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Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif.

Pogenberg V, Ballesteros-Álvarez J, Schober R, Sigvaldadóttir I, Obarska-Kosinska A, Milewski M, Schindl R, Ögmundsdóttir MH, Steingrímsson E, Wilmanns M.

Nucleic Acids Res. 2019 Nov 28. pii: gkz1104. doi: 10.1093/nar/gkz1104. [Epub ahead of print]


Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.

Schober R, Bonhenry D, Lunz V, Zhu J, Krizova A, Frischauf I, Fahrner M, Zhang M, Waldherr L, Schmidt T, Derler I, Stathopulos PB, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2019 Nov 19;12(608). pii: eaax3194. doi: 10.1126/scisignal.aax3194.


Optoelectronic control of single cells using organic photocapacitors.

Jakešová M, Silverå Ejneby M, Đerek V, Schmidt T, Gryszel M, Brask J, Schindl R, Simon DT, Berggren M, Elinder F, Głowacki ED.

Sci Adv. 2019 Apr 5;5(4):eaav5265. doi: 10.1126/sciadv.aav5265. eCollection 2019 Apr.


TRPC-mediated Ca2+ signaling and control of cellular functions.

Curcic S, Schober R, Schindl R, Groschner K.

Semin Cell Dev Biol. 2019 Oct;94:28-39. doi: 10.1016/j.semcdb.2019.02.001. Epub 2019 Mar 2. Review.


Mechanistic insights into the Orai channel by molecular dynamics simulations.

Bonhenry D, Schober R, Schmidt T, Waldherr L, Ettrich RH, Schindl R.

Semin Cell Dev Biol. 2019 Oct;94:50-58. doi: 10.1016/j.semcdb.2019.01.002. Epub 2019 Jan 15. Review.


STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription.

Schober R, Waldherr L, Schmidt T, Graziani A, Stilianu C, Legat L, Groschner K, Schindl R.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1079-1091. doi: 10.1016/j.bbamcr.2018.11.001. Epub 2018 Nov 6. Review.


Studies of Structure-Function and Subunit Composition of Orai/STIM Channel.

Fahrner M, Schindl R, Romanin C.

In: Kozak JA, Putney JW Jr., editors. Calcium Entry Channels in Non-Excitable Cells. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 2.


An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.

Lichtenegger M, Tiapko O, Svobodova B, Stockner T, Glasnov TN, Schreibmayer W, Platzer D, de la Cruz GG, Krenn S, Schober R, Shrestha N, Schindl R, Romanin C, Groschner K.

Nat Chem Biol. 2018 Apr;14(4):396-404. doi: 10.1038/s41589-018-0015-6. Epub 2018 Mar 19.


Communication between N terminus and loop2 tunes Orai activation.

Fahrner M, Pandey SK, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber HJ, Hinterdorfer P, Ettrich R, Romanin C, Derler I.

J Biol Chem. 2018 Jan 26;293(4):1271-1285. doi: 10.1074/jbc.M117.812693. Epub 2017 Dec 13.


Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.

Frischauf I, Litviňuková M, Schober R, Zayats V, Svobodová B, Bonhenry D, Lunz V, Cappello S, Tociu L, Reha D, Stallinger A, Hochreiter A, Pammer T, Butorac C, Muik M, Groschner K, Bogeski I, Ettrich RH, Romanin C, Schindl R.

Sci Signal. 2017 Nov 28;10(507). pii: eaao0358. doi: 10.1126/scisignal.aao0358.


The STIM-Orai Pathway: The Interactions Between STIM and Orai.

Fahrner M, Schindl R, Muik M, Derler I, Romanin C.

Adv Exp Med Biol. 2017;993:59-81. doi: 10.1007/978-3-319-57732-6_4. Review.


Cellular interfaces with hydrogen-bonded organic semiconductor hierarchical nanocrystals.

Sytnyk M, Jakešová M, Litviňuková M, Mashkov O, Kriegner D, Stangl J, Nebesářová J, Fecher FW, Schöfberger W, Sariciftci NS, Schindl R, Heiss W, Głowacki ED.

Nat Commun. 2017 Jul 21;8(1):91. doi: 10.1038/s41467-017-00135-0.


In vitro evaluation of the potential toxic effects of palladium nanoparticles on fibroblasts and lung epithelial cells.

Iavicoli I, Farina M, Fontana L, Lucchetti D, Leso V, Fanali C, Cufino V, Boninsegna A, Leopold K, Schindl R, Brucker D, Sgambato A.

Toxicol In Vitro. 2017 Aug;42:191-199. doi: 10.1016/j.tiv.2017.04.024. Epub 2017 May 1.


Subchronic exposure to palladium nanoparticles affects serum levels of cytokines in female Wistar rats.

Iavicoli I, Fontana L, Leso V, Corbi M, Marinaccio A, Leopold K, Schindl R, Lucchetti D, Calapà F, Sgambato A.

Hum Exp Toxicol. 2018 Mar;37(3):309-320. doi: 10.1177/0960327117702952. Epub 2017 Apr 7.


Determination of traffic-related palladium in tunnel dust and roadside soil.

Leopold K, Wörle K, Schindl R, Huber L, Maier M, Schuster M.

Sci Total Environ. 2017 Apr 1;583:169-175. doi: 10.1016/j.scitotenv.2017.01.048. Epub 2017 Jan 20.


Cholesterol modulates Orai1 channel function.

Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C.

Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808.


A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.

Frischauf I, Zayats V, Deix M, Hochreiter A, Jardin I, Muik M, Lackner B, Svobodová B, Pammer T, Litviňuková M, Sridhar AA, Derler I, Bogeski I, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2015 Dec 22;8(408):ra131. doi: 10.1126/scisignal.aab1901.


Geochemical behaviour of palladium in soils and Pd/PdO model substances in the presence of the organic complexing agents L-methionine and citric acid.

Zereini F, Wiseman CL, Vang M, Albers P, Schneider W, Schindl R, Leopold K.

Environ Sci Process Impacts. 2016 Jan;18(1):22-31. doi: 10.1039/c5em00521c.


Exposure to Palladium Nanoparticles Affects Serum Levels of Cytokines in Female Wistar Rats.

Iavicoli I, Fontana L, Corbi M, Leso V, Marinaccio A, Leopold K, Schindl R, Sgambato A.

PLoS One. 2015 Nov 30;10(11):e0143801. doi: 10.1371/journal.pone.0143801. eCollection 2015.


The influence of ethylenediamine tetra acetic acid (EDTA) on the transformation and solubility of metallic palladium and palladium(II) oxide in the environment.

Zereini F, Wiseman CL, Vang M, Albers P, Schneider W, Schindl R, Leopold K.

Environ Sci Process Impacts. 2015 May;17(5):915-21. doi: 10.1039/c5em00078e. Epub 2015 Mar 27.


The effects of palladium nanoparticles on the renal function of female Wistar rats.

Fontana L, Leso V, Marinaccio A, Cenacchi G, Papa V, Leopold K, Schindl R, Bocca B, Alimonti A, Iavicoli I.

Nanotoxicology. 2015;9(7):843-51. doi: 10.3109/17435390.2014.980759. Epub 2015 Sep 4.


A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).

Fahrner M, Muik M, Schindl R, Butorac C, Stathopulos P, Zheng L, Jardin I, Ikura M, Romanin C.

J Biol Chem. 2014 Nov 28;289(48):33231-44. doi: 10.1074/jbc.M114.610022. Epub 2014 Oct 23.


Palladium nanoparticles induce disturbances in cell cycle entry and progression of peripheral blood mononuclear cells: paramount role of ions.

Petrarca C, Clemente E, Di Giampaolo L, Mariani-Costantini R, Leopold K, Schindl R, Lotti LV, Mangifesta R, Sabbioni E, Niu Q, Bernardini G, Di Gioacchino M.

J Immunol Res. 2014;2014:295092. doi: 10.1155/2014/295092. Epub 2014 Jul 3.


STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.

Stathopulos PB, Schindl R, Fahrner M, Zheng L, Gasmi-Seabrook GM, Muik M, Romanin C, Ikura M.

Nat Commun. 2013;4:2963. doi: 10.1038/ncomms3963.


Characterization of stainless steel assisted bare gold nanoparticles and their analytical potential.

López-Lorente AI, Simonet BM, Valcárcel M, Eppler S, Schindl R, Kranz C, Mizaikoff B.

Talanta. 2014 Jan;118:321-7. doi: 10.1016/j.talanta.2013.10.028. Epub 2013 Oct 24.


The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.

Derler I, Plenk P, Fahrner M, Muik M, Jardin I, Schindl R, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2013 Oct 4;288(40):29025-34. doi: 10.1074/jbc.M113.501510. Epub 2013 Aug 13.


Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.

Zhang X, González-Cobos JC, Schindl R, Muik M, Ruhle B, Motiani RK, Bisaillon JM, Zhang W, Fahrner M, Barroso M, Matrougui K, Romanin C, Trebak M.

Mol Cell Biol. 2013 Sep;33(18):3715-23. doi: 10.1128/MCB.00554-13. Epub 2013 Jul 22.


Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.

González-Cobos JC, Zhang X, Zhang W, Ruhle B, Motiani RK, Schindl R, Muik M, Spinelli AM, Bisaillon JM, Shinde AV, Fahrner M, Singer HA, Matrougui K, Barroso M, Romanin C, Trebak M.

Circ Res. 2013 Mar 29;112(7):1013-25. doi: 10.1161/CIRCRESAHA.111.300220. Epub 2013 Jan 24.


The action of selective CRAC channel blockers is affected by the Orai pore geometry.

Derler I, Schindl R, Fritsch R, Heftberger P, Riedl MC, Begg M, House D, Romanin C.

Cell Calcium. 2013 Feb;53(2):139-51. doi: 10.1016/j.ceca.2012.11.005. Epub 2012 Dec 5.


Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.

Schindl R, Fritsch R, Jardin I, Frischauf I, Kahr H, Muik M, Riedl MC, Groschner K, Romanin C.

J Biol Chem. 2012 Oct 12;287(42):35612-20. doi: 10.1074/jbc.M112.400952. Epub 2012 Aug 29.


Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.

Muik M, Schindl R, Fahrner M, Romanin C.

Cell Mol Life Sci. 2012 Dec;69(24):4163-76. doi: 10.1007/s00018-012-1072-8. Epub 2012 Jul 17. Review.


Gating and permeation of Orai channels.

Derler I, Schindl R, Fritsch R, Romanin C.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1304-22. Review.


STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.

Muik M, Fahrner M, Schindl R, Stathopulos P, Frischauf I, Derler I, Plenk P, Lackner B, Groschner K, Ikura M, Romanin C.

EMBO J. 2011 May 4;30(9):1678-89. doi: 10.1038/emboj.2011.79. Epub 2011 Mar 22.


Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

Frischauf I, Schindl R, Bergsmann J, Derler I, Fahrner M, Muik M, Fritsch R, Lackner B, Groschner K, Romanin C.

J Biol Chem. 2011 Mar 11;286(10):8577-84. doi: 10.1074/jbc.M110.187179. Epub 2011 Jan 10.


Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry.

Zheng L, Stathopulos PB, Schindl R, Li GY, Romanin C, Ikura M.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1337-42. doi: 10.1073/pnas.1015125108. Epub 2011 Jan 7.


Protein–Protein Interactions in TRPC Channel Complexes.

Eder P, Schindl R, Romanin C, Groschner K.

In: Liedtke WB, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 24.


Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.

Sponder G, Svidova S, Schindl R, Wieser S, Schweyen RJ, Romanin C, Froschauer EM, Weghuber J.

FEBS J. 2010 Sep;277(17):3514-25. doi: 10.1111/j.1742-4658.2010.07761.x. Epub 2010 Jul 23.


Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.

Schindl R, Frischauf I, Bergsmann J, Muik M, Derler I, Lackner B, Groschner K, Romanin C.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19623-8. doi: 10.1073/pnas.0907714106. Epub 2009 Nov 3.


Mechanistic view on domains mediating STIM1-Orai coupling.

Fahrner M, Muik M, Derler I, Schindl R, Fritsch R, Frischauf I, Romanin C.

Immunol Rev. 2009 Sep;231(1):99-112. doi: 10.1111/j.1600-065X.2009.00815.x. Review.


Recent progress on STIM1 domains controlling Orai activation.

Schindl R, Muik M, Fahrner M, Derler I, Fritsch R, Bergsmann J, Romanin C.

Cell Calcium. 2009 Oct;46(4):227-32. doi: 10.1016/j.ceca.2009.08.003. Epub 2009 Sep 4. Review.


A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.

Derler I, Fahrner M, Muik M, Lackner B, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Sep 11;284(37):24933-8. doi: 10.1074/jbc.C109.024083. Epub 2009 Jul 21.


Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.

Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Aug 7;284(32):21696-706. doi: 10.1074/jbc.M109.018408. Epub 2009 Jun 8.


Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant.

Derler I, Fahrner M, Carugo O, Muik M, Bergsmann J, Schindl R, Frischauf I, Eshaghi S, Romanin C.

J Biol Chem. 2009 Jun 5;284(23):15903-15. doi: 10.1074/jbc.M808312200. Epub 2009 Apr 14.


A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.

Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C.

J Biol Chem. 2009 Mar 27;284(13):8421-6. doi: 10.1074/jbc.C800229200. Epub 2009 Feb 3.


The STIM/Orai coupling machinery.

Frischauf I, Schindl R, Derler I, Bergsmann J, Fahrner M, Romanin C.

Channels (Austin). 2008 Jul-Aug;2(4):261-8. Epub 2008 Jul 21. Review.


CRAC inhibitors: identification and potential.

Derler I, Fritsch R, Schindl R, Romanin C.

Expert Opin Drug Discov. 2008 Jul;3(7):787-800. doi: 10.1517/17460441.3.7.787.


2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.

Schindl R, Bergsmann J, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C.

J Biol Chem. 2008 Jul 18;283(29):20261-7. doi: 10.1074/jbc.M803101200. Epub 2008 May 21.


Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.

J Biol Chem. 2008 Mar 21;283(12):8014-22. doi: 10.1074/jbc.M708898200. Epub 2008 Jan 10.


Mrs2p forms a high conductance Mg2+ selective channel in mitochondria.

Schindl R, Weghuber J, Romanin C, Schweyen RJ.

Biophys J. 2007 Dec 1;93(11):3872-83. Epub 2007 Sep 7.


The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.

Schindl R, Frischauf I, Kahr H, Fritsch R, Krenn M, Derndl A, Vales E, Muik M, Derler I, Groschner K, Romanin C.

Cell Calcium. 2008 Mar;43(3):260-9. Epub 2007 Jul 12.


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