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Items: 1 to 50 of 190

1.

Imatinib uptake into cells is not mediated by organic cation transporters OCT1, OCT2, or OCT3, but is influenced by extracellular pH.

Blanc Mettral J, Faller N, Cruchon S, Sottas L, Buclin T, Schild L, Choong E, Nahimana A, Decosterd LA.

Drug Metab Lett. 2019 Feb 7. doi: 10.2174/1872312813666190207150207. [Epub ahead of print]

PMID:
30734690
2.

Tafazzin-dependent cardiolipin composition in C6 glioma cells correlates with changes in mitochondrial and cellular functions, and cellular proliferation.

Gürtler S, Wolke C, Otto O, Heise N, Scholz F, Laporte A, Elsner M, Jörns A, Weinert S, Döring M, Jansing S, Gardemann A, Lendeckel U, Schild L.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):452-465. doi: 10.1016/j.bbalip.2019.01.006. Epub 2019 Jan 9.

PMID:
30639735
3.

The Differentiation of Spinal Cord Motor Neurons is Associated with Changes of the Mitochondrial Phospholipid Cardiolipin.

Keilhoff G, Mbou RP, Lucas B, Schild L.

Neuroscience. 2019 Feb 21;400:169-183. doi: 10.1016/j.neuroscience.2019.01.005. Epub 2019 Jan 11.

PMID:
30639394
4.

RAS-MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma.

Eleveld TF, Schild L, Koster J, Zwijnenburg DA, Alles LK, Ebus ME, Volckmann R, Tijtgat GA, van Sluis P, Versteeg R, Molenaar JJ.

Cancer Res. 2018 Nov 1;78(21):6297-6307. doi: 10.1158/0008-5472.CAN-18-1045. Epub 2018 Aug 16.

PMID:
30115695
5.

Human Mutations in SLC2A9 (Glut9) Affect Transport Capacity for Urate.

Ruiz A, Gautschi I, Schild L, Bonny O.

Front Physiol. 2018 Jun 18;9:476. doi: 10.3389/fphys.2018.00476. eCollection 2018.

6.

Feruloyl esterase immobilization in mesoporous silica particles and characterization in hydrolysis and transesterification.

Bonzom C, Schild L, Gustafsson H, Olsson L.

BMC Biochem. 2018 Feb 2;19(1):1. doi: 10.1186/s12858-018-0091-y.

7.

Effects of siRNA-dependent knock-down of cardiolipin synthase and tafazzin on mitochondria and proliferation of glioma cells.

Ohlig T, Le DV, Gardemann A, Wolke C, Gürtler S, Peter D, Schild L, Lendeckel U.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Apr;1863(4):379-387. doi: 10.1016/j.bbalip.2018.01.003. Epub 2018 Jan 9.

PMID:
29325722
8.

Gynostemma pentaphyllum is neuroprotective in a rat model of cardiopulmonary resuscitation.

Keilhoff G, Esser T, Titze M, Ebmeyer U, Schild L.

Exp Ther Med. 2017 Dec;14(6):6034-6046. doi: 10.3892/etm.2017.5315. Epub 2017 Oct 16.

9.

High-potential defense mechanisms of neocortex in a rat model of transient asphyxia induced cardiac arrest.

Keilhoff G, Esser T, Titze M, Ebmeyer U, Schild L.

Brain Res. 2017 Nov 1;1674:42-54. doi: 10.1016/j.brainres.2017.08.018. Epub 2017 Aug 19.

PMID:
28827077
10.

p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy.

Moreno-Smith M, Lakoma A, Chen Z, Tao L, Scorsone KA, Schild L, Aviles-Padilla K, Nikzad R, Zhang Y, Chakraborty R, Molenaar JJ, Vasudevan SA, Sheehan V, Kim ES, Paust S, Shohet JM, Barbieri E.

Clin Cancer Res. 2017 Nov 1;23(21):6629-6639. doi: 10.1158/1078-0432.CCR-17-0668. Epub 2017 Aug 18.

11.

A Missense Mutation in the Extracellular Domain of αENaC Causes Liddle Syndrome.

Salih M, Gautschi I, van Bemmelen MX, Di Benedetto M, Brooks AS, Lugtenberg D, Schild L, Hoorn EJ.

J Am Soc Nephrol. 2017 Nov;28(11):3291-3299. doi: 10.1681/ASN.2016111163. Epub 2017 Jul 14.

12.

The effects of kratom on restraint-stress-induced analgesia and its mechanisms of action.

Vázquez López JL, Schild L, Günther T, Schulz S, Neurath H, Becker A.

J Ethnopharmacol. 2017 Jun 9;205:178-185. doi: 10.1016/j.jep.2017.05.008. Epub 2017 May 10.

PMID:
28501425
13.

Proton and non-proton activation of ASIC channels.

Gautschi I, van Bemmelen MX, Schild L.

PLoS One. 2017 Apr 6;12(4):e0175293. doi: 10.1371/journal.pone.0175293. eCollection 2017.

14.

Renal Fanconi Syndrome and Hypophosphatemic Rickets in the Absence of Xenotropic and Polytropic Retroviral Receptor in the Nephron.

Ansermet C, Moor MB, Centeno G, Auberson M, Hu DZ, Baron R, Nikolaeva S, Haenzi B, Katanaeva N, Gautschi I, Katanaev V, Rotman S, Koesters R, Schild L, Pradervand S, Bonny O, Firsov D.

J Am Soc Nephrol. 2017 Apr;28(4):1073-1078. doi: 10.1681/ASN.2016070726. Epub 2016 Oct 31.

15.

Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system.

Wolter J, Schild L, Bock F, Hellwig A, Gadi I, Al-Dabet MM, Ranjan S, Rönicke R, Nawroth PP, Petersen KU, Mawrin C, Shahzad K, Isermann B.

J Thromb Haemost. 2016 Nov;14(11):2212-2226. doi: 10.1111/jth.13494. Epub 2016 Oct 20.

16.

Sciatic nerve ligation causes impairment of mitochondria associated with changes in distribution, respiration, and cardiolipin composition in related spinal cord neurons in rats.

Keilhoff G, Becker A, Kropf S, Schild L.

Mol Cell Biochem. 2016 Oct;421(1-2):41-54. doi: 10.1007/s11010-016-2782-2. Epub 2016 Aug 17.

PMID:
27535238
17.

The mitochondrial phospholipid cardiolipin is involved in the regulation of T-cell proliferation.

Mürke E, Stoll S, Lendeckel U, Reinhold D, Schild L.

Biochim Biophys Acta. 2016 Aug;1861(8 Pt A):748-54. doi: 10.1016/j.bbalip.2016.05.001. Epub 2016 May 7.

PMID:
27163692
18.

High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition.

Bate-Eya LT, den Hartog IJ, van der Ploeg I, Schild L, Koster J, Santo EE, Westerhout EM, Versteeg R, Caron HN, Molenaar JJ, Dolman ME.

Oncotarget. 2016 May 10;7(19):27946-58. doi: 10.18632/oncotarget.8547.

19.

A novel method for estimating transgender status using electronic medical records.

Roblin D, Barzilay J, Tolsma D, Robinson B, Schild L, Cromwell L, Braun H, Nash R, Gerth J, Hunkeler E, Quinn VP, Tangpricha V, Goodman M.

Ann Epidemiol. 2016 Mar;26(3):198-203. doi: 10.1016/j.annepidem.2016.01.004. Epub 2016 Feb 4.

20.

Effect of limited ischemia time on the amount and function of mitochondria within human skeletal muscle cells.

Jawhar A, Ponelies N, Schild L.

Eur J Trauma Emerg Surg. 2016 Dec;42(6):767-773. Epub 2015 Nov 25.

PMID:
26608839
21.

Cardiolipin composition correlates with prostate cancer cell proliferation.

Sapandowski A, Stope M, Evert K, Evert M, Zimmermann U, Peter D, Päge I, Burchardt M, Schild L.

Mol Cell Biochem. 2015 Dec;410(1-2):175-85. doi: 10.1007/s11010-015-2549-1. Epub 2015 Aug 28.

PMID:
26314254
22.

The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface.

van Bemmelen MX, Huser D, Gautschi I, Schild L.

PLoS One. 2015 Aug 7;10(8):e0135191. doi: 10.1371/journal.pone.0135191. eCollection 2015.

23.

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations.

Eleveld TF, Oldridge DA, Bernard V, Koster J, Colmet Daage L, Diskin SJ, Schild L, Bentahar NB, Bellini A, Chicard M, Lapouble E, Combaret V, Legoix-Né P, Michon J, Pugh TJ, Hart LS, Rader J, Attiyeh EF, Wei JS, Zhang S, Naranjo A, Gastier-Foster JM, Hogarty MD, Asgharzadeh S, Smith MA, Guidry Auvil JM, Watkins TB, Zwijnenburg DA, Ebus ME, van Sluis P, Hakkert A, van Wezel E, van der Schoot CE, Westerhout EM, Schulte JH, Tytgat GA, Dolman ME, Janoueix-Lerosey I, Gerhard DS, Caron HN, Delattre O, Khan J, Versteeg R, Schleiermacher G, Molenaar JJ, Maris JM.

Nat Genet. 2015 Aug;47(8):864-71. doi: 10.1038/ng.3333. Epub 2015 Jun 29.

24.

Dual Color Neural Activation and Behavior Control with Chrimson and CoChR in Caenorhabditis elegans.

Schild LC, Glauser DA.

Genetics. 2015 Aug;200(4):1029-34. doi: 10.1534/genetics.115.177956. Epub 2015 May 28.

25.

Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes.

Diakopoulos KN, Lesina M, Wörmann S, Song L, Aichler M, Schild L, Artati A, Römisch-Margl W, Wartmann T, Fischer R, Kabiri Y, Zischka H, Halangk W, Demir IE, Pilsak C, Walch A, Mantzoros CS, Steiner JM, Erkan M, Schmid RM, Witt H, Adamski J, Algül H.

Gastroenterology. 2015 Mar;148(3):626-638.e17. doi: 10.1053/j.gastro.2014.12.003. Epub 2014 Dec 11.

PMID:
25497209
26.

Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes.

Steiner J, Martins-de-Souza D, Schiltz K, Sarnyai Z, Westphal S, Isermann B, Dobrowolny H, Turck CW, Bogerts B, Bernstein HG, Horvath TL, Schild L, Keilhoff G.

Front Cell Neurosci. 2014 Nov 18;8:384. doi: 10.3389/fncel.2014.00384. eCollection 2014.

27.

The balance between cytoplasmic and nuclear CaM kinase-1 signaling controls the operating range of noxious heat avoidance.

Schild LC, Zbinden L, Bell HW, Yu YV, Sengupta P, Goodman MB, Glauser DA.

Neuron. 2014 Dec 3;84(5):983-96. doi: 10.1016/j.neuron.2014.10.039. Epub 2014 Nov 20.

28.

Lipidomic analysis of molecular cardiolipin species in livers exposed to ischemia/reperfusion.

Martens JC, Keilhoff G, Halangk W, Wartmann T, Gardemann A, Päge I, Schild L.

Mol Cell Biochem. 2015 Feb;400(1-2):253-63. doi: 10.1007/s11010-014-2282-1. Epub 2014 Nov 23.

PMID:
25416448
29.
30.

Oxidation of cardiolipin is involved in functional impairment and disintegration of liver mitochondria by hypoxia/reoxygenation in the presence of increased Ca²⁺ concentrations.

Martens JC, Keilhoff G, Gardemann A, Schild L.

Mol Cell Biochem. 2014 Sep;394(1-2):119-27. doi: 10.1007/s11010-014-2087-2. Epub 2014 May 18.

PMID:
24838120
31.

Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A.

García Segarra N, Gautschi I, Mittaz-Crettol L, Kallay Zetchi C, Al-Qusairi L, Van Bemmelen MX, Maeder P, Bonafé L, Schild L, Roulet-Perez E.

J Neurol Sci. 2014 Jul 15;342(1-2):69-78. doi: 10.1016/j.jns.2014.04.027. Epub 2014 Apr 27.

PMID:
24836863
32.

Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea.

Faller N, Gautschi I, Schild L.

PLoS One. 2014 Apr 10;9(4):e94267. doi: 10.1371/journal.pone.0094267. eCollection 2014.

33.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

34.

Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours.

Bate-Eya LT, Ebus ME, Koster J, den Hartog IJ, Zwijnenburg DA, Schild L, van der Ploeg I, Dolman ME, Caron HN, Versteeg R, Molenaar JJ.

Eur J Cancer. 2014 Feb;50(3):628-37. doi: 10.1016/j.ejca.2013.11.015. Epub 2013 Dec 6.

PMID:
24321263
35.

Dynamic switching between escape and avoidance regimes reduces Caenorhabditis elegans exposure to noxious heat.

Schild LC, Glauser DA.

Nat Commun. 2013;4:2198. doi: 10.1038/ncomms3198.

PMID:
23887613
36.

A randomized prospective trial of a worksite intervention program to increase physical activity.

Gazmararian JA, Elon L, Newsome K, Schild L, Jacobson KL.

Am J Health Promot. 2013 Sep-Oct;28(1):32-40. doi: 10.4278/ajhp.110525-QUAN-220. Epub 2013 Mar 7.

PMID:
23470188
37.

Spontaneous hypothermia is not able to completely counteract cardiac arrest-induced mitochondrial impairment in the rat heart.

Keilhoff G, Ebmeyer U, Schild L.

Neonatology. 2013;103(2):131-3. doi: 10.1159/000345224. Epub 2012 Dec 1.

PMID:
23208449
39.

A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation.

Wagener J, Schneider JJ, Baxmann S, Kalbacher H, Borelli C, Nuding S, Küchler R, Wehkamp J, Kaeser MD, Mailänder-Sanchez D, Braunsdorf C, Hube B, Schild L, Forssmann WG, Korting HC, Liepke C, Schaller M.

J Invest Dermatol. 2013 Jan;133(1):144-53. doi: 10.1038/jid.2012.254. Epub 2012 Jul 26.

40.

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy.

Lamers F, Schild L, Koster J, Speleman F, Øra I, Westerhout EM, van Sluis P, Versteeg R, Caron HN, Molenaar JJ.

BMC Cancer. 2012 Jul 12;12:285. doi: 10.1186/1471-2407-12-285.

41.

Candida albicans scavenges host zinc via Pra1 during endothelial invasion.

Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D.

PLoS Pathog. 2012;8(6):e1002777. doi: 10.1371/journal.ppat.1002777. Epub 2012 Jun 28.

42.

Preconditioning of brain slices against hypoxia induced injury by a Gynostemma pentaphyllum extract--stimulation of anti-oxidative enzyme expression.

Schild L, Cotte T, Keilhoff G, Brödemann R.

Phytomedicine. 2012 Jun 15;19(8-9):812-8. doi: 10.1016/j.phymed.2012.03.012. Epub 2012 Apr 17.

PMID:
22516894
43.

Composition of molecular cardiolipin species correlates with proliferation of lymphocytes.

Schild L, Lendeckel U, Gardemann A, Wiswedel I, Schmidt CA, Wolke C, Walther R, Grabarczyk P, Busemann C.

Exp Biol Med (Maywood). 2012 Apr;237(4):372-9. doi: 10.1258/ebm.2011.011311. Epub 2012 Apr 4.

PMID:
22490512
44.

Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract.

Müller C, Gardemann A, Keilhoff G, Peter D, Wiswedel I, Schild L.

Phytomedicine. 2012 Mar 15;19(5):395-401. doi: 10.1016/j.phymed.2011.12.002. Epub 2012 Feb 29.

PMID:
22381945
45.

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes.

Molenaar JJ, Koster J, Zwijnenburg DA, van Sluis P, Valentijn LJ, van der Ploeg I, Hamdi M, van Nes J, Westerman BA, van Arkel J, Ebus ME, Haneveld F, Lakeman A, Schild L, Molenaar P, Stroeken P, van Noesel MM, Ora I, Santo EE, Caron HN, Westerhout EM, Versteeg R.

Nature. 2012 Feb 22;483(7391):589-93. doi: 10.1038/nature10910.

PMID:
22367537
46.

Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth.

Lamers F, Schild L, den Hartog IJ, Ebus ME, Westerhout EM, Ora I, Koster J, Versteeg R, Caron HN, Molenaar JJ.

Eur J Cancer. 2012 Nov;48(16):3093-103. doi: 10.1016/j.ejca.2012.01.037. Epub 2012 Feb 25.

47.

Dronedarone prevents microcirculatory abnormalities in the left ventricle during atrial tachypacing in pigs.

Bukowska A, Hammwöhner M, Sixdorf A, Schild L, Wiswedel I, Röhl FW, Wolke C, Lendeckel U, Aderkast C, Bochmann S, Chilukoti RK, Mostertz J, Bramlage P, Goette A.

Br J Pharmacol. 2012 Jun;166(3):964-80. doi: 10.1111/j.1476-5381.2011.01784.x.

48.

Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression.

Lamers F, Schild L, Koster J, Versteeg R, Caron HN, Molenaar JJ.

Eur J Cancer. 2012 Mar;48(5):763-71. doi: 10.1016/j.ejca.2011.10.012. Epub 2011 Nov 14.

49.

Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe.

Lamers F, van der Ploeg I, Schild L, Ebus ME, Koster J, Hansen BR, Koch T, Versteeg R, Caron HN, Molenaar JJ.

Endocr Relat Cancer. 2011 Oct 27;18(6):657-68. doi: 10.1530/ERC-11-0207. Print 2011 Oct.

PMID:
21859926
50.

The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation.

Seider K, Brunke S, Schild L, Jablonowski N, Wilson D, Majer O, Barz D, Haas A, Kuchler K, Schaller M, Hube B.

J Immunol. 2011 Sep 15;187(6):3072-86. doi: 10.4049/jimmunol.1003730. Epub 2011 Aug 17.

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