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Items: 1 to 50 of 423

1.

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia.

Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8228-E8235. doi: 10.1073/pnas.1807000115. Epub 2018 Aug 13.

2.

Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function.

Xu Z, Lo WS, Beck DB, Schuch LA, Oláhová M, Kopajtich R, Chong YE, Alston CL, Seidl E, Zhai L, Lau CF, Timchak D, LeDuc CA, Borczuk AC, Teich AF, Juusola J, Sofeso C, Müller C, Pierre G, Hilliard T, Turnpenny PD, Wagner M, Kappler M, Brasch F, Bouffard JP, Nangle LA, Yang XL, Zhang M, Taylor RW, Prokisch H, Griese M, Chung WK, Schimmel P.

Am J Hum Genet. 2018 Jul 5;103(1):100-114. doi: 10.1016/j.ajhg.2018.06.006.

3.

Distinct ways of G:U recognition by conserved tRNA binding motifs.

Chong YE, Guo M, Yang XL, Kuhle B, Naganuma M, Sekine SI, Yokoyama S, Schimmel P.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):7527-7532. doi: 10.1073/pnas.1807109115. Epub 2018 Jul 2.

4.

Publisher Correction: ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase.

Vo MN, Terrey M, Lee JW, Roy B, Moresco JJ, Sun L, Fu H, Liu Q, Weber TG, Yates JR 3rd, Fredrick K, Schimmel P, Ackerman SL.

Nature. 2018 Aug;560(7720):E35. doi: 10.1038/s41586-018-0271-3.

PMID:
29925958
5.

ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase.

Vo MN, Terrey M, Lee JW, Roy B, Moresco JJ, Sun L, Fu H, Liu Q, Weber TG, Yates JR 3rd, Fredrick K, Schimmel P, Ackerman SL.

Nature. 2018 May;557(7706):510-515. doi: 10.1038/s41586-018-0137-8. Epub 2018 May 16. Erratum in: Nature. 2018 Aug;560(7720):E35.

PMID:
29769718
6.

Publisher Correction: Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.

Song Y, Zhou H, Vo MN, Shi Y, Nawaz MH, Vargas-Rodriguez O, Diedrich JK, Yates JR 3rd, Kishi S, Musier-Forsyth K, Schimmel P.

Nat Commun. 2018 Mar 13;9(1):1113. doi: 10.1038/s41467-018-03594-1.

7.

Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.

Song Y, Zhou H, Vo MN, Shi Y, Nawaz MH, Vargas-Rodriguez O, Diedrich JK, Yates JR, Kishi S, Musier-Forsyth K, Schimmel P.

Nat Commun. 2017 Dec 22;8(1):2281. doi: 10.1038/s41467-017-02201-z. Erratum in: Nat Commun. 2018 Mar 13;9(1):1113.

8.

An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function.

Xu X, Zhou H, Zhou Q, Hong F, Vo MN, Niu W, Wang Z, Xiong X, Nakamura K, Wakasugi K, Schimmel P, Yang XL.

RNA Biol. 2018;15(4-5):649-658. doi: 10.1080/15476286.2017.1377868. Epub 2017 Nov 3.

9.

The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis.

Schimmel P.

Nat Rev Mol Cell Biol. 2018 Jan;19(1):45-58. doi: 10.1038/nrm.2017.77. Epub 2017 Sep 6. Review.

PMID:
28875994
10.

Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.

Blocquel D, Li S, Wei N, Daub H, Sajish M, Erfurth ML, Kooi G, Zhou J, Bai G, Schimmel P, Jordanova A, Yang XL.

Nucleic Acids Res. 2017 Jul 27;45(13):8091-8104. doi: 10.1093/nar/gkx455.

11.

Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.

Sun L, Song Y, Blocquel D, Yang XL, Schimmel P.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14300-14305. Epub 2016 Nov 28.

12.

Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair.

Sun L, Gomes AC, He W, Zhou H, Wang X, Pan DW, Schimmel P, Pan T, Yang XL.

J Am Chem Soc. 2016 Oct 5;138(39):12948-12955. Epub 2016 Sep 26.

13.

p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish.

Song Y, Shi Y, Carland TM, Lian S, Sasaki T, Schork NJ, Head SR, Kishi S, Schimmel P.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8460-5. doi: 10.1073/pnas.1608139113. Epub 2016 Jul 8.

14.

Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase.

Wei Z, Xu Z, Liu X, Lo WS, Ye F, Lau CF, Wang F, Zhou JJ, Nangle LA, Yang XL, Zhang M, Schimmel P.

Nucleic Acids Res. 2016 Feb 18;44(3):1247-55. doi: 10.1093/nar/gkw002. Epub 2016 Jan 14.

15.

The Mystery of the LUCA: Franklin M. Harold In Search of Cell History: The Evolution of Life's Building Blocks.

Schimmel P.

FASEB J. 2015 Jun;29(6):2205-2206. doi: 10.1096/fj.15-0601ufm. No abstract available.

PMID:
29443580
16.

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.

Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ Jr, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R.

Sci Transl Med. 2015 May 20;7(288):288ra77. doi: 10.1126/scitranslmed.aaa3575.

17.

Alexander Rich (1924-2015).

Schimmel P.

Nature. 2015 May 21;521(7552):291. doi: 10.1038/521291a. No abstract available.

PMID:
25993953
18.

Coordinated care affects hospitalization and prognosis in amyotrophic lateral sclerosis: a cohort study.

Cordesse V, Sidorok F, Schimmel P, Holstein J, Meininger V.

BMC Health Serv Res. 2015 Apr 2;15:134. doi: 10.1186/s12913-015-0810-7.

19.

A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.

Sajish M, Schimmel P.

Nature. 2015 Mar 19;519(7543):370-3. doi: 10.1038/nature14028. Epub 2014 Dec 22.

20.

Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy.

Liu Y, Satz JS, Vo MN, Nangle LA, Schimmel P, Ackerman SL.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17570-5. doi: 10.1073/pnas.1420196111. Epub 2014 Nov 24.

21.

RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration.

Ishimura R, Nagy G, Dotu I, Zhou H, Yang XL, Schimmel P, Senju S, Nishimura Y, Chuang JH, Ackerman SL.

Science. 2014 Jul 25;345(6195):455-9. doi: 10.1126/science.1249749.

22.

Human tRNA synthetase catalytic nulls with diverse functions.

Lo WS, Gardiner E, Xu Z, Lau CF, Wang F, Zhou JJ, Mendlein JD, Nangle LA, Chiang KP, Yang XL, Au KF, Wong WH, Guo M, Zhang M, Schimmel P.

Science. 2014 Jul 18;345(6194):328-32. doi: 10.1126/science.1252943.

23.

The selective tRNA aminoacylation mechanism based on a single G•U pair.

Naganuma M, Sekine S, Chong YE, Guo M, Yang XL, Gamper H, Hou YM, Schimmel P, Yokoyama S.

Nature. 2014 Jun 26;510(7506):507-11. doi: 10.1038/nature13440. Epub 2014 Jun 11.

24.

Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis.

Zhou JJ, Wang F, Xu Z, Lo WS, Lau CF, Chiang KP, Nangle LA, Ashlock MA, Mendlein JD, Yang XL, Zhang M, Schimmel P.

J Biol Chem. 2014 Jul 11;289(28):19269-75. doi: 10.1074/jbc.C114.571026. Epub 2014 Jun 4.

25.

Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases.

Wang F, Xu Z, Zhou J, Lo WS, Lau CF, Nangle LA, Yang XL, Zhang M, Schimmel P.

J Biol Chem. 2013 Oct 11;288(41):29223-8. doi: 10.1074/jbc.C113.490599. Epub 2013 Sep 3.

26.

Evaluation of the Hepa Wash® treatment in pigs with acute liver failure.

Al-Chalabi A, Matevossian E, V Thaden AK, Luppa P, Neiss A, Schuster T, Yang Z, Schreiber C, Schimmel P, Nairz E, Perren A, Radermacher P, Huber W, Schmid RM, Kreymann B.

BMC Gastroenterol. 2013 May 13;13:83. doi: 10.1186/1471-230X-13-83.

27.

[Analysis of clinical pathway in changing and disabling neurological diseases].

Cordesse V, Jametal T, Guy C, Lefebvre S, Roussel M, Ruggeri J, Schimmel P, Holstein J, Meininger V.

Rev Neurol (Paris). 2013 Jun-Jul;169(6-7):476-84. doi: 10.1016/j.neurol.2012.12.004. Epub 2013 Apr 24. Review. French.

PMID:
23623808
28.

Essential nontranslational functions of tRNA synthetases.

Guo M, Schimmel P.

Nat Chem Biol. 2013 Mar;9(3):145-53. doi: 10.1038/nchembio.1158. Review.

29.

Anticodon G recognition by tRNA synthetases mimics the tRNA core.

Klipcan L, Safro M, Schimmel P.

Trends Biochem Sci. 2013 May;38(5):229-32. doi: 10.1016/j.tibs.2012.11.002. Epub 2012 Dec 19.

30.

ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.

Zhou H, Sun L, Yang XL, Schimmel P.

Nature. 2013 Feb 7;494(7435):121-4. doi: 10.1038/nature11774. Epub 2012 Dec 23.

31.

Structural switch of lysyl-tRNA synthetase between translation and transcription.

Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, Shapiro R, Song J, Dagan A, Pozo J, Kim S, Marshall AG, Schimmel P, Yang XL, Nechushtan H, Razin E, Guo M.

Mol Cell. 2013 Jan 10;49(1):30-42. doi: 10.1016/j.molcel.2012.10.010. Epub 2012 Nov 15.

32.

Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing.

Xu Z, Wei Z, Zhou JJ, Ye F, Lo WS, Wang F, Lau CF, Wu J, Nangle LA, Chiang KP, Yang XL, Zhang M, Schimmel P.

Structure. 2012 Sep 5;20(9):1470-7. doi: 10.1016/j.str.2012.08.001.

33.

Homeostatic mechanisms by alternative forms of tRNA synthetases.

Guo M, Schimmel P.

Trends Biochem Sci. 2012 Oct;37(10):401-3. doi: 10.1016/j.tibs.2012.07.003. Epub 2012 Aug 2.

34.

Uncovering of a short internal peptide activates a tRNA synthetase procytokine.

Lee PS, Zhang HM, Marshall AG, Yang XL, Schimmel P.

J Biol Chem. 2012 Jun 8;287(24):20504-8. doi: 10.1074/jbc.C112.369439. Epub 2012 May 1.

35.

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.

Sajish M, Zhou Q, Kishi S, Valdez DM Jr, Kapoor M, Guo M, Lee S, Kim S, Yang XL, Schimmel P.

Nat Chem Biol. 2012 Apr 15;8(6):547-54. doi: 10.1038/nchembio.937.

36.

Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis.

Park MC, Kang T, Jin D, Han JM, Kim SB, Park YJ, Cho K, Park YW, Guo M, He W, Yang XL, Schimmel P, Kim S.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):E640-7. doi: 10.1073/pnas.1200194109. Epub 2012 Feb 15.

37.

Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor.

Wang J, Fang P, Schimmel P, Guo M.

J Phys Chem B. 2012 Jun 14;116(23):6798-805. doi: 10.1021/jp212457w. Epub 2012 Mar 2.

38.

Structural analyses clarify the complex control of mistranslation by tRNA synthetases.

Guo M, Schimmel P.

Curr Opin Struct Biol. 2012 Feb;22(1):119-26. doi: 10.1016/j.sbi.2011.11.008. Epub 2011 Dec 10. Review.

39.

Mistranslation and its control by tRNA synthetases.

Schimmel P.

Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27;366(1580):2965-71. doi: 10.1098/rstb.2011.0158.

40.

Functional expansion of the tRNA world under stress.

Yang XL, Schimmel P.

Mol Cell. 2011 Aug 19;43(4):500-2. doi: 10.1016/j.molcel.2011.08.004. No abstract available.

41.

Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex.

Fang P, Zhang HM, Shapiro R, Marshall AG, Schimmel P, Yang XL, Guo M.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8239-44. doi: 10.1073/pnas.1100224108. Epub 2011 May 2.

42.

Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase.

Vo MN, Yang XL, Schimmel P.

J Biol Chem. 2011 Apr 1;286(13):11563-8. doi: 10.1074/jbc.C110.213876. Epub 2011 Feb 10.

43.

The RNP bridge between two worlds.

Schimmel P.

Nat Rev Mol Cell Biol. 2011 Mar;12(3):135. doi: 10.1038/nrm3061. Epub 2011 Feb 2. No abstract available.

PMID:
21285979
44.

p23H implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis.

Nawaz MH, Merriman E, Yang XL, Schimmel P.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2723-8. doi: 10.1073/pnas.1019400108. Epub 2011 Feb 1.

45.

Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase.

Guo M, Shapiro R, Morris GM, Yang XL, Schimmel P.

J Phys Chem B. 2010 Dec 16;114(49):16273-9. doi: 10.1021/jp1082517. Epub 2010 Nov 8.

46.

Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster.

Han GW, Yang XL, McMullan D, Chong YE, Krishna SS, Rife CL, Weekes D, Brittain SM, Abdubek P, Ambing E, Astakhova T, Axelrod HL, Carlton D, Caruthers J, Chiu HJ, Clayton T, Duan L, Feuerhelm J, Grant JC, Grzechnik SK, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kumar A, Marciano D, Miller MD, Morse AT, Nigoghossian E, Okach L, Paulsen J, Reyes R, van den Bedem H, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Elsliger MA, Schimmel P, Wilson IA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1326-34. doi: 10.1107/S1744309110037619. Epub 2010 Sep 23.

47.

A model of ischemic isolated acute liver failure in pigs: standardizing monitoring and treatment.

Al-Chalabi A, Matevossian E, Preissel A, Perren A, Yang Z, Schuster T, Schreiber C, Schimmel P, Nairz E, Yan H, Geiger A, Kreymann B.

Eur Surg Res. 2010;45(2):86-97. doi: 10.1159/000319878. Epub 2010 Sep 18.

PMID:
20847566
48.

New functions of aminoacyl-tRNA synthetases beyond translation.

Guo M, Yang XL, Schimmel P.

Nat Rev Mol Cell Biol. 2010 Sep;11(9):668-74. doi: 10.1038/nrm2956. Epub 2010 Aug 11. Review.

49.

The elephant on the couch: side-effects of psychotherapy.

Schimmel P.

Aust N Z J Psychiatry. 2010 May;44(5):489. doi: 10.3109/00048671003606094. No abstract available.

PMID:
20397794
50.

Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase.

Guo M, Shapiro R, Schimmel P, Yang XL.

Acta Crystallogr D Biol Crystallogr. 2010 Mar;66(Pt 3):243-50. doi: 10.1107/S0907444909055462. Epub 2010 Feb 12.

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