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Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin.

Hines RM, Maric HM, Hines DJ, Modgil A, Panzanelli P, Nakamura Y, Nathanson AJ, Cross A, Deeb T, Brandon NJ, Davies P, Fritschy JM, Schindelin H, Moss SJ.

Nat Commun. 2018 Aug 7;9(1):3130. doi: 10.1038/s41467-018-05481-1.


Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.

Skinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR, Rosner MR.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13453-13458. doi: 10.1073/pnas.1711543114. Epub 2017 Dec 5.


The GlyR Extracellular β8-β9 Loop - A Functional Determinant of Agonist Potency.

Janzen D, Schaefer N, Delto C, Schindelin H, Villmann C.

Front Mol Neurosci. 2017 Oct 9;10:322. doi: 10.3389/fnmol.2017.00322. eCollection 2017.


Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme.

Misra M, Kuhn M, Löbel M, An H, Statsyuk AV, Sotriffer C, Schindelin H.

Structure. 2017 Jul 5;25(7):1120-1129.e3. doi: 10.1016/j.str.2017.05.001. Epub 2017 Jun 1.


The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97.

Hänzelmann P, Schindelin H.

Front Mol Biosci. 2017 Apr 13;4:21. doi: 10.3389/fmolb.2017.00021. eCollection 2017. Review.


Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.

Kasaragod VB, Schindelin H.

Structure. 2016 May 3;24(5):782-788. doi: 10.1016/j.str.2016.02.023. Epub 2016 Apr 21.


Disturbances of Ligand Potency and Enhanced Degradation of the Human Glycine Receptor at Affected Positions G160 and T162 Originally Identified in Patients Suffering from Hyperekplexia.

Atak S, Langlhofer G, Schaefer N, Kessler D, Meiselbach H, Delto C, Schindelin H, Villmann C.

Front Mol Neurosci. 2015 Dec 22;8:79. doi: 10.3389/fnmol.2015.00079. eCollection 2015.


Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions.

Hänzelmann P, Schindelin H.

Structure. 2016 Jan 5;24(1):140-147. doi: 10.1016/j.str.2015.10.027. Epub 2015 Dec 17.


Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97.

Hänzelmann P, Schindelin H.

Structure. 2016 Jan 5;24(1):127-139. doi: 10.1016/j.str.2015.10.026. Epub 2015 Dec 17.


Specificity of Collybistin-Phosphoinositide Interactions: IMPACT OF THE INDIVIDUAL PROTEIN DOMAINS.

Ludolphs M, Schneeberger D, Soykan T, Schäfer J, Papadopoulos T, Brose N, Schindelin H, Steinem C.

J Biol Chem. 2016 Jan 1;291(1):244-54. doi: 10.1074/jbc.M115.673400. Epub 2015 Nov 6.


Crystallizing the 6S and 8S spliceosomal assembly intermediates: a complex project.

Pelz JP, Schindelin H, van Pee K, Kuper J, Kisker C, Diederichs K, Fischer U, Grimm C.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2040-53. doi: 10.1107/S1399004715014832. Epub 2015 Sep 26.


Control of p97 function by cofactor binding.

Buchberger A, Schindelin H, Hänzelmann P.

FEBS Lett. 2015 Sep 14;589(19 Pt A):2578-89. doi: 10.1016/j.febslet.2015.08.028. Epub 2015 Aug 29. Review.


Synthesis of hydrolysis-resistant pyridoxal 5'-phosphate analogs and their biochemical and X-ray crystallographic characterization with the pyridoxal phosphatase chronophin.

Knobloch G, Jabari N, Stadlbauer S, Schindelin H, Köhn M, Gohla A.

Bioorg Med Chem. 2015 Jun 15;23(12):2819-27. doi: 10.1016/j.bmc.2015.02.049. Epub 2015 Mar 4.


The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization.

Delto CF, Heisler FF, Kuper J, Sander B, Kneussel M, Schindelin H.

Structure. 2015 Feb 3;23(2):364-73. doi: 10.1016/j.str.2014.11.016. Epub 2015 Jan 8.


Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin.

Maric HM, Kasaragod VB, Hausrat TJ, Kneussel M, Tretter V, Strømgaard K, Schindelin H.

Nat Commun. 2014 Dec 22;5:5767. doi: 10.1038/ncomms6767.


Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors.

Maric HM, Kasaragod VB, Haugaard-Kedström L, Hausrat TJ, Kneussel M, Schindelin H, Strømgaard K.

Angew Chem Int Ed Engl. 2015 Jan 7;54(2):490-4. doi: 10.1002/anie.201409043. Epub 2014 Nov 20.


SUMO-mimicking peptides inhibiting protein SUMOylation.

Zhao B, Villhauer EB, Bhuripanyo K, Kiyokawa H, Schindelin H, Yin J.

Chembiochem. 2014 Dec 15;15(18):2662-6. doi: 10.1002/cbic.201402472. Epub 2014 Nov 20.


Modulation of gephyrin-glycine receptor affinity by multivalency.

Maric HM, Kasaragod VB, Schindelin H.

ACS Chem Biol. 2014 Nov 21;9(11):2554-62. doi: 10.1021/cb500303a. Epub 2014 Sep 10.


Energetically significant networks of coupled interactions within an unfolded protein.

Cho JH, Meng W, Sato S, Kim EY, Schindelin H, Raleigh DP.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12079-84. doi: 10.1073/pnas.1402054111. Epub 2014 Aug 6.


A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.

Soykan T, Schneeberger D, Tria G, Buechner C, Bader N, Svergun D, Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N.

EMBO J. 2014 Sep 17;33(18):2113-33. doi: 10.15252/embj.201488143. Epub 2014 Jul 30.


Structure of the ubiquitin-activating enzyme loaded with two ubiquitin molecules.

Schäfer A, Kuhn M, Schindelin H.

Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1311-20. doi: 10.1107/S1399004714002910. Epub 2014 Apr 30.


Chronophin dimerization is required for proper positioning of its substrate specificity loop.

Kestler C, Knobloch G, Tessmer I, Jeanclos E, Schindelin H, Gohla A.

J Biol Chem. 2014 Jan 31;289(5):3094-103. doi: 10.1074/jbc.M113.536482. Epub 2013 Dec 14.


Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.

Seifried A, Knobloch G, Duraphe PS, Segerer G, Manhard J, Schindelin H, Schultz J, Gohla A.

J Biol Chem. 2014 Feb 7;289(6):3416-31. doi: 10.1074/jbc.M113.503359. Epub 2013 Dec 13.


Structural characterization of gephyrin by AFM and SAXS reveals a mixture of compact and extended states.

Sander B, Tria G, Shkumatov AV, Kim EY, Grossmann JG, Tessmer I, Svergun DI, Schindelin H.

Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2050-60. doi: 10.1107/S0907444913018714. Epub 2013 Sep 20.


Profiling the cross reactivity of ubiquitin with the Nedd8 activating enzyme by phage display.

Zhao B, Zhang K, Bhuripanyo K, Choi CH, Villhauer EB, Li H, Zheng N, Kiyokawa H, Schindelin H, Yin J.

PLoS One. 2013 Aug 1;8(8):e70312. doi: 10.1371/journal.pone.0070312. Print 2013.


Phage display to identify Nedd8-mimicking peptides as inhibitors of the Nedd8 transfer cascade.

Zhao B, Zhang K, Villhauer EB, Bhuripanyo K, Kiyokawa H, Schindelin H, Yin J.

Chembiochem. 2013 Jul 22;14(11):1323-30. doi: 10.1002/cbic.201300234. Epub 2013 Jul 3.


Structural basis of assembly chaperone- mediated snRNP formation.

Grimm C, Chari A, Pelz JP, Kuper J, Kisker C, Diederichs K, Stark H, Schindelin H, Fischer U.

Mol Cell. 2013 Feb 21;49(4):692-703. doi: 10.1016/j.molcel.2012.12.009. Epub 2013 Jan 17.


The crystal structure of the protein-disulfide isomerase family member ERp27 provides insights into its substrate binding capabilities.

Kober FX, Koelmel W, Kuper J, Drechsler J, Mais C, Hermanns HM, Schindelin H.

J Biol Chem. 2013 Jan 18;288(3):2029-39. doi: 10.1074/jbc.M112.410522. Epub 2012 Nov 28.


Inhibiting the protein ubiquitination cascade by ubiquitin-mimicking short peptides.

Zhao B, Choi CH, Bhuripanyo K, Villhauer EB, Zhang K, Schindelin H, Yin J.

Org Lett. 2012 Nov 16;14(22):5760-3. doi: 10.1021/ol3027736. Epub 2012 Nov 7.


Orthogonal ubiquitin transfer through engineered E1-E2 cascades for protein ubiquitination.

Zhao B, Bhuripanyo K, Zhang K, Kiyokawa H, Schindelin H, Yin J.

Chem Biol. 2012 Oct 26;19(10):1265-77. doi: 10.1016/j.chembiol.2012.07.023.


Specificity of the E1-E2-E3 enzymatic cascade for ubiquitin C-terminal sequences identified by phage display.

Zhao B, Bhuripanyo K, Schneider J, Zhang K, Schindelin H, Boone D, Yin J.

ACS Chem Biol. 2012 Dec 21;7(12):2027-35. doi: 10.1021/cb300339p. Epub 2012 Oct 2.


Gephyrin, the enigmatic organizer at GABAergic synapses.

Tretter V, Mukherjee J, Maric HM, Schindelin H, Sieghart W, Moss SJ.

Front Cell Neurosci. 2012 May 15;6:23. doi: 10.3389/fncel.2012.00023. eCollection 2012.


Structural insights into functional modes of proteins involved in ubiquitin family pathways.

Hänzelmann P, Schäfer A, Völler D, Schindelin H.

Methods Mol Biol. 2012;832:547-76. doi: 10.1007/978-1-61779-474-2_39.


Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site.

Maric HM, Mukherjee J, Tretter V, Moss SJ, Schindelin H.

J Biol Chem. 2011 Dec 9;286(49):42105-14. doi: 10.1074/jbc.M111.303412. Epub 2011 Oct 17.


The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrin.

Mukherjee J, Kretschmannova K, Gouzer G, Maric HM, Ramsden S, Tretter V, Harvey K, Davies PA, Triller A, Schindelin H, Moss SJ.

J Neurosci. 2011 Oct 12;31(41):14677-87. doi: 10.1523/JNEUROSCI.2001-11.2011.


Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin.

Tretter V, Kerschner B, Milenkovic I, Ramsden SL, Ramerstorfer J, Saiepour L, Maric HM, Moss SJ, Schindelin H, Harvey RJ, Sieghart W, Harvey K.

J Biol Chem. 2011 Oct 28;286(43):37702-11. doi: 10.1074/jbc.M111.291336. Epub 2011 Aug 31.


Hierarchical binding of cofactors to the AAA ATPase p97.

Hänzelmann P, Buchberger A, Schindelin H.

Structure. 2011 Jun 8;19(6):833-43. doi: 10.1016/j.str.2011.03.018.


The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.

Hänzelmann P, Stingele J, Hofmann K, Schindelin H, Raasi S.

J Biol Chem. 2010 Jun 25;285(26):20390-8. doi: 10.1074/jbc.M110.112532. Epub 2010 Apr 28.


And yet it moves: active site remodeling in the SUMO E1.

Völler D, Schindelin H.

Structure. 2010 Mar 14;18(4):419-21. doi: 10.1016/j.str.2010.03.005.


An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation.

Zhao G, Li G, Schindelin H, Lennarz WJ.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16197-202. doi: 10.1073/pnas.0908321106. Epub 2009 Sep 4.


Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains.

Hänzelmann P, Dahl JU, Kuper J, Urban A, Müller-Theissen U, Leimkühler S, Schindelin H.

Protein Sci. 2009 Dec;18(12):2480-91. doi: 10.1002/pro.260.


ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications.

Lees NS, Hänzelmann P, Hernandez HL, Subramanian S, Schindelin H, Johnson MK, Hoffman BM.

J Am Chem Soc. 2009 Jul 8;131(26):9184-5. doi: 10.1021/ja903978u.


Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.

Zürn A, Zabel U, Vilardaga JP, Schindelin H, Lohse MJ, Hoffmann C.

Mol Pharmacol. 2009 Mar;75(3):534-41. doi: 10.1124/mol.108.052399. Epub 2008 Dec 23.


Structural and mechanistic insights into lunatic fringe from a kinetic analysis of enzyme mutants.

Luther KB, Schindelin H, Haltiwanger RS.

J Biol Chem. 2009 Jan 30;284(5):3294-305. doi: 10.1074/jbc.M805502200. Epub 2008 Nov 21.


Structural and mutational studies on the importance of oligosaccharide binding for the activity of yeast PNGase.

Zhao G, Li G, Zhou X, Matsuo I, Ito Y, Suzuki T, Lennarz WJ, Schindelin H.

Glycobiology. 2009 Feb;19(2):118-25. doi: 10.1093/glycob/cwn108. Epub 2008 Oct 14.


The catalytic activity of protein-disulfide isomerase requires a conformationally flexible molecule.

Tian G, Kober FX, Lewandrowski U, Sickmann A, Lennarz WJ, Schindelin H.

J Biol Chem. 2008 Nov 28;283(48):33630-40. doi: 10.1074/jbc.M806026200. Epub 2008 Sep 24.


Tyrosine phosphorylation of ATPase p97 regulates its activity during ERAD.

Li G, Zhao G, Schindelin H, Lennarz WJ.

Biochem Biophys Res Commun. 2008 Oct 17;375(2):247-51. doi: 10.1016/j.bbrc.2008.08.018. Epub 2008 Aug 13.


Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.

Lee I, Schindelin H.

Cell. 2008 Jul 25;134(2):268-78. doi: 10.1016/j.cell.2008.05.046.


The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins.

Schmitz J, Chowdhury MM, Hänzelmann P, Nimtz M, Lee EY, Schindelin H, Leimkühler S.

Biochemistry. 2008 Jun 17;47(24):6479-89. doi: 10.1021/bi800477u. Epub 2008 May 21.


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