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Items: 32

1.

Structure and function of placental exchange surfaces in goodeid fishes (Teleostei: Atheriniformes).

Schindler JF.

J Morphol. 2015 Aug;276(8):991-1003. doi: 10.1002/jmor.20292. Epub 2014 May 2.

PMID:
24797516
2.

Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase.

Selness SR, Boehm TL, Walker JK, Devadas B, Durley RC, Kurumbail R, Shieh H, Xing L, Hepperle M, Rucker PV, Jerome KD, Benson AG, Marrufo LD, Madsen HM, Hitchcock J, Owen TJ, Christie L, Promo MA, Hickory BS, Alvira E, Naing W, Blevis-Bal R, Devraj RV, Messing D, Schindler JF, Hirsch J, Saabye M, Bonar S, Webb E, Anderson G, Monahan JB.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4059-65. doi: 10.1016/j.bmcl.2011.04.120. Epub 2011 May 13.

PMID:
21640588
3.

A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.

Mourey RJ, Burnette BL, Brustkern SJ, Daniels JS, Hirsch JL, Hood WF, Meyers MJ, Mnich SJ, Pierce BS, Saabye MJ, Schindler JF, South SA, Webb EG, Zhang J, Anderson DR.

J Pharmacol Exp Ther. 2010 Jun;333(3):797-807. doi: 10.1124/jpet.110.166173. Epub 2010 Mar 17.

PMID:
20237073
4.

Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides.

Baima ET, Guzova JA, Mathialagan S, Nagiec EE, Hardy MM, Song LR, Bonar SL, Weinberg RA, Selness SR, Woodard SS, Chrencik J, Hood WF, Schindler JF, Kishore N, Mbalaviele G.

J Biol Chem. 2010 Apr 30;285(18):13498-506. doi: 10.1074/jbc.M109.099895. Epub 2010 Feb 18.

5.

Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain.

Hall T, Emmons TL, Chrencik JE, Gormley JA, Weinberg RA, Leone JW, Hirsch JL, Saabye MJ, Schindler JF, Day JE, Williams JM, Kiefer JR, Lightle SA, Harris MS, Guru S, Fischer HD, Tomasselli AG.

Protein Expr Purif. 2010 Jan;69(1):54-63. doi: 10.1016/j.pep.2009.09.011. Epub 2009 Sep 23.

PMID:
19781647
6.

Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.

Hope HR, Anderson GD, Burnette BL, Compton RP, Devraj RV, Hirsch JL, Keith RH, Li X, Mbalaviele G, Messing DM, Saabye MJ, Schindler JF, Selness SR, Stillwell LI, Webb EG, Zhang J, Monahan JB.

J Pharmacol Exp Ther. 2009 Dec;331(3):882-95. doi: 10.1124/jpet.109.158329. Epub 2009 Aug 31.

PMID:
19720877
7.

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.

Xing L, Shieh HS, Selness SR, Devraj RV, Walker JK, Devadas B, Hope HR, Compton RP, Schindler JF, Hirsch JL, Benson AG, Kurumbail RG, Stegeman RA, Williams JM, Broadus RM, Walden Z, Monahan JB.

Biochemistry. 2009 Jul 14;48(27):6402-11. doi: 10.1021/bi900655f.

PMID:
19496616
8.

Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation.

Sommers CD, Thompson JM, Guzova JA, Bonar SL, Rader RK, Mathialagan S, Venkatraman N, Holway VW, Kahn LE, Hu G, Garner DS, Huang HC, Chiang PC, Schindler JF, Hu Y, Meyer DM, Kishore NN.

J Pharmacol Exp Ther. 2009 Aug;330(2):377-88. doi: 10.1124/jpet.108.147538. Epub 2009 May 28.

PMID:
19478133
9.

A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models.

Mbalaviele G, Sommers CD, Bonar SL, Mathialagan S, Schindler JF, Guzova JA, Shaffer AF, Melton MA, Christine LJ, Tripp CS, Chiang PC, Thompson DC, Hu Y, Kishore N.

J Pharmacol Exp Ther. 2009 Apr;329(1):14-25. doi: 10.1124/jpet.108.143800. Epub 2009 Jan 23.

PMID:
19168710
10.

p38 pathway kinases as anti-inflammatory drug targets.

Schindler JF, Monahan JB, Smith WG.

J Dent Res. 2007 Sep;86(9):800-11. Review.

PMID:
17720847
11.

Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

Anderson DR, Meyers MJ, Vernier WF, Mahoney MW, Kurumbail RG, Caspers N, Poda GI, Schindler JF, Reitz DB, Mourey RJ.

J Med Chem. 2007 May 31;50(11):2647-54. Epub 2007 May 5.

PMID:
17480064
14.

Examination of the kinetic mechanism of mitogen-activated protein kinase activated protein kinase-2.

Schindler JF, Godbey A, Hood WF, Bolten SL, Broadus RM, Kasten TP, Cassely AJ, Hirsch JL, Merwood MA, Nagy MA, Fok KF, Saabye MJ, Morgan HM, Compton RP, Mourey RJ, Wittwer AJ, Monahan JB.

Biochim Biophys Acta. 2002 Jul 29;1598(1-2):88-97.

PMID:
12147348
15.

Haloalkane dehalogenases: structure of a Rhodococcus enzyme.

Newman J, Peat TS, Richard R, Kan L, Swanson PE, Affholter JA, Holmes IH, Schindler JF, Unkefer CJ, Terwilliger TC.

Biochemistry. 1999 Dec 7;38(49):16105-14.

PMID:
10587433
16.

In vivo screening of haloalkane dehalogenase mutants.

Chang CH, Schindler JF, Unkefer CJ, Vanderberg LA, Brainard JR, Terwilliger TC.

Bioorg Med Chem. 1999 Oct;7(10):2175-81.

PMID:
10579523
17.

Uncompetitive inhibitors of alcohol dehydrogenases.

Plapp BV, Chadha VK, Leidal KG, Cho H, Scholze M, Schindler JF, Berst KB, Ramaswamy S.

Adv Exp Med Biol. 1999;463:295-303. No abstract available.

PMID:
10352698
18.

Haloalkane dehalogenases: steady-state kinetics and halide inhibition.

Schindler JF, Naranjo PA, Honaberger DA, Chang CH, Brainard JR, Vanderberg LA, Unkefer CJ.

Biochemistry. 1999 May 4;38(18):5772-8.

PMID:
10231528
19.

A Raman spectroscopic characterization of bonding in the complex of horse liver alcohol dehydrogenase with NADH and N-cyclohexylformamide.

Deng H, Schindler JF, Berst KB, Plapp BV, Callender R.

Biochemistry. 1998 Oct 6;37(40):14267-78.

PMID:
9760265
20.

Inhibition of human alcohol dehydrogenases by formamides.

Schindler JF, Berst KB, Plapp BV.

J Med Chem. 1998 May 7;41(10):1696-701.

PMID:
9572895
21.

Conversion of cysteinyl residues to unnatural amino acid analogs. Examination in a model system.

Schindler JF, Viola RE.

J Protein Chem. 1996 Nov;15(8):737-42.

PMID:
9008297
22.

Mechanism-based inactivation of L-aspartase from Escherichia coli.

Schindler JF, Viola RE.

Biochemistry. 1994 Aug 9;33(31):9365-70.

PMID:
8049238
23.

Mutagenic investigation of conserved functional amino acids in Escherichia coli L-aspartase.

SaribaƟ AS, Schindler JF, Viola RE.

J Biol Chem. 1994 Mar 4;269(9):6313-9.

24.

Crystallization and preliminary X-ray studies of L-aspartase from Escherichia coli.

Shi W, Kidd R, Giorgianni F, Schindler JF, Viola RE, Farber GK.

J Mol Biol. 1993 Dec 20;234(4):1248-9.

PMID:
8263924
25.
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29.

Ovarian structural specializations facilitate aplacental matrotrophy in Jenynsia lineata (cyprinodontiformes, osteichthyes).

Schindler JF, de Vries U.

J Morphol. 1988 Dec;198(3):331-339. doi: 10.1002/jmor.1051980307.

PMID:
29890789
31.

Ultrastructure of embryonic anal processes in Girardinichthys viviparus (Cyprinodontiformes, Osteichthyes).

Schindler JF, De Vries U.

J Morphol. 1986 May;188(2):203-224. doi: 10.1002/jmor.1051880207.

PMID:
29966402
32.

Microspectrophotometric and scanning microphotometric studies of carp (Cyprinus carpio L.) erythrocytes.

Schindler JF, de Vries U, Lindner E.

Histochemistry. 1985;82(5):483-9.

PMID:
3928536

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