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A common neural signature of brain injury in concussion and subconcussion.

Hirad AA, Bazarian JJ, Merchant-Borna K, Garcea FE, Heilbronner S, Paul D, Hintz EB, van Wijngaarden E, Schifitto G, Wright DW, Espinoza TR, Mahon BZ.

Sci Adv. 2019 Aug 7;5(8):eaau3460. doi: 10.1126/sciadv.aau3460. eCollection 2019 Aug.


A multivoxel pattern analysis framework with mutual connectivity analysis investigating changes in resting state connectivity in patients with HIV associated neurocognitve disorder.

DSouza AM, Abidin AZ, Schifitto G, Wismüller A.

Magn Reson Imaging. 2019 Oct;62:121-128. doi: 10.1016/j.mri.2019.06.001. Epub 2019 Jun 9.


Progressive brain atrophy in chronically infected and treated HIV+ individuals.

Nir TM, Jahanshad N, Ching CRK, Cohen RA, Harezlak J, Schifitto G, Lam HY, Hua X, Zhong J, Zhu T, Taylor MJ, Campbell TB, Daar ES, Singer EJ, Alger JR, Thompson PM, Navia BA; HIV Neuroimaging Consortium.

J Neurovirol. 2019 Jun;25(3):342-353. doi: 10.1007/s13365-019-00723-4. Epub 2019 Feb 14.


Automated diagnosis of HIV-associated neurocognitive disorders using large-scale Granger causality analysis of resting-state functional MRI.

Chockanathan U, DSouza AM, Abidin AZ, Schifitto G, Wismüller A.

Comput Biol Med. 2019 Mar;106:24-30. doi: 10.1016/j.compbiomed.2019.01.006. Epub 2019 Jan 15.


Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.

Singh MV, Kotla S, Le NT, Ae Ko K, Heo KS, Wang Y, Fujii Y, Thi Vu H, McBeath E, Thomas TN, Jin Gi Y, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates KJ, Hurley C, Fujiwara K, Maggirwar SB, Schifitto G, Abe JI.

Circulation. 2019 Feb 26;139(9):1199-1216. doi: 10.1161/CIRCULATIONAHA.118.036232.


Identification and functional characterization of HIV-associated neurocognitive disorders with large-scale Granger causality analysis on resting-state functional MRI.

Chockanathan U, DSouza AM, Abidin AZ, Schifitto G, Wismüller A.

Proc SPIE Int Soc Opt Eng. 2018 Feb;10575. pii: 105750Z. doi: 10.1117/12.2293888. Epub 2018 Feb 27.


Electrocardiogram Abnormalities Suggest Aberrant Cardiac Conduction in Huntington's Disease.

Stephen CD, Hung J, Schifitto G, Hersch SM, Rosas HD.

Mov Disord Clin Pract. 2018 Apr 11;5(3):306-311. doi: 10.1002/mdc3.12596. eCollection 2018 May-Jun.


Functional and structural connectivity of the amygdala underpins locus of control in mild cognitive impairment.

Ren P, Chapman B, Zhang Z, Schifitto G, Lin F.

Neuroimage Clin. 2018 Jul 23;20:297-304. doi: 10.1016/j.nicl.2018.07.021. eCollection 2018.


Plane-Wave Imaging Improves Single-Track Location Shear Wave Elasticity Imaging.

Ahmed R, Gerber SA, McAleavey SA, Schifitto G, Doyley MM.

IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Aug;65(8):1402-1414. doi: 10.1109/TUFFC.2018.2842468. Epub 2018 Jun 1.


Mutual connectivity analysis of resting-state functional MRI data with local models.

DSouza AM, Abidin AZ, Chockanathan U, Schifitto G, Wismüller A.

Neuroimage. 2018 Sep;178:210-223. doi: 10.1016/j.neuroimage.2018.05.038. Epub 2018 May 17.


Visualizing Angle-Independent Principal Strains in the Longitudinal View of the Carotid Artery: Phantom and In Vivo Evaluation.

Nayak R, Schifitto G, Doyley MM.

Ultrasound Med Biol. 2018 Jul;44(7):1379-1391. doi: 10.1016/j.ultrasmedbio.2018.03.012. Epub 2018 Apr 22.


Alteration of brain network topology in HIV-associated neurocognitive disorder: A novel functional connectivity perspective.

Abidin AZ, DSouza AM, Nagarajan MB, Wang L, Qiu X, Schifitto G, Wismüller A.

Neuroimage Clin. 2017 Dec 7;17:768-777. doi: 10.1016/j.nicl.2017.11.025. eCollection 2018.


Combination antiretroviral therapy improves cognitive performance and functional connectivity in treatment-naïve HIV-infected individuals.

Zhuang Y, Qiu X, Wang L, Ma Q, Mapstone M, Luque A, Weber M, Tivarus M, Miller E, Arduino RC, Zhong J, Schifitto G.

J Neurovirol. 2017 Oct;23(5):704-712. doi: 10.1007/s13365-017-0553-9. Epub 2017 Aug 8.


The CREST-E study of creatine for Huntington disease: A randomized controlled trial.

Hersch SM, Schifitto G, Oakes D, Bredlau AL, Meyers CM, Nahin R, Rosas HD; Huntington Study Group CREST-E Investigators and Coordinators.

Neurology. 2017 Aug 8;89(6):594-601. doi: 10.1212/WNL.0000000000004209. Epub 2017 Jul 12.


Noninvasive carotid artery elastography using multielement synthetic aperture imaging: Phantom and in vivo evaluation.

Nayak R, Schifitto G, Doyley MM.

Med Phys. 2017 Aug;44(8):4068-4082. doi: 10.1002/mp.12329. Epub 2017 Jun 30.


Principal Strain Vascular Elastography: Simulation and Preliminary Clinical Evaluation.

Nayak R, Huntzicker S, Ohayon J, Carson N, Dogra V, Schifitto G, Doyley MM.

Ultrasound Med Biol. 2017 Mar;43(3):682-699. doi: 10.1016/j.ultrasmedbio.2016.11.010. Epub 2017 Jan 2.


Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis.

Jackson JW, Singh MV, Singh VB, Jones LD, Davidson GA, Ture S, Morrell CN, Schifitto G, Maggirwar SB.

PLoS One. 2016 Jun 6;11(6):e0157115. doi: 10.1371/journal.pone.0157115. eCollection 2016.


Spatial regression analysis of serial DTI for subject-specific longitudinal changes of neurodegenerative disease.

Liu B, Qiu X, Zhu T, Tian W, Hu R, Ekholm S, Schifitto G, Zhong J.

Neuroimage Clin. 2016 Feb 21;11:291-301. doi: 10.1016/j.nicl.2016.02.009. eCollection 2016.


Improved spatial regression analysis of diffusion tensor imaging for lesion detection during longitudinal progression of multiple sclerosis in individual subjects.

Liu B, Qiu X, Zhu T, Tian W, Hu R, Ekholm S, Schifitto G, Zhong J.

Phys Med Biol. 2016 Mar 21;61(6):2497-513. doi: 10.1088/0031-9155/61/6/2497. Epub 2016 Mar 7.


Are Structural Changes Induced by Lithium in the HIV Brain Accompanied by Changes in Functional Connectivity?

Tivarus ME, Pester B, Schmidt C, Lehmann T, Zhu T, Zhong J, Leistritz L, Schifitto G.

PLoS One. 2015 Oct 5;10(10):e0139118. doi: 10.1371/journal.pone.0139118. eCollection 2015.


Simulation of changes in diffusion related to different pathologies at cellular level after traumatic brain injury.

Lin M, He H, Schifitto G, Zhong J.

Magn Reson Med. 2016 Jul;76(1):290-300. doi: 10.1002/mrm.25816. Epub 2015 Aug 10.


Plasma and Cerebrospinal Fluid Biomarkers Predict Cerebral Injury in HIV-Infected Individuals on Stable Combination Antiretroviral Therapy.

Anderson AM, Harezlak J, Bharti A, Mi D, Taylor MJ, Daar ES, Schifitto G, Zhong J, Alger JR, Brown MS, Singer EJ, Campbell TB, McMahon DD, Buchthal S, Cohen R, Yiannoutsos C, Letendre SL, Navia BA; HIV Neuroimaging Consortium.

J Acquir Immune Defic Syndr. 2015 May 1;69(1):29-35. doi: 10.1097/QAI.0000000000000532.


Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment.

Sacktor N, Miyahara S, Evans S, Schifitto G, Cohen B, Haughey N, Drewes JL, Graham D, Zink MC, Anderson C, Nath A, Pardo CA, McCarthy S, Hosey L, Clifford D; ACTG A5235 team.

J Neurovirol. 2014 Dec;20(6):620-6. doi: 10.1007/s13365-014-0292-0. Epub 2014 Nov 7.


Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART.

Harezlak J, Cohen R, Gongvatana A, Taylor M, Buchthal S, Schifitto G, Zhong J, Daar ES, Alger JR, Brown M, Singer EJ, Campbell TB, McMahon D, So YT, Yiannoutsos CT, Navia BA; HIV Neuroimaging Consortium.

J Neurovirol. 2014 Jun;20(3):294-303. doi: 10.1007/s13365-014-0246-6. Epub 2014 Apr 3.


Disrupted cerebral metabolite levels and lower nadir CD4 + counts are linked to brain volume deficits in 210 HIV-infected patients on stable treatment.

Hua X, Boyle CP, Harezlak J, Tate DF, Yiannoutsos CT, Cohen R, Schifitto G, Gongvatana A, Zhong J, Zhu T, Taylor MJ, Campbell TB, Daar ES, Alger JR, Singer E, Buchthal S, Toga AW, Navia B, Thompson PM; HIV Neuroimaging Consortium.

Neuroimage Clin. 2013 Aug 3;3:132-42. doi: 10.1016/j.nicl.2013.07.009. eCollection 2013.


SPatial REgression Analysis of Diffusion tensor imaging (SPREAD) for longitudinal progression of neurodegenerative disease in individual subjects.

Zhu T, Hu R, Tian W, Ekholm S, Schifitto G, Qiu X, Zhong J.

Magn Reson Imaging. 2013 Dec;31(10):1657-67. doi: 10.1016/j.mri.2013.07.016. Epub 2013 Oct 5.


Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.

Ma Q, Gelbard HA, Maggirwar SB, Dewhurst S, Gendelman HE, Peterson DR, DiFrancesco R, Hochreiter JS, Morse GD, Schifitto G.

J Neurovirol. 2013 Jun;19(3):254-60. doi: 10.1007/s13365-013-0172-z. Epub 2013 Jun 5.


Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy.

Gongvatana A, Harezlak J, Buchthal S, Daar E, Schifitto G, Campbell T, Taylor M, Singer E, Algers J, Zhong J, Brown M, McMahon D, So YT, Mi D, Heaton R, Robertson K, Yiannoutsos C, Cohen RA, Navia B; HIV Neuroimaging Consortium.

J Neurovirol. 2013 Jun;19(3):209-18. doi: 10.1007/s13365-013-0162-1. Epub 2013 Apr 24.


Valproic acid inhibits the release of soluble CD40L induced by non-nucleoside reverse transcriptase inhibitors in human immunodeficiency virus infected individuals.

Davidson DC, Schifitto G, Maggirwar SB.

PLoS One. 2013;8(3):e59950. doi: 10.1371/journal.pone.0059950. Epub 2013 Mar 28.


Noninvasive vascular elastography using plane-wave and sparse-array imaging.

Korukonda S, Nayak R, Carson N, Schifitto G, Dogra V, Doyley MM.

IEEE Trans Ultrason Ferroelectr Freq Control. 2013 Feb;60(2):332-42. doi: 10.1109/TUFFC.2013.2569.


NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials.

Brown S, Simpson DM, Moyle G, Brew BJ, Schifitto G, Larbalestier N, Orkin C, Fisher M, Vanhove GF, Tobias JK.

AIDS Res Ther. 2013 Jan 28;10(1):5. doi: 10.1186/1742-6405-10-5.


Patterns of white matter injury in HIV infection after partial immune reconstitution: a DTI tract-based spatial statistics study.

Zhu T, Zhong J, Hu R, Tivarus M, Ekholm S, Harezlak J, Ombao H, Navia B, Cohen R, Schifitto G.

J Neurovirol. 2013 Feb;19(1):10-23. doi: 10.1007/s13365-012-0135-9. Epub 2012 Nov 21.


HIV neuropathy: an in vivo confocal microscopic study.

Almodovar JL, Schifitto G, McDermott MP, Ferguson M, Herrmann DN.

J Neurovirol. 2012 Dec;18(6):503-10. doi: 10.1007/s13365-012-0130-1. Epub 2012 Oct 16.


CCL3L1 gene copy number in individuals with and without HIV-associated neurocognitive disorder.

Brown A, Sacktor N, Marder K, Cohen B, Schifitto G, Skolasky RL, Creighton J, Guo L, McArthur JC.

Curr Biomark Find. 2012 Jan 1;2012(2):1-6.


Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial.

Sacktor N, Miyahara S, Deng L, Evans S, Schifitto G, Cohen BA, Paul R, Robertson K, Jarocki B, Scarsi K, Coombs RW, Zink MC, Nath A, Smith E, Ellis RJ, Singer E, Weihe J, McCarthy S, Hosey L, Clifford DB; ACTG A5235 team.

Neurology. 2011 Sep 20;77(12):1135-42. doi: 10.1212/WNL.0b013e31822f0412. Epub 2011 Sep 7.


Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies.

Tate DF, Sampat M, Harezlak J, Fiecas M, Hogan J, Dewey J, McCaffrey D, Branson D, Russell T, Conley J, Taylor M, Schifitto G, Zhong J, Daar ES, Alger J, Brown M, Singer E, Campbell T, McMahon D, Tso Y, Matesan J, Letendre S, Paulose S, Gaugh M, Tripoli C, Yiannoutsos C, Bigler ED, Cohen RA, Guttmann CR, Navia B; HIV Neuroimaging Consortium.

J Neurovirol. 2011 Aug;17(4):368-79. doi: 10.1007/s13365-011-0033-6. Epub 2011 May 10. Erratum in: J Neurovirol. 2011 Aug;17(4):380-1. Schifitto, Giavoni [corrected to Schifitto, Giovanni].


Osteopontin enhances HIV replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals.

Brown A, Islam T, Adams R, Nerle S, Kamara M, Eger C, Marder K, Cohen B, Schifitto G, McArthur JC, Sacktor N, Pardo CA.

J Neurovirol. 2011 Aug;17(4):382-92. doi: 10.1007/s13365-011-0035-4. Epub 2011 May 10.


Peripheral neuropathy in HIV: prevalence and risk factors.

Evans SR, Ellis RJ, Chen H, Yeh TM, Lee AJ, Schifitto G, Wu K, Bosch RJ, McArthur JC, Simpson DM, Clifford DB.

AIDS. 2011 Apr 24;25(7):919-28. doi: 10.1097/QAD.0b013e328345889d.


Quantification of accuracy and precision of multi-center DTI measurements: a diffusion phantom and human brain study.

Zhu T, Hu R, Qiu X, Taylor M, Tso Y, Yiannoutsos C, Navia B, Mori S, Ekholm S, Schifitto G, Zhong J.

Neuroimage. 2011 Jun 1;56(3):1398-411. doi: 10.1016/j.neuroimage.2011.02.010. Epub 2011 Feb 18.


Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment.

Harezlak J, Buchthal S, Taylor M, Schifitto G, Zhong J, Daar E, Alger J, Singer E, Campbell T, Yiannoutsos C, Cohen R, Navia B; HIV Neuroimaging Consortium.

AIDS. 2011 Mar 13;25(5):625-33. doi: 10.1097/QAD.0b013e3283427da7.


Clinical, laboratory, and neuroimaging characteristics of fatigue in HIV-infected individuals.

Schifitto G, Deng L, Yeh TM, Evans SR, Ernst T, Zhong J, Clifford D.

J Neurovirol. 2011 Feb;17(1):17-25. doi: 10.1007/s13365-010-0010-5. Epub 2010 Dec 23.


Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.

Davidson DC, Hirschman MP, Spinelli SL, Morrell CN, Schifitto G, Phipps RP, Maggirwar SB.

J Immunol. 2011 Jan 1;186(1):584-91. doi: 10.4049/jimmunol.1001911. Epub 2010 Nov 29.


Cerebral metabolite abnormalities in human immunodeficiency virus are associated with cortical and subcortical volumes.

Cohen RA, Harezlak J, Gongvatana A, Buchthal S, Schifitto G, Clark U, Paul R, Taylor M, Thompson P, Tate D, Alger J, Brown M, Zhong J, Campbell T, Singer E, Daar E, McMahon D, Tso Y, Yiannoutsos CT, Navia B; HIV Neuroimaging Consortium.

J Neurovirol. 2010 Nov;16(6):435-44. doi: 10.3109/13550284.2010.520817. Epub 2010 Oct 20.


Memantine for AIDS dementia complex: open-label report of ACTG 301.

Zhao Y, Navia BA, Marra CM, Singer EJ, Chang L, Berger J, Ellis RJ, Kolson DL, Simpson D, Miller EN, Lipton SA, Evans SR, Schifitto G; Adult Aids Clinical Trial Group (ACTG) 301 Team.

HIV Clin Trials. 2010 Jan-Feb;11(1):59-67. doi: 10.1310/hct1101-59.


Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial.

Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R; 1066 HIV Neuropathy Study Group.

Neurology. 2010 Feb 2;74(5):413-20. doi: 10.1212/WNL.0b013e3181ccc6ef.


Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era.

Cohen RA, Harezlak J, Schifitto G, Hana G, Clark U, Gongvatana A, Paul R, Taylor M, Thompson P, Alger J, Brown M, Zhong J, Campbell T, Singer E, Daar E, McMahon D, Tso Y, Yiannoutsos CT, Navia B.

J Neurovirol. 2010 Feb;16(1):25-32. doi: 10.3109/13550280903552420.


Neuroprotective activities of CEP-1347 in models of neuroAIDS.

Eggert D, Dash PK, Gorantla S, Dou H, Schifitto G, Maggirwar SB, Dewhurst S, Poluektova L, Gelbard HA, Gendelman HE.

J Immunol. 2010 Jan 15;184(2):746-56. doi: 10.4049/jimmunol.0902962. Epub 2009 Dec 4.


Lopinavir cerebrospinal fluid steady-state trough concentrations in HIV-infected adults.

DiCenzo R, DiFrancesco R, Cruttenden K, Donnelly J, Schifitto G.

Ann Pharmacother. 2009 Dec;43(12):1972-7. doi: 10.1345/aph.1M399. Epub 2009 Nov 24.


Selegiline and oxidative stress in HIV-associated cognitive impairment.

Schifitto G, Yiannoutsos CT, Ernst T, Navia BA, Nath A, Sacktor N, Anderson C, Marra CM, Clifford DB; ACTG 5114 Team.

Neurology. 2009 Dec 8;73(23):1975-81. doi: 10.1212/WNL.0b013e3181c51a48. Epub 2009 Nov 4.


Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance.

Marra CM, Zhao Y, Clifford DB, Letendre S, Evans S, Henry K, Ellis RJ, Rodriguez B, Coombs RW, Schifitto G, McArthur JC, Robertson K; AIDS Clinical Trials Group 736 Study Team.

AIDS. 2009 Jul 17;23(11):1359-66. doi: 10.1097/QAD.0b013e32832c4152.

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