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Items: 1 to 50 of 150

1.

Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase.

Heckt T, Brylka LJ, Neven M, Amling M, Schinke T.

PLoS One. 2019 Jul 17;14(7):e0219734. doi: 10.1371/journal.pone.0219734. eCollection 2019.

2.

Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.

Yorgan TA, Peters S, Amling M, Schinke T.

Bone. 2019 Oct;127:155-163. doi: 10.1016/j.bone.2019.06.008. Epub 2019 Jun 14.

3.

A System to Determine Risk of Osteoporosis in Patients With Autoimmune Hepatitis.

Schmidt T, Schmidt C, Strahl A, Mussawy H, Rolvien T, Jandl NM, Casar C, Oheim R, Schinke T, Lohse AW, Amling M, Schramm C, Barvencik F.

Clin Gastroenterol Hepatol. 2019 Jun 1. pii: S1542-3565(19)30593-2. doi: 10.1016/j.cgh.2019.05.043. [Epub ahead of print]

PMID:
31163277
4.

Secreted factors from synovial fibroblasts immediately regulate gene expression in articular chondrocytes.

Bonitz M, Schaffer C, Amling M, Poertner R, Schinke T, Jeschke A.

Gene. 2019 May 25;698:1-8. doi: 10.1016/j.gene.2019.02.065. Epub 2019 Feb 27.

PMID:
30825594
5.

Th17 cell frequency is associated with low bone mass in primary sclerosing cholangitis.

Schmidt T, Schwinge D, Rolvien T, Jeschke A, Schmidt C, Neven M, Butscheidt S, Kriz M, Kunzmann L, Mussawy H, Hubert J, Hawellek T, Rüther W, Oheim R, Barvencik F, Lohse AW, Schramm C, Schinke T, Amling M.

J Hepatol. 2019 May;70(5):941-953. doi: 10.1016/j.jhep.2018.12.035. Epub 2019 Jan 11.

PMID:
30641095
6.

Publisher Correction: Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice.

Fischer V, Haffner-Luntzer M, Prystaz K, Vom Scheidt A, Busse B, Schinke T, Amling M, Ignatius A.

Sci Rep. 2018 Nov 16;8(1):17205. doi: 10.1038/s41598-018-35539-5.

7.

Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand.

Luther J, Yorgan TA, Rolvien T, Ulsamer L, Koehne T, Liao N, Keller D, Vollersen N, Teufel S, Neven M, Peters S, Schweizer M, Trumpp A, Rosigkeit S, Bockamp E, Mundlos S, Kornak U, Oheim R, Amling M, Schinke T, David JP.

Sci Transl Med. 2018 Nov 7;10(466). pii: eaau7137. doi: 10.1126/scitranslmed.aau7137.

PMID:
30404864
8.

A novel FAM20C mutation causing hypophosphatemic osteomalacia with osteosclerosis (mild Raine syndrome) in an elderly man with spontaneous osteonecrosis of the knee.

Rolvien T, Kornak U, Schinke T, Amling M, Oheim R.

Osteoporos Int. 2019 Mar;30(3):685-689. doi: 10.1007/s00198-018-4667-6. Epub 2018 Aug 27.

PMID:
30151622
9.

The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover.

Pohl S, Angermann A, Jeschke A, Hendrickx G, Yorgan TA, Makrypidi-Fraune G, Steigert A, Kuehn SC, Rolvien T, Schweizer M, Koehne T, Neven M, Winter O, Velho RV, Albers J, Streichert T, Pestka JM, Baldauf C, Breyer S, Stuecker R, Muschol N, Cox TM, Saftig P, Paganini C, Rossi A, Amling M, Braulke T, Schinke T.

J Bone Miner Res. 2018 Dec;33(12):2186-2201. doi: 10.1002/jbmr.3563. Epub 2018 Aug 24.

PMID:
30075049
10.

Comparison of Bone Microarchitecture Between Adult Osteogenesis Imperfecta and Early-Onset Osteoporosis.

Rolvien T, Stürznickel J, Schmidt FN, Butscheidt S, Schmidt T, Busse B, Mundlos S, Schinke T, Kornak U, Amling M, Oheim R.

Calcif Tissue Int. 2018 Nov;103(5):512-521. doi: 10.1007/s00223-018-0447-8. Epub 2018 Jun 26.

PMID:
29946973
11.

Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation.

Geissler S, Textor M, Stumpp S, Seitz S, Lekaj A, Brunk S, Klaassen S, Schinke T, Klein C, Mundlos S, Kornak U, Kühnisch J.

PLoS One. 2018 Jun 7;13(6):e0198510. doi: 10.1371/journal.pone.0198510. eCollection 2018.

12.

Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells.

Di Lorenzo G, Velho RV, Winter D, Thelen M, Ahmadi S, Schweizer M, De Pace R, Cornils K, Yorgan TA, Grüb S, Hermans-Borgmeyer I, Schinke T, Müller-Loennies S, Braulke T, Pohl S.

Mol Cell Proteomics. 2018 Aug;17(8):1612-1626. doi: 10.1074/mcp.RA118.000720. Epub 2018 May 17.

13.

Impaired mineral quality in dentin in X-linked hypophosphatemia.

Coyac BR, Falgayrac G, Penel G, Schmitt A, Schinke T, Linglart A, McKee MD, Chaussain C, Bardet C.

Connect Tissue Res. 2018 Dec;59(sup1):91-96. doi: 10.1080/03008207.2017.1417989.

PMID:
29745817
14.

[Mutual influence of immune system and bones].

Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A.

Z Rheumatol. 2018 May;77(Suppl 1):8-11. doi: 10.1007/s00393-018-0454-1. Review. German. No abstract available.

PMID:
29675686
15.

Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis.

Hendrickx G, Borra VM, Steenackers E, Yorgan TA, Hermans C, Boudin E, Waterval JJ, Jansen IDC, Aydemir TB, Kamerling N, Behets GJ, Plumeyer C, D'Haese PC, Busse B, Everts V, Lammens M, Mortier G, Cousins RJ, Schinke T, Stokroos RJ, Manni JJ, Van Hul W.

PLoS Genet. 2018 Apr 5;14(4):e1007321. doi: 10.1371/journal.pgen.1007321. eCollection 2018 Apr.

16.

Mutational analysis uncovers monogenic bone disorders in women with pregnancy-associated osteoporosis: three novel mutations in LRP5, COL1A1, and COL1A2.

Butscheidt S, Delsmann A, Rolvien T, Barvencik F, Al-Bughaili M, Mundlos S, Schinke T, Amling M, Kornak U, Oheim R.

Osteoporos Int. 2018 Jul;29(7):1643-1651. doi: 10.1007/s00198-018-4499-4. Epub 2018 Mar 29.

PMID:
29594386
17.

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U.

PLoS Genet. 2018 Mar 21;14(3):e1007242. doi: 10.1371/journal.pgen.1007242. eCollection 2018 Mar.

18.

Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling.

Bartelt A, Behler-Janbeck F, Beil FT, Koehne T, Müller B, Schmidt T, Heine M, Ochs L, Yilmaz T, Dietrich M, Tuckermann JP, Amling M, Herz J, Schinke T, Heeren J, Niemeier A.

Bone Res. 2018 Feb 26;6:4. doi: 10.1038/s41413-017-0006-3. eCollection 2018.

19.

Disease Duration and Stage Influence Bone Microstructure in Patients With Primary Biliary Cholangitis.

Schmidt T, Schmidt C, Schmidt FN, Butscheidt S, Mussawy H, Hubert J, Hawellek T, Oehler N, Barvencik F, Lohse AW, Schinke T, Schramm C, Amling M, Rolvien T.

J Bone Miner Res. 2018 Jun;33(6):1011-1019. doi: 10.1002/jbmr.3410. Epub 2018 Mar 25.

20.

The high bone mass phenotype of Lrp5-mutant mice is not affected by megakaryocyte depletion.

Yorgan T, David JP, Amling M, Schinke T.

Biochem Biophys Res Commun. 2018 Mar 4;497(2):659-666. doi: 10.1016/j.bbrc.2018.02.127. Epub 2018 Feb 15.

PMID:
29454962
21.

Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice.

Brylka LJ, Köppert S, Babler A, Kratz B, Denecke B, Yorgan TA, Etich J, Costa IG, Brachvogel B, Boor P, Schinke T, Jahnen-Dechent W.

PLoS One. 2017 Oct 31;12(10):e0187030. doi: 10.1371/journal.pone.0187030. eCollection 2017.

22.

Differences in maxillomandibular morphology among patients with mucopolysaccharidoses I, II, III, IV and VI: a retrospective MRI study.

Koehne T, Köhn A, Friedrich RE, Kordes U, Schinke T, Muschol N, Kahl-Nieke B.

Clin Oral Investig. 2018 Apr;22(3):1541-1549. doi: 10.1007/s00784-017-2240-x. Epub 2017 Oct 18.

PMID:
29046964
23.

Clinical Significance of DXA and HR-pQCT in Autosomal Dominant Osteopetrosis (ADO II).

Butscheidt S, Rolvien T, Kornak U, Schmidt FN, Schinke T, Amling M, Oheim R.

Calcif Tissue Int. 2018 Jan;102(1):41-52. doi: 10.1007/s00223-017-0332-x. Epub 2017 Oct 10.

PMID:
29018903
24.

A novel COL1A2 C-propeptide cleavage site mutation causing high bone mass osteogenesis imperfecta with a regional distribution pattern.

Rolvien T, Kornak U, Stürznickel J, Schinke T, Amling M, Mundlos S, Oheim R.

Osteoporos Int. 2018 Jan;29(1):243-246. doi: 10.1007/s00198-017-4224-8. Epub 2017 Sep 15.

PMID:
28916840
25.

High Bone Turnover in Mice Carrying a Pathogenic Notch2 Mutation Causing Hajdu-Cheney Syndrome.

Vollersen N, Hermans-Borgmeyer I, Cornils K, Fehse B, Rolvien T, Triviai I, Jeschke A, Oheim R, Amling M, Schinke T, Yorgan TA.

J Bone Miner Res. 2018 Jan;33(1):70-83. doi: 10.1002/jbmr.3283. Epub 2017 Sep 20.

26.

Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity.

Kroner J, Kovtun A, Kemmler J, Messmann JJ, Strauss G, Seitz S, Schinke T, Amling M, Kotrba J, Froebel J, Dudeck J, Dudeck A, Ignatius A.

J Bone Miner Res. 2017 Dec;32(12):2431-2444. doi: 10.1002/jbmr.3234. Epub 2017 Sep 11.

27.

Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice.

Fischer V, Haffner-Luntzer M, Prystaz K, Vom Scheidt A, Busse B, Schinke T, Amling M, Ignatius A.

Sci Rep. 2017 Aug 3;7(1):7223. doi: 10.1038/s41598-017-07511-2. Erratum in: Sci Rep. 2018 Nov 16;8(1):17205.

28.

Tissue-specific mineralization defects in the periodontium of the Hyp mouse model of X-linked hypophosphatemia.

Coyac BR, Falgayrac G, Baroukh B, Slimani L, Sadoine J, Penel G, Biosse-Duplan M, Schinke T, Linglart A, McKee MD, Chaussain C, Bardet C.

Bone. 2017 Oct;103:334-346. doi: 10.1016/j.bone.2017.07.026. Epub 2017 Jul 29.

PMID:
28764922
29.

Severe bone loss and multiple fractures in SCN8A-related epileptic encephalopathy.

Rolvien T, Butscheidt S, Jeschke A, Neu A, Denecke J, Kubisch C, Meisler MH, Pueschel K, Barvencik F, Yorgan T, Oheim R, Schinke T, Amling M.

Bone. 2017 Oct;103:136-143. doi: 10.1016/j.bone.2017.06.025. Epub 2017 Jul 1.

PMID:
28676440
30.

Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone.

Rolvien T, Krause M, Jeschke A, Yorgan T, Püschel K, Schinke T, Busse B, Demay MB, Amling M.

Bone. 2017 Oct;103:78-87. doi: 10.1016/j.bone.2017.06.022. Epub 2017 Jun 27.

PMID:
28666969
31.

Differential effects of Calca-derived peptides in male mice with diet-induced obesity.

Bartelt A, Jeschke A, Müller B, Gaziano I, Morales M, Yorgan T, Heckt T, Heine M, Gagel RF, Emeson RB, Amling M, Niemeier A, Heeren J, Schinke T, Keller J.

PLoS One. 2017 Jun 30;12(6):e0180547. doi: 10.1371/journal.pone.0180547. eCollection 2017.

32.

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing.

Bergdolt S, Kovtun A, Hägele Y, Liedert A, Schinke T, Amling M, Huber-Lang M, Ignatius A.

PLoS One. 2017 Jun 14;12(6):e0179512. doi: 10.1371/journal.pone.0179512. eCollection 2017.

33.

The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans.

Boudin E, Yorgan T, Fijalkowski I, Sonntag S, Steenackers E, Hendrickx G, Peeters S, De Maré A, Vervaet B, Verhulst A, Mortier G, D'Haese P, Schinke T, Van Hul W.

J Bone Miner Res. 2017 Aug;32(8):1739-1749. doi: 10.1002/jbmr.3160.

34.

The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta.

Gioia R, Tonelli F, Ceppi I, Biggiogera M, Leikin S, Fisher S, Tenedini E, Yorgan TA, Schinke T, Tian K, Schwartz JM, Forte F, Wagener R, Villani S, Rossi A, Forlino A.

Hum Mol Genet. 2017 Aug 1;26(15):2897-2911. doi: 10.1093/hmg/ddx171.

35.

Letter to the Editor, concerning: "FGF23-regulated production of fetuin-A (AHSG) in osteocytes".

Jahnen-Dechent W, Brylka L, Schinke T, McKee MD.

Bone. 2016 Dec;93:223-224. doi: 10.1016/j.bone.2016.01.031. Epub 2016 May 31. No abstract available.

PMID:
27260648
36.

Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts.

Heckt T, Keller J, Peters S, Streichert T, Chalaris A, Rose-John S, Mell B, Joe B, Amling M, Schinke T.

Bone. 2016 Nov;92:85-93. doi: 10.1016/j.bone.2016.08.016. Epub 2016 Aug 20.

PMID:
27554428
37.

A Novel ANO5 Mutation Causing Gnathodiaphyseal Dysplasia With High Bone Turnover Osteosclerosis.

Rolvien T, Koehne T, Kornak U, Lehmann W, Amling M, Schinke T, Oheim R.

J Bone Miner Res. 2017 Feb;32(2):277-284. doi: 10.1002/jbmr.2980. Epub 2016 Sep 9.

38.

Inhibition of Midkine Augments Osteoporotic Fracture Healing.

Haffner-Luntzer M, Kemmler J, Heidler V, Prystaz K, Schinke T, Amling M, Kovtun A, Rapp AE, Ignatius A, Liedert A.

PLoS One. 2016 Jul 13;11(7):e0159278. doi: 10.1371/journal.pone.0159278. eCollection 2016.

39.

Mannose 6-phosphate-dependent targeting of lysosomal enzymes is required for normal craniofacial and dental development.

Koehne T, Markmann S, Schweizer M, Muschol N, Friedrich RE, Hagel C, Glatzel M, Kahl-Nieke B, Amling M, Schinke T, Braulke T.

Biochim Biophys Acta. 2016 Sep;1862(9):1570-80. doi: 10.1016/j.bbadis.2016.05.018. Epub 2016 May 27.

40.

Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus.

Haffner-Luntzer M, Heilmann A, Rapp AE, Roessler R, Schinke T, Amling M, Ignatius A, Liedert A.

Br J Pharmacol. 2016 Jul;173(14):2237-49. doi: 10.1111/bph.13503. Epub 2016 May 29.

41.

Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton.

Yorgan T, Vollersen N, Riedel C, Jeschke A, Peters S, Busse B, Amling M, Schinke T.

Bone. 2016 Jun;87:136-46. doi: 10.1016/j.bone.2016.04.012. Epub 2016 Apr 14.

PMID:
27102824
42.

Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts.

Uluçkan Ö, Jimenez M, Karbach S, Jeschke A, Graña O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G, Wagner EF.

Sci Transl Med. 2016 Mar 16;8(330):330ra37. doi: 10.1126/scitranslmed.aad8996. Epub 2016 Mar 16.

PMID:
27089206
43.

Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton.

Haffner-Luntzer M, Heilmann A, Heidler V, Liedert A, Schinke T, Amling M, Yorgan TA, Vom Scheidt A, Ignatius A.

J Orthop Res. 2016 Nov;34(11):1914-1921. doi: 10.1002/jor.23221. Epub 2016 Mar 14.

44.

Rsk2, the Kinase Mutated in Coffin-Lowry Syndrome, Controls Cementum Formation.

Koehne T, Jeschke A, Petermann F, Seitz S, Neven M, Peters S, Luther J, Schweizer M, Schinke T, Kahl-Nieke B, Amling M, David JP.

J Dent Res. 2016 Jul;95(7):752-60. doi: 10.1177/0022034516634329. Epub 2016 Feb 29.

PMID:
26927527
45.

Can we induce osteoporosis in animals comparable to the human situation?

Oheim R, Schinke T, Amling M, Pogoda P.

Injury. 2016 Jan;47 Suppl 1:S3-9. doi: 10.1016/S0020-1383(16)30002-X. Review.

PMID:
26768287
46.

No obvious phenotypic abnormalities in mice lacking the Pate4 gene.

Heckt T, Keller J, Reusch R, Hartmann K, Krasemann S, Hermans-Borgmeyer I, Amling M, Schinke T.

Biochem Biophys Res Commun. 2016 Jan 22;469(4):1069-74. doi: 10.1016/j.bbrc.2015.12.104. Epub 2015 Dec 28.

PMID:
26731031
47.

Deficiency of Thrombospondin-4 in Mice Does Not Affect Skeletal Growth or Bone Mass Acquisition, but Causes a Transient Reduction of Articular Cartilage Thickness.

Jeschke A, Bonitz M, Simon M, Peters S, Baum W, Schett G, Ruether W, Niemeier A, Schinke T, Amling M.

PLoS One. 2015 Dec 2;10(12):e0144272. doi: 10.1371/journal.pone.0144272. eCollection 2015.

48.

Impaired bone remodeling and its correction by combination therapy in a mouse model of mucopolysaccharidosis-I.

Kuehn SC, Koehne T, Cornils K, Markmann S, Riedel C, Pestka JM, Schweizer M, Baldauf C, Yorgan TA, Krause M, Keller J, Neven M, Breyer S, Stuecker R, Muschol N, Busse B, Braulke T, Fehse B, Amling M, Schinke T.

Hum Mol Genet. 2015 Dec 15;24(24):7075-86. doi: 10.1093/hmg/ddv407. Epub 2015 Oct 1.

PMID:
26427607
49.

Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells.

Jeschke A, Catala-Lehnen P, Sieber S, Bickert T, Schweizer M, Koehne T, Wintges K, Marshall RP, Mautner A, Duchstein L, Otto B, Horst AK, Amling M, Kreienkamp HJ, Schinke T.

J Immunol. 2015 Oct 15;195(8):3675-84. doi: 10.4049/jimmunol.1402392. Epub 2015 Sep 11.

50.

The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice.

Baldauf C, Jeschke A, Kanbach V, Catala-Lehnen P, Baumhoer D, Gerull H, Buhs S, Amling M, Nollau P, Harroch S, Schinke T.

PLoS One. 2015 Sep 11;10(9):e0137745. doi: 10.1371/journal.pone.0137745. eCollection 2015.

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