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Items: 1 to 50 of 143


Copy-number variation introduced by long transgenes compromises mouse male fertility independently of pachytene checkpoints.

Mihola O, Kobets T, Krivankova K, Linhartova E, Gasic S, Schimenti JC, Trachtulec Z.

Chromosoma. 2020 Mar;129(1):69-82. doi: 10.1007/s00412-019-00730-8. Epub 2020 Jan 15.


Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5-CD44+ cells.

Fu DJ, Wang L, Chouairi FK, Rose IM, Abetov DA, Miller AD, Yamulla RJ, Schimenti JC, Flesken-Nikitin A, Nikitin AY.

Nat Commun. 2020 Jan 3;11(1):84. doi: 10.1038/s41467-019-13847-2.


CDK2 kinase activity is a regulator of male germ cell fate.

Singh P, Patel RK, Palmer N, Grenier JK, Paduch D, Kaldis P, Grimson A, Schimenti JC.

Development. 2019 Nov 6;146(21). pii: dev180273. doi: 10.1242/dev.180273.


Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD, Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG, Yu H.

Nat Commun. 2019 Sep 12;10(1):4141. doi: 10.1038/s41467-019-11959-3.


A predicted deleterious allele of the essential meiosis gene MND1, present in ~ 3% of East Asians, does not disrupt reproduction in mice.

Tran TN, Martinez J, Schimenti JC.

Mol Hum Reprod. 2019 Oct 28;25(10):668-673. doi: 10.1093/molehr/gaz048.


Germline genome protection: implications for gamete quality and germ cell tumorigenesis.

Bloom JC, Loehr AR, Schimenti JC, Weiss RS.

Andrology. 2019 Jul;7(4):516-526. doi: 10.1111/andr.12651. Epub 2019 May 22. Review.


Female-biased embryonic death from inflammation induced by genomic instability.

McNairn AJ, Chuang CH, Bloom JC, Wallace MD, Schimenti JC.

Nature. 2019 Mar;567(7746):105-108. doi: 10.1038/s41586-019-0936-6. Epub 2019 Feb 20.


A putative human infertility allele of the meiotic recombinase DMC1 does not affect fertility in mice.

Tran TN, Schimenti JC.

Hum Mol Genet. 2018 Nov 15;27(22):3911-3918. doi: 10.1093/hmg/ddy286.


Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".

Schimenti JC, Handel MA.

Biol Reprod. 2018 Dec 1;99(6):1119-1128. doi: 10.1093/biolre/ioy133. Review.


Whole Mount Immunofluorescence and Follicle Quantification of Cultured Mouse Ovaries.

Rinaldi VD, Bloom JC, Schimenti JC.

J Vis Exp. 2018 May 2;(135). doi: 10.3791/57593.


The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.

Rinaldi VD, Bolcun-Filas E, Kogo H, Kurahashi H, Schimenti JC.

Mol Cell. 2017 Sep 21;67(6):1026-1036.e2. doi: 10.1016/j.molcel.2017.07.027. Epub 2017 Aug 24.


Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death.

Rinaldi VD, Hsieh K, Munroe R, Bolcun-Filas E, Schimenti JC.

Genetics. 2017 Aug;206(4):1823-1828. doi: 10.1534/genetics.117.203455. Epub 2017 Jun 2.


Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog.

McNairn AJ, Rinaldi VD, Schimenti JC.

Genetics. 2017 Feb;205(2):529-537. doi: 10.1534/genetics.116.196808. Epub 2016 Dec 16.


The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice.

Kartha N, Shen L, Maskin C, Wallace M, Schimenti JC.

Genetics. 2016 Aug;203(4):1601-11. doi: 10.1534/genetics.115.184879. Epub 2016 Jun 8.


L. C. Dunn and Donald Charles on Quantitative Traits in the Mouse.

Schimenti JC.

Genetics. 2016 Mar;202(3):867-8. doi: 10.1534/genetics.116.187534. No abstract available.


Transcriptional profiling of cortical versus cancellous bone from mechanically-loaded murine tibiae reveals differential gene expression.

Kelly NH, Schimenti JC, Ross FP, van der Meulen MC.

Bone. 2016 May;86:22-9. doi: 10.1016/j.bone.2016.02.007. Epub 2016 Feb 12.


Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation.

Bai G, Smolka MB, Schimenti JC.

PLoS Genet. 2016 Jan 14;12(1):e1005787. doi: 10.1371/journal.pgen.1005787. eCollection 2016 Jan.


MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.

Luo Y, Schimenti JC.

Genesis. 2015 Nov;53(11):678-84. doi: 10.1002/dvg.22901. Epub 2015 Oct 14.


The genetics of human infertility by functional interrogation of SNPs in mice.

Singh P, Schimenti JC.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10431-6. doi: 10.1073/pnas.1506974112. Epub 2015 Aug 3.


Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes.

Lee CY, Horn HF, Stewart CL, Burke B, Bolcun-Filas E, Schimenti JC, Dresser ME, Pezza RJ.

Cell Rep. 2015 Apr 28;11(4):551-63. doi: 10.1016/j.celrep.2015.03.045. Epub 2015 Apr 16.


Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male Mice.

Melville KM, Kelly NH, Surita G, Buchalter DB, Schimenti JC, Main RP, Ross FP, van der Meulen MC.

J Bone Miner Res. 2015 Aug;30(8):1468-80. doi: 10.1002/jbmr.2488. Epub 2015 May 22.


Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.

Pattabiraman S, Baumann C, Guisado D, Eppig JJ, Schimenti JC, De La Fuente R.

J Cell Biol. 2015 Jan 5;208(1):53-69. doi: 10.1083/jcb.201404109. Epub 2014 Dec 29.


A mouse geneticist's practical guide to CRISPR applications.

Singh P, Schimenti JC, Bolcun-Filas E.

Genetics. 2015 Jan;199(1):1-15. doi: 10.1534/genetics.114.169771. Epub 2014 Sep 29. Review.


Applying "Gold Standards" to In-Vitro-Derived Germ Cells.

Handel MA, Eppig JJ, Schimenti JC.

Cell. 2014 Sep 25;159(1):216. doi: 10.1016/j.cell.2014.09.018. Epub 2014 Sep 25. No abstract available.


A method for isolating high quality RNA from mouse cortical and cancellous bone.

Kelly NH, Schimenti JC, Patrick Ross F, van der Meulen MC.

Bone. 2014 Nov;68:1-5. doi: 10.1016/j.bone.2014.07.022. Epub 2014 Jul 26.


Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling.

Luo Y, Hartford SA, Zeng R, Southard TL, Shima N, Schimenti JC.

PLoS Genet. 2014 Jul 10;10(7):e1004471. doi: 10.1371/journal.pgen.1004471. eCollection 2014 Jul. Erratum in: PLoS Genet. 2014 Sep;10(9):e1004730.


Applying "gold standards" to in-vitro-derived germ cells.

Handel MA, Eppig JJ, Schimenti JC.

Cell. 2014 Jun 5;157(6):1257-61. doi: 10.1016/j.cell.2014.05.019. Erratum in: Cell. 2014 Sep 25;159(1):216.


Induced pluripotent stem cells have similar immunogenic and more potent immunomodulatory properties compared with bone marrow-derived stromal cells in vitro.

Schnabel LV, Abratte CM, Schimenti JC, Felippe MJ, Cassano JM, Southard TL, Cross JA, Fortier LA.

Regen Med. 2014;9(5):621-35. doi: 10.2217/rme.14.29. Epub 2014 Apr 28.


miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment.

Cheng CY, Hwang CI, Corney DC, Flesken-Nikitin A, Jiang L, Öner GM, Munroe RJ, Schimenti JC, Hermeking H, Nikitin AY.

Cell Rep. 2014 Mar 27;6(6):1000-1007. doi: 10.1016/j.celrep.2014.02.023. Epub 2014 Mar 13. Erratum in: Cell Rep. 2015 Sep 29;12(12):2181.


STAG3 is a strong candidate gene for male infertility.

Llano E, Gomez-H L, García-Tuñón I, Sánchez-Martín M, Caburet S, Barbero JL, Schimenti JC, Veitia RA, Pendas AM.

Hum Mol Genet. 2014 Jul 1;23(13):3421-31. doi: 10.1093/hmg/ddu051. Epub 2014 Mar 7.


Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway.

Bolcun-Filas E, Rinaldi VD, White ME, Schimenti JC.

Science. 2014 Jan 31;343(6170):533-6. doi: 10.1126/science.1247671.


IQ motif-containing G (Iqcg) is required for mouse spermiogenesis.

Harris TP, Schimenti KJ, Munroe RJ, Schimenti JC.

G3 (Bethesda). 2014 Feb 19;4(2):367-72. doi: 10.1534/g3.113.009563.


Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength.

Melville KM, Kelly NH, Khan SA, Schimenti JC, Ross FP, Main RP, van der Meulen MC.

J Bone Miner Res. 2014 Feb;29(2):370-9. doi: 10.1002/jbmr.2082.


Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.

Wallace MD, Southard TL, Schimenti KJ, Schimenti JC.

Oncogene. 2014 Jul 10;33(28):3688-95. doi: 10.1038/onc.2013.339. Epub 2013 Aug 26.


AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice.

Schimenti KJ, Feuer SK, Griffin LB, Graham NR, Bovet CA, Hartford S, Pendola J, Lessard C, Schimenti JC, Ward JO.

Genetics. 2013 Jun;194(2):447-57. doi: 10.1534/genetics.113.150789. Epub 2013 Apr 22.


An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.

Li XZ, Roy CK, Dong X, Bolcun-Filas E, Wang J, Han BW, Xu J, Moore MJ, Schimenti JC, Weng Z, Zamore PD.

Mol Cell. 2013 Apr 11;50(1):67-81. doi: 10.1016/j.molcel.2013.02.016. Epub 2013 Mar 21.


The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.

Park J, Long DT, Lee KY, Abbas T, Shibata E, Negishi M, Luo Y, Schimenti JC, Gambus A, Walter JC, Dutta A.

Mol Cell Biol. 2013 Apr;33(8):1632-44. doi: 10.1128/MCB.01503-12. Epub 2013 Feb 11.


Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.

Flachs P, Mihola O, Simeček P, Gregorová S, Schimenti JC, Matsui Y, Baudat F, de Massy B, Piálek J, Forejt J, Trachtulec Z.

PLoS Genet. 2012;8(11):e1003044. doi: 10.1371/journal.pgen.1003044. Epub 2012 Nov 1.


Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.

Su YQ, Sun F, Handel MA, Schimenti JC, Eppig JJ.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18653-60. doi: 10.1073/pnas.1216904109. Epub 2012 Oct 22.


Tissue-specific functional networks for prioritizing phenotype and disease genes.

Guan Y, Gorenshteyn D, Burmeister M, Wong AK, Schimenti JC, Handel MA, Bult CJ, Hibbs MA, Troyanskaya OG.

PLoS Comput Biol. 2012;8(9):e1002694. doi: 10.1371/journal.pcbi.1002694. Epub 2012 Sep 27.


Using genetic networks and homology to understand the evolution of phenotypic traits.

McCune AR, Schimenti JC.

Curr Genomics. 2012 Mar;13(1):74-84. doi: 10.2174/138920212799034785.


Genetics of meiosis and recombination in mice.

Bolcun-Filas E, Schimenti JC.

Int Rev Cell Mol Biol. 2012;298:179-227. doi: 10.1016/B978-0-12-394309-5.00005-5. Review.


Genetic background affects induced pluripotent stem cell generation.

Schnabel LV, Abratte CM, Schimenti JC, Southard TL, Fortier LA.

Stem Cell Res Ther. 2012 Aug 3;3(4):30. doi: 10.1186/scrt121.


Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver.

Wallace MD, Pfefferle AD, Shen L, McNairn AJ, Cerami EG, Fallon BL, Rinaldi VD, Southard TL, Perou CM, Schimenti JC.

Genetics. 2012 Oct;192(2):385-96. doi: 10.1534/genetics.112.142802. Epub 2012 Jul 30.


MARF1 regulates essential oogenic processes in mice.

Su YQ, Sugiura K, Sun F, Pendola JK, Cox GA, Handel MA, Schimenti JC, Eppig JJ.

Science. 2012 Mar 23;335(6075):1496-9. doi: 10.1126/science.1214680.


Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.

Chuang CH, Yang D, Bai G, Freeland A, Pruitt SC, Schimenti JC.

Nucleic Acids Res. 2012 Jun;40(11):4914-24. doi: 10.1093/nar/gks176. Epub 2012 Feb 22.


MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.

Hughes CR, Guasti L, Meimaridou E, Chuang CH, Schimenti JC, King PJ, Costigan C, Clark AJ, Metherell LA.

J Clin Invest. 2012 Mar;122(3):814-20. doi: 10.1172/JCI60224. Epub 2012 Feb 22.


Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.

Fukuda T, Pratto F, Schimenti JC, Turner JM, Camerini-Otero RD, Höög C.

PLoS Genet. 2012 Feb;8(2):e1002485. doi: 10.1371/journal.pgen.1002485. Epub 2012 Feb 9.


Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells.

La Salle S, Palmer K, O'Brien M, Schimenti JC, Eppig J, Handel MA.

Biol Reprod. 2012 Feb 29;86(2):45. doi: 10.1095/biolreprod.111.095752. Print 2012 Feb.

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