi: 10.3390/ijerph110706871.

18.

Investigation of the effects of short-term inhalation of carbon nanoparticles on brains and lungs of c57bl/6j and p47(phox-/-) mice.

van Berlo D, Hullmann M, Wessels A, Scherbart AM, Cassee FR, Gerlofs-Nijland ME, Albrecht C, Schins RPF.

Neurotoxicology. 2014 Jul;43:65-72. doi: 10.1016/j.neuro.2014.04.008. Epub 2014 May 1.

PMID:
24792328
19.

Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung.

van Berlo D, Wilhelmi V, Boots AW, Hullmann M, Kuhlbusch TA, Bast A, Schins RP, Albrecht C.

Arch Toxicol. 2014 Sep;88(9):1725-37. doi: 10.1007/s00204-014-1220-z. Epub 2014 Mar 25.

PMID:
24664304
20.

A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes.

Clift MJ, Endes C, Vanhecke D, Wick P, Gehr P, Schins RP, Petri-Fink A, Rothen-Rutishauser B.

Toxicol Sci. 2014 Jan;137(1):55-64. doi: 10.1093/toxsci/kft216. Epub 2013 Nov 27.

21.

Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner.

Wilhelmi V, Fischer U, Weighardt H, Schulze-Osthoff K, Nickel C, Stahlmecke B, Kuhlbusch TA, Scherbart AM, Esser C, Schins RP, Albrecht C.

PLoS One. 2013 Jun 3;8(6):e65704. doi: 10.1371/journal.pone.0065704. Print 2013.

22.

Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity.

van Berlo D, Clift MJ, Albrecht C, Schins RP.

Swiss Med Wkly. 2012 Nov 5;142:w13698. doi: 10.4414/smw.2012.13698. eCollection 2012. Review.

23.

Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria.

Clift MJ, Raemy DO, Endes C, Ali Z, Lehmann AD, Brandenberger C, Petri-Fink A, Wick P, Parak WJ, Gehr P, Schins RP, Rothen-Rutishauser B.

Nanotoxicology. 2013 Dec;7(8):1373-85. doi: 10.3109/17435390.2012.741725. Epub 2012 Nov 12.

PMID:
23078217
24.

Toxicology of ambient particulate matter.

van Berlo D, Hullmann M, Schins RP.

Exp Suppl. 2012;101:165-217. doi: 10.1007/978-3-7643-8340-4_7. Review.

PMID:
22945570
25.

Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells.

Boots AW, Gerloff K, Bartholomé R, van Berlo D, Ledermann K, Haenen GR, Bast A, van Schooten FJ, Albrecht C, Schins RP.

Biochim Biophys Acta. 2012 Jul;1823(7):1151-62. doi: 10.1016/j.bbamcr.2012.04.012. Epub 2012 May 1.

26.

Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells.

Gerloff K, Pereira DI, Faria N, Boots AW, Kolling J, Förster I, Albrecht C, Powell JJ, Schins RP.

Nanotoxicology. 2013 Jun;7(4):353-66. doi: 10.3109/17435390.2012.662249. Epub 2012 Mar 20.

27.

Distinctive toxicity of TiO2 rutile/anatase mixed phase nanoparticles on Caco-2 cells.

Gerloff K, Fenoglio I, Carella E, Kolling J, Albrecht C, Boots AW, Förster I, Schins RP.

Chem Res Toxicol. 2012 Mar 19;25(3):646-55. doi: 10.1021/tx200334k. Epub 2012 Feb 10.

PMID:
22263745
28.

Comparison of micro- and nanoscale Fe⁺³-containing (Hematite) particles for their toxicological properties in human lung cells in vitro.

Bhattacharya K, Hoffmann E, Schins RF, Boertz J, Prantl EM, Alink GM, Byrne HJ, Kuhlbusch TA, Rahman Q, Wiggers H, Schulz C, Dopp E.

Toxicol Sci. 2012 Mar;126(1):173-82. doi: 10.1093/toxsci/kfs014. Epub 2012 Jan 18.

PMID:
22262566
29.

Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts.

Wilhelmi V, Fischer U, van Berlo D, Schulze-Osthoff K, Schins RP, Albrecht C.

Toxicol In Vitro. 2012 Mar;26(2):323-34. doi: 10.1016/j.tiv.2011.12.006. Epub 2011 Dec 14.

PMID:
22198050
30.

Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms.

Scherbart AM, Langer J, Bushmelev A, van Berlo D, Haberzettl P, van Schooten FJ, Schmidt AM, Rose CR, Schins RP, Albrecht C.

Part Fibre Toxicol. 2011 Oct 13;8:31. doi: 10.1186/1743-8977-8-31.

31.

Oxidative stress and DNA damage responses in rat and mouse lung to inhaled carbon nanoparticles.

Wessels A, Van Berlo D, Boots AW, Gerloff K, Scherbart AM, Cassee FR, Gerlofs-Nijland ME, Van Schooten FJ, Albrecht C, Schins RP.

Nanotoxicology. 2011 Mar;5(1):66-78. doi: 10.3109/17435390.2010.494773. Epub 2010 Jun 14.

PMID:
21417689
32.

Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages.

Ghiazza M, Scherbart AM, Fenoglio I, Grendene F, Turci F, Martra G, Albrecht C, Schins RP, Fubini B.

Chem Res Toxicol. 2011 Jan 14;24(1):99-110. doi: 10.1021/tx1003003. Epub 2010 Dec 20.

PMID:
21171611
33.

Particles which may occur in food or food packaging can exert cytotoxicity and (oxidative) DNA damage in target cells of the human intestine.

Gerloff K, Albrecht C, Boots AW, Förster I, Schins RP.

Nanotoxicology. 2011 Jun;5(2):282-3. doi: 10.3109/17435390.2010.525670. Epub 2010 Nov 1. No abstract available.

PMID:
21034372
34.

Possible genotoxic mechanisms of nanoparticles: criteria for improved test strategies.

Donaldson K, Poland CA, Schins RP.

Nanotoxicology. 2010 Dec;4:414-20. doi: 10.3109/17435390.2010.482751. Review.

PMID:
20925449
35.

Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells.

Winter M, Beer HD, Hornung V, Krämer U, Schins RP, Förster I.

Nanotoxicology. 2011 Sep;5(3):326-40. doi: 10.3109/17435390.2010.506957. Epub 2010 Sep 16.

PMID:
20846021
36.

Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.

van Berlo D, Wessels A, Boots AW, Wilhelmi V, Scherbart AM, Gerloff K, van Schooten FJ, Albrecht C, Schins RP.

Free Radic Biol Med. 2010 Dec 1;49(11):1685-93. doi: 10.1016/j.freeradbiomed.2010.08.031. Epub 2010 Sep 7.

PMID:
20828610
37.

Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles.

Weissenberg A, Sydlik U, Peuschel H, Schroeder P, Schneider M, Schins RP, Abel J, Unfried K.

Free Radic Biol Med. 2010 Aug 15;49(4):597-605. doi: 10.1016/j.freeradbiomed.2010.05.011. Epub 2010 Jun 4.

PMID:
20570722
38.

NF-kappaB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells.

van Berlo D, Knaapen AM, van Schooten FJ, Schins RP, Albrecht C.

Part Fibre Toxicol. 2010 May 21;7:13. doi: 10.1186/1743-8977-7-13.

39.

Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain.

Gerlofs-Nijland ME, van Berlo D, Cassee FR, Schins RP, Wang K, Campbell A.

Part Fibre Toxicol. 2010 May 17;7:12. doi: 10.1186/1743-8977-7-12.

40.

Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain.

van Berlo D, Albrecht C, Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, Palomero-Gallagher N, Bidmon HJ, van Schooten FJ, Krutmann J, Schins RP.

Arch Toxicol. 2010 Jul;84(7):553-62. doi: 10.1007/s00204-010-0551-7. Epub 2010 May 14.

41.

Oxidant generation and toxicity of size-fractionated ambient particles in human lung epithelial cells.

Wessels A, Birmili W, Albrecht C, Hellack B, Jermann E, Wick G, Harrison RM, Schins RP.

Environ Sci Technol. 2010 May 1;44(9):3539-45. doi: 10.1021/es9036226.

PMID:
20355702
42.

Elemental composition and oxidative properties of PM(2.5) in Estonia in relation to origin of air masses - results from the ECRHS II in Tartu.

Orru H, Kimmel V, Kikas U, Soon A, Künzli N, Schins RP, Borm PJ, Forsberg B.

Sci Total Environ. 2010 Mar 1;408(7):1515-22. doi: 10.1016/j.scitotenv.2009.12.006. Epub 2010 Jan 27.

PMID:
20106505
43.

Increased micronucleus frequencies in surrogate and target cells from workers exposed to crystalline silica-containing dust.

Demircigil GC, Coskun E, Vidinli N, Erbay Y, Yilmaz M, Cimrin A, Schins RP, Borm PJ, Burgaz S.

Mutagenesis. 2010 Mar;25(2):163-9. doi: 10.1093/mutage/gep057. Epub 2009 Nov 25.

PMID:
19939883
44.

Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line.

Jalava PI, Hirvonen MR, Sillanpää M, Pennanen AS, Happo MS, Hillamo R, Cassee FR, Gerlofs-Nijland M, Borm PJ, Schins RP, Janssen NA, Salonen RO.

Inhal Toxicol. 2009 Oct;21(12):994-1006. doi: 10.1080/08958370802695710.

PMID:
19772479
45.

Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macrophages.

van Berlo D, Haberzettl P, Gerloff K, Li H, Scherbart AM, Albrecht C, Schins RP.

Chem Res Toxicol. 2009 Sep;22(9):1548-58. doi: 10.1021/tx900046x.

PMID:
19697923
46.

Particle induced toxicity in relation to transition metal and polycyclic aromatic hydrocarbon contents.

Gerlofs-Nijland ME, Rummelhard M, Boere AJ, Leseman DL, Duffin R, Schins RP, Borm PJ, Sillanpää M, Salonen RO, Cassee FR.

Environ Sci Technol. 2009 Jul 1;43(13):4729-36.

PMID:
19673258
47.

Development of in vitro systems for nanotoxicology: methodological considerations.

Stone V, Johnston H, Schins RP.

Crit Rev Toxicol. 2009;39(7):613-26. doi: 10.1080/10408440903120975. Review.

PMID:
19650720
48.

Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells.

Bhattacharya K, Davoren M, Boertz J, Schins RP, Hoffmann E, Dopp E.

Part Fibre Toxicol. 2009 Jun 21;6:17. doi: 10.1186/1743-8977-6-17.

49.

Increase of inflammatory markers after indoor renovation activities: the LISA birth cohort study.

Herberth G, Gubelt R, Röder S, Krämer U, Schins RP, Diez U, Borte M, Heinrich J, Wichmann HE, Herbarth O, Lehmann I; LISAplus study group.

Pediatr Allergy Immunol. 2009 Sep;20(6):563-70. doi: 10.1111/j.1399-3038.2008.00819.x. Epub 2009 May 31.

PMID:
19496969
50.

Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells.

Baulig A, Singh S, Marchand A, Schins R, Barouki R, Garlatti M, Marano F, Baeza-Squiban A.

Toxicology. 2009 Jul 10;261(3):126-35. doi: 10.1016/j.tox.2009.05.007. Epub 2009 May 19.

PMID:
19460412

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