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Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use.

Ishikawa M, García-Mateo N, Čusak A, López-Hernández I, Fernández-Martínez M, Müller M, Rüttiger L, Singer W, Löwenheim H, Kosec G, Fujs Š, Martínez-Martínez L, Schimmang T, Petković H, Knipper M, Durán-Alonso MB.

Sci Rep. 2019 Feb 20;9(1):2410. doi: 10.1038/s41598-019-38634-3.


Myc is dispensable for cardiomyocyte development but rescues Mycn-deficient hearts through functional replacement and cell competition.

Muñoz-Martín N, Sierra R, Schimmang T, Villa Del Campo C, Torres M.

Development. 2019 Feb 1;146(3). pii: dev170753. doi: 10.1242/dev.170753.


BDNF-Live-Exon-Visualization (BLEV) Allows Differential Detection of BDNF Transcripts in vitro and in vivo.

Singer W, Manthey M, Panford-Walsh R, Matt L, Geisler HS, Passeri E, Baj G, Tongiorgi E, Leal G, Duarte CB, Salazar IL, Eckert P, Rohbock K, Hu J, Strotmann J, Ruth P, Zimmermann U, Rüttiger L, Ott T, Schimmang T, Knipper M.

Front Mol Neurosci. 2018 Sep 27;11:325. doi: 10.3389/fnmol.2018.00325. eCollection 2018.


Visualizing BDNF Transcript Usage During Sound-Induced Memory Linked Plasticity.

Matt L, Eckert P, Panford-Walsh R, Geisler HS, Bausch AE, Manthey M, Müller NIC, Harasztosi C, Rohbock K, Ruth P, Friauf E, Ott T, Zimmermann U, Rüttiger L, Schimmang T, Knipper M, Singer W.

Front Mol Neurosci. 2018 Jul 31;11:260. doi: 10.3389/fnmol.2018.00260. eCollection 2018.


Transcription factor induced conversion of human fibroblasts towards the hair cell lineage.

Duran Alonso MB, Lopez Hernandez I, de la Fuente MA, Garcia-Sancho J, Giraldez F, Schimmang T.

PLoS One. 2018 Jul 6;13(7):e0200210. doi: 10.1371/journal.pone.0200210. eCollection 2018.


Gαi Proteins are Indispensable for Hearing.

Beer-Hammer S, Lee SC, Mauriac SA, Leiss V, Groh IAM, Novakovic A, Piekorz RP, Bucher K, Chen C, Ni K, Singer W, Harasztosi C, Schimmang T, Zimmermann U, Pfeffer K, Birnbaumer L, Forge A, Montcouquiol M, Knipper M, Nürnberg B, Rüttiger L.

Cell Physiol Biochem. 2018;47(4):1509-1532. doi: 10.1159/000490867. Epub 2018 Jun 21.


An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.

Anderson MJ, Schimmang T, Lewandoski M.

PLoS Genet. 2016 May 4;12(5):e1006018. doi: 10.1371/journal.pgen.1006018. eCollection 2016 May.


BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury.

Chumak T, Rüttiger L, Lee SC, Campanelli D, Zuccotti A, Singer W, Popelář J, Gutsche K, Geisler HS, Schraven SP, Jaumann M, Panford-Walsh R, Hu J, Schimmang T, Zimmermann U, Syka J, Knipper M.

Mol Neurobiol. 2016 Oct;53(8):5607-27. doi: 10.1007/s12035-015-9474-x. Epub 2015 Oct 17.


Gene expression profiling of the inner ear.

Schimmang T, Maconochie M.

J Anat. 2016 Feb;228(2):255-69. doi: 10.1111/joa.12376. Epub 2015 Sep 25. Review.


Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea.

Vendrell V, López-Hernández I, Durán Alonso MB, Feijoo-Redondo A, Abello G, Gálvez H, Giráldez F, Lamonerie T, Schimmang T.

Development. 2015 Aug 15;142(16):2792-800. doi: 10.1242/dev.122465. Epub 2015 Jul 9.


Is there a relationship between brain-derived neurotrophic factor for driving neuronal auditory circuits with onset of auditory function and the changes following cochlear injury or during aging?

Schimmang T, Durán Alonso B, Zimmermann U, Knipper M.

Neuroscience. 2014 Dec 26;283:26-43. doi: 10.1016/j.neuroscience.2014.07.025. Epub 2014 Jul 24. Review.


Progressive effects of N-myc deficiency on proliferation, neurogenesis, and morphogenesis in the olfactory epithelium.

Wittmann W, Schimmang T, Gunhaga L.

Dev Neurobiol. 2014 Jun;74(6):643-56. doi: 10.1002/dneu.22162. Epub 2014 Jan 16.


L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression.

Zuccotti A, Lee SC, Campanelli D, Singer W, Satheesh SV, Patriarchi T, Geisler HS, Köpschall I, Rohbock K, Nothwang HG, Hu J, Hell JW, Schimmang T, Rüttiger L, Knipper M.

Front Mol Neurosci. 2013 Aug 9;6:20. doi: 10.3389/fnmol.2013.00020. eCollection 2013.


Coupling the cell cycle to development and regeneration of the inner ear.

Schimmang T, Pirvola U.

Semin Cell Dev Biol. 2013 May;24(5):507-13. doi: 10.1016/j.semcdb.2013.04.004. Epub 2013 May 9. Review.


Generation of inner ear sensory cells from bone marrow-derived human mesenchymal stem cells.

Durán Alonso MB, Feijoo-Redondo A, Conde de Felipe M, Carnicero E, García AS, García-Sancho J, Rivolta MN, Giráldez F, Schimmang T.

Regen Med. 2012 Nov;7(6):769-83. doi: 10.2217/rme.12.65.


Transcription factors that control inner ear development and their potential for transdifferentiation and reprogramming.

Schimmang T.

Hear Res. 2013 Mar;297:84-90. doi: 10.1016/j.heares.2012.11.001. Epub 2012 Nov 14. Review.


Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: a novel molecular paradigm for understanding tinnitus.

Singer W, Zuccotti A, Jaumann M, Lee SC, Panford-Walsh R, Xiong H, Zimmermann U, Franz C, Geisler HS, Köpschall I, Rohbock K, Varakina K, Verpoorten S, Reinbothe T, Schimmang T, Rüttiger L, Knipper M.

Mol Neurobiol. 2013 Feb;47(1):261-79. doi: 10.1007/s12035-012-8372-8. Epub 2012 Nov 16.


Roles of Wnt8a during formation and patterning of the mouse inner ear.

Vendrell V, Vázquez-Echeverría C, López-Hernández I, Alonso BD, Martinez S, Pujades C, Schimmang T.

Mech Dev. 2013 Feb;130(2-3):160-8. doi: 10.1016/j.mod.2012.09.009. Epub 2012 Oct 4.


Lack of brain-derived neurotrophic factor hampers inner hair cell synapse physiology, but protects against noise-induced hearing loss.

Zuccotti A, Kuhn S, Johnson SL, Franz C, Singer W, Hecker D, Geisler HS, Köpschall I, Rohbock K, Gutsche K, Dlugaiczyk J, Schick B, Marcotti W, Rüttiger L, Schimmang T, Knipper M.

J Neurosci. 2012 Jun 20;32(25):8545-53. doi: 10.1523/JNEUROSCI.1247-12.2012.


Cell and tissue therapy in regenerative medicine.

Sánchez A, Schimmang T, García-Sancho J.

Adv Exp Med Biol. 2012;741:89-102. doi: 10.1007/978-1-4614-2098-9_7.


Cell- and gene-therapy approaches to inner ear repair.

Conde de Felipe MM, Feijoo Redondo A, García-Sancho J, Schimmang T, Durán Alonso MB.

Histol Histopathol. 2011 Jul;26(7):923-40. doi: 10.14670/HH-26.923. Review.


N-myc controls proliferation, morphogenesis, and patterning of the inner ear.

Domínguez-Frutos E, López-Hernández I, Vendrell V, Neves J, Gallozzi M, Gutsche K, Quintana L, Sharpe J, Knoepfler PS, Eisenman RN, Trumpp A, Giráldez F, Schimmang T.

J Neurosci. 2011 May 11;31(19):7178-89. doi: 10.1523/JNEUROSCI.0785-11.2011.


Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice.

Lubka-Pathak M, Shah AA, Gallozzi M, Müller M, Zimmermann U, Löwenheim H, Pfister M, Knipper M, Blin N, Schimmang T.

Cell Mol Life Sci. 2011 Aug;68(16):2739-49. doi: 10.1007/s00018-010-0586-1. Epub 2010 Nov 15.


Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition.

Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot L.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22364-8. doi: 10.1073/pnas.0910086106. Epub 2009 Dec 15.


Tissue-specific requirements for FGF8 during early inner ear development.

Domínguez-Frutos E, Vendrell V, Alvarez Y, Zelarayan LC, López-Hernández I, Ros M, Schimmang T.

Mech Dev. 2009 Oct;126(10):873-81. doi: 10.1016/j.mod.2009.07.004. Epub 2009 Jul 18.


Differential requirements for Fgf3 and Fgf8 during mouse forebrain development.

Theil T, Dominguez-Frutos E, Schimmang T.

Dev Dyn. 2008 Nov;237(11):3417-23. doi: 10.1002/dvdy.21765.


Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.

Vázquez-Echeverría C, Dominguez-Frutos E, Charnay P, Schimmang T, Pujades C.

Dev Biol. 2008 Oct 1;322(1):167-78. doi: 10.1016/j.ydbio.2008.07.025. Epub 2008 Jul 30.


Efficient transfer of embryonic stem cells into the cochlea via a non-invasive vestibular route.

Praetorius M, Vicario I, Schimmang T.

Acta Otolaryngol. 2008 Jul;128(7):720-3. doi: 10.1080/00016480701714236.


The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP-mediated cell death.

Delgado I, Domínguez-Frutos E, Schimmang T, Ros MA.

Dev Dyn. 2008 Mar;237(3):649-58. doi: 10.1002/dvdy.21452.


Expression and functions of FGF ligands during early otic development.

Schimmang T.

Int J Dev Biol. 2007;51(6-7):473-81. Review.


Differential requirements for FGF3, FGF8 and FGF10 during inner ear development.

Zelarayan LC, Vendrell V, Alvarez Y, Domínguez-Frutos E, Theil T, Alonso MT, Maconochie M, Schimmang T.

Dev Biol. 2007 Aug 15;308(2):379-91. Epub 2007 Jun 2.


An integrated gene regulatory network controls stem cell proliferation in teeth.

Wang XP, Suomalainen M, Felszeghy S, Zelarayan LC, Alonso MT, Plikus MV, Maas RL, Chuong CM, Schimmang T, Thesleff I.

PLoS Biol. 2007 Jun;5(6):e159.


Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy.

Aggarwal VS, Liao J, Bondarev A, Schimmang T, Lewandoski M, Locker J, Shanske A, Campione M, Morrow BE.

Hum Mol Genet. 2006 Nov 1;15(21):3219-28. Epub 2006 Sep 25.


Efficient transfer of HSV-1 amplicon vectors into embryonic stem cells and their derivatives.

Riethmacher D, Lim F, Schimmang T.

Methods Mol Biol. 2006;329:265-72.


BDNF mRNA expression and protein localization are changed in age-related hearing loss.

Rüttiger L, Panford-Walsh R, Schimmang T, Tan J, Zimmermann U, Rohbock K, Köpschall I, Limberger A, Müller M, Fraenzer JT, Cimerman J, Knipper M.

Neurobiol Aging. 2007 Apr;28(4):586-601. Epub 2006 Mar 31.


FGF signalling controls expression of vomeronasal receptors during embryogenesis.

Lioubinski O, Alonso MT, Alvarez Y, Vendrell V, Garrosa M, Murphy P, Schimmang T.

Mech Dev. 2006 Jan;123(1):17-23. Epub 2005 Dec 2.


Differential roles of fibroblast growth factor-2 during development and maintenance of auditory sensory epithelia.

Carnicero E, Zelarayan LC, Rüttiger L, Knipper M, Alvarez Y, Alonso MT, Schimmang T.

J Neurosci Res. 2004 Sep 15;77(6):787-97.


Requirements for FGF3 and FGF10 during inner ear formation.

Alvarez Y, Alonso MT, Vendrell V, Zelarayan LC, Chamero P, Theil T, Bösl MR, Kato S, Maconochie M, Riethmacher D, Schimmang T.

Development. 2003 Dec;130(25):6329-38.


Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss.

Schimmang T, Tan J, Müller M, Zimmermann U, Rohbock K, Kôpschall I, Limberger A, Minichiello L, Knipper M.

Development. 2003 Oct;130(19):4741-50.


A novel vestibular approach for gene transfer into the inner ear.

Praetorius M, Knipper M, Schick B, Tan J, Limberger A, Carnicero E, Alonso MT, Schimmang T.

Audiol Neurootol. 2002 Nov-Dec;7(6):324-34.


Herpes simplex virus type 1-mediated transfer of neurotrophin-3 stimulates survival of chicken auditory sensory neurons.

Carnicero E, Knipper M, Tan J, Alonso MT, Schimmang T.

Neurosci Lett. 2002 Mar 22;321(3):149-52.


Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons.

Postigo A, Calella AM, Fritzsch B, Knipper M, Katz D, Eilers A, Schimmang T, Lewin GR, Klein R, Minichiello L.

Genes Dev. 2002 Mar 1;16(5):633-45.


Roles of fibroblast growth factor 2 during innervation of the avian inner ear.

Carnicero E, Garrido JJ, Alonso MT, Schimmang T.

J Neurochem. 2001 May;77(3):786-95.


Induction of inner ear fate by FGF3.

Vendrell V, Carnicero E, Giraldez F, Alonso MT, Schimmang T.

Development. 2000 May;127(10):2011-9.


The hairless gene of the mouse: relationship of phenotypic effects with expression profile and genotype.

Cachón-González MB, San-José I, Cano A, Vega JA, García N, Freeman T, Schimmang T, Stoye JP.

Dev Dyn. 1999 Oct;216(2):113-26.


Defining responsiveness of avian cochlear neurons to brain-derived neurotrophic factor and nerve growth factor by HSV-1-mediated gene transfer.

Garrido JJ, Alonso MT, Lim F, Carnicero E, Giraldez F, Schimmang T.

J Neurochem. 1998 Jun;70(6):2336-46.


Organoculture of otic vesicle and ganglion.

Garrido JJ, Schimmang T, Represa J, Giraldez F.

Curr Top Dev Biol. 1998;36:115-31. Review. No abstract available.


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