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Items: 16


Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors.

Vasan N, Razavi P, Johnson JL, Shao H, Shah H, Antoine A, Ladewig E, Gorelick A, Lin TY, Toska E, Xu G, Kazmi A, Chang MT, Taylor BS, Dickler MN, Jhaveri K, Chandarlapaty S, Rabadan R, Reznik E, Smith ML, Sebra R, Schimmoller F, Wilson TR, Friedman LS, Cantley LC, Scaltriti M, Baselga J.

Science. 2019 Nov 8;366(6466):714-723. doi: 10.1126/science.aaw9032.


Phase II randomised discontinuation trial of the MET/VEGF receptor inhibitor cabozantinib in metastatic melanoma.

Daud A, Kluger HM, Kurzrock R, Schimmoller F, Weitzman AL, Samuel TA, Moussa AH, Gordon MS, Shapiro GI.

Br J Cancer. 2017 Feb 14;116(4):432-440. doi: 10.1038/bjc.2016.419. Epub 2017 Jan 19.


Cabozantinib in chemotherapy-pretreated metastatic castration-resistant prostate cancer: results of a phase II nonrandomized expansion study.

Smith MR, Sweeney CJ, Corn PG, Rathkopf DE, Smith DC, Hussain M, George DJ, Higano CS, Harzstark AL, Sartor AO, Vogelzang NJ, Gordon MS, de Bono JS, Haas NB, Logothetis CJ, Elfiky A, Scheffold C, Laird AD, Schimmoller F, Basch EM, Scher HI.

J Clin Oncol. 2014 Oct 20;32(30):3391-9. doi: 10.1200/JCO.2013.54.5954. Epub 2014 Sep 15.


Effects of cabozantinib on pain and narcotic use in patients with castration-resistant prostate cancer: results from a phase 2 nonrandomized expansion cohort.

Basch E, Autio KA, Smith MR, Bennett AV, Weitzman AL, Scheffold C, Sweeney C, Rathkopf DE, Smith DC, George DJ, Higano CS, Harzstark AL, Sartor AO, Gordon MS, Vogelzang NJ, de Bono JS, Haas NB, Corn PG, Schimmoller F, Scher HI.

Eur Urol. 2015 Feb;67(2):310-8. doi: 10.1016/j.eururo.2014.02.013. Epub 2014 Feb 20.


Cabozantinib inhibits growth of androgen-sensitive and castration-resistant prostate cancer and affects bone remodeling.

Nguyen HM, Ruppender N, Zhang X, Brown LG, Gross TS, Morrissey C, Gulati R, Vessella RL, Schimmoller F, Aftab DT, Corey E.

PLoS One. 2013 Oct 25;8(10):e78881. doi: 10.1371/journal.pone.0078881. eCollection 2013. Erratum in: PLoS One. 2014;9(8):e106797.


Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions.

Dai J, Zhang H, Karatsinides A, Keller JM, Kozloff KM, Aftab DT, Schimmoller F, Keller ET.

Clin Cancer Res. 2014 Feb 1;20(3):617-30. doi: 10.1158/1078-0432.CCR-13-0839. Epub 2013 Oct 4.


Amyloid forming proteases: therapeutic targets for Alzheimer's disease.

Schimmöller F, Higaki JN, Cordell B.

Curr Pharm Des. 2002;8(28):2521-31. Review.


Characterization of a 76 kDa endosomal, multispanning membrane protein that is highly conserved throughout evolution.

Schimmöller F, Díaz E, Mühlbauer B, Pfeffer SR.

Gene. 1998 Aug 31;216(2):311-8.


Rab GTPases, directors of vesicle docking.

Schimmöller F, Simon I, Pfeffer SR.

J Biol Chem. 1998 Aug 28;273(35):22161-4. Review. No abstract available.


Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast.

Sütterlin C, Doering TL, Schimmöller F, Schröder S, Riezman H.

J Cell Sci. 1997 Nov;110 ( Pt 21):2703-14.


A novel Rab9 effector required for endosome-to-TGN transport.

Díaz E, Schimmöller F, Pfeffer SR.

J Cell Biol. 1997 Jul 28;138(2):283-90.


Vesicle traffic: get your coat!

Schimmöller F, Itin C, Pfeffer S.

Curr Biol. 1997 Apr 1;7(4):R235-7. Review.


The Golgi-localization of yeast Emp47p depends on its di-lysine motif but is not affected by the ret1-1 mutation in alpha-COP.

Schröder S, Schimmöller F, Singer-Krüger B, Riezman H.

J Cell Biol. 1995 Nov;131(4):895-912.


The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi.

Schimmöller F, Singer-Krüger B, Schröder S, Krüger U, Barlowe C, Riezman H.

EMBO J. 1995 Apr 3;14(7):1329-39.


Calcium-independent calmodulin requirement for endocytosis in yeast.

Kübler E, Schimmöller F, Riezman H.

EMBO J. 1994 Dec 1;13(23):5539-46.


Involvement of Ypt7p, a small GTPase, in traffic from late endosome to the vacuole in yeast.

Schimmöller F, Riezman H.

J Cell Sci. 1993 Nov;106 ( Pt 3):823-30.

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